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What makes the Omicron variant spread so easily?

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What makes the Omicron variant spread so easily?

The Omicron variant arrived in the US proper round Thanksgiving. Lower than a month later, it’s the nation’s dominant coronavirus pressure, accounting for 73% of recent infections final week, in response to the Facilities for Illness Management and Prevention.

How did that occur? Infectious illness consultants say there are two key components that decide how shortly a virus will unfold: how simply it’s transmitted and the way effectively it eludes the physique’s defenses.

Early analysis suggests Omicron has benefits in each areas. However the knowledge additionally counsel the variant’s larger fee of transmission hasn’t led to extra hospitalizations or deaths.

Preliminary outcomes from a Dec. 14 research led by Alejandro B. Balazs of the Ragon Institute in Cambridge, Mass., discovered that Omicron was twice as infectious because the Delta variant and 4 occasions extra infectious than the unique virus. That research, which has but to be peer-reviewed, relied on a comparatively small pattern of 239 sufferers in and round Boston, so the outcomes might not be consultant of Omicron’s habits normally.

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Nonetheless, stated Dr. David Delight, an infectious illness specialist at UC San Diego, “simply taking a look at [the current situation] epidemiologically, we all know one thing is means completely different this time round.”

With so many unvaccinated folks on the market, he added, “it was only a matter of time earlier than we’d see a mutated model of the virus that’s simply higher at infecting vaccinated folks.”

It’s virtually an evolutionary crucial, stated Jasmine Plummer, a analysis scientist at Cedars-Sinai Medical Heart in Los Angeles who was a part of the crew that found the Epsilon variant of the virus final winter.

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“Variants come up due to viruses making an attempt to outlive,” Plummer stated. “All viruses evolve to evade their host. So we knew an Omicron was coming.”

And right here we’re.

Fast replication

One secret of Omicron’s success seems to be its means to copy quickly. Researchers from the College of Hong Kong reported that in contrast with Delta, Omicron “infects and multiplies 70 occasions sooner” within the bronchus, the principle airways into the lungs. Its benefit over the unique virus is even larger, they added. The distinction was obvious a mere 24 hours after an infection.

If that’s certainly the case, it implies that folks contaminated by the Omicron variant have much more virus of their throats ready to be expelled into the air once they exhale — and particularly once they cough or sneeze. It additionally means that they might be infectious sooner, which additionally would velocity the unfold of the illness.

One doubtlessly useful signal from the Hong Kong analysis: Omicron moved extra slowly from the throat into the lungs. Of their experiments, the scientists discovered the brand new pressure replicated within the lungs at lower than one-tenth the speed of the unique virus. That “could counsel decrease severity of illness,” in response to the college.

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Delight stated Omicron is spreading extra simply inside households, suggesting the virus will get spewed into the air extra simply. One other risk is {that a} smaller quantity of Omicron is required to trigger an an infection, he stated.

There’s loads we nonetheless don’t find out about how the Omicron variant is transmitted, however the CDC expects that “anybody with Omicron an infection can unfold the virus to others, even when they’re vaccinated or don’t have signs.”

Delight put it one other means: “We all know this illness spreads through folks, thus the one option to be fairly certain you’re not going to get it’s to not be round folks.”

The spike protein

The coronavirus that causes COVID-19 employs a spike-shaped protein on its floor to penetrate wholesome cells and use them to churn out copies of itself. The vaccines out there in the US immediate the creation of antibodies that acknowledge that spike protein and goal it for destruction by the physique’s immune system.

Omicron has an unprecedented variety of mutations that have an effect on the spike. About three dozen have been tallied by Balazs and his crew, and their location suggests they make it tougher for antibodies to acknowledge an Omicron virus particle. That’s true no matter whether or not the antibodies have been generated by a vaccine or a earlier an infection, they wrote.

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Researchers on the College of British Columbia in Canada examined the Omicron proteins affected by these mutations on a molecular degree. They discovered that, on stability, the modifications enabled the spike protein to bond extra strongly to human cells than the unique coronavirus might. They posted their findings on BioRXiv, a web site the place scientists search suggestions on preliminary work.

Sriram Subramaniam, the senior writer of the research, stated in an interview with the college that even small modifications within the spike protein “have doubtlessly huge implications for a way the virus is transmitted, how our physique fights it off, and the effectiveness of remedies.”

He added: “Our experiments affirm what we’re seeing in the true world — that the Omicron spike protein is much better than different variants at … evading the immunity produced by each vaccines and pure an infection.”

Subramaniam stated it was notable that the immunity generated by vaccines was more practical towards Omicron than the immunity from a earlier an infection in unvaccinated sufferers. It’s one other signal “that vaccination stays our greatest protection towards the Omicron variant,” he stated.

