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Severe depression eased by single dose of synthetic ‘magic mushroom’ | CNN

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Severe depression eased by single dose of synthetic ‘magic mushroom’ | CNN



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A single dose of an artificial model of the mind-altering part of magic mushrooms, psilocybin, improved melancholy in folks with a treatment-resistant type of the illness, a brand new research discovered.

The randomized, double-blind scientific trial, which authors known as “the biggest of its variety,” in contrast outcomes of a 25-milligram dose to a 10-milligram and 1-milligram dose of an artificial psilocybin, COMP360, that was administered within the presence of skilled therapists.

Outcomes of the research, printed Wednesday in The New England Journal of Medication, discovered “an instantaneous, quick, rapid-acting, sustained response to 25 milligrams (of COMP360),” stated research coauthor Dr. Man Goodwin, a professor emeritus of psychiatry on the College of Oxford in the UK.

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“This drug might be extracted from magic mushrooms, however that isn’t the way in which our compound is generated. It’s synthesized in a purely chemical course of to provide a crystalline kind,” stated Goodwin, who’s the chief medical officer of COMPASS Pathways, the corporate that manufactures COMP360 and carried out the research.

Consultants within the subject discovered the research findings promising.

“They clearly discovered a dose impact and clinically significant enchancment in simply three weeks,” stated Dr. Matthew Johnson, a professor in psychedelics and consciousness at Johns Hopkins Medication in Baltimore. He was not concerned within the new research.

“If you happen to have been within the 25-milligram group, you have been practically thrice as prone to reply than in case you have been within the 1-milligram group,” stated Johnson, who coauthored security pointers for psychedelic analysis in 2008.

The fast response to remedy was notable as nicely.

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“The utmost impact (was) seen the day after receiving the remedy. This contrasts with customary antidepressants, which take a number of weeks to succeed in most impact,” stated Dr. Anthony Cleare, a professor of psychopharmacology and affective issues at King’s Faculty London, in a press release. He was not concerned within the research.

Nevertheless, there are a variety of points that want additional research earlier than this drug can be accessible for scientific use, consultants stated.

“The results did begin to put on off by three months, and we have to understand how greatest to forestall the melancholy returning,” Cleare stated, including that not sufficient is but identified about potential unwanted effects.

“Whereas the security profile appears encouraging total, nice care is clearly wanted when utilizing psychoactive substances comparable to psilocybin. Bigger research are on the way in which that we hope will assist reply these points,” he stated.

The scientific trial occurred at 22 websites in america, Canada, the UK and 7 nations in Europe. The research was designed to check the security of various dosages of the proprietary model of psilocybin.

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The 233 research individuals had treatment-resistant melancholy, which may solely be identified after an individual fails to reply to two programs of antidepressants. Of the 9 million folks within the US with medically handled melancholy, 3 million sufferers are immune to remedy, research have estimated. Globally, some 100 million folks have treatment-resistant melancholy, Goodwin stated.

Individuals with the situation are at a excessive threat of bodily sickness, incapacity, hospitalization and suicide, the research stated.

Any research individuals on antidepressants have been required to wean themselves from these drugs previous to the beginning of the trial. Psychedelic remedy doesn’t work on people who find themselves actively taking antidepressants — the receptors the place psychedelics connect within the mind are already flooded with serotonin from their present mood-altering medication.

“Contributors have been requested to stay off antidepressant remedy throughout the first 3 weeks after the trial-drug administration; nevertheless, these drugs may very well be began at any time throughout the trial if deemed clinically needed by a doctor investigator,” the research stated.

Melancholy severity for every particular person was assessed the day earlier than remedy utilizing a psychological scale extensively utilized by clinicians. Counselors skilled to supply psychological assist have been current throughout the psychedelic journeys, which lasted between six and eight hours. Contributors have been additionally given two extra remedy classes within the first week, the research stated.

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Melancholy ranges have been documented the day after the “journey” and one other 5 occasions over a 12-week interval. About 37% of people that took the 25-milligram dose confirmed enchancment. The truth is, 29% have been thought-about to be in remission at week three, the research discovered.

