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Why exercise is as good for your brain as it is for your body

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Why exercise is as good for your brain as it is for your body

A satisfying night’s sleep has long been branded as the cure to all ills, particularly when clearing damaging toxins from the brain.

Neuroscientists have long believed that deep sleep helps the clearance of problematic debris from the brain, flushing away many of the proteins and metabolites thought to be involved in the development of Alzheimer’s and other dementias. 

This is hardly reassuring for the insomniacs amongst us. However definitive proof has always been hard to come by, and a new study in the journal Nature Neuroscience has poured cold water on the theory. While sleep is still vital for many aspects of health, Bill Wisden, a professor at the UK Dementia Research Institute who was involved in leading the study, says that being active may actually play a far bigger role in toxin clearance. 

“We have shown that brain clearance is highly efficient during the waking state,” he says. “In general, being awake, active, and exercising may more efficiently clean the brain of toxins.”

This is undoubtedly good news for anyone who struggles to get a solid seven hours a night. After all, a brisk half-hour walk is something most of us can manage even after a night of tossing and turning.

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Wisden’s suggestion fits in with a growing number of research breakthroughs in recent years that indicate the sheer importance of exercise for all aspects of the brain. 

Toxin clearance

Exercise’s role in removing waste from the brain is currently an area of active investigation in research labs across the globe. The working theory relates to certain shape-shifting brain cells known as microglial cells which can take on different personas depending on your state of health.

In some psychiatric conditions such as schizophrenia and even Long Covid, the disease process causes microglia to take on a visibly spiky form, generating inflammation and interfering with the brain’s natural workings.

However, researchers suspect that exercise may actively induce microglia to take on a healthier anti-inflammatory guise. This means they would act as helpful scavengers, clearing detritus and ensuring that the synaptic connections between neurons are clean and functioning properly.

“Microglia are there to survey everything,” says Dr Rebecca MacPherson, associate professor at Brock University in Canada where she runs a lab studying how exercise benefits the brain. “We’re exploring this idea that exercise activates them in a way that enhances the way they clear the products of metabolism.”

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The brain fertiliser

Research has repeatedly shown that being physically active reduces the risk of all forms of dementia by 28%, and Alzheimer’s disease in particular by 45%.

Over the years scientists have conducted various experiments in which participants have been randomised into two different groups, with one group following an exercise program and the other remaining sedentary. Almost all of them have reported that the exercise program group performed better on cognitive tests, with the same trend found in healthy participants, stroke survivors, and even Alzheimer’s patients.

Much of this is thought to be down to a molecule called brain-derived neurotrophic factor or BDNF. This molecule has gained a reputation among neuroscientists as ‘the brain fertiliser’ for its remarkable ability to stimulate the growth of new neurons and strengthen the connections between them.

“Muscle contractions increase BDNF while your platelets in the blood actually store a lot of BDNF,” says MacPherson. “So with increased blood flow due to exercise, your platelets can release more of it into the circulation.”

Through studies carried out in cells and animals, MacPherson’s lab has even shown that BDNF prevents the accumulation of tiny beta-amyloid protein fragments in the brain by altering the activity of different enzymes, which could explain why exercise helps to diminish the risk of Alzheimer’s.

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But BDNF is not the only beneficial molecule released when you exercise. Last year, a study in the journal Neuron showed that exercise causes the production of a hormone called irisin which is capable of clearing amyloid plaques.

Christiane Wrann, an assistant professor of medicine at Harvard Medical School, who was involved in the study, has been so fascinated by irisin that she is now looking to develop an artificial form of it as a therapeutic for various neurodegenerative diseases including Alzheimer’s and Parkinson’s.

“It’s a small hormone which works on neuroinflammation and plaque clearance which makes it very relevant for Alzheimer’s disease,” she says. “I think there’s three or four properties of irisin that make it a really promising drug target.”

How much exercise and which intensity is best?

MacPherson gives a wry smile when this question is broached. “Everyone wants to know exactly what they need to do, and that’s a difficult one to answer,” she says.

The NHS guidelines advise you to do some sort of aerobic exercise, or physical activity which raises your heart rate, for at least 30 minutes per day, five days per week.

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MacPherson says that BDNF production correlates with exercise intensity, so your body will produce more when doing higher-intensity forms of activity such as interval training. However, she says it is important for people to do what they feel capable of, and any form of exercise, no matter how mild, will still hold some benefit for the body and the brain.

“I think as an individual, you need to think, how much time do I have and what do I enjoy?” she says. “Even if you’re only able to do moderate intensity exercise, you still get an increase in BDNF, and there’s also the increased blood flow which delivers more oxygen and nutrients to the brain which will also enhance brain cell growth.”

