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Is age reversal possible? Researchers from Harvard, Maine, and MIT prove yes!

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Is age reversal possible? Researchers from Harvard, Maine, and MIT prove yes!


Researchers from Harvard Medical School, the University of Maine, and MIT have announced a stunning breakthrough in the quest for age reversal. Their revolutionary chemical method for reversing cellular aging could potentially change the landscape of age-related diseases and regenerative medicine, bringing the world one step closer to the elusive fountain of youth.

Researchers from Harvard, Maine, and MIT have made a breakthrough in age reversal using a chemical method to reverse cellular aging. Their study identified six chemical combinations that rejuvenated aged cells within a week without causing unregulated cell growth. (Unsplash)

The study, titled “Chemically induced reprogramming to reverse cellular aging,” was published in the prestigious scientific journal Aging on July 12, 2023. Led by renowned scientist Dr. David A. Sinclair, the team of researchers including Jae-Hyun Yang, Christopher A. Petty, and Maria Vina Lopez, explored the possibility of rejuvenating cells using chemical interventions rather than genetic manipulation.

Their research builds upon a previous Nobel Prize-winning breakthrough, which demonstrated that specific genes, known as Yamanaka factors, could transform adult cells into induced pluripotent stem cells (iPSCs). However, concerns about potential cancerous effects limited the practical application of this method. In this study, the scientists aimed to find chemical combinations that could reverse cellular aging without compromising cell safety.

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Using advanced cell-based assays and aging clocks, the team identified six chemical combinations that successfully restored youthfulness to aged cells within a week. The rejuvenated cells exhibited significant changes in transcriptomic age and nucleocytoplasmic protein compartmentalization. Excitingly, the researchers achieved these results without causing unregulated cell growth, thus addressing a critical limitation of previous gene therapy approaches.

There are countless applications of this discovery. Along with being a potential game changer for regenerative medicine and reversing age-related diseases, the study also offers a glimpse into a future where injuries can be repaired more efficiently, vision can be improved, and whole-body rejuvenation becomes attainable. The researchers expect a day when a single pill could reverse the effects of aging, transforming the way we approach healthcare and extending the human lifespan.

As of now, plans for human clinical trials using the lab’s age reversal gene therapy are already in motion, following successful outcomes in monkeys. The team of researchers wants to make age reversal treatments widely accessible, thereby offering hope to millions of people worldwide.

Dr. Sinclair, the lead scientist on the project, said, “Until recently, the best we could do was slow aging. New discoveries suggest we can now reverse it. This process has previously required gene therapy, limiting its widespread use.” With these groundbreaking findings, it seems that the dream of reversing the aging process is closer to becoming a reality than ever before.

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Maine

Opinion: Voter ID referendum is unnecessary, expensive, and harmful to Maine voters

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Opinion: Voter ID referendum is unnecessary, expensive, and harmful to Maine voters


The BDN Opinion section operates independently and does not set news policies or contribute to reporting or editing articles elsewhere in the newspaper or on bangordailynews.com

Anna Kellar is the executive director of the League of Women Voters of Maine.

This past November, my 98-year-old grandmother was determined that she wasn’t going to miss out on voting for president. She was worried that her ballot wouldn’t arrive in the mail in time. Fortunately, her daughter — my aunt — was able to pick up a ballot for her, bring it to her to fill out, and then return it to the municipal office.

Thousands of Maine people, including elderly and disabled people like my grandmother, rely on third-party ballot delivery to be able to vote. What they don’t know is that a referendum heading to voters this year wants to take away that ability and install other barriers to our constitutional right to vote.

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The “Voter ID for Maine” citizen’s initiative campaign delivered their signatures to the Secretary of State this week, solidifying the prospect of a November referendum. The League of Women Voters of Maine (LWVME) opposes this ballot initiative. We know it is a form of voter suppression.

The voter ID requirement proposed by this campaign would be one of the most restrictive anywhere in the county. It would require photo ID to vote and to vote absentee, and it would exclude a number of currently accepted IDs.

But that’s not all. The legislation behind the referendum is also an attack on absentee voting. It will repeal ongoing absentee voting, where a voter can sign up to have an absentee ballot mailed to them automatically for each election cycle, and it limits the use and number of absentee ballot dropboxes to the point where some towns may find it impractical to offer them. It makes it impossible for voters to request an absentee ballot over the phone. It prevents an authorized third party from delivering an absentee ballot, a service that many elderly and disabled Mainers rely on.

Absentee voting is safe and secure and a popular way to vote for many Mainers. We should be looking for ways to make it more convenient for Maine voters to cast their ballots, not putting obstacles in their way.

