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Is age reversal possible? Researchers from Harvard, Maine, and MIT prove yes!

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Is age reversal possible? Researchers from Harvard, Maine, and MIT prove yes!


Researchers from Harvard Medical School, the University of Maine, and MIT have announced a stunning breakthrough in the quest for age reversal. Their revolutionary chemical method for reversing cellular aging could potentially change the landscape of age-related diseases and regenerative medicine, bringing the world one step closer to the elusive fountain of youth.

Researchers from Harvard, Maine, and MIT have made a breakthrough in age reversal using a chemical method to reverse cellular aging. Their study identified six chemical combinations that rejuvenated aged cells within a week without causing unregulated cell growth. (Unsplash)

The study, titled “Chemically induced reprogramming to reverse cellular aging,” was published in the prestigious scientific journal Aging on July 12, 2023. Led by renowned scientist Dr. David A. Sinclair, the team of researchers including Jae-Hyun Yang, Christopher A. Petty, and Maria Vina Lopez, explored the possibility of rejuvenating cells using chemical interventions rather than genetic manipulation.

Their research builds upon a previous Nobel Prize-winning breakthrough, which demonstrated that specific genes, known as Yamanaka factors, could transform adult cells into induced pluripotent stem cells (iPSCs). However, concerns about potential cancerous effects limited the practical application of this method. In this study, the scientists aimed to find chemical combinations that could reverse cellular aging without compromising cell safety.

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Using advanced cell-based assays and aging clocks, the team identified six chemical combinations that successfully restored youthfulness to aged cells within a week. The rejuvenated cells exhibited significant changes in transcriptomic age and nucleocytoplasmic protein compartmentalization. Excitingly, the researchers achieved these results without causing unregulated cell growth, thus addressing a critical limitation of previous gene therapy approaches.

There are countless applications of this discovery. Along with being a potential game changer for regenerative medicine and reversing age-related diseases, the study also offers a glimpse into a future where injuries can be repaired more efficiently, vision can be improved, and whole-body rejuvenation becomes attainable. The researchers expect a day when a single pill could reverse the effects of aging, transforming the way we approach healthcare and extending the human lifespan.

As of now, plans for human clinical trials using the lab’s age reversal gene therapy are already in motion, following successful outcomes in monkeys. The team of researchers wants to make age reversal treatments widely accessible, thereby offering hope to millions of people worldwide.

Dr. Sinclair, the lead scientist on the project, said, “Until recently, the best we could do was slow aging. New discoveries suggest we can now reverse it. This process has previously required gene therapy, limiting its widespread use.” With these groundbreaking findings, it seems that the dream of reversing the aging process is closer to becoming a reality than ever before.

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Maine

Beware of these proliferating Maine rental scams

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Beware of these proliferating Maine rental scams


Housing
This section of the BDN aims to help readers understand Maine’s housing crisis, the volatile real estate market and the public policy behind them. Read more Housing coverage here.

A unicorn apartment was listed in the pricey city of Ellsworth: a 2-bedroom with all utilities included for just $700 per month.

If that sounds too good to be true, it is, and the scam was not hard to detect.

The unit was posted by an anonymous Facebook user in a local forum without a specific address. A palm tree was faintly visible through the front door in one photo. When a reporter inquired about the post, someone used a Montana company’s name and sent a link to apply for a private showing in exchange for a $70 deposit.

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A quick call to the Montana company, which deals only in home sales in that state, is not behind the scam listing. A representative said the agency gets daily calls from Facebook users around the nation telling them scammers are impersonating them.

These kinds of apartment listing scams, often seen on Facebook or Craigslist, have picked up steam in recent years as the nation’s housing crisis deepens and more have become desperate for affordable places to live. The scams often promise below-market rents in cities squeezed for that kind of inventory, meaning the fraudsters target those who are most vulnerable.

“Rental scams in a very tight market are very prevalent,” Phil Chin, a lead volunteer with AARP Maine’s fraud watch network, said. “People under the pressure of income are trying to get the best for a lower price, and seniors are always at disadvantage only because they don’t have the wherewithal to do all this checking around.”

These kinds of scams are “unconscionable” for targeting families looking for affordable housing, Attorney General Aaron Frey said in a statement. His office has received multiple complaints on the issue.