The scientific reason exercise boosts your mood 

Exercise has also been known to have the capacity to provide relief to people struggling with symptoms of depression, such as low mood or anhedonia, which refers to a loss of pleasure in previously rewarding activities.

At University College London, cognitive neuroscientist Professor Jonathan Roiser is currently leading a Wellcome-funded clinical trial to try and understand more about why exercise is so beneficial for mental health.

“I’ve long been interested in the information processing aspects which go wrong in depression and how they contribute to symptoms,” he says. “There are other symptoms that tend to cluster together with anhedonia such as fatigue and difficulty with decision-making, and there are some hints that exercise is specifically targeting these kinds of symptoms.”

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Roiser’s trial will examine the greater benefits of aerobic exercise, where participants get out of breath and break sweat, compared to mild stretching and relaxation, in people with depression.

The aim is to get further proof for some of the major theories behind how exercise benefits mental health, such as stimulating the production of dopamine, which is involved in motivation, as well as dampening down inflammation.

“A lot of depressed people experience what we call chronic inflammation which prevents dopamine neurons from firing and perhaps contributes to their symptoms,” he says. “So the anti-inflammatory effects of exercise are a core part of how we think it’s working.”

As we discover more and more about how exercise protects the body, it could even lead to a new class of drugs, known as exercise mimetics which could provide some of the benefits of physical activity to the disabled and frail.

But for the rest of us, researchers have one simple message – whether it’s the gym or playing sports, making time to stay active will keep your mind healthier for longer.

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“Whether it’s improving mood or cognitive function, exercise is one of the best things you can do for your brain,” says Wrann.

Fitness

I’m a running coach — I’ve just tested shoes actually designed for women’s feet, and they’re a total game changer

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I’m a running coach — I’ve just tested shoes actually designed for women’s feet, and they’re a total game changer

Why you can trust TechRadar


We spend hours testing every product or service we review, so you can be sure you’re buying the best. Find out more about how we test.

QLVR ENDVR: Two minute review

Most running shoes feel familiar for a reason: the formula has barely changed in millennia. We have archaeological evidence of shoes being fastened with “shoelaces” as far back as around 3,500 BC, yet the basic lace-up running trainer remains the default.

QLVR (pronounced “clever”) set out to challenge that. Its debut shoe, the ENDVR, is a laceless “running slipper” built around a women-specific mechanical structure, with a slip-on Wing Fit system inspired by the way a bird’s wing opens and closes around movement.

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Mere minutes of daily vigorous exercise can cut your risk of 8 diseases | CNN

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Mere minutes of daily vigorous exercise can cut your risk of 8 diseases | CNN

Move more. Sit less. For many years, that’s been accepted guidance for people wanting to get healthier.

Now that message is getting refined, with a growing body of research suggesting that certain types of movements may be more beneficial than others when it comes to health benefits.

The intensity of your exercise may matter as well. A new study published in the European Heart Journal found that a small amount of vigorous activity may be linked to lower risk of eight different chronic diseases.

The findings raise questions about why intensity matters and how people can incorporate more intense exercise routines into everyday life. To better understand the study’s implications, I spoke with CNN wellness expert Dr. Leana Wen, an emergency physician and clinical associate professor at George Washington University. She previously served as Baltimore’s health commissioner.

Before beginning any new exercise program, consult your doctor. Stop immediately if you experience pain.

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CNN: What did this study examine about exercise and its relationship to chronic disease?

Dr. Leana Wen: This investigation looked at how the intensity of physical activity is related to the risk of developing a range of chronic diseases. Researchers analyzed data from two very large groups in the UK Biobank, which is a long-term health study in the United Kingdom that tracks medical and lifestyle information from hundreds of thousands of participants. One group included about 96,000 people who wore wrist activity trackers that objectively measured their movement, and the other included more than 375,000 people who self-reported their activity.

The researchers followed participants over an average of about nine years and examined the development of eight conditions: major cardiovascular events, atrial fibrillation, type 2 diabetes, immune-related inflammatory diseases, fatty liver disease, chronic respiratory disease, chronic kidney disease and dementia, as well as overall mortality.

The key finding was that the proportion of activity done at vigorous intensity mattered. People who had more than about 4% of their total activity classified as vigorous had substantially lower risks of developing these conditions compared with people who had no vigorous activity at all. The numbers were stunning, with the participants having the following results:


  • 63% lower risk of dementia,

  • 60% lower risk of type 2 diabetes,

  • 48% lower risk of fatty liver disease,

  • 44% lower risk of chronic respiratory disease,

  • 41% lower risk of chronic kidney disease,

  • 39% lower risk of immune-mediated inflammatory diseases,

  • 31% lower risk of major cardiovascular events,

  • 29% lower risk of atrial fibrillation, and

  • 46% lower risk of death from any cause.

