Health
Hormone therapy boosts weight loss drug results by 35% in women, study finds
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For women struggling with weight gain after menopause, a new study suggests that adding hormone therapy to a popular obesity drug may lead to greater weight loss.
Postmenopausal women lost about 35% more weight when using menopausal hormone therapy alongside tirzepatide — a GLP-1-based, Food and Drug Administration-approved drug for the overweight and obese — compared to those taking the drug alone, according to a Mayo Clinic study.
The findings, published in February in The Lancet Obstetrics, Gynaecology, & Women’s Health, highlight a possible new strategy for addressing weight gain after menopause, when hormonal shifts can increase the risk of obesity, cardiovascular disease and Type 2 diabetes.
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“This study provides important insights for developing more effective and personalized strategies for managing cardiometabolic risk in postmenopausal women,” Dr. Regina Castaneda, the study’s first author, said in a statement.
A new study found that postmenopausal women lost more weight when combining hormone therapy with a GLP-1-based drug. (iStock)
Researchers analyzed 120 postmenopausal women who were overweight or obese who took tirzepatide for at least 12 months, including 40 who also used hormone therapy and 80 who did not.
Hormone therapy is commonly used to treat menopause symptoms like hot flashes and night sweats, while tirzepatide helps regulate appetite and blood sugar.
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Women in the hormone therapy group lost an average of 19.2% of their body weight, compared to 14.0% in the non-hormone group — about 35% greater relative weight loss — with more women reaching significant weight-loss thresholds, according to the study.
Despite the results, researchers emphasized that the study was observational and cannot prove cause and effect.
Hormonal changes after menopause can increase weight gain and health risks. (iStock)
“Because this was not a randomized trial, we cannot say hormone therapy caused additional weight loss,” said Dr. Maria Daniela Hurtado Andrade, an endocrinologist at Mayo Clinic and senior author of the study.
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Outside experts agree that the findings must be interpreted cautiously.
“As with all observational studies, we need to interpret this study with a grain of salt,” Dr. Gillian Goddard, a board-certified endocrinologist, told Fox News Digital.
Goddard, who is also an adjunct assistant professor of medicine at the NYU Grossman School of Medicine, noted that the findings show a link but do not prove that hormone therapy, which usually includes estrogen, directly caused the additional weight loss.
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“There may be important differences between the two groups,” she added. “For one thing, the group taking estrogen may be healthier than the groups that didn’t take estrogen. … Healthier people are more likely to eat a healthy diet and exercise in addition to taking tirzepatide. That could lead to more weight loss.”
Tirzepatide, a GLP-1-based drug, may be more effective for weight loss when paired with hormone therapy, according to researchers. (iStock)
Symptom relief from the therapy may have also improved sleep and well-being, making it easier for the group to maintain diet and exercise routines, Hurtado Andrade noted.
Researchers also pointed to a possible biological explanation. Preclinical data suggest estrogen may enhance the appetite-suppressing effects of GLP-1-based medications like tirzepatide, according to the study.
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Goddard said that theory is plausible but unproven.
Hormone therapy may ease menopause symptoms and help women stay on track with diet and exercise. (iStock)
“The other possibility is that estrogen interacts with tirzepatide in some way that makes it more potent,” she said. “We will need randomized studies to get a better handle on that.”
As for safety, experts say using the two together appears safe for most women. However, hormone therapy is not recommended for all patients, especially those with a history of certain cancers, blood clots or other underlying health risks, according to the Mayo Clinic.
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Researchers say future randomized trials will aim to confirm the findings and explore whether the combination also improves broader cardiometabolic health outcomes, according to the study.
Experts say more research is needed to confirm whether hormone therapy directly boosts weight loss results with GLP-1 drugs. (iStock)
“If confirmed, this work could speed the development and adoption of new, evidence-based strategies to reduce this risk for millions of postmenopausal women navigating this life stage,” Hurtado Andrade said.
Fox News Digital has reached out to the study authors for comment.
Health
Pediatricians group stands up for kids’ rapidly shrinking recess time: ‘Very powerful benefit’
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Recess may look like downtime, but pediatricians say cutting it could cost kids far more than a few minutes on the playground.
The American Academy of Pediatrics released updated guidance for the first time in more than a decade that urges schools to protect recess, highlighting that the unstructured break delivers major benefits for kids’ health, learning and behavior.
“It has a very powerful benefit if it’s used to the fullest,” said Dr. Robert Murray, a lead author of the new guidance, which was published Monday in the journal Pediatrics.
Researchers say recess helps students reset between lessons, improving focus and memory. It also gives kids time to build social skills, boost confidence and stay physically active, a key factor as 1 in 5 U.S. children and teens struggle with obesity.
