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Experimental cholesterol pill cuts heart attack risk with 'convenient' once-daily dose

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Experimental cholesterol pill cuts heart attack risk with 'convenient' once-daily dose

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A new daily pill could provide an easier, more convenient way to lower cholesterol and reduce heart attack and stroke risk.

The experimental medication, called Obicetrapib, underwent a Phase 3 clinical trial at Monash University in Australia.

The trial included more than 2,500 people averaging 65 years of age. All had either been diagnosed with heart disease or had genetically high cholesterol, according to a university press release. 

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All participants were receiving “maximum tolerated doses” of cholesterol-lowering therapy.

One group received Obicetrapib and another group took a placebo, while still maintaining their existing cholesterol drugs. 

A new daily pill could provide an easier, more convenient way to lower cholesterol and reduce heart attack and stroke risk. (iStock)

After 12 weeks, the participants taking the new drug showed a 32.6% reduction in LDL cholesterol and a 33.5% drop in lipoprotein(a) [Lp(a)], the release stated.

The findings were presented last month at the European Atherosclerosis Society Congress in the U.K. and were also published in The New England Journal of Medicine.

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“We know that many people at high risk of heart attack or stroke don’t get their cholesterol levels low enough, even on the best available treatments,” said study lead Professor Stephen Nicholls, director of Monash University’s Victorian Heart Institute and Monash Health’s Victorian Heart Hospital, in the release.

“We know that many people at high risk of heart attack or stroke don’t get their cholesterol levels low enough, even on the best available treatments.”

“Obicetrapib offers a promising new option — not only did it lower LDL cholesterol by over 30%, but we also saw a reduction in Lp(a), which is much harder to treat and has been linked to increased heart disease risk.”

LDL cholesterol

Low-density lipoprotein (LDL), which is sometimes called “bad cholesterol,” is associated with negative health effects when present in high amounts. (iStock)

Low-density lipoprotein (LDL), which is sometimes called “bad cholesterol,” is associated with negative health effects when present in high amounts.

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LDL can build up in the blood vessels and increase heart attack and stroke risk, the researchers cautioned.

Lipoprotein(a), or Lp(a), is a protein that is known to greatly increase the chances of a heart attack when it’s present in high levels in the blood.

Unlike LDL, Lp(a) is an inherited risk factor that can’t be modified with healthy behaviors or medications.

Man holding chest

Lipoprotein(a), or Lp(a), is a protein that is known to greatly increase the chances of a heart attack when it’s present in high levels in the blood. (iStock)

Obicetrapib was found to be “well-tolerated” by the participants, the researchers noted. 

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“This could be a valuable tool in the fight against heart disease,” Nicholls added. “It’s convenient, it’s effective, and it may help close the gap for patients who’ve run out of options.”

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The study — which was funded by NewAmsterdam Pharma, a developer of Obicetrapib that is based in the Netherlands — did have some limitations, the researchers noted.

man puts pill in mouth

Obicetrapib was found to be “well-tolerated” by the participants, the researchers noted.  (iStock)

For example, the participants were not chosen based on high Lp(a), which means the study did not determine how the drug impacted those with elevated levels of the protein.

Additionally, the study assessed changes in LDL levels, but did not measure actual heart attack or stroke outcomes.

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More studies are needed to follow patients for longer time periods and to include more diverse cohorts, the researchers acknowledged.

Fox News Digital reached out to the researchers for additional comment.

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TikTok Users Swear by Protein Jell-O for Weight Loss: Does It Work?

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TikTok Users Swear by Protein Jell-O for Weight Loss: Does It Work?


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'Western diet' blamed for growing risk of GI cancers among young adults

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'Western diet' blamed for growing risk of GI cancers among young adults

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The rates of gastrointestinal (GI) cancers are rising among young adults, with a new peer-reviewed study pointing to the American diet and lifestyle as the primary culprits.

The rising risk in younger generations may be linked more to environmental factors than genetics, stated the report, which was recently published in the British Journal of Surgery.

“Some shared risk factors for early-onset (EO) GI cancer include obesity, sedentary lifestyle, excessive alcohol consumption and smoking,” lead researcher Sara Char, M.D., at the Dana Farber Cancer Institute in Boston, told Fox News Digital.

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The study notes that recent generations are more likely to adopt a “Western-pattern diet” and a “sedentary lifestyle.”

Colorectal is the most common type of early-onset GI cancer, but pancreatic, esophageal, gastric, biliary, appendiceal and neuroendocrine cancers are also rising in adults under 50, Char noted.

The report notes that recent generations are more likely to adopt a “Western-pattern diet” and a sedentary lifestyle. (iStock)

Adults born in 1990 have twice the risk of colon cancer and four times the risk of rectal cancer compared to those born in 1950, according to a previous study published in the Journal of the National Cancer Institute.

How diet impacts risk

Paul Oberstein, M.D., director of the Gastrointestinal Medical Oncology Program at NYU Langone’s Perlmutter Cancer Center, told Fox News Digital that a person’s diet does indeed impact the risk of colon cancer.

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“It is reported from previous studies that when someone has a higher amount of foods typical of a Western diet, they have a higher risk of colon cancer,” said Oberstein, who was not involved in the research.

A “Western diet” typically includes a higher intake of red and processed meats, processed and added sugars, and highly processed and refined grains, according to the oncologist.

A doctor holding a dark blue ribbon for colon cancer

Adults born in 1990 have twice the risk of colon cancer and four times the risk of rectal cancer compared to those born in 1950. (iStock)

Processed deli meats, sugary drinks and processed grain snacks are also commonly associated with this type of diet. 

Research and recommendations

While the incidence of colon cancer in this group overall remains low, Oberstein recommends investing in more research to explore which factors are causing the increase.

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“We need to conduct more research on whether diet, vitamin supplements, alcohol or other things we ingest or use are contributing to this increase,” he said. 

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The expert also emphasized the importance of following the recommended colon cancer screening guidelines, which begin at 45 years old for most people, and seeking medical attention if any symptoms appear.

Belly fat

“We need to conduct more research on whether diet, vitamin supplements, alcohol or other things we ingest or use are contributing to this increase,” an oncologist said.  (iStock)

Common warning signs include changes in bowel habits, blood in the stool, unexplained back or abdominal pain, or unintentional weight loss, all of which warrant speaking to a doctor for an “urgent evaluation,” according to Char.

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The researcher added that younger individuals can take preventative measures such as not smoking, avoiding excessive alcohol, limiting red meat consumption, staying physically active and maintaining a healthy body weight.

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John Goodman, 72, Says His 200-Lb. Weight Loss Helps Him ‘Live Life Better’

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John Goodman, 72, Says His 200-Lb. Weight Loss Helps Him ‘Live Life Better’


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