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Cannabis compounds could reverse disease affecting one-third of adults

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Cannabis compounds could reverse disease affecting one-third of adults

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Compounds found in cannabis could provide a new roadmap for treating the world’s most common chronic liver disorder, according to a study released by the Hebrew University of Jerusalem.

The research, published in the British Journal of Pharmacology, found that cannabidiol (CBD) and cannabigerol (CBG) significantly reduced liver fat and improved metabolic health in experimental models.

CBD is the more widely studied non-intoxicating cannabinoid, while CBG is a less common “precursor” cannabinoid from which CBD is formed.

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Unlike THC, the primary psychoactive component in cannabis, these compounds do not produce a “high,” making them viable candidates for long-term medical treatment, the study suggests.

Metabolic dysfunction-associated steatotic liver disease (MASLD) currently affects approximately one-third of the global adult population, according to health data.

Metabolic dysfunction-associated steatotic liver disease (MASLD) currently affects approximately one-third of the global adult population. (iStock)

The condition, which is closely linked to obesity and insulin resistance, has few approved pharmaceutical treatments, the researchers said, leaving patients to rely largely on lifestyle changes that can be difficult to maintain. 

“Our findings identify a new mechanism by which CBD and CBG enhance hepatic energy and lysosomal function,” said lead study author Joseph Tam, director of the Multidisciplinary Center for Cannabinoid Research at Hebrew University, in a press release.

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The study highlights a process called “metabolic remodeling,” in which the cannabis compounds created a “backup battery” for the liver by increasing levels of phosphocreatine, a high-energy molecule stored in muscle cells.

This energy reserve helps the organ function under the stress of a high-fat diet, which was an unexpected discovery, the team noted.

Researchers focused on CBD and CBG, two non-psychoactive compounds that offer therapeutic benefits without the “high” associated with THC. (iStock)

The researchers also found that CBD and CBG restored the activity of “cellular cleaning crews” known as cathepsins, enzymes that work within the cell’s recycling centers to break down harmful fats and waste.

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With this process, the liver was better able to clear out dangerous lipids, including triglycerides and ceramides, which are known to trigger inflammation, the study showed.

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While both compounds were effective, CBG showed more robust results in certain areas, such as reducing total body fat mass, lowering “bad” LDL cholesterol and improving insulin sensitivity.

Researchers say this study opens a new path for using plant-based compounds to treat metabolic diseases by focusing on how cells manage energy and waste.

The discovery of a phosphocreatine “backup battery” in the liver marks a significant shift in how scientists understand the organ’s ability to survive high-fat diets. (iStock)

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Limitations and caveats

Despite the promising results, the research team cautioned that the study was conducted in a controlled experimental environment. Further clinical trials are necessary to determine the proper application for human patients.

Other recent studies have pointed to potential issues with using cannabis as a medical tool.

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A major analysis published in JAMA examined more than 2,500 scientific papers from the last 15 years, including other reviews, clinical trials and guidelines focused on medical marijuana.

The 2025 review highlighted significant gaps between public perception and scientific evidence regarding cannabis’ effectiveness for most medical conditions.

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Other recent studies have pointed to issues with the efficacy of cannabis as a medical tool. (iStock)

The researchers concluded that there are very few conditions for which cannabinoid therapies have clear, well-established benefits backed by high-quality clinical data.

“Whenever a substance is widely used, there is likely to be a very wide set of outcomes,” Alex Dimitriu, MD, who is double board-certified in psychiatry and sleep medicine and founder of Menlo Park Psychiatry & Sleep Medicine, previously told Fox News Digital. “This study points to the reality that this widely used substance is not a panacea.”

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The strongest evidence supports FDA-approved cannabinoid medications for treating specific conditions, including HIV/AIDS-related appetite loss, chemotherapy-induced nausea and vomiting, and certain severe pediatric seizure disorders, according to the review.

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Anyone interested in using marijuana for medical purposes should speak to a healthcare provider to discuss potential risks and benefits.

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Healthy diets spark lung cancer risk in non-smokers as pesticides loom

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Healthy diets spark lung cancer risk in non-smokers as pesticides loom

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Eating a diet high in fruits and vegetables was found to have a surprising link to lung cancer among younger non-smokers, early research suggests.