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Students play ball during recess at St. Agnes Elementary School in Phoenix, Ariz., on March 3, 2020. (Dario Lopez-Mills/AP)
Despite those benefits, recess time has been shrinking for years. Since the mid-2000s, up to 40% of school districts have reduced or eliminated it, according to data from the Springboard to Active Schools group and U.S. Centers for Disease Control and Prevention.
The group is pushing schools to reverse that trend, recommending at least 20 minutes of daily recess and multiple breaks. It further warned against using it as punishment.
Whittier Elementary School students enjoy recess in Mesa, Ariz., on Oct. 18, 2022. (Matt York/AP)
“If the child is disruptive or rude and disrespectful, recess is one of the things that teachers use to punish kids,” Murray said, noting that those students often need it most.
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Doctors also stress that recess isn’t just for younger children. As screen time rises, older students need time to unplug, move and recharge.
Elementary school students play tag outside on the grass during recess. (iStock)
“As kids get older, they’re more on their screens,” said Dr. Lauren Fiechtner, a pediatric specialist. “So it’s really helpful, I think, for outdoor activity and recess to be happening. Recess is great. We all kind of need recess.”
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In other countries such as Denmark, Japan and the United Kingdom, students already get more frequent breaks, often after every 45 to 50 minutes of instruction. Experts say this model could help U.S. schools improve both learning and student well-being.
The Associated Press contributed to this report.
Health
Cruise ship linked to deadly Hantavirus outbreak arrives off Tenerife as passenger evacuation begins
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The cruise ship linked to a deadly Hantavirus outbreak arrived early Sunday off the Spanish island of Tenerife, where passengers began to evacuate and fly to their home countries.
Passengers are being tested by Spanish health authorities to ensure they are asymptomatic before being transported ashore in small boats, Spanish officials said, according to Reuters.
Spanish health authorities confirmed that the first plane carrying the Spanish passengers has departed for a military hospital in Madrid, where they will be under quarantine.
The 17 Americans aboard the MV Hondius will be flown to a medical center in Nebraska after health officials allow them to disembark.
AMERICANS TO BE EVACUATED FROM HANTAVIRUS CRUISE SHIP AS GLOBAL HEALTH CHIEF TRAVELS TO QUARANTINE ISLAND
The cruise ship MV Hondius arrives at the port of Granadilla de Abona after being affected by a Hantavirus outbreak, in Tenerife, Spain, May 10, 2026. (REUTERS/Hannah McKay)
A Centers for Disease Control and Prevention (CDC) official told ABC News on Saturday morning that federal officials currently do not plan to mandate quarantine when the American passengers arrive in Nebraska.
They will instead be screened upon arrival in the U.S. and either stay briefly at Nebraska’s National Quarantine Unit or return home to monitor for symptoms for 42 days while staying in contact with local health authorities, the official said.
The ship set course for Spain on Wednesday from the coast of Cape Verde after the WHO and European Union requested assistance in managing the outbreak.
The ship’s arrival comes hours after World Health Organization Director-General Dr. Tedros Adhanom Ghebreyesus arrived on the island.
The WHO said Friday that eight people aboard the ship had fallen ill, including three who died. Six cases have been confirmed, with two others suspected.
HANTAVIRUS DEATHS ON CRUISE SHIP HIGHLIGHT DANGERS OF RODENT-BORNE DISEASE
A cruise ship linked to a Hantavirus outbreak anchored near the Spanish island of Tenerife ahead of a planned evacuation. (REUTERS/Hannah McKay)
In a statement Saturday, Ghebreyesus said the public health risk remains low.
“I know you are worried. I know that when you hear the word ‘outbreak’ and watch a ship sail toward your shores, memories surface that none of us have fully put to rest,” he said.
“The pain of 2020 is still real, and I do not dismiss it for a single moment. But I need you to hear me clearly: this is not another COVID-19. The current public health risk from Hantavirus remains low. My colleagues and I have said this unequivocally, and I will say it again to you now,” he continued.
ARGENTINA INVESTIGATORS ZERO IN ON POSSIBLE ORIGIN POINT OF HANTAVIRUS IN DEADLY CRUISE OUTBREAK
A police boat operates next to the cruise ship MV Hondius at the port of Granadilla de Abona after being affected by a hantavirus outbreak, in Tenerife, Spain, May 10, 2026. (REUTERS/Hannah McKay)
Ghebreyesus noted that the virus identified aboard the ship is the Andes strain of hantavirus, which can be severe.
“Three people have lost their lives, and our hearts go out to their families,” he wrote, reiterating that the public health risk posed by the virus remained low.
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An ambulance evacuates patients from the MV Hondius cruise ship to the airport in Praia, Cape Verde, on May 6, 2026. (Misper Apawu/AP)
About 30 crew members are expected to remain on board as the vessel continues to the Netherlands, where it will be disinfected.
Fox News Digital’s Robert McGreevy, The Associated Press and Reuters contributed to this report.
Health
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