By week 12, nevertheless, the optimistic impression on depressive signs had waned and now not reached a stage of statistical significance, the research discovered.

“The incidence of sustained response at week 12 was 20% within the 25-mg group, 5% within the 10-mg group, and 10% within the 1-mg group,” wrote psychobiologist Dr. Bertha Madras, director of the laboratory of habit neurobiology at Harvard Medical College’s McLean Hospital in Belmont, Massachusetts, in an accompanying editorial. She didn’t take part within the research.

“That is not a spectacular response fee for a psychiatric remedy … and we’d solely anticipate this to worsen over an extended follow-up interval,” stated Dr. Ravi Das, an affiliate professor of academic psychology analysis strategies and statistics at College Faculty London by way of e mail. He who was not concerned with the research.

As well as, “there have been an uneven variety of severely depressed sufferers in every group; with considerably fewer severely depressed folks within the obvious ‘efficient’ (25mg) dose group,” Das stated in a press release. “This doesn’t look like acknowledged within the paper.”

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Headache, nausea, fatigue and dizziness plagued 77% of the research individuals and occurred in any respect dosage ranges, which consultants say is a typical response on the day of psilocybin administration.

A small variety of folks in all three dosage teams skilled suicidal ideas or injured themselves over the 12-week follow-up interval, the research discovered. Throughout the first three weeks alone, two folks within the 25-milligram group thought of suicide and two deliberately injured themselves. Two folks within the 10-milligram group have been suicidal, one self-injured and one was hospitalized for extreme melancholy, the research reported.

These behaviors are “frequent in treatment-resistant melancholy research — most instances occurred greater than per week after the COMP360 psilocybin session,” the corporate stated.

“Do not forget that that is in individuals who have been assessed to not be at vital threat of suicide after they entered the trial. The numbers have been pretty small, however that is one thing that may have to be taken fastidiously into consideration in any later-stage trials,” stated Kevin McConway, professor emeritus of utilized statistics at The Open College, a British public analysis college.

The research outcomes are promising, however many questions stay and it’s unknown if this drug would achieve success for several types of melancholy, stated McConway, who was not concerned within the research.

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“They’ll’t inform us how efficient this psilocybin plus remedy remedy is compared with different current drug or non-drug therapies for melancholy,” stated McConway, noting that as a subsequent step for follow-up trials.

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Northvolt dilemma: Can European EVs avoid relying on Asian batteries?

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Northvolt dilemma: Can European EVs avoid relying on Asian batteries?

Two months before Northvolt filed for bankruptcy in the US, Robin Zeng, known as China’s “battery king”, had a quick but grim answer as to why European battery makers were struggling to make good products.

“They have a wrong design . . . they have a wrong process . . . and they have the wrong equipment. How can they scale up?” the chief executive of CATL told Nicolai Tangen, the head of Norway’s $1.8tn oil fund. “So almost all mistakes together.”

The bleak assessment from the world’s biggest electric vehicle battery manufacturer captures the scale of the failure for the industries behind the critical technology for Europe’s decarbonisation, leaving governments, companies and investors at a loss as to how to recraft the continent’s strategy to compete with China.

“How are we not taking this more seriously? The European car industry is the heartland of European industry’s supposed prowess,” said one long-standing investor in Northvolt after the collapse into US bankruptcy last week of Europe’s biggest battery hope. “The depth of the crisis for the European car industry is almost unlimited. It’s incredibly grim.”

Brussels took its first steps to establish a battery supply chain across Europe in 2017, with Northvolt at the heart of its ambitions. The bloc has since increased its share of the global battery market from 3 per cent to 17 per cent with annual turnover of €81bn in 2023 after spending more than €6bn of the EU budget to support cross-border battery projects and research and innovation.

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But in terms of EV batteries, Asian participants including CATL, BYD, and LG Energy Solution and SK On of South Korea, control about 70 per cent of the global market. Many of the 30 gigafactory projects in Europe have also been designed and built with the help of Chinese and Korean companies.

