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Cannabis compounds could reverse disease affecting one-third of adults

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Cannabis compounds could reverse disease affecting one-third of adults

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Compounds found in cannabis could provide a new roadmap for treating the world’s most common chronic liver disorder, according to a study released by the Hebrew University of Jerusalem.

The research, published in the British Journal of Pharmacology, found that cannabidiol (CBD) and cannabigerol (CBG) significantly reduced liver fat and improved metabolic health in experimental models.

CBD is the more widely studied non-intoxicating cannabinoid, while CBG is a less common “precursor” cannabinoid from which CBD is formed.

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Unlike THC, the primary psychoactive component in cannabis, these compounds do not produce a “high,” making them viable candidates for long-term medical treatment, the study suggests.

Metabolic dysfunction-associated steatotic liver disease (MASLD) currently affects approximately one-third of the global adult population, according to health data.

Metabolic dysfunction-associated steatotic liver disease (MASLD) currently affects approximately one-third of the global adult population. (iStock)

The condition, which is closely linked to obesity and insulin resistance, has few approved pharmaceutical treatments, the researchers said, leaving patients to rely largely on lifestyle changes that can be difficult to maintain. 

“Our findings identify a new mechanism by which CBD and CBG enhance hepatic energy and lysosomal function,” said lead study author Joseph Tam, director of the Multidisciplinary Center for Cannabinoid Research at Hebrew University, in a press release.

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The study highlights a process called “metabolic remodeling,” in which the cannabis compounds created a “backup battery” for the liver by increasing levels of phosphocreatine, a high-energy molecule stored in muscle cells.

This energy reserve helps the organ function under the stress of a high-fat diet, which was an unexpected discovery, the team noted.

Researchers focused on CBD and CBG, two non-psychoactive compounds that offer therapeutic benefits without the “high” associated with THC. (iStock)

The researchers also found that CBD and CBG restored the activity of “cellular cleaning crews” known as cathepsins, enzymes that work within the cell’s recycling centers to break down harmful fats and waste.

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With this process, the liver was better able to clear out dangerous lipids, including triglycerides and ceramides, which are known to trigger inflammation, the study showed.

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While both compounds were effective, CBG showed more robust results in certain areas, such as reducing total body fat mass, lowering “bad” LDL cholesterol and improving insulin sensitivity.

Researchers say this study opens a new path for using plant-based compounds to treat metabolic diseases by focusing on how cells manage energy and waste.

The discovery of a phosphocreatine “backup battery” in the liver marks a significant shift in how scientists understand the organ’s ability to survive high-fat diets. (iStock)

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Limitations and caveats

Despite the promising results, the research team cautioned that the study was conducted in a controlled experimental environment. Further clinical trials are necessary to determine the proper application for human patients.

Other recent studies have pointed to potential issues with using cannabis as a medical tool.

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A major analysis published in JAMA examined more than 2,500 scientific papers from the last 15 years, including other reviews, clinical trials and guidelines focused on medical marijuana.

The 2025 review highlighted significant gaps between public perception and scientific evidence regarding cannabis’ effectiveness for most medical conditions.

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Other recent studies have pointed to issues with the efficacy of cannabis as a medical tool. (iStock)

The researchers concluded that there are very few conditions for which cannabinoid therapies have clear, well-established benefits backed by high-quality clinical data.

“Whenever a substance is widely used, there is likely to be a very wide set of outcomes,” Alex Dimitriu, MD, who is double board-certified in psychiatry and sleep medicine and founder of Menlo Park Psychiatry & Sleep Medicine, previously told Fox News Digital. “This study points to the reality that this widely used substance is not a panacea.”

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The strongest evidence supports FDA-approved cannabinoid medications for treating specific conditions, including HIV/AIDS-related appetite loss, chemotherapy-induced nausea and vomiting, and certain severe pediatric seizure disorders, according to the review.

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Anyone interested in using marijuana for medical purposes should speak to a healthcare provider to discuss potential risks and benefits.

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Selena Gomez says she was ‘misdiagnosed’ before receiving bipolar diagnosis

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Selena Gomez says she was ‘misdiagnosed’ before receiving bipolar diagnosis

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Actress and singer Selena Gomez continues to be outspoken about mental health following her diagnosis with bipolar disorder.

The former Disney star announced her diagnosis in 2020 during an Instagram Live video call with fellow Disney Channel standout Miley Cyrus. Gomez has since described this discovery as a relief, although not an easy path.

In a recent episode of the “Friends Keep Secrets” podcast, Gomez – the co-founder of mental health publication Wondermind – shared details about her journey to diagnosis.

