President Donald Trump and Louisiana Gov. Jeff Landry have discussed U.S. Rep. Julia Letlow challenging U.S. Sen. Bill Cassidy in next year’s Republican primary, according to multiple people familiar with the matter.

The Republican governor’s promotion of a new challenger to Cassidy reflects unease within Trump’s base about the two-term senator. Cassidy voted to convict Trump in Trump’s 2021 impeachment trial over the riot at the U.S. Capitol on Jan. 6, 2021. And Cassidy, who is a medical doctor, expressed doubts about Trump’s pick of Robert F. Kennedy Jr. as the nation’s health secretary before voting to confirm Kennedy.

Republicans hold a 53-47 majority in the Senate and have a favorable electoral map in the 2026 midterms to help them keep control. But Cassidy is among several GOP senators up for reelection next year who are facing challenging primaries over past moves to distance themselves from Trump.

For the senator, “the biggest hurdle is going to be the impeachment vote. That’s what he has to overcome. And I don’t think he has the mindset to say, ‘I made a mistake,’” said Eddie Rispone, the Republican nominee for Louisiana governor in 2019 and a Cassidy supporter. “And Louisiana is a big Trump state.”

Landry, a close Trump ally, spoke last month with the president about Letlow as a potential Senate candidate, according to two people with knowledge of the conversation. They were granted anonymity to share contents of a conversation they were not authorized to discuss publicly.

A spokesperson for Letlow declined to comment on a potential campaign for Senate or the discussion between Landry and Trump. Landry’s office declined to comment.

Landry, elected in 2023, has been advocating for Letlow to consider a run, according to the people who confirmed their April conversation about Letlow. A Senate seat would be a safe bet for a Republican given that Trump received 60% of the vote in carrying Louisiana last year.

Republican insiders describe Landry and Cassidy not as close, but as having a cordial working relationship despite a difference in their feelings of loyalty to Trump, which creates some distance between Cassidy and segments of the party base in the state.

“Senator Cassidy delivers conservative results for the people of Louisiana,” Cassidy spokesperson Ashley Bosch said in a statement. “He’s worked hard to support the President’s agenda and we’re confident voters will re-elect him next year.”

Letlow is a three-term Republican representative from northeast Louisiana. She won the seat in a special election in March 2021 after her husband, Luke, had been elected but died of complications from COVID-19.

Letlow sits on the influential House Appropriations Committee. Her district was a mostly rural swath of northeast Louisiana when she arrived in Congress. It has shifted as a result of a redistricting map ordered by the U.S. Supreme Court in 2024 and now also include parts of metropolitan Baton Rouge, where Cassidy lives.

Cassidy already faces one major challenger, Louisiana State Treasurer John Fleming, a former congressman.

Some Republican activists in the state condemned Cassidy for his 2021 vote to convict Trump, a vote Cassidy said afterward he was “at peace” casting.

The state Republican executive committee voted unanimously to censure Cassidy. The Republican committee in Bossier Parish, which includes the city of Shreveport in northwest Louisiana, adopted a censure measure describing Cassidy as “an object of extreme shame” and called for his resignation.

Trump revived his public contempt for Cassidy a year ago after the senator spoke out when the then-former president promised to pardon those convicted in connection with the Capitol riot; Trump did that after taking office in January.

In an April 2024 post on Truth Social, Trump called Cassidy “one of the worst Senators in the United States Senate” and a “disloyal lightweight.”

Louisiana’s new congressional primary election system also could be a wrinkle for Cassidy.

Until the new system was adopted this year, congressional candidates from all parties seeking the same office ran on the same ballot regardless of party affiliation. In these so-called jungle primaries, only a candidate who received 50% of the vote would win the office outright. If no one reached the threshold, the top two finishers would face each other in a runoff.

Next year, only voters who note Republican affiliation on their voter registration — and those who affiliate with no party — will be able to participate in the GOP Senate primary. The effect is seen as a potential challenge for Cassidy, who had benefited from the less-partisan nature of the old system.

“It does tighten it a little bit for him, because you do have the far-right Republicans — for them, it’s going to be hard to forgive him for that impeachment vote,” Rispone said.

Still, Cassidy has a clear fundraising advantage, with more than $7.4 million in his campaign account at the end of the first quarter. Cassidy has also begun laying the campaign groundwork in Louisiana and is expected to announce his candidacy formally in the coming weeks.

And in a sign things might not be as bad with Trump as they were, Cassidy received different sort of recognition from the president at an economic event at the White House this month.

“We have some great people, great senators, here,” Trump said. “Bill Cassidy, thank you, Bill.”

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