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Experimental women's cancer drug boosts survival rates in notable study

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Experimental women's cancer drug boosts survival rates in notable study

A new drug is showing promise in tackling treatment-resistant ovarian cancer.

Relacorilant, the drug tested in a phase 3 ROSELLA trial with Corcept Therapeutics in California, was found to improve overall survival and progression of the disease when matched with a chemotherapy drug called nab-paclitaxel.

The ROSELLA trial, conducted in collaboration with The GOG Foundation, analyzed 381 patients around the world, including the U.S., Europe, South Korea, Brazil, Argentina, Canada and Australia, according to a press release.

AI DETECTS OVARIAN CANCER BETTER THAN HUMAN EXPERTS IN NEW STUDY

The large, randomized phase 3 study revealed a 30% reduction in risk of disease progression in patients with platinum-resistant ovarian cancer, compared to those just treated with nab-paclitaxel. (Some types of chemotherapy contain the element platinum.)

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Patients whose disease returns less than six months after receiving platinum-containing therapy have “platinum-resistant” disease, according to Corcept Therapeutics. (iStock)

The researchers also noted “significant improvement” in overall survival with this combination of drugs.

Relacorilant, which is administered as an oral pill, was reportedly “well-tolerated” by patients without increased side effects.

“A 30% decrease in risk of recurrence and a 31% decreased risk of death is promising.”

The drug is administered by mouth one day before, the day of and one day after nab-paclitaxel therapy, which is given via infusion every week.

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The findings will be presented at a medical conference later this year, researchers say. Results from the Phase 2 were published in the Journal of Clinical Oncology in 2023.

OVARIAN CANCER TREATMENT ON FAST TRACK FOR FDA APPROVAL AS CHEMO ALTERNATIVES EMERGE: ‘WE’RE MAKING PROGRESS’

Ovarian cancer is the fifth most common cause of cancer death in women and is the deadliest of gynecologic cancers, according to the Ovarian Cancer Research Alliance.

Alexander B. Olawaiye, MD, director of gynecological cancer research at Magee-Women’s Hospital at the University of Pittsburgh and principal investigator in the ROSELLA trial, discussed the results with Fox News Digital.

cancer researcher looks into a microscope

Relacorilant, which is administered as an oral pill, was reportedly “well-tolerated” by patients without increased side effects. (iStock)

Olawaiye echoed that this new agent is the “first of its kind” in the battle against cancers that don’t have many treatment options.

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“That’s what makes the findings of this study really exciting, because it did show a very significant improvement in both progression-free survival and overall survival,” he said.

OVARIAN CANCER SIGNS, SYMPTOMS, DIAGNOSIS AND TREATMENT OPTIONS

The expert shared his gratitude to his research team, mentioning that they “never stopped trying” for women undergoing treatment.

“I want to congratulate the women that are being treated for ovarian cancer — first, for helping us to do this trial and second, for the potential that we may now have another option on the block.”

female cancer survivor rings the bell

Patients in the trial showed a 30% decrease in death risk, according to researchers. (iStock)

Dr. Brian Slomovitz, director of gynecologic oncology and co-chair of the Cancer Research Committee at Mount Sinai Medical Center in Miami Beach, Florida, also commented on these findings in an interview with Fox News Digital.

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“We know ovarian cancer is very, very difficult to treat, particularly in those patients who have a disease that’s resistant to the standard chemotherapies,” he said.

“For a long time, we’ve been trying to find treatments that can help patients not only keep the disease away longer, but also live longer. And most of the trials, unfortunately, have been negative.”

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Slomovitz, a member of The GOG Foundation, said he considers the ROSELLA trial an “opportunity to use a unique drug” that has shown “positive, encouraging results.”

“A 30% decrease in risk of recurrence and a 31% decreased risk of death is promising,” he stated.

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oncologist hooking up a woman battling cancer to an IV

Relacorilant is administered one day before, the day of and one day after nab-paclitaxel chemotherapy, which is given via infusion every week. (iStock)

“To see data like this is refreshing, and it represents something that’s exciting for our patients who suffer from ovarian cancer.”

Olawaiye shared his hope for the treatment to receive clinical approval “pretty soon.”