The observational study, led by Jorge Nieva, M.D., of the USC Norris Comprehensive Cancer Center at Keck Medicine, was presented this month at the American Association for Cancer Research (AACR) annual meeting in San Diego. It has not yet been peer-reviewed. 

Researchers looked at dietary, smoking and demographic data for 187 patients who were diagnosed with lung cancer at age 50 or younger. 

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They found that among non-smokers, there was a link between healthier-than-average diets – rich in fruits, vegetables and whole grains – and the chance of lung cancer development.

Young lung cancer patients ate more servings of dark green vegetables, legumes and whole grains compared to the average U.S. adult, the researchers found.

Eating a diet high in fruits and vegetables was found to have a surprising link to lung cancer among younger non-smokers, early research suggests. (iStock)

The researchers hypothesized that pesticides applied to conventionally grown produce could be a possible factor in the disease association.

“Commercially produced (non-organic) fruits, vegetables and whole grains are more likely to be associated with a higher residue of pesticides than dairy, meat and many processed foods,” according to Nieva. He also noted that agricultural workers exposed to pesticides tend to have higher rates of lung cancer.

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“There is a large subset of lung cancer patients whose disease is not caused by smoking,” Nieva told Fox News Digital.

The disease is becoming more common in non-smokers 50 and younger, especially women – despite the fact that smoking rates have been falling for decades, the researcher noted.

The researchers hypothesized that pesticides applied to conventionally grown produce could be a possible factor in the disease association. (iStock)

“These patients tend to have eaten much healthier diets before their diagnosis than the average American,” he went on. “We need to support research into understanding why Americans – and women in particular – who no longer smoke very much are still having lung cancer,” he said.

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DEATHS FROM ONE TYPE OF CANCER ARE SURGING AMONG YOUNGER ADULTS WITHOUT COLLEGE DEGREES

The study did have some limitations, Nieva acknowledged, primarily that it relied on survey data and was limited by the participants’ memories of their food intake.  

“Also, the survey participants were self-selected, and this could have biased the findings,” he told Fox News Digital.

“There is a large subset of lung cancer patients whose disease is not caused by smoking.”

The researchers did not test specific foods for pesticides, relying instead on average pesticide levels for certain types of food. Looking ahead, they plan to test patients’ blood and urine samples to directly measure pesticide levels, Nieva said.

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Although the study shows only an association and does not prove that pesticides caused lung cancer, Nieva recommends that people wash their produce before eating and choose organic foods whenever possible.

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“This work represents a critical step toward identifying modifiable environmental factors that may contribute to lung cancer in young adults,” said Nieva. “Our hope is that these insights can guide both public health recommendations and future investigation into lung cancer prevention.”  

“It is possible that the increased lung cancer risk could be due to pesticide exposure in whole farmed foods, but is by no means certain,” a doctor said. (AP Photo/Charlie Neibergall)

Dr. Marc Siegel, Fox News senior medical analyst, said the study is “interesting,” but that it “raises far more questions than it answers.”

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“It is a small study (around 150) and observational, so no proof,” the doctor, who was not involved in the research, told Fox News Digital.

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“It is possible that the increased lung cancer risk could be due to pesticide exposure in whole farmed foods, but it is by no means certain,” Siegel went on. “How much exposure is needed? How much of it gets into food and in which areas? This requires much further study.”

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Kayla Nichols, communications director for Pesticide Action & Agroecology Network, a distributed global network, said the organization agrees with the study’s conclusion that more research should be done on the rise in lung cancer, particularly in individuals eating diets higher in produce and fiber.

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“There is a large subset of lung cancer patients whose disease is not caused by smoking,” the researcher told Fox News Digital. (iStock)

“There is a bounty of existing research that already links pesticide exposure to increased risk of multiple types of cancers,” Nichols, who was also not involved in the study, told Fox News Digital. She called for more research on chronic, low-level exposures to pesticides, as well as more effective policies to protect the public from pesticide residues on food.

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The study was supported by the National Institutes of Health and the National Cancer Institute, as well as industry partners including AstraZeneca and Genentech, among others.

Fox News Digital reached out to several pesticide companies and trade groups for comment.