Northvolt chief executive Peter Carlsson. The Swedish group was at the heart of Brussels’ ambitions to establish a battery supply chain across Europe © Charlie Bibby/FT
Robin Zeng
CATL chief executive Robin Zeng said European battery makers had the ‘wrong design . . . they have a wrong process . . . and they have the wrong equipment’ © Lam Yik/Bloomberg

As the EU’s ambitions have faltered, the struggles of Northvolt have come to embody the challenge the continent faces. The bloc wants to continue encouraging costly investments in the clean technologies needed to meet its ambitious climate goals, while at the same time stemming the wave of plant closures and job cuts that are already spreading across the automotive sector and heavy industries. 

“It’s fair to say we’re at a pivotal moment right now,” said Wouter IJzermans, executive director at the Batteries European Partnership Association. 

People involved in the Northvolt saga said options were narrowing for Europe to address its dependence on China and other parts of Asia for the technology and materials that will be critical as the automotive industry transitions to electric vehicles. 

Efforts are still being made by other start-ups such as France’s Verkor and Volkswagen’s battery business PowerCo, but they are facing either diminished ambitions or tougher financing prospects.

PowerCo is considering building just one out of the two production lines previously planned for its plant in Salzgitter in Germany due to slowing market demand. 

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Verkor counts Renault as its main client and recently finalised a new €1.3bn financing round to back the construction of a plant in the northern French port city of Dunkirk. But its chief executive Benoit Lemaignan said financing talks were arduous on the back of Northvolt’s woes and the slowdown in the growth of electric vehicle sales this year.

A mural of a VW electric vehicle at the construction site of the Volkswagen AG SalzGiga fuel cell gigafactory, operated by PowerCo, in Salzgitter, Germany in 2023
The Volkswagen fuel cell gigafactory under construction in Salzgitter, Germany, last year © Krisztian Bocsi/Bloomberg

“There was a whole fresh round of audit work and validation of the set-up, our chemistry, the machines and all the equipment,” Lemaignan said. “It’s not something automatic, to find financing today. It’s an issue that goes well beyond Verkor, and affects the financing of all of the energy and climate transition industries.” 

In France, there is also Automotive Cells Company, a venture backed by carmakers Stellantis and Mercedes-Benz, and oil major TotalEnergies, which started producing batteries in 2023. But this year ACC paused plans to expand further with plants in Germany and Italy as it considered switching to a lower-cost form of battery technology and adjusted to a slower EV adoption rate. 

“There are expansion phases and crisis phases, if you draw a parallel with other industries. Perhaps we’re living through the first big challenges for Europe’s battery industry. But there will be factories and there will be clients, we’re seeing that more and more,” Lemaignan said.

Consequences from Northvolt’s US bankruptcy filing are already being felt, with carmakers being forced once again to turn to their Asian suppliers to reduce their exposure to its collapse. 

Germany’s Porsche has never confirmed its relationship with Northvolt, but a person familiar with the agreement between the two companies said the Swedish start-up was contracted to make the batteries for the all-electric Porsche 718, scheduled for launch next year.

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As Northvolt’s troubles deepened, the sports-car maker began looking for alternative suppliers. While Porsche also buys batteries from South Korea’s Samsung SDI, LGES and China’s CATL, the person added that diversification was a complicated task at relatively short notice.

A cell assembly worker in the dry area of a production line at the Automotive Cells Company (ACC) gigafactory in Douvrin, France
France’s ACC, a venture backed by Stellantis, Mercedes-Benz and TotalEnergies, started producing batteries in 2023 © Nathan Laine/Bloomberg

Northvolt’s demise means the battle for dominance of the European market is likely to play out between Asian battery makers. 

LGES and SK On both have European plants, in Poland and Hungary respectively, while CATL has a factory in Germany and a second site in Hungary due to begin production next year.