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Many of the advertised units do not exist, the Federal Trade Commission wrote in an advisory. Some exist but are not for rent. One Maine homeowner recently discovered that his house was for rent on Craigslist without his knowledge, said Christopher Taub, Frey’s deputy. The ad included photos and almost got one renter to send money to a Nigerian email address.

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“Fortunately, the shopper contacted the Maine homeowner and discovered the scam before sending any funds to the scam artist,” Taub said. “Other consumers haven’t been so lucky only to arrive at their paid vacation home for the week or new apartment to find out that it isn’t for rent at all.”

Often, Facebook users are wise to these scams and will comment that they appear to be one. But Facebook allows any poster to restrict their comments, allowing many fraudulent listings to go unchecked. Neither Craigslist nor Meta, Facebook’s parent company, responded to a request for comment on scam apartment listings.

To avoid being scammed, it’s important to confirm the person listing an apartment is legitimate or from a known and trusted business before sending them money, Taub said. Call the property management company and ask lots of questions or visit it yourself, the office advised.

The Federal Trade Commission recommends searching online for the rental location’s address and the name of the property owner. If the two don’t match, that’s a red flag. If there’s no address listed at all, like the Ellsworth unit, that’s another sign of a scam.

Though Maine landlords are allowed to charge application fees, it can only be for specific reasons including a background check, a credit check or some other screening process, according to Pine Tree Legal Assistance. Frey warns against paying any such fees by cash, wiring money, sending gift cards or paying by cryptocurrency, as you can’t get that money back.

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“It’s a hard one to deal with. People are under income pressure,” said Chin of AARP Maine. “They have to be vigilant on their own, … but it’s hard to keep your wits about you when you’re facing eviction.”



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Vendors prep for Maine Harvest Festival & Craft Show this weekend

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Vendors prep for Maine Harvest Festival & Craft Show this weekend


BANGOR, Maine (WABI) – You don’t need to be a farmer to enjoy Maine’s harvest this weekend!

Maine Harvest Festival & Craft Show is returning to Bangor’s Cross Insurance Center both Saturday and Sunday.

Open from 10 a.m. to 4 p.m. both days, there will be over 80 local artisans, farmers and crafters selling a wide variety of goods, making it a perfect stop for Christmas gifts or Thanksgiving additions!

WABI got a glimpse into the Cross Insurance Center Friday as vendors prepped their booths ahead of the weekend.

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New this year: admission is free!

Organizers say it is in response to low admission numbers post-COVID and to incentivize as many people as possible to come shop local.

“At the Cross Center, we really want to celebrate our community, and we want to make sure we give people, our local vendors a spotlight to reach the community,” says Brad LaBree, Cross Insurance Center’s Director of Sales and Marketing.

The event will also give attendees a chance to participate in the Cross Insurance Center’s ticket giveaway to upcoming shows a part of their Broadway series.

LaBree says Cross Insurance Center is expecting about a 5,000-person turnout this weekend.

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Maine LifeFlight helicopters disrupted by laser strike

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Maine LifeFlight helicopters disrupted by laser strike


LifeFlight crews talk on the tarmac at the Sanford Seacoast Regional Airport in July. Shawn Patrick Ouellette/Staff Photographer

A LifeFlight crew was disrupted by a laser last week while flying back to their base in Sanford.

The light was pointed at the helicopter, which was flying at about 2,000 feet in the air around 7:45 p.m. on Monday, Nov. 11, according to LifeFlight of Maine, a nonprofit that provides emergency medical transportation. While the pilot was able to fly back safely, those flashes of light can temporarily blind the crew, who are often wearing night vision goggles, the company said.

The Federal Aviation Administration has monitored thousands of nationwide laser strikes, where someone points the beam at an aircraft. As of Sept. 30, a total of 8,863 incidents were reported to the agency, 24 of which happened in Maine. In 2023, the nationwide total was 13,304.

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This is the fourth laser strike reported by a Maine LifeFlight pilot in two years, the company said.

Pointing a laser at aircraft is a federal crime, punishable by a fine, up to five years in prison, or both. And according to Maine law, pointing a laser at a uniformed law enforcement officer or injuring another person with a laser is a Class D crime.

This story will be updated.



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