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Fellow musician and husband Benny Blanco asked his wife if she knew she was bipolar before being officially diagnosed.

“I knew something was wrong, but I think I was misdiagnosed,” she responded. “I think people were just assuming – and I would try multiple therapists.”

Actress and singer Selena Gomez continues to be outspoken about mental health following her diagnosis with bipolar disorder. (Michael Buckner/2026GG/Penske Media via Getty Images)

“It’s actually really hard when we’re talking about these things, and for me to go, ‘Go get a therapist.’ All of it is so … complicated.”

Gomez detailed how her diagnosis required talking to “multiple different people,” stressing the importance of not giving up.

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“I’m so grateful I went to four different rehabs because it all helped me understand it,” she said.

Blanco revealed that Gomez sometimes experiences a manic episode without recognizing it.

“She’ll start to realize she’s having it after it’s happening, and sometimes she doesn’t even remember when it’s happening,” he said.

“It’s such a delicate thing because … you’re not supposed to, technically, talk to the person about it while they’re deep in it.”

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Blanco added that Gomez is “so hyper aware” of when she’s experiencing mania.

“I’m equally proud to say that I do have moments of mania,” she said. “I’m not ashamed at all, because I can catch them a bit quicker.”

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“It is helpful to have a partner who will understand … and meet you where you are,” the singer added.

Since her diagnosis, Gomez said she lives life more “freely.”

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“The whole hypocrisy of shaming people for therapy, or people not understanding it, is that it’s just not for you,” she said. “But for me, it finally allowed me to go, ‘Oh, that’s why I handled things the way I [did]. That’s why all the other people were able to get over things quickly, and I wasn’t.’”

Blanco (left) revealed that Gomez sometimes experiences a manic episode without recognizing it. (Emma McIntyre)

Gomez added, “I’d act out of fear, I’d act out of love, I’d act out of passion, it was all inconsistent. It was crazy.”

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The actress encouraged others that no matter the diagnosis, “you are not defined by a term.”

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“It’s just informative to seek and talk and listen to podcasts or listen to certain things that will help you get information,” she said. “I do believe there is a lot of hope.”

Signs of bipolar disorder

About 2.8% of adults in the U.S. have experienced bipolar in the last year, while 4.4% experience it during their lifetime, according to the National Institutes of Health.

Formerly called manic depression or “manic-depressive disorder,” bipolar disorder is characterized by dramatic shifts in mood, energy and activity levels, affecting the ability to carry out daily tasks.

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This can include emotional highs, referred to as mania or hypomania, and lows, known as depression, per Mayo Clinic.

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Symptoms can differ depending on bipolar type.

“You are not defined by a term.”

Manic and hypomanic episodes typically include three or more of the following symptoms:

  • Increased activity, energy or agitation
  • Feeling too self-confident, or having a distorted sense of well-being
  • Needing less sleep than usual
  • Speaking quickly or being unusually talkative
  • Having racing thoughts or jumping from one topic to the next
  • Being easily distracted
  • Making poor decisions

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Major depressive episodes include symptoms like feeling sad, empty and hopeless. (iStock)

Major depressive episodes typically include five or more of the following symptoms.

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  • Feeling depressed, sad, empty, hopeless or tearful
  • Having a loss of interest or feeling no pleasure in most activities
  • Losing weight when not dieting, or overeating and gaining weight
  • Sleeping too much or too little
  • Feeling restless or acting slower than usual
  • Feeling very tired or losing energy
  • Feeling worthless or guilty when unnecessary
  • Struggling with thinking or concentrating, leading to an inability to make decisions
  • Thinking about, planning or attempting suicide

Formerly called manic depression or “manic-depressive disorder,” bipolar disorder is characterized by dramatic shifts in mood, energy and activity levels. (iStock)

Seeking diagnosis

Mayo Clinic encourages anyone experiencing these symptoms to seek help from a professional.

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Diagnosis can be made through a physical exam and lab testing, as well as mental health assessments and tracking of moods, sleep patterns and other factors.

After diagnosis, Mayo Clinic recommends paying attention to warning signs to prevent episodes. Getting enough sleep, taking medications as directed, and abstaining from drugs and alcohol can also help.

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Fox News Digital reached out to Gomez’s representation and Wondermind for comment.

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Happier and healthier people do these 6 things every day, says wellness expert

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Happier and healthier people do these 6 things every day, says wellness expert

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The goal for most people is to live a long and happy life.

There are several habits that happy and healthy people observe as they age, according to behavioral scientist and happiness expert Arthur Brooks, professor at the Harvard Kennedy School and Harvard Business School in Boston.