Make no mistake: This campaign is a broad attack on voting rights that, if implemented, would disenfranchise many Maine people. It’s disappointing to see Mainers try to impose these barriers on their fellow Mainers’ right to vote when this state is justly proud of its high voter participation rates. These restrictions can and will harm every type of voter, with senior and rural voters experiencing the worst of the disenfranchisement. It will be costly, too. Taxpayers will be on the hook to pay for a new system that is unnecessary, expensive, and harmful to Maine voters.

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All of the evidence suggests that voter IDs don’t prevent voter fraud. Maine has safeguards in place to prevent fraud, cyber attacks, and other kinds of foul play that would attempt to subvert our elections. This proposal is being imported to Maine from an out-of-state playbook (see the latest Ohio voter suppression law) that just doesn’t fit Maine. The “Voter ID for Maine” campaign will likely mislead Mainers into thinking that requiring an ID isn’t a big deal, but it will have immediate impacts on eligible voters. Unfortunately, that may be the whole point, and that’s what the proponents of this measure will likely refuse to admit.

This is not a well-intentioned nonpartisan effort. And we should call this campaign what it is: a broad attack on voting rights in order to suppress voters.

Maine has strong voting rights. We are a leader in the nation. Our small, rural, working-class state has one of the highest voter turnout rates in the country. That’s something to be proud of. We rank this high because of our secure elections, same-day voter registration, no-excuse absentee ballots, and no photo ID laws required to vote. Let’s keep it this way and oppose this voter suppression initiative.



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Maine Democratic Party leader won’t seek reelection

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Maine Democratic Party leader won’t seek reelection


Maine Democratic Party leader won’t seek reelection

Bev Uhlenhake Maine Democratic Party

The chair of the Maine Democratic Party announced Thursday she won’t seek reelection when members select leaders later this month.

Bev Uhlenhake, a former city councilor and mayor in Brewer and former chair of the Penobscot County Democrats, has served as chair of the state party since January 2023. She is also a previous vice chair of the party.

In a written statement, Uhlenhake noted some of the recent successes and challenges facing Democrats, including the reelection of Democratic majorities in both the Maine House and Senate last November, though by narrower margins, and winning three of Maine’s four electoral votes for Vice President Kamala Harris.

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“While we have laid a solid foundation from which Maine Democrats can build toward even greater success in 2026 and beyond, I have decided to step away from Maine Democratic Party leadership for personal and professional reasons, and will not seek reelection,” Uhlenhake said.

Party Vice Chair Julian Rogers, who was also elected to his post in 2023, announced he also won’t seek reelection to leadership, but will resume a previous role he held as vice chair of the party’s committee on Diversity, Equity, Inclusion & Belonging.

Democratic State Committee members will vote for the party’s next leaders in elections to be held on Sunday, Jan. 26.

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Shenna Bellows sworn in for third term as Maine Secretary of State

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Shenna Bellows sworn in for third term as Maine Secretary of State


AUGUSTA, Maine — Secretary of State Shenna Bellows was sworn into office for her third term Wednesday.  Governor Janet Mills conducted the formal swearing-in of all the constitutional officers, which includes Bellows, State Treasurer Joseph Perry, Attorney General Aaron Frey and State Auditor Matthew Dunlap. In her remarks following the swearing-in, Bellows shared a message of transparency and accessibility in continuing to serve the people of Maine. “It is incumbent upon us as elected officials to make government work for the people of Maine,” Bellows said. “We must reduce bureaucracy, improve efficiency, modernize our systems, and above all, bring people together in community to make life better for the people of Maine.”

The Department of the Secretary of State includes three bureaus: The Maine State Archives, the Bureau of Motor Vehicles and the Bureau of Corporations, Elections and Commissions.

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Bellows emphasized her commitment to ensuring free, safe, and secure elections, modernizing government services, and preserving Maine’s history through the State Archives. She highlighted the importance of standing up for the rule of law and democracy, referring to the legacy of Civil War General Joshua Chamberlain and referencing the events at the U.S. Capitol on January 6, 2021. “This is our Chamberlain moment. We must stand up for the rule of law and do the right thing even when it is hard. As your Secretary of State, I pledge to always ensure that we have free, safe and secure elections and that we adhere to the Constitution and the rule of law in every aspect of everything that we do,” said Bellows. Bellows, Maine’s 50th Secretary of State, previously served two terms in the Maine Senate from 2016-2020 and was the executive director of the Holocaust and Human Rights Center of Maine before her election in 2021.



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