But Tim Bush, a Seoul-based battery analyst at UBS, said there was little prospect at present that the Asian battery makers would be able to help the EU to meet its target for 90 per cent of the continent’s EV batteries to be produced locally by 2030.

Bush noted that Korean battery makers were already paring back their investments in Europe, having invested billions of dollars in plants in North America that have been running at low utilisation rates because of lower than expected consumer demand for EVs.

Potential Chinese battery investments on the continent were also likely to be complicated by the ongoing trade dispute between Brussels and Beijing over EU tariffs on Chinese electric vehicles, he added.

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“The Koreans are not expanding, the Chinese have suspended construction and Europe’s new entrants are dropping like flies,” said Bush.

Against such obstacles, the European Commission is weighing plans to require Chinese developers to have plants and bring their intellectual property to Europe in order to access EU subsidies, the FT has previously reported. 

With European start-ups still behind in their ability to manufacture batteries at scale, industry executives say the only solution may be to continue their reliance on Asian participants until homegrown companies can absorb technology knowhow on battery chemistry, mass production and equipment manufacturing.

“We need to find a deal with China because we won’t be able to compete . . . without the support of the Chinese companies that control the mining industry, chemicals, refining and their capacity and competence,” Luca De Meo, Renault’s chief executive, told reporters last month.

But the dilemma is how long Europe needs to wait for the technology transfers to complete, and whether it would already have lost the race by then.

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“If you really zoom out, what does Europe want to be? I really question whether Europe wants to give up yet another industry like it did with solar panels. Europe is not a leader in AI. I want my kids to grow up somewhere where there are a lot of jobs,” said a Northvolt executive.

Reporting by Kana Inagaki and Harriet Agnew in London, Patricia Nilsson in Frankfurt, Sarah White in Paris, Alice Hancock in Brussels, Christian Davies in Seoul, and Richard Milne in Oslo

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2 Dartmouth fraternity members and a sorority have been charged in death of a student

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2 Dartmouth fraternity members and a sorority have been charged in death of a student

A bicyclist passes a college tour group outside the Baker Library at Dartmouth College, April 7, 2023, in Hanover, N.H.

Charles Krupa/AP


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Charles Krupa/AP

Two members of a Dartmouth College fraternity and a sorority have been charged in the death of a student who was found dead in a river over the summer after attending an off-campus party where alcohol was allegedly served to people who were under 21.

Won Jang, a 20-year-old who was a student at the college and a member of the Beta Alpha Omega fraternity, attended a party off campus in July held by Alpha Phi, a sorority, the Hanover Police Department in New Hampshire said in a statement Friday. The department said Jang and most of the other attendees were under 21 years old and drinking alcohol that was bought and served by Beta Alpha Omega members who were over 21.

After the party, several attendees decided to go for a swim in the Connecticut River, but when a heavy rainstorm occurred many of them left in groups.

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“No one in these groups noticed that Jang was unaccounted for. It was confirmed via multiple interviews, to include Jang’s family, that he could not swim,” Hanover police said in a statement.

An autopsy report later determined that Jang’s cause of death was drowning, according to police. His blood alcohol level was .167, the department said. That amount is more than twice the state’s legal amount allowed for drivers 21 and older.

Jang was an undergraduate student from Middletown, Delaware studying biomedical engineering and was a student mentor, according to The Dartmouth. Scott Brown, dean of the college, said Jang “wholeheartedly embraced opportunities at Dartmouth to pursue his academic and personal passions,” according to the paper.

Two members of Beta Alpha Omega fraternity were each charged with a misdemeanor for providing alcohol to persons under 21 years old. The Alpha Phi sorority was also charged with a misdemeanor violation of facilitating an underage alcohol house, the police also said.

Neither Alpha Phi nor Beta Alpha Omega responded to a request for comment.

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Dartmouth College said both the Alpha Phi chapter on campus and Beta Alpha Omega were “immediately suspended” after Jang’s death and an internal investigation was launched. The suspensions are still in effect “pending the results of Dartmouth’s internal investigation and conduct process” that the college said is still underway.