In a recent appearance on Dr. Rhonda Patrick’s FoundMyFitness podcast, Brooks referenced data from the Harvard Study of Adult Development – an 85-year longitudinal study of adult life – which identified six typical habits of people who are happier and healthier.

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While the first three habits are “obvious,” Brooks said, the other three are often overlooked.

No. 1: Follow a healthy diet

Research shows that a nutritious, balanced diet supports both physical health and mental well-being over time.

No. 2: Exercise frequently

For exercise, Brooks noted that doing too much can backfire. Those who are “exercise maniacs” could run the risk of doing “mechanical ill” to the body, he warned.

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No. 3: Abstain from smoking and drinking

“They’re very moderate on substances, none of them were addicts,” Brooks said. “Or if they had trouble with it, they quit.”

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“Lifelong smokers have a seven in 10 chance of dying of a smoking-related illness – and that’s an unhappy way to go.”

“And actually, you’re probably not happy and there’s a lot of compensation that’s going on,” he continued. “That’s how a lot of former alcoholics re-sample: They become addicted.”

Balanced exercise is a strong, foundation habit for health and happiness. (iStock)

No. 4: Never stop learning

People who are lifelong learners tend to be healthier and happier, according to the expert.

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“That’s usually a lot of reading, but it’s just curiosity is how that comes about, which is really, really important,” he said on the podcast.

Lifelong learning can boost happiness and overall health, according to the expert. (iStock)

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No. 5: Become a skilled problem-solver

Brooks described this concept as “your technique for dealing with life’s problems.”

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“You’ve got to get good at it,” he said. “You need skill at dealing with life’s problems. If you don’t get good at it, you’re going to be bad when things actually crop up.”

People who have the best lives have a strong marriage and/or close friendships, Brooks said. (iStock)

“All the happy and well people have their way [of dealing] with it, and they’re highly skilled in doing it.”

Some healthy ways to cope include therapy, meditation, prayer and journaling, according to Brooks.

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No. 6: Love

“People who have the best lives, who are happy and well when they’re older, have a strong marriage and/or close friendships,” Brooks said.

“That’s it. There’s no substitute for love. Happiness is love – full stop.”

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Sleeping 11 minutes longer each night shows surprising health benefit, study finds

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Sleeping 11 minutes longer each night shows surprising health benefit, study finds

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The secret to a healthier heart may not be a major lifestyle overhaul, but rather a series of small, sustainable daily habits.

New research published in the European Journal of Preventive Cardiology found that combining modest shifts in daily habits is associated with a significantly reduced risk of major cardiovascular events, including heart attacks, stroke and heart failure.

The study, which followed more than 53,000 adults over an eight-year period, highlighted how even the smallest increase in rest can yield clinically meaningful benefits.

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Researchers found that sleeping for just 11 minutes more per night was a key component of a lifestyle shift associated with a 10% lower risk of major cardiovascular events.

Small daily habits like getting just 11 extra minutes of sleep each night can significantly reduce the risk of heart problems. (iStock)

This modest increase in sleep was most effective when paired with an additional 4.5 minutes of moderate-to-vigorous physical activity and eating an extra quarter-cup of vegetables every day.

“We show that combining small changes in a few areas of our lives can have a surprisingly large positive impact on our cardiovascular health,” said lead author Nicholas Koemel, a research fellow at the University of Sydney.

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While every extra minute counts, the study identified an ideal range for maximum heart protection that could slash the risk of heart disease by 57% compared to those with the least healthy habits.

The primary pillar of that profile was achieving eight to nine hours of sleep per night, the study noted.

Getting eight to nine hours of sleep each night, along with consistent healthy habits, can reduce the risk of heart disease by up to 57%. (iStock)

This optimal routine also included completing 42 minutes or more of moderate physical activity per day and maintaining a diet high in fish, whole grains, and dairy while remaining low in processed meats and sugary drinks.

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“Making even modest shifts in our daily routines is likely to have cardiovascular benefits as well as create opportunities for further changes in the long run,” Koemel added. “I would encourage people not to overlook the importance of making a small change or two to your daily routine, no matter how small they may seem.”

Researchers utilized wearable devices to track the sleep and movement of participants, providing more accurate data than previous self-reported studies.

This ideal routine also involves a diet rich in fish, whole grains, and dairy while limiting processed meats and sugary drinks. (iStock)

Several limitations were noted for the research.

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The study was observational, meaning it showed a strong link between these small habits and heart health but could not prove that one directly caused the other.

The findings were also based on participants reporting their own dietary habits, which may not always be perfectly accurate.

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The researchers emphasized that studying these behaviors together is more meaningful than looking at them in isolation because sleep, diet and movement are constantly influencing one another in a daily cycle.

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