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Immune amnesia: Why even mild measles infections can lead to serious disease later

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Immune amnesia: Why even mild measles infections can lead to serious disease later

Dr. Adam Ratner has heard a lot of myths and misunderstandings about measles in his decades as a New York City pediatric infectious disease specialist.

A troubling untruth he’s seen circulating on social media during the current outbreak is that being infected with the virus instead of getting vaccinated confers benefits on the immune system — a strength-training program of sorts for the cells.

The truth, Ratner said, “is exactly the opposite.”

Measles is a highly contagious virus that presents as a rash and cold-like symptoms for many patients, and can lead to serious or fatal complications for others. An outbreak that began in west Texas in January has since infected nearly 500 people across 19 states, including eight people in California.

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An insidious but lesser-known consequence of even a mild measles infection is that it kills the very cells that remember which pathogens the patient has previously fought and how those battles were won. As a result, recurring bugs that might have caused only minor symptoms make patients as sick as if they’d never encountered them before.

Measles destroys lymphocytes that defend against other bugs to make way for ones that defend against measles, an immunity won at the cost of other protections.

This “immune amnesia,” physicians say, leaves patients vulnerable to reccurrences of diseases their immune cells were previously able to resist.

If a child gets sick with measles, “for the next two or three years, you kind of have to be looking over your kid’s shoulder, wondering if some otherwise routine virus or bacteria that they should be very well protected against is potentially going to land them in the hospital,” said Dr. Michael Mina, an epidemiologist who was previously an assistant professor of immunology and infectious diseases at Harvard Medical School.

“Even if your measles virus infection seemed mild and you kind of blew through it, it doesn’t mean that it was mild on your immune system,” Mina added.

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Take rotavirus, Ratner said, which causes severe diarrhea that can be life-threatening for children if untreated. A child who has rotavirus once will have antibodies that offer protection against future infections.

But a measles infection, said Ratner, author of the recent book “Booster Shots: The Urgent Lessons of Measles and the Uncertain Future of Children’s Health,“ “could wipe out that immunity and they could be just as vulnerable to rotavirus as if they had never seen it before.”

Immune amnesia results from the measles virus’ plan of attack. Viral particles travel via airborne droplets of saliva, mucus and cells that make their way into a new body when their unsuspecting host breathes them in.

From there, they sneak past the protective barrier lining the respiratory system and head to the lymph nodes in search of cells that express a particular protein called signaling lymphocytic activation molecule, or SLAM.

The virus then rides around the bloodstream on these hijacked SLAM-expressing cells, further infecting and destroying other SLAM expressers it meets on the way.

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Among the SLAM-expressing cells that measles wrecks are memory B and T cells, two crucial players in a functioning immune system. Memory B cells manufacture the right antibodies quickly when a familiar microbe appears. Memory T cells recognize and kill viruses that your cells have encountered in the past.

A measles infection feeds on these memory cells. Vaccines, in contrast, stimulate the production of memory B and T cells without consuming others in the process.

This was not yet understood in the decades before the measles, mumps and rubella vaccine’s approval in 1963, when measles was a common childhood disease that killed some 400 children in the U.S. each year.

“For 100 years or more, we’ve known that measles does cause an acute susceptibility to other infections,” Mina said.

A measles infection temporarily suppresses the immune system, Mina said, and it was long assumed that opportunistic infections around the time of the illness were the result of that short-term suppression.

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In 2015, Mina and colleagues published a paper that looked at mortality data in the U.S., the United Kingdom and Denmark before and after measles vaccines were introduced. They found that whenever there were measles outbreaks, childhood deaths from all other infectious diseases remained significantly higher for two to three years in outbreak locations, an increase that accounted for up to half of all childhood deaths from infectious disease.

Once those countries rolled out the MMR vaccine, measles cases fell, as expected. But so did childhood deaths from other infectious diseases, by about half.

Three years later, Mina and his collaborators took blood samples from 77 unvaccinated children in a community in the Netherlands before and then two to six months after the children contracted measles. They found that the virus wiped out 11% to 73% of the children’s preexisting antibodies to a host of pathogens.

Just as children in preschool fall ill constantly with common diseases they’re encountering for the first time, unvaccinated children who contract measles are at higher risk in the ensuing years for common early childhood sicknesses such as respiratory infections, earaches and viruses that cause diarrhea, said Shelly Bolotin, a scientist at Public Health Ontario in Canada and director of the Center for Vaccine Preventable Diseases at the University of Toronto.