For more Health articles, visit www.foxnews.com/health

As research and technology advance, various cancer treatments have surfaced in the last several years.

      

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Olawaiye commented that the past two decades have been a “very exciting time,” as there’s been an “explosion of approvals” for cancer therapies.

“Today’s news about Relacorilant is just another addition,” he said.

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She Worked in a Harvard Lab to Reverse Aging, Until ICE Jailed Her

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She Worked in a Harvard Lab to Reverse Aging, Until ICE Jailed Her

Ms. Petrova’s return flight from Paris landed in Boston on the evening of Feb. 16. As the plane sat on the tarmac, she texted back and forth with Dr. Peshkin, trying to confirm how she should handle the package in customs. But by then, the passengers were already filing off the plane, he said, and Ms. Petrova cut short the conversation.

At first, Ms. Petrova said, her re-entry felt normal. At passport control, an officer examined the J-1 visa that Harvard had sponsored, identifying her as a biomedical researcher. The officer stamped her passport, admitting her to the country.

Then, as she headed toward the baggage claim, a Border Patrol officer approached her and asked to search her suitcase. All she could think was that the embryo samples inside would be ruined; RNA degrades easily. She explained that she didn’t know the rules. The officer was polite, she recalled, and told her she would be allowed to leave.

Then a different officer came into the room, and the tone of the conversation changed, Ms. Petrova said. This officer asked detailed questions about the samples, Ms. Petrova’s work history and her travel in Europe. The official then informed Ms. Petrova that she was canceling her visa and asked her whether she was afraid to be deported to Russia.

“Yes, I am scared to go back to Russia,” she said, according to a Department of Homeland Security transcript provided by her lawyer. “I am afraid the Russian Federation will kill me for protesting against them.”

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Ms. Petrova’s attorney, Greg Romanovsky, said that Customs and Border Protection had overreached its authority by canceling her visa. He acknowledged that she had violated customs regulations but said it was a minor offense, punishable by forfeiture and a fine.

To cancel her visa, Mr. Romanovsky said, the agents needed to identify grounds for excluding her. “There are many, many grounds of inadmissibility, but violating a customs rule is certainly not one of them,” he said.

Lucas Guttentag, a professor at Stanford Law School, reviewed documents in the case and agreed. He said that Ms. Petrova had been legally admitted to the United States, and then “the government itself created the alleged improper immigration status that is now the basis for her detention.”

“Subjecting anyone to this process is wrong, and this case is both shocking and revealing,” said Mr. Guttentag, who served as a senior Justice Department advisor under President Biden and senior advisor to the D.H.S. during the Obama administration.

In February, customs officials detained Ms. Petrova at Logan International Airport in Boston for failing to declare samples of frog embryos.Credit…M. Scott Brauer for The New York Times

A spokesperson for the D.H.S., asked why Ms. Petrova’s visa had been canceled, said that a canine inspection found petri dishes and vials of embryonic stem cells in her luggage without proper permits.

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“The individual was lawfully detained after lying to federal officers about carrying biological substances into the country,” the spokesperson said. “Messages on her phone revealed she planned to smuggle the materials through customs without declaring them. She knowingly broke the law and took deliberate steps to evade it.”

When the border patrol agent canceled Ms. Petrova’s visa, she became an undocumented immigrant, among the thousands detained since Mr. Trump took office. She was sent to the Richwood Detention Center to await a hearing in which she will present her case for asylum to an immigration judge.

“If she wins, she will not be deported,” Mr. Romanovsky said. “If she loses, she will be deported to Russia.”

He has also filed a petition for her release in federal court, and pressed ICE to release her on parole. “I am basically pleading for mercy,” he said. “In a different environment, I think she would have been out a long time ago.”

Ms. Petrova has spent the last month in a dormitory lined with rows of bunk beds. It is cold, and at night, the women sometimes shiver under thin blankets. Once a day, they are allowed an hour outside. Breakfast comes at different times, sometimes as early as 3:30 a.m. The hardest thing, she said, is the constant noise. The facility’s psychiatrist gave her earplugs to help her sleep.

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Unable to work, she observes the women around her. Around half are Latin Americans in their 30s and 40s who crossed the border for economic reasons, she said. A second group is made up of Asians and citizens of former Soviet states, who crossed the border legally, seeking political asylum.