However that protection might not be very efficient with out a booster.

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Balazs’ research discovered that the safety afforded by vaccines or a earlier coronavirus an infection was “dramatically decreased” towards Omicron. The one exception was in individuals who’d just lately acquired a booster dose of the vaccine; they “exhibited potent neutralization of Omicron,” in response to the research.

That will assist to clarify why “breakthrough” circumstances and reinfections look like rising quickly. A South African analysis crew reported on Dec. 2 greater than 35,000 COVID-19 reinfections among the many 2.8 million individuals who’d examined constructive over the earlier three months.

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Cluster of farmworkers diagnosed with rare animal-borne disease in Ventura County

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Cluster of farmworkers diagnosed with rare animal-borne disease in Ventura County

A cluster of workers at Ventura County berry farms have been diagnosed with a rare disease often transmitted through sick animals’ urine, according to a public health advisory distributed to local doctors by county health officials Tuesday.

The bacterial infection, leptospirosis, has resulted in severe symptoms for some workers, including meningitis, an inflammation of the brain lining and spinal cord. Symptoms for mild cases included headaches and fevers.

The disease, which can be fatal, rarely spreads from human to human, according to the U.S. Centers for Disease Control and Prevention.

Ventura County Public Health has not given an official case count but said it had not identified any cases outside of the agriculture sector. The county’s agriculture commissioner was aware of 18 cases, the Ventura County Star reported.

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The health department said it was first contacted by a local physician in October, who reported an unusual trend in symptoms among hospital patients.

After launching an investigation, the department identified leptospirosis as a probable cause of the illness and found most patients worked on caneberry farms that utilize hoop houses — greenhouse structures to shelter the crops.

As the investigation to identify any additional cases and the exact sources of exposure continues, Ventura County Public Health has asked healthcare providers to consider a leptospirosis diagnosis for sick agricultural workers, particularly berry harvesters.

Rodents are a common source and transmitter of disease, though other mammals — including livestock, cats and dogs — can transmit it as well.

The disease is spread through bodily fluids, such as urine, and is often contracted through cuts and abrasions that contact contaminated water and soil, where the bacteria can survive for months.

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Humans can also contract the illness through contaminated food; however, the county health agency has found no known health risks to the general public, including through the contact or consumption of caneberries such as raspberries and blackberries.

Symptom onset typically occurs between two and 30 days after exposure, and symptoms can last for months if untreated, according to the CDC.

The illness often begins with mild symptoms, with fevers, chills, vomiting and headaches. Some cases can then enter a second, more severe phase that can result in kidney or liver failure.

Ventura County Public Health recommends agriculture and berry harvesters regularly rinse any cuts with soap and water and cover them with bandages. They also recommend wearing waterproof clothing and protection while working outdoors, including gloves and long-sleeve shirts and pants.

While there is no evidence of spread to the larger community, according to the department, residents should wash hands frequently and work to control rodents around their property if possible.

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Pet owners can consult a veterinarian about leptospirosis vaccinations and should keep pets away from ponds, lakes and other natural bodies of water.

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Political stress: Can you stay engaged without sacrificing your mental health?

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Political stress: Can you stay engaged without sacrificing your mental health?

It’s been two weeks since Donald Trump won the presidential election, but Stacey Lamirand’s brain hasn’t stopped churning.

“I still think about the election all the time,” said the 60-year-old Bay Area resident, who wanted a Kamala Harris victory so badly that she flew to Pennsylvania and knocked on voters’ doors in the final days of the campaign. “I honestly don’t know what to do about that.”

Neither do the psychologists and political scientists who have been tracking the country’s slide toward toxic levels of partisanship.

Fully 69% of U.S. adults found the presidential election a significant source of stress in their lives, the American Psychological Assn. said in its latest Stress in America report.

The distress was present across the political spectrum, with 80% of Republicans, 79% of Democrats and 73% of independents surveyed saying they were stressed about the country’s future.

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That’s unhealthy for the body politic — and for voters themselves. Stress can cause muscle tension, headaches, sleep problems and loss of appetite. Chronic stress can inflict more serious damage to the immune system and make people more vulnerable to heart attacks, strokes, diabetes, infertility, clinical anxiety, depression and other ailments.

In most circumstances, the sound medical advice is to disengage from the source of stress, therapists said. But when stress is coming from politics, that prescription pits the health of the individual against the health of the nation.

“I’m worried about people totally withdrawing from politics because it’s unpleasant,” said Aaron Weinschenk, a political scientist at the University of Wisconsin–Green Bay who studies political behavior and elections. “We don’t want them to do that. But we also don’t want them to feel sick.”

Modern life is full of stressors of all kinds: paying bills, pleasing difficult bosses, getting along with frenemies, caring for children or aging parents (or both).