“In order to correct that depletion [of B and T cells], you need to be reexposed to everything you were immune to before, and this can take years,” she said.

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As of late March, 97% of the people sickened in the current outbreak were unvaccinated or didn’t disclose their vaccine status. The measles virus is attenuated in the MMR vaccine, meaning that it has been altered to produce the appropriate immune response without triggering the disease itself. In the case of measles, that means no mass destruction of the cells that hold the immune system’s memory.

“It doesn’t have this very, very damaging effect, which is why we recommend vaccination, because we get all of the immunity with none of the adverse consequences,” Bolotin said.

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Video: NASA Announces Artemis III Crew

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Video: NASA Announces Artemis III Crew

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NASA Announces Artemis III Crew

NASA announced the crew of Artemis III mission, which will fly to low-Earth orbit to test rendezvous and docking maneuvers with one or two lunar landers.

“I am excited to welcome you as the next crew in the Artemis journey to successfully return to the moon — this time to stay.” “I’m honored by the role that I’ve been given. I’m also very humbled by the task in front of us. But first and foremost, I’m grateful.” “So with that, the Artemis II crew, comrade, hands you the baton. You got the controls.” “As you know, we had a significant anomaly at our Launch Complex 36A on May 28. We’ve redoubled our efforts and are moving forward.”

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NASA announced the crew of Artemis III mission, which will fly to low-Earth orbit to test rendezvous and docking maneuvers with one or two lunar landers.

By Alisa Shodiyev Kaff

June 9, 2026

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Santa Monica Mountains’ last steelhead trout survived the Palisades fire — and even had babies

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Santa Monica Mountains’ last steelhead trout survived the Palisades fire — and even had babies

Scientists feared the Santa Monica Mountains’ last remaining steelhead trout were dead, smothered by debris flows unleashed by the Palisades fire.

But the endangered fish surprised them: A team of biologists recently spotted 30 of the rare trout — and 21 babies — in Topanga Creek.

“There was a lot of happy dancing in the creek,” said Rosi Dagit, principal conservation biologist for the Resource Conservation District of the Santa Monica Mountains, which works with public and private landowners to conserve natural resources.

That’s because the steelhead here are endangered, at both the state and federal levels. Once, they swam in most streams of the Santa Monicas, but their numbers plummeted amid overfishing and coastal development. Increasingly frequent wildfire has further stressed their habitat. Topanga Creek, a biodiversity hot spot, is home to their last known population in the mountains that stretch from the Hollywood Hills to Point Mugu in Ventura County.

The trout that were spotted, including this one, are part of a distinct Southern California population that’s listed as endangered at the state and federal levels.

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(RCDSMM Stream Team)

The California Department of Fish and Wildlife spearheaded a complex mission to rescue trout threatened by the Palisades fire that sparked in January 2025.

Time was of the essence. The fire hadn’t yet been fully contained. But rain was on the way, which would sweep massive amounts of sediment from the denuded hillsides into the water. Fish are often killed this way.

Crews stunned the fish with electricity, scooped them up in buckets, trucked them to a hatchery and ultimately moved them to Arroyo Hondo Creek in Santa Barbara County.

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Within days, Topanga Creek was choked with mud. Some assumed the fish left behind were goners.

But in March, the conservation district’s team found four. The following month, when water conditions were clearer, they saw more.

“These fish continue to amaze me,” said Kyle Evans, environmental program manager for the state Department of Fish and Wildlife, who had seen the damage to the creek. “I had seen populations get wiped out in similar situations. So when I heard, I was thrilled.”

Evans surmises the fish that survived were in an area of the creek where less charred material and sediment were swept in.

“These fish likely hunkered down, were hiding under some rocks or places to try to get away from the main concentration of flow,” he said. “And luckily they weren’t buried.”

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The ones that were spotted were fairly small, around 6 to 14 inches. Rainbow trout and steelhead trout are the same species, but with different lifestyles. If the fish remain in freshwater, they’ll be considered rainbows. However, they can migrate to the ocean and become steelhead, where they typically grow larger before returning to their natal waters to spawn.

Topanga Creek hasn’t fully recovered from the damage it sustained, but scientists say it’s looking better. Surveys last year were “so depressing,” Dagit said, with very few animals, and stretches that were essentially transformed into flat roads from all the sediment buildup. Some of the riparian canopy burned right down to the creek.

Then came 32 inches of rain over the last nine months, scouring out and moving sediment, creating deeper pools. Dagit said they recently found newt egg masses for the first time in years, as well as a few adult newts and many frogs. Plants that provide cover are starting to recover.