None of them deserve to be held under these conditions, she said. “I thought this was impossible, to be in this situation,” she said. “Even immigrants here, they have to have some rights. But it seems that nobody really cares about our rights here.”

It has challenged the view of America that she formed in Russia. “This is not the kind of America I used to know,” she said.

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Golfer Phil Mickelson’s strict weight loss diet: Doctor shares what to know

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Golfer Phil Mickelson’s strict weight loss diet: Doctor shares what to know

Professional golfer Phil Mickelson, who made his 32nd start in The Masters this week, has been open about his commitment to health and wellness.

The six-time major champion and three-time Masters winner has said he follows a five-day prolonged fast, which led to him dropping 25 pounds in 2023.

Intermittent fasting (IF) has become a popular weight-loss strategy in recent years.

THIS WEIGHT LOSS PLAN PERFORMS BETTER THAN TRADITIONAL DIETING, STUDY FINDS

There are several types of intermittent fasting — but they all follow the same concept of alternating between fasting and eating. 

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Phil Mickelson is pictured competing in golf tournaments 24 years apart, in 2001 (left) and 2025 (right). The six-time major champion and three-time Masters winner has said he follows a five-day prolonged fast, which led to him dropping 25 pounds in 2023. (Reuters / AP )

With a time-restricted approach, the dieter only eats during a certain window. For example, with the 16/8 method, the person fasts for 16 hours and then can eat within an eight-hour span, between 10 a.m. and 6 p.m. 

Other versions involve fasting for a full 24 hours once or twice per week — or only consuming limited calories on fasting days.

FASTING-LIKE DIET COULD SLOW THE AGING PROCESS, STUDY SUGGESTS: ‘LIVING LONGER AND HEALTHIER’

Dr. Christopher Rhodes — a longevity, fasting and biomimetics researcher in California, shared his thoughts on Mickelson’s radical fasting program, which also includes drinking coffee with supplements.

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“A five-day prolonged fast like the one Phil Mickelson follows will have profound effects on metabolism and weight loss,” he told Fox News Digital.

Phil Mickelson watches on the sixth hole during the first round at the Masters golf tournament, Thursday, April 10, 2025, in Augusta, Ga. (AP Photo/Julia Demaree Nikhinson)

Phil Mickelson watches on the sixth hole during the first round at the Masters golf tournament on April 10, 2025, in Augusta, Georgia. The athlete has been open about his commitment to health and wellness. (AP Photos)

“It fundamentally shifts the energy state and fuel sources in the body and forces stored fat to be burned as energy, but certainly at the expense of elite athletic performance, especially in the later stages of a fast.”

Potential risks

Fasting for longer than 24 hours will deplete the body’s glycogen stores and cause it to enter ketosis, a state where it primarily burns fat and ketones for energy, according to Rhodes, who is also the founder of nutrition company Mimio Health.

“While this will accelerate fat loss and provide benefits to overall metabolic health, the body will still need to produce some of its own glucose in order to support brain function and will start to break down protein sources, like muscle, to maintain proper glucose levels.”

“A five-day prolonged fast like the one Phil Mickelson follows will have profound effects on metabolism and weight loss.”

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Over time, this will result in muscle breakdown, strength loss, fatigue and lower overall energy levels, which could hinder athletic performance, according to the expert.

Mickelson has spoken about his own muscle loss as a result of his fasting.

“I also lost muscle, so I had to start lifting, and I’ve been lifting and slowly have been getting my speed and strength back to where I need it to be,” he said during the 2023 Masters.

Intermittent fasting

There are several types of intermittent fasting — but they all follow the same concept of alternating between fasting and eating.  (iStock)

For elite athletes, maintaining muscle mass and metabolic flexibility is critical, Rhodes said.

“Extended fasts may slow down recovery, impair high-intensity exercise performance and even reduce power output if not properly managed.” 

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The doctor cautioned that a prolonged five-day fast should not be performed more than a few times per year, with plenty of recovery time in between.

FASTING COULD REDUCE SIGNS OF ALZHEIMER’S DISEASE, STUDIES SUGGEST: ‘PROFOUND EFFECTS’

Certain groups — such as those at risk of muscle loss, like the elderly — should avoid five-day fasts, he said.

