Science
Immune amnesia: Why even mild measles infections can lead to serious disease later
Dr. Adam Ratner has heard a lot of myths and misunderstandings about measles in his decades as a New York City pediatric infectious disease specialist.
A troubling untruth he’s seen circulating on social media during the current outbreak is that being infected with the virus instead of getting vaccinated confers benefits on the immune system — a strength-training program of sorts for the cells.
The truth, Ratner said, “is exactly the opposite.”
Measles is a highly contagious virus that presents as a rash and cold-like symptoms for many patients, and can lead to serious or fatal complications for others. An outbreak that began in west Texas in January has since infected nearly 500 people across 19 states, including eight people in California.
An insidious but lesser-known consequence of even a mild measles infection is that it kills the very cells that remember which pathogens the patient has previously fought and how those battles were won. As a result, recurring bugs that might have caused only minor symptoms make patients as sick as if they’d never encountered them before.
Measles destroys lymphocytes that defend against other bugs to make way for ones that defend against measles, an immunity won at the cost of other protections.
This “immune amnesia,” physicians say, leaves patients vulnerable to reccurrences of diseases their immune cells were previously able to resist.
If a child gets sick with measles, “for the next two or three years, you kind of have to be looking over your kid’s shoulder, wondering if some otherwise routine virus or bacteria that they should be very well protected against is potentially going to land them in the hospital,” said Dr. Michael Mina, an epidemiologist who was previously an assistant professor of immunology and infectious diseases at Harvard Medical School.
“Even if your measles virus infection seemed mild and you kind of blew through it, it doesn’t mean that it was mild on your immune system,” Mina added.
Take rotavirus, Ratner said, which causes severe diarrhea that can be life-threatening for children if untreated. A child who has rotavirus once will have antibodies that offer protection against future infections.
But a measles infection, said Ratner, author of the recent book “Booster Shots: The Urgent Lessons of Measles and the Uncertain Future of Children’s Health,“ “could wipe out that immunity and they could be just as vulnerable to rotavirus as if they had never seen it before.”
Immune amnesia results from the measles virus’ plan of attack. Viral particles travel via airborne droplets of saliva, mucus and cells that make their way into a new body when their unsuspecting host breathes them in.
From there, they sneak past the protective barrier lining the respiratory system and head to the lymph nodes in search of cells that express a particular protein called signaling lymphocytic activation molecule, or SLAM.
The virus then rides around the bloodstream on these hijacked SLAM-expressing cells, further infecting and destroying other SLAM expressers it meets on the way.
Among the SLAM-expressing cells that measles wrecks are memory B and T cells, two crucial players in a functioning immune system. Memory B cells manufacture the right antibodies quickly when a familiar microbe appears. Memory T cells recognize and kill viruses that your cells have encountered in the past.
A measles infection feeds on these memory cells. Vaccines, in contrast, stimulate the production of memory B and T cells without consuming others in the process.
This was not yet understood in the decades before the measles, mumps and rubella vaccine’s approval in 1963, when measles was a common childhood disease that killed some 400 children in the U.S. each year.
“For 100 years or more, we’ve known that measles does cause an acute susceptibility to other infections,” Mina said.
A measles infection temporarily suppresses the immune system, Mina said, and it was long assumed that opportunistic infections around the time of the illness were the result of that short-term suppression.
In 2015, Mina and colleagues published a paper that looked at mortality data in the U.S., the United Kingdom and Denmark before and after measles vaccines were introduced. They found that whenever there were measles outbreaks, childhood deaths from all other infectious diseases remained significantly higher for two to three years in outbreak locations, an increase that accounted for up to half of all childhood deaths from infectious disease.
Once those countries rolled out the MMR vaccine, measles cases fell, as expected. But so did childhood deaths from other infectious diseases, by about half.
Three years later, Mina and his collaborators took blood samples from 77 unvaccinated children in a community in the Netherlands before and then two to six months after the children contracted measles. They found that the virus wiped out 11% to 73% of the children’s preexisting antibodies to a host of pathogens.
Just as children in preschool fall ill constantly with common diseases they’re encountering for the first time, unvaccinated children who contract measles are at higher risk in the ensuing years for common early childhood sicknesses such as respiratory infections, earaches and viruses that cause diarrhea, said Shelly Bolotin, a scientist at Public Health Ontario in Canada and director of the Center for Vaccine Preventable Diseases at the University of Toronto.
“In order to correct that depletion [of B and T cells], you need to be reexposed to everything you were immune to before, and this can take years,” she said.