She provided photos comparing certain pools last year and this year, some dramatically transformed. In September 2025, the Shrine Pool could have been an overgrown hiking trail. This April, it was filled with shallow water.

Shrine Pool, Sept. 2025, left, and the same location, April 2026, right.

The Shrine Pool in September 2025, left, and the same location in April 2026, right, with RCDSMM’s Isaac Yelchin donning a wetsuit.

(RCDSMM Stream Team)

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Topanga Creek is home to another endangered fish, the small but hardy northern tidewater goby, often described as cute. Not long before the trout operation, Dagit led a rescue of hundreds of these fish too. Many were repatriated to the lagoon at the mouth of the creek in a moving ceremony last June.

There’s still the matter of what to do with the trout that were moved to Santa Barbara County last year. Evans would like to bring them home to the Santa Monicas at some point, but isn’t sure if it will happen. On one hand, they could bolster the small, genetically isolated surviving population. On the other, they might inadvertently bring in a disease or bacteria. There is some time to decide. Evans estimates the creek still needs to recover for two to three more years.

For now, the fish are functioning fine in their adopted creek. Experts worried the trauma wrought by the move would disrupt their spawning process, but they had babies that spring. This year, they spawned again.

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Pacifica pier cracks, another coastal casualty as seas continue to rise

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Pacifica pier cracks, another coastal casualty as seas continue to rise

The Pacifica Municipal Pier was shut down and taped off Thursday after city workers noticed cracks running through the landmark structure and concrete chunks falling into the ocean.

It’s just one of many coastal California structures that have recently crumbled under pressure from a rising and relentless ocean.

Officials from the small, beach city south of San Francisco said the pier was closed due to “cracking, separation, and displacement of the concrete walkway and structural elements.”

It will stay closed while structural engineers asses its safety.

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Photos taken by city employees show a wide crack that runs from top to bottom and across the structure as well. Other photos show a large horizontal crack under the foundation of a small restaurant on the pier, the Chit Chat Cafe.

The cafe was also shut down.

This is not the first time the 53-year-old pier has shown signs of stress. In 2021, part of it was shut down after handrails along the edge collapsed. And in 2023, after a series of storms pummeled the Central California coast, damaging parts of the pier, the structure was partially closed for more than year.

Those same storms caused extensive damage in Aptos and Capitola, 70 miles south, where piers and waterfront infrastructure were swept away or damaged.

In 2024, a 150- to 180- foot section of the Santa Cruz wharf was ripped off by powerful waves.

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At least 10 of the state’s dozens of coastal public piers were closed for part or all of 2024 due to structural damage sustained in winter storms since 2022. At least five others have longer-term upgrades planned to address structural issues.

“These things are costly to maintain,” said Zach Plopper, senior environmental director at Surfrider. “They are a part of our California coastal culture in many ways, but we’re going to need to reckon with, one, the state that they’re in, and two, the continuous and worsening threats they’re going to experience,”

He said most of the piers were constructed in the early 1900s, and they weren’t built to withstand decades of rough seas, storms and rising sea level.

“With this incoming El Niño, which is forecasted to be significant, and this marine heat wave we’re in the midst of, we’re kind of in uncharted waters as far as what this winter could bring in terms of storms and swells to the California coast, and we’re likely going to see a lot more damage,” he said. “Not just piers, but roads and other coastal infrastructure up and down the state.”

There was no storm in Pacifica earlier this week, so no single event could be blamed for the destruction.

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However, a 2025 report from an outside engineering firm, GHD, found that several sections of the pier were in “poor” or “serious” condition, and they recommended closure before anticipated storms or events that could “subject the piles to high winds, swells and large waves.”

The firm found several areas of the pier where concrete was missing and rebar was exposed and corroding.

“The pier has continued to experience high winds and large waves in a harsh marine environment,” the engineers wrote in the report, noting that continuous exposure to seawater or marine spray was “detrimental” to the structure.

A 2023 city report estimated it would cost $19 million to repair.

That same year, a state law was enacted to require local governments along the California coast to plan for sea level rise in the coming decades.

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Sea level has risen some 8 inches, on average, along the coast in the past 150 years, Plopper said, and researchers anticipate another foot in the next 25 years.

“We’re going to see profound shifts on our coastline, none that we have ever experienced before, and building static structures on the coast just doesn’t work all that well,” he said. “We’re going to have to make some really hard decisions.”

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