“While fasting can improve insulin sensitivity, cognition, cellular function and metabolic efficiency, shorter intermittent fasting windows or fasting-mimicking strategies may offer similar metabolic benefits without the drawbacks of extreme caloric restriction,” Rhodes added.

Smart supplements

Mickelson reportedly drinks coffee with supplements during his fasts, something Rhodes recommends as a means of preserving energy and muscle mass during weight loss.

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“During prolonged fasting, the body begins to break down both protein and fat for energy, which can lead to muscle loss,” he said.

hot pot of coffee

Mickelson reportedly drinks coffee with supplements during his fasts, something Rhodes recommends as a means of preserving energy and muscle mass during weight loss. (iStock)

“Supplements such as amino acids, fatty acids, electrolytes and certain metabolic bioactives can help mitigate this.”

The doctor noted that supplementing with branched-chain amino acids (BCAAs), creatine or HMB (hydroxymethylbutyrate) can help to preserve muscle tissue, performance and strength while staying in a fasted state. 

INTERMITTENT FASTING COULD REDUCE HAIR GROWTH, STUDY REVEALS

“Likewise, supplementing with essential vitamins, minerals, amino acids and omega 3s like EPA and DHA, which the body cannot produce on its own, would be crucial for maintaining high-level functionality during prolonged multi-day fasting,” he added.

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Masters Golf Photo Gallery

Phil Mickelson hits from the fairway on the first hole during the first round at the Masters golf tournament on April 10, 2025, in Augusta, Georgia. For elite athletes, maintaining muscle mass and metabolic flexibility is critical, Rhodes said. (AP Photos)

Caffeine from coffee can also serve to provide calorie-free energy, Rhodes noted, while also suppressing appetite and providing a cognitive boost to combat potential fasting-induced brain fog. 

“Prolonged fasting can deplete electrolytes like sodium, potassium and magnesium, which are essential for muscle function, hydration and energy production,” he said. “If his supplements include these electrolytes, they may help prevent cramping and fatigue.”

Importance of strength training

Regarding Mickelson’s comments about lifting weights during his fasting stints, Rhodes agreed that weightlifting is essential for preserving and building muscle during weight loss. 

“The body operates on a ‘use it or lose it’ principle, especially during periods of caloric restriction or fasting, where it’s actively needing to mobilize energy sources from the body to sustain itself,” the doctor said. 

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“Muscle is one of the most energetically costly tissues to sustain, so if we’re not using it on a daily basis, the body will preferentially start breaking down muscle to conserve energy.”

Woman lifting weights

Weightlifting is essential for preserving and building muscle during weight loss, experts agree. (iStock)

Resistance training sends a signal to the body that lean mass is essential for survival and tells it to prevent excessive muscle breakdown, prioritizing fat for fuel.

“For athletes like Mickelson, weightlifting also helps maintain neuromuscular coordination, joint integrity and power output,” Rhodes said. 

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“Strength training improves insulin sensitivity, enhances metabolic rate and ensures that weight loss comes primarily from fat rather than muscle.”

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It’s also important to refuel after a fast with adequate protein intake, the expert added.

Finding healthy patterns

Ultimately, according to Rhodes, the best way to support long-term weight loss and metabolic health is to find a pattern of eating that works for the individual and can be sustained for the long haul. 

“During prolonged fasting, the body begins to break down both protein and fat for energy, which can lead to muscle loss.”

“While some find that periods of fasting are helpful in resetting their hunger and satiety cues and developing a better relationship with food, others may find it too restrictive and overwhelming, setting themselves up for failure and rebound binging down the road,” he said. 

For more Health articles, visit www.foxnews.com/health

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“Every person is different, but prioritizing nutrient-dense, minimally processed foods that are rich in fiber, protein and healthy fats can aid significantly in reducing cravings and improving quality of life and meal satisfaction.”

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Experts Doubt Kennedy’s Timetable for Finding the Cause of Autism

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Experts Doubt Kennedy’s Timetable for Finding the Cause of Autism

Robert F. Kennedy Jr., the nation’s health secretary, pledged on Thursday to seek out experts globally to discover the reasons for the increasing rates of autism in the United States.