The stress that stems from politics isn’t fundamentally different from other kinds of stress. What’s unique about it is the way it encompasses and enhances other sources of stress, said Brett Ford, a social psychologist at the University of Toronto who studies the link between emotions and political engagement.

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For instance, she said, elections have the potential to make everyday stressors like money and health concerns more difficult to manage as candidates debate policies that could raise the price of gas or cut off access to certain kinds of medical care.

Layered on top of that is the fact that political disagreements have morphed into moral conflicts that are perceived as pitting good against evil.

“When someone comes into power who is not on the same page as you morally, that can hit very deeply,” Ford said.

Partisanship and polarization have raised the stakes as well. Voters who feel a strong connection to a political party become more invested in its success. That can make a loss at the ballot box feel like a personal defeat, she said.

There’s also the fact that we have limited control over the outcome of an election. A patient with heart disease can improve their prognosis by taking medicine, changing their diet, getting more exercise or quitting smoking. But a person with political stress is largely at the mercy of others.

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“Politics is many forms of stress all rolled into one,” Ford said.

Weinschenk observed this firsthand the day after the election.

“I could feel it when I went into my classroom,” said the professor, whose research has found that people with political anxiety aren’t necessarily anxious in general. “I have a student who’s transgender and a couple of students who are gay. Their emotional state was so closed down.”

That’s almost to be expected in a place like Wisconsin, whose swing-state status caused residents to be bombarded with political messages. The more campaign ads a person is exposed to, the greater the risk of being diagnosed with anxiety, depression or another psychological ailment, according to a 2022 study in the journal PLOS One.

Political messages seem designed to keep voters “emotionally on edge,” said Vaile Wright, a licensed psychologist in Villa Park, Ill., and a member of the APA’s Stress in America team.

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“It encourages emotion to drive our decision-making behavior, as opposed to logic,” Wright said. “When we’re really emotionally stimulated, it makes it so much more challenging to have civil conversation. For politicians, I think that’s powerful, because emotions can be very easily manipulated.”

Making voters feel anxious is a tried-and-true way to grab their attention, said Christopher Ojeda, a political scientist at UC Merced who studies mental health and politics.

“Feelings of anxiety can be mobilizing, definitely,” he said. “That’s why politicians make fear appeals — they want people to get engaged.”

On the other hand, “feelings of depression are demobilizing and take you out of the political system,” said Ojeda, author of “The Sad Citizen: How Politics is Depressing and Why it Matters.”

“What [these feelings] can tell you is, ‘Things aren’t going the way I want them to. Maybe I need to step back,’” he said.

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Genessa Krasnow has been seeing a lot of that since the election.

The Seattle entrepreneur, who also campaigned for Harris, said it grates on her to see people laughing in restaurants “as if nothing had happened.” At a recent book club meeting, her fellow group members were willing to let her vent about politics for five minutes, but they weren’t interested in discussing ways they could counteract the incoming president.

“They’re in a state of disengagement,” said Krasnow, who is 56. She, meanwhile, is looking for new ways to reach young voters.

“I am exhausted. I am so sad,” she said. “But I don’t believe that disengaging is the answer.”

That’s the fundamental trade-off, Ojeda said, and there’s no one-size-fits-all solution.

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“Everyone has to make a decision about how much engagement they can tolerate without undermining their psychological well-being,” he said.

Lamirand took steps to protect her mental health by cutting social media ties with people whose values aren’t aligned with hers. But she will remain politically active and expects to volunteer for phone-banking duty soon.

“Doing something is the only thing that allows me to feel better,” Lamirand said. “It allows me to feel some level of control.”

Ideally, Ford said, people would not have to choose between being politically active and preserving their mental health. She is investigating ways to help people feel hopeful, inspired and compassionate about political challenges, since these emotions can motivate action without triggering stress and anxiety.

“We want to counteract this pattern where the more involved you are, the worse you are,” Ford said.

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The benefits would be felt across the political spectrum. In the APA survey, similar shares of Democrats, Republicans and independents agreed with statements like, “It causes me stress that politicians aren’t talking about the things that are most important to me,” and, “The political climate has caused strain between my family members and me.”

“Both sides are very invested in this country, and that is a good thing,” Wright said. “Antipathy and hopelessness really doesn’t serve us in the long run.”

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Video: SpaceX Unable to Recover Booster Stage During Sixth Test Flight

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Video: SpaceX Unable to Recover Booster Stage During Sixth Test Flight

President-elect Donald Trump joined Elon Musk in Texas and watched the launch from a nearby location on Tuesday. While the Starship’s giant booster stage was unable to repeat a “chopsticks” landing, the vehicle’s upper stage successfully splashed down in the Indian Ocean.

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