These results are amazing. Imagine if someone invented a medication that could reduce the risks of all these diseases at once — it would be very popular! Crucially, even people who exercised a lot still benefited if the proportion of time they spent doing vigorous physical activity was increased. Conversely, people who were relatively inactive also benefited from adding just a little bit of higher-intensity exercise to their daily routines.

CNN: What counts as “vigorous” physical activity?

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Wen: Vigorous activity is generally defined as exercise that substantially raises your heart rate and breathing. A simple way to gauge it is the “talk test.” If you can speak comfortably in full sentences while exercising, you are likely in the low to moderate range. If you are so out of breath that you can only say a few words at a time, that is vigorous.

Running, cycling, lap swimming or climbing stairs quickly could count. But this also depends on people’s baseline fitness. For some individuals, taking longer strides with walking can be vigorous exercise. Others who are already fairly fit would need to do more. It’s also important to remember that vigorous activity doesn’t have to be in the context of a structured exercise plan. Short bursts of effort in daily life, such as rushing to catch a bus or carrying heavy groceries upstairs, can also qualify if they raise your heart rate and make you breathless.

CNN: Why might higher intensity exercise provide additional health benefits?

Wen: Higher intensity activity places greater demands on the body in a shorter period. This type of movement can improve cardiovascular fitness, increase insulin sensitivity and support metabolic health more efficiently than lower-intensity activity alone. Some studies have also linked vigorous activity with cognitive benefits.

Greater intensity may have distinct benefits across different organ systems. The researchers found that some conditions, such as immune-mediated inflammatory diseases, appeared to be more strongly linked to the intensity of activity than to the total amount. On the other hand, type 2 diabetes and kidney disease were influenced by both how much activity people did and how intense it was. Why this is the case is not yet known, but intensity appears to have a significant impact across diseases affecting multiple organs.

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CNN: How much vigorous activity do people need?

Wen: The threshold for people seeing a benefit appears to be relatively low. The researchers found that once people reached more than about 4% of their total activity as vigorous, their risk of developing chronic diseases dropped substantially.

To put that into practical terms, we are not talking about professional athletes dedicating their lives to hours of high-intensity training. Everyday people may see benefits from just doing a few minutes of vigorous effort daily.

CNN: How can people realistically incorporate vigorous activity into their daily routines?

Wen: One helpful way to think practically is that vigorous activity does not have to happen all at once. It can be accumulated in short bursts throughout the day.

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People can take the stairs instead of the elevator and do so at a faster pace than usual. When they are heading to work, they can add some speed walking. They can park farther away when grocery shopping and walk briskly while carrying groceries.

Structured exercise also can incorporate intervals where people alternate between moderate and more intense effort. If you’re swimming laps, you can warm up at a more leisurely pace, then do a few laps at a faster pace, then again at a leisurely pace and repeat. This suggestion applies to any other aerobic exercise: Aim for multiple intervals of at least 30 seconds to a minute each where your body is working hard enough that you feel noticeably out of breath.

CNN: What about someone who is older or has mobility issues?

Wen: Not everyone can or should engage in high-intensity activity in the same way. Vigorous activity is relative to that person’s baseline. For someone who is not used to exercise, even a short period of slightly faster walking or standing up repeatedly from a chair could be considered high intensity. And not everyone may be able to walk. In that case, some exercises from the chair can have aerobic benefits.

Individuals who have specific medical conditions should consult with their primary care clinicians before embarking on a new exercise routine. People with mobility issues also may benefit from working with a physical therapist who can help to tailor exercises appropriate to their specific situation.

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CNN: What is the key takeaway for people trying to improve their health?

Wen: To me, the main takeaway from this study is that it’s not only how much total exercise you get but also how hard you push yourself that matters. And you don’t have to have a lot of high-intensity exercise: Adding just a little has substantial health benefits across a wide range of chronic health conditions.

At the same time, exercise needs be practical. People should look for opportunities to safely increase intensity in ways that fit their daily lives. The most effective approach to physical activity is a balanced one: Exercise regularly, incorporate more challenging activities when you can and build habits that are sustainable over time.

Get inspired by a weekly roundup on living well, made simple. Sign up for CNN’s Life, But Better newsletter for information and tools designed to improve your well-being.

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‘Not what the fitness industry is trying to sell you’: this is the one simple move everyone really needs to be doing, according to an exercise scientist

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‘Not what the fitness industry is trying to sell you’: this is the one simple move everyone really needs to be doing, according to an exercise scientist

Ask any exercise scientist what they would prescribe to someone serious about staying strong into their 50s and beyond, and the answer is rarely what you’d hope for — and certainly not what the fitness industry is currently trying to sell you.

It isn’t long sessions on one of the best under-desk treadmills or a stationary bike like the Peloton, nor the kind of machine-based exercises that isolate muscles without ever teaching them to work together.

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