“We’ve launched a massive testing and research effort that’s going to involve hundreds of scientists from around the world,” Mr. Kennedy announced at a cabinet meeting held by President Trump. “By September, we will know what has caused the autism epidemic and we’ll be able to eliminate those exposures.”

“There will be no bigger news conference than that,” Mr. Trump replied.

But scientists who have worked for decades to find a cause greeted Mr. Kennedy’s predicted timeline with skepticism.

They said that a single answer would be hard to identify in a field of possible contributors including pesticides, air pollution and maternal diabetes.

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Dr. Philip Landrigan, a pediatrician and expert on environmental toxins, pointed to the current mass layoffs and cutbacks for research at Mr. Kennedy’s Department of Health and Human Services as one reason for doubting such quick progress.

“Given that a great deal of research on autism and other pediatric diseases in hospitals and medical schools is currently coming to a halt because of federal funding cuts from H.H.S.,” he said, “it is very difficult for me to imagine what profound scientific breakthrough could be achieved between now and September.”

Mr. Kennedy’s office did not offer many details on the plan. Later on Thursday, Mr. Kennedy revealed a few more clues, saying that the National Institutes of Health would lead the effort.

He said the Centers for Disease Control and Prevention would soon release data showing that the autism diagnoses had now increased to one of every 31 children. Many scientists and doctors attributed the rise in autism rates over the last several decades in part to growing awareness of the disorder and to expanded diagnoses along a spectrum.

“We are launching requests to scientists from all over the country and all over the world,” Mr. Kennedy said in an interview on Fox News. “Everything is on the table: our food system, our water, our air, different ways of parenting, all the kind of changes that may have triggered this epidemic.”

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In the interview, Mr. Kennedy also said an important part of the effort would be to compare autism rates in vaccinated and unvaccinated children. It’s an angle that many scientists dismiss, saying that parents who vaccinate their children are also more likely to get a diagnosis, given higher rates of interaction with health providers.

Many scientists who have observed Mr. Kennedy’s dogged opposition to many vaccines over two decades — and his frequent attempts to tie autism to vaccines — have dismissed his claims, citing the scientific consensus that debunked any such link. Scrutiny of his pledges to begin “gold standard” research only heightened in recent weeks when David Geier, a largely discredited researcher, was hired at H.H.S. to study any potential link between vaccines and autism.

Irva Hertz-Picciotto, director of environmental epidemiology of neurodevelopment at the University of California at Davis MIND Institute, said she had been seeking a cause for autism for 20 years.

It’s an exciting time for the field, she said, with multiple studies beginning to point to factors that could play a role. Among the possible links are pesticide exposure through food or nearby agricultural fields; workplace exposures to solvents; fevers or infections during pregnancy; maternal diabetes; and exposure to chemicals in plastics called phthalates or to PFAS, known as “forever chemicals” for their tendency to persist in the environment.

Some studies have found that the effect of environmental exposures can vary based on a person’s genes, “emphasizing the complexity of this syndrome.” Dr. Hertz-Picciotto said it was challenging to get funding for clinical studies that could shed light on a cause of autism, but new research could help advance the field. Those studies, though, could take years.

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That all of the research could be sorted out by September, she said, was “ludicrous.”

Dr. Alice Kuo, the chief of pediatric medicine who cares for children and adults with autism at the University of California, Los Angeles, said she was involved in a yearslong project by the National Institutes of Health called the National Children’s Study. It followed thousands of children and parents and elicited information, including the possible causes of autism. The study was costly and ended far earlier than planned, Dr. Kuo said.

She said an effort to do something as rigorous would take months to plan and design — and years to arrive at an answer.

In a social media post on Thursday, Mr. Kennedy recognized the assistance of the president and the Make America Healthy Again Commission — a subgroup of the cabinet that includes Linda McMahon, the education secretary, and Russell Vought, director of the Office of Management and Budget. Like Mr. Kennedy, they are not doctors or scientists.

“Thanks to your MAHA Commission, we’ll soon identify the root causes of the autism epidemic,” Mr. Kennedy wrote in a social media post.

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Created by an executive order in February, the commission is charged with assessing in 100 days the threat to children of food ingredients, chemicals, medications and other exposures. Within 180 days, the commission is expected to submit a strategy to the president to address its findings.

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