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Deaths from one type of cancer are surging among younger adults without college degrees

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Deaths from one type of cancer are surging among younger adults without college degrees

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Colorectal cancer, once considered a disease of older age, is becoming a crisis for younger adults. New research shows one group getting hit the hardest – those without a college degree.

A recent study from the American Cancer Society analyzed data from over 101,000 adults aged 25 to 49 who died from colorectal cancer between 1994 and 2023.

While death rates remained stable for college graduates, they climbed significantly for those without a bachelor’s degree, the findings showed.

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For young adults with a high school education or less, the mortality rate rose from 4.0 to 5.2 per 100,000 people, while the rate for those with at least a bachelor’s degree stayed flat, at approximately 2.7 per 100,000.

This does not mean that a degree offers some kind of biological protection, researchers cautioned.

Colorectal cancer, once considered a disease of older age, is becoming a crisis for younger adults. (iStock)

The difference is likely driven by the conditions in which people live and work, which often correlate with education levels, the researchers noted.

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The study suggests that the higher death rates are likely driven by differences in the prevalence of risk factors, including obesity, physical inactivity, smoking and diet, which are “known to be elevated among children and young adults with lower [socioeconomic status].”

Because the study relied on death certificates, researchers couldn’t say exactly why college graduates had better outcomes.

Because the researchers didn’t have the patients’ actual medical records, they couldn’t see things like frequency of screenings or treatment options, which would impact survival outcomes. (iStock)

Certificates typically list the cause of death, age, race and education level, but they do not include a person’s full medical history.

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Because the researchers didn’t have the patients’ actual medical records, they couldn’t see things like frequency of screenings or treatment options, which would impact survival outcomes.

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Colorectal cancer is now the leading cause of cancer death for men under 50 and the second leading cause for women in the same age group, according to recent statistics.

While colorectal cancer death rates remained stable for college graduates, they climbed significantly for those without a bachelor’s degree, the findings showed. (iStock)

Because the disease is highly treatable when caught early, the U.S. Preventive Services Task Force (USPSTF) lowered the recommended screening age from 50 to 45 in 2021.

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Common signs and symptoms of colorectal cancer can include a change in bowel habits, such as diarrhea, constipation or narrowing of the stool, that lasts for more than a few days, according to the American Cancer Society.

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Other signs that warrant seeing a doctor include blood in the stool or a persistent feeling of needing to go to the bathroom but being unable to go.

The research was published in JAMA Oncology.

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Cancer tied to woman’s vaping habit since age 15 as she’s now given just months to live

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Cancer tied to woman’s vaping habit since age 15 as she’s now given just months to live

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A young woman who started vaping at the age of 15 has been given just 18 months to live — after being diagnosed with lung cancer in her early 20s. 

Kayley Boda, 22, of Manchester, in the United Kingdom, was engaging in heavy vaping on a regular basis when she started coughing up a brown substance with “grainy bits” in it in January 2025, news agency SWNS reported. 

The retail assistant said doctors turned her away eight times, telling her she had a chest infection — until she began coughing up blood.    

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After seven biopsies, Boda was diagnosed with lung cancer. She underwent surgery to remove the lower lobe of her right lung, as well as chemotherapy — and in February 2026, got the all-clear, the same source reported.

Two months later, though, doctors said the cancer had come back in the pleural lining. Now she’s been given 18 months to live.

Kayley Boda, 22, is shown in the hospital. She started coughing up a brown substance with “grainy bits” in January 2025, she said. She had been vaping since the age of 15.  (SWNS)

The young woman has now issued a warning to others to be aware of the dangers of vaping.

Boda said she smoked a bit as a young teenager. She took up vaping after that. 

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Then, “a few months after I switched from reusable vapes to disposable ones, I started coughing up brown, grainy mucus,” as SWNS reported.

TOURISTS MAY FACE STEEP FINES AND JAIL TIME FOR VAPES AT THIS VACATION HOT SPOT

“Doctors turned me away eight times with a chest infection. … Then I started coughing up blood, so they did an X-ray and found a shadow on my lung,” she added.

“They told me they were 99% sure, [since I was] so young, that it wasn’t cancer, so not to worry about it. When I got the results back, and they told me it was lung cancer, it felt so surreal.”