“Dartmouth has long valued the contributions that Greek organizations bring to the student experience, when they are operating within their stated values and standards,” the college said in a statement to NPR. “These organizations, as well as all Dartmouth students and community members, have a responsibility to ensure Dartmouth remains a safe, respectful, equitable, and inclusive community for students, faculty, and staff.”

The college also said that because of federal law it “cannot comment on individual disciplinary matters.”

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US retailers stretch out Black Friday deals to lure flagging shoppers

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US retailers stretch out Black Friday deals to lure flagging shoppers

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US retailers are extending their one-day seasonal Black Friday discount offers into a sales event lasting weeks in a bid to tempt US consumers to keep spending, as data suggests that their spree which has driven economic growth is beginning to falter.

Walmart, Amazon, Target and Macy’s are among the US retailers already offering deep discounts under the banner of Black Friday, long before it actually arrives this week.

Despite this, general merchandise unit sales were down 3 per cent year-on-year in the week ending 16 November according to data from Circana, which compiles retail point-of-sale data.

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The National Retail Federation forecasts that winter holiday sales will reach almost $1tn in the US in November and December, a record $902 a head. But the rate of spending growth is expected to be about 2.5-3.5 per cent, the slowest since 2018.

“We’re seeing this drag-out of incentives to try to widen the window within which [retailers] can draw more consumers,” said Gregory Daco, chief economist at adviser EY Parthenon. “The likely reality in this holiday season is that we see fairly subdued sales because volumes are growing, but at a moderate pace — and [retailers have] much less pricing power.”

Retailers were “incentivising via discounts and different forms of promotions” for those at the lower end of the income spectrum while also “trying to grab higher-income individuals to make purchases during this wider window”, he said.

Although headline inflation has ebbed from the historic highs of the past couple of years, consumers “remain extremely frustrated by the persistence of high prices”, the University of Michigan said this week in a monthly survey.

Consumer spending has been the main driver of America’s robust economic growth in recent months. But consumer confidence is still well below the long-run average, sentiment surveys show.

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The prospect of a fresh round of tariffs under Donald Trump’s incoming presidency raises the risk that inflation could take off again, economists have warned — posing a fresh drag on sentiment.

“Donald Trump’s return to the White House with a Republican majority [probably leads] to higher inflation, slower GDP growth and increased budget deficits,” Roland Fumasi, food and agribusiness analyst at Rabobank, said in a note.

If Trump increases tariffs, that would “lead to a rebound in inflation and a slowdown in economic growth”, he said.

“The negative impact on growth could be mitigated by tax cuts and deregulation by a Republican Congress. However, this would increase the budget deficit and reinforce inflation, especially in combination with reduced immigration,” he added.

Black Friday is one of the busiest times of year for consumer goods stores, and the period between Thanksgiving and Cyber Monday — the Monday following the holiday, when electronics vendors discount goods — is critical to retailers’ annual revenue.

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NRF chief economist Jack Kleinhenz said that households’ finances were in “good shape”, offering “an impetus for strong spending heading into the holiday season”, although “households will spend more cautiously”.

Brian Cornell, Target chief executive, told analysts this week that consumers were becoming “increasingly resourceful” in the way that they shopped, “focusing on deals and then stocking up when they find them”.

The store group, which disappointed Wall Street this week by forecasting flat sales in the fourth quarter, ran a three-day “Early Black Friday” promotion in early November. On Thursday it launched a promotion titled “Black Friday deals” which will last to the end of the month, including items such as half-price Christmas trees and headphones.

Walmart, the world’s largest retailer, launched the first of two week-long “Black Friday Deals” events on November 11. The second will begin on Monday, offering markdowns on televisions, iPhones, toys and jeans, among other items.

Amazon’s “Black Friday Week” began on Thursday. Home Depot’s “Black Friday Savings” offer lasts from November 7 to December 4.

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Additional reporting by Will Schmitt in New York and Madeleine Speed in London

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