As of late March, 97% of the people sickened in the current outbreak were unvaccinated or didn’t disclose their vaccine status. The measles virus is attenuated in the MMR vaccine, meaning that it has been altered to produce the appropriate immune response without triggering the disease itself. In the case of measles, that means no mass destruction of the cells that hold the immune system’s memory.
“It doesn’t have this very, very damaging effect, which is why we recommend vaccination, because we get all of the immunity with none of the adverse consequences,” Bolotin said.
Science
Video: Engineer Is First Paraplegic Person in Space
new video loaded: Engineer Is First Paraplegic Person in Space
transcript
transcript
Engineer Is First Paraplegic Person in Space
A paraplegic engineer from Germany became the first wheelchair user to rocket into space. The small craft that blasted her to the edge of space was operated by Jeff Bezos’ company Blue Origin.
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Capsule touchdown. There’s CM 7 Sarah Knights and Jake Mills. They’re going to lift Michi down into the wheelchair, and she has completed her journey to space and back.
December 21, 2025
Science
This City’s Best Winter Show Is in Its Pitch-Dark Skies
The result is a starry sky visible even from the heart of the city. Flagstaff’s Buffalo Park, just a couple miles from downtown, measures about a 4 on the Bortle scale, which quantifies the level of light pollution. (The scale goes from 1, the darkest skies possible, to 9, similar to the light-polluted night sky of, say, New York City. To see the Milky Way, the sky must be below a 5.)
Science
Social media users in the Central Valley are freaking out about unusual fog, and what might be in it
A 400-mile blanket of fog has socked in California’s Central Valley for weeks. Scientists and meteorologists say the conditions for such persistent cloud cover are ripe: an early wet season, cold temperatures and a stable, unmoving high pressure system.
But take a stroll through X, Instagram or TikTok, and you’ll see not everyone is so sanguine.
People are reporting that the fog has a strange consistency and that it’s nefariously littered with black and white particles that don’t seem normal. They’re calling it “mysterious” and underscoring the name “radiation” fog, which is the scientific descriptor for such natural fog events — not an indication that they carry radioactive material.
An X user with the handle Wall Street Apes posted a video of a man who said he is from Northern California drawing his finger along fog condensate on the grill of his truck. His finger comes up covered in white.
“What is this s— right here?” the man says as the camera zooms in on his finger. “There’s something in the fog that I can’t explain … Check y’all … y’all crazy … What’s going on? They got asbestos in there.”
Another user, @wesleybrennan87, posted a photo of two airplane contrails crisscrossing the sky through a break in the fog.
“For anyone following the dense Tule (Radiation) fog in the California Valley, it lifted for a moment today, just to see they’ve been pretty active over our heads …” the user posted.
Scientists confirm there is stuff in the fog. But what it is and where it comes from, they say, is disappointingly mundane.
The Central Valley is known to have some of the worst air pollution in the country.
And “fog is highly susceptible to pollutants,” said Peter Weiss-Penzias, a fog researcher at UC Santa Cruz.
Fog “droplets have a lot of surface area and are suspended in the air for quite a long time — days or weeks even — so during that time the water droplets can absorb a disproportionate quantity of gasses and particles, which are otherwise known as pollutants,” he said.
He said while he hasn’t done any analyses of the Central Valley fog during this latest event, it’s not hard to imagine what could be lurking in the droplets.
“It could be a whole alphabet soup of different things. With all the agriculture in this area, industry, automobiles, wood smoke, there’s a whole bunch” of contenders, Weiss-Penzias said.
Reports of the fog becoming a gelatinous goo when left to sit are also not entirely surprising, he said, considering all the airborne biological material — fungal spores, nutrients and algae — floating around that can also adhere to the Velcro-like drops of water.
He said the good news is that while the primary route of exposure for people of this material is inhalation, the fog droplets are relatively big. That means when they are breathed in, they won’t go too deep into the lungs — not like the particulate matter we inhale during sunny, dry days. That stuff can get way down into lung tissue.
The bigger concern is ingestion, as the fog covers plants or open water cisterns, he said.
So make sure you’re washing your vegetables, and anything you leave outside that you might nosh on later.
Dennis Baldocchi, a UC Berkeley fog researcher, agreed with Weiss-Penzias’ assessment, and said the storm system predicted to move in this weekend will likely push the fog out and free the valley of its chilly, dirty shawl.
But, if a high pressure system returns in the coming weeks, he wouldn’t be surprised to see the region encased in fog once again.
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