Boda said she was “very naive” before her diagnosis and thought that “something like this would never happen to me.”

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She said that she had surgery to remove half of her right lung.

“After the surgery, I started chemo and I had a terrible reaction to it. I couldn’t lift my head up. I was throwing up blood. I was urinating blood. I couldn’t eat. I couldn’t sleep.”

VACATION HOT SPOT CRACKS DOWN ON VAPING WITH JAIL THREATS AND HEFTY FINES

She said that when she got the “all clear [in Feb. 2026], it felt amazing, but just two months later I was told the cancer had come back, and I have 18 months to live.”

She added, “I’m 22. This isn’t meant to happen to somebody my age.”

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“Stay off the vapes because they will catch up with you.”  

She blames her cancer on vaping, she said.  

“My symptoms started a few months after I started disposable vapes, and there’s no lung cancer in my family,” she said. “I haven’t vaped for three months, I’ve made my partner stop, I’ve made my mom stop, I’m urging all my friends to stop. Stay off the vapes,” she continued, “because they will catch up with you.”  

When doctors did an X-ray, they found a shadow on Boda’s right lung. She was later diagnosed with lung cancer and has undergone surgery to remove the lower lobe of her right lung, as well as chemotherapy. (SWNS)

She said she’d been using reusable vapes since the age of 15 and began using disposable vapes a few months before her cancer symptoms started.

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In November 2024, when she developed a rash all over her body, doctors said it could have been due to shingles, chicken pox or scabies, she told SWNS.    

‘Nothing worked’

“I got treated for all three, and nothing worked,” Boda said. “It got to the point where I was cutting myself from scratching so hard.” 

A few months after that, she began coughing up a dark brown mucus, with “grainy bits, the consistency of sugar, in it,” she said. When the coughing continued, she visited the doctor’s office, but was told it could be scarring from pneumonia or a chest infection, she also said.    

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It wasn’t until March 2025 that she began coughing up bright red blood. At that point, doctors gave her a chest X-ray and told her they’d found a shadow on her lower right lung.    

Over the next four months, she had seven biopsies as doctors took samples from the “shadow.” In August, when she went to get the results, she was told she had stage one lung cancer.

Boda is shown in the hospital. She was diagnosed with lung cancer and had surgery to remove the lower lobe of her right lung, as well as chemotherapy. (SWNS)

In September 2025, she had surgery to remove the lower lobe of her right lung, and the surrounding lymph nodes. During the surgery, doctors upstaged her cancer from stage one to stage three after finding cancer in six surrounding lymph nodes, she said.  

Following the surgery, Boda was unable to breathe properly and had to learn to walk all over again.  

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“The oncologist said this is so rare.”

After finishing chemotherapy in February 2026, Kayley was given the all clear, leaving her feeling elated. 

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However, just a month after that, she began experiencing extreme chest pains and was told by doctors she had a pleural effusion — a build-up of fluid in the lungs. She had the fluid removed, but when doctors tested it, they discovered her cancer had returned to the pleural lining of her lungs, giving her 18 months to live.  

“The oncologist said this is so rare, and usually something they see in patients that are 80 years old,” she said, as SWNS reported.  

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Increasingly, vacation hot spots are enforcing strict bans on the use of e-cigarettes in public venues.  (iStock)

Boda claimed that doctors were unable to pin her cancer to a specific cause — but told her that smoking and vaping definitely didn’t help.

Since her diagnosis, she has stopped and is urging others to stop, too.    

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She’s hoping to raise the thousands of dollars needed for treatment to try to prolong her life, she said.  

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Last year, Fox News Digital reported on the case of a Pennsylvania woman, 26, who said she vaped for just one year before her lungs collapsed. She was 22 when she took up the habit, she said in an interview. 

“Everybody warned me about it, but I didn’t listen — I wish that I did,” she said.

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Dr. David Campbell, clinical director and program director at Recover Together Bend in Oregon, told Fox News Digital at that time that signs of collapsed lungs include sharp chest or shoulder pain, shortness of breath and difficulty breathing.

Lung issues are just one of the many health issues linked to vaping, he warned. The habit can also increase the risk of heart disease and stroke, as well as exposure to harmful heavy metals.

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Melissa Rudy of Fox News Digital contributed reporting. 

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