The Arizona Cardinals and San Francisco 49ers play on Sunday, Oct. 6, at Levi’s Stadium in a game on the NFL Week 5 schedule.

Which team will win the NFL Week 5 game?

Check out these NFL Week 5 picks and NFL Week 5 predictions for the game, which can be seen at 1:05 p.m. MST on FOX (stream with free trial from FUBO).

The 49ers are a 7.5-point favorite over the Cardinals in NFL Week 5 odds for the game, courtesy of BetMGM Sportsbook.

San Francisco is -375 on the moneyline, while Arizona is +300.

The over/under (point total) is set at 49.5 points.

Watch Cardinals at 49ers live with FUBO (free trial)

Jeremy Cluff writes: “The 49ers are the biggest favorite of the week. Can the Cardinals shock San Francisco? Can they even keep this game close? Not the way they are playing.”

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Bookies.com: Bet the Cardinals with the points vs 49ers

Bill Speros writes: “The 49ers active roster remains in flux. But their defense will be enough to win this one at home. But a full TD cover might be too much to ask, especially given how the Cardinals can score big-yardage-play TDs with Kyler Murray and Marvin Harrison Jr. Especially in garbage time.”

NFL Week 5 odds: Point spreads, moneylines, over/unders for betting on NFL games this week

The site’s formula predicts that the Cardinals will win the NFL Week 5 game against the 49ers.

NFL Week 5 schedule: Television channels, how to watch, stream games

ESPN: 49ers have a 70.5% chance to beat Cardinals on Sunday

The site gives the Cardinals a 29.2% shot at winning the NFL Week 5 game, with the remaining percentage accounting for a tie.

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Dimers: 49ers 26, Cardinals 19

It writes: “After extensive simulations, our model gives the Cardinals a win probability of 23%, while the 49ers have a win probability of 77%.”

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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The biggest storyline surrounding the San Francisco Giants heading into the offseason is whether or not they will keep Farhan Zaidi after missing the playoffs again. Zaidi has spoken about it, but recently a former coworker of his came to his defense. On a local Bay Area radio show, Oakland Athletics executive, Billy Beane, went to bat for Zaidi.

Zaidi worked under Beane from 2011 until 2014, where the Giants President of Baseball Operations worked his way up to assistant general manager before he left for a job with the Los Angeles Dodgers. The Oakland legend had nothing but nice things to say about Zaidi and his time working with him.

“I’m obviously a little biased. I adore Farhan; he’s brilliant … there’s no funnier, warmer, more enjoyable person to be around, and so in that sense — and listen, I’ve worked with this guy. This guy is really, really smart, very smart. He cares so much. … When Farhan left [the A’s] to [work with] the [Los Angeles] Dodgers, I think my kids cried. I mean, that’s how much they adored [him]. My wife felt the same way,” he said while on the ‘Murph & Markus’ show on KNBR.

While in college, Zaidi read the book ‘Moneyball’ and was so inspired that he applied to work for the A’s, and then worked himself up from there. He was Beane’s right hand man during his time there and Beane thinks that he wouldn’t be jobless for long should he be fired.

“Here’s what I would say: If that man’s a free agent [this offseason], there will be no shortage of people who would love to have him with them. You’re asking the wrong person … because I’ve been with this guy. He’s brilliant. He’s a wonderful human being, and so am I biased? Maybe. But also, objectively, I’ve seen this guy work,” he continued.

When the Giants nabbed Zaidi from the Dodgers, it was considered a great hire. Even a couple years in, when San Francisco won 107 games, he was praised. However, that has been in for his time with the Giants.

There are things have led to where Zaidi is at, such as the team not playing their youngsters, that has caused some of the frustration.

All that being said, his track record will almost guarantee that he gets another front office job quickly, as Beane said. Now, it’s time for the San Francisco brass to make a decision.