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Severe depression eased by single dose of synthetic ‘magic mushroom’ | CNN

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Severe depression eased by single dose of synthetic ‘magic mushroom’ | CNN



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A single dose of an artificial model of the mind-altering part of magic mushrooms, psilocybin, improved melancholy in folks with a treatment-resistant type of the illness, a brand new research discovered.

The randomized, double-blind scientific trial, which authors known as “the biggest of its variety,” in contrast outcomes of a 25-milligram dose to a 10-milligram and 1-milligram dose of an artificial psilocybin, COMP360, that was administered within the presence of skilled therapists.

Outcomes of the research, printed Wednesday in The New England Journal of Medication, discovered “an instantaneous, quick, rapid-acting, sustained response to 25 milligrams (of COMP360),” stated research coauthor Dr. Man Goodwin, a professor emeritus of psychiatry on the College of Oxford in the UK.

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“This drug might be extracted from magic mushrooms, however that isn’t the way in which our compound is generated. It’s synthesized in a purely chemical course of to provide a crystalline kind,” stated Goodwin, who’s the chief medical officer of COMPASS Pathways, the corporate that manufactures COMP360 and carried out the research.

Consultants within the subject discovered the research findings promising.

“They clearly discovered a dose impact and clinically significant enchancment in simply three weeks,” stated Dr. Matthew Johnson, a professor in psychedelics and consciousness at Johns Hopkins Medication in Baltimore. He was not concerned within the new research.

“If you happen to have been within the 25-milligram group, you have been practically thrice as prone to reply than in case you have been within the 1-milligram group,” stated Johnson, who coauthored security pointers for psychedelic analysis in 2008.

The fast response to remedy was notable as nicely.

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“The utmost impact (was) seen the day after receiving the remedy. This contrasts with customary antidepressants, which take a number of weeks to succeed in most impact,” stated Dr. Anthony Cleare, a professor of psychopharmacology and affective issues at King’s Faculty London, in a press release. He was not concerned within the research.

Nevertheless, there are a variety of points that want additional research earlier than this drug can be accessible for scientific use, consultants stated.

“The results did begin to put on off by three months, and we have to understand how greatest to forestall the melancholy returning,” Cleare stated, including that not sufficient is but identified about potential unwanted effects.

“Whereas the security profile appears encouraging total, nice care is clearly wanted when utilizing psychoactive substances comparable to psilocybin. Bigger research are on the way in which that we hope will assist reply these points,” he stated.

The scientific trial occurred at 22 websites in america, Canada, the UK and 7 nations in Europe. The research was designed to check the security of various dosages of the proprietary model of psilocybin.

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The 233 research individuals had treatment-resistant melancholy, which may solely be identified after an individual fails to reply to two programs of antidepressants. Of the 9 million folks within the US with medically handled melancholy, 3 million sufferers are immune to remedy, research have estimated. Globally, some 100 million folks have treatment-resistant melancholy, Goodwin stated.

Individuals with the situation are at a excessive threat of bodily sickness, incapacity, hospitalization and suicide, the research stated.

Any research individuals on antidepressants have been required to wean themselves from these drugs previous to the beginning of the trial. Psychedelic remedy doesn’t work on people who find themselves actively taking antidepressants — the receptors the place psychedelics connect within the mind are already flooded with serotonin from their present mood-altering medication.

“Contributors have been requested to stay off antidepressant remedy throughout the first 3 weeks after the trial-drug administration; nevertheless, these drugs may very well be began at any time throughout the trial if deemed clinically needed by a doctor investigator,” the research stated.

Melancholy severity for every particular person was assessed the day earlier than remedy utilizing a psychological scale extensively utilized by clinicians. Counselors skilled to supply psychological assist have been current throughout the psychedelic journeys, which lasted between six and eight hours. Contributors have been additionally given two extra remedy classes within the first week, the research stated.

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Melancholy ranges have been documented the day after the “journey” and one other 5 occasions over a 12-week interval. About 37% of people that took the 25-milligram dose confirmed enchancment. The truth is, 29% have been thought-about to be in remission at week three, the research discovered.

By week 12, nevertheless, the optimistic impression on depressive signs had waned and now not reached a stage of statistical significance, the research discovered.

“The incidence of sustained response at week 12 was 20% within the 25-mg group, 5% within the 10-mg group, and 10% within the 1-mg group,” wrote psychobiologist Dr. Bertha Madras, director of the laboratory of habit neurobiology at Harvard Medical College’s McLean Hospital in Belmont, Massachusetts, in an accompanying editorial. She didn’t take part within the research.

“That is not a spectacular response fee for a psychiatric remedy … and we’d solely anticipate this to worsen over an extended follow-up interval,” stated Dr. Ravi Das, an affiliate professor of academic psychology analysis strategies and statistics at College Faculty London by way of e mail. He who was not concerned with the research.

As well as, “there have been an uneven variety of severely depressed sufferers in every group; with considerably fewer severely depressed folks within the obvious ‘efficient’ (25mg) dose group,” Das stated in a press release. “This doesn’t look like acknowledged within the paper.”

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Headache, nausea, fatigue and dizziness plagued 77% of the research individuals and occurred in any respect dosage ranges, which consultants say is a typical response on the day of psilocybin administration.

A small variety of folks in all three dosage teams skilled suicidal ideas or injured themselves over the 12-week follow-up interval, the research discovered. Throughout the first three weeks alone, two folks within the 25-milligram group thought of suicide and two deliberately injured themselves. Two folks within the 10-milligram group have been suicidal, one self-injured and one was hospitalized for extreme melancholy, the research reported.

These behaviors are “frequent in treatment-resistant melancholy research — most instances occurred greater than per week after the COMP360 psilocybin session,” the corporate stated.

“Do not forget that that is in individuals who have been assessed to not be at vital threat of suicide after they entered the trial. The numbers have been pretty small, however that is one thing that may have to be taken fastidiously into consideration in any later-stage trials,” stated Kevin McConway, professor emeritus of utilized statistics at The Open College, a British public analysis college.

The research outcomes are promising, however many questions stay and it’s unknown if this drug would achieve success for several types of melancholy, stated McConway, who was not concerned within the research.

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“They’ll’t inform us how efficient this psilocybin plus remedy remedy is compared with different current drug or non-drug therapies for melancholy,” stated McConway, noting that as a subsequent step for follow-up trials.

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Iowa floodwaters breach levees as even more rain dumps onto parts of the Midwest

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Iowa floodwaters breach levees as even more rain dumps onto parts of the Midwest

A tornado is seen near Cedar Rapids, Iowa, on Tuesday. More severe weather was forecast to move into the region, potentially bringing large hail, damaging winds and tornadoes in parts of western Iowa and eastern Nebraska, according to the National Weather Service.

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Nick Rohlman/The Gazette/AP

DES MOINES, Iowa — Tornado warnings, flash flooding and large hail added insult to injury for people in the Midwest already contending with heat, humidity and intense flooding after days of rain.

The National Weather Service on Tuesday afternoon and evening issued multiple tornado warnings in parts of Iowa and Nebraska as local TV news meteorologists showed photos of large hail and spoke of very heavy rain.

Earlier on Tuesday, floodwaters breached levees in Iowa, creating dangerous conditions that prompted evacuations.

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A vast swath of lands from eastern Nebraska and South Dakota to Iowa and Minnesota has been under siege from flooding from torrential rains since last week, while also being hit with a scorching heat wave. Up to 18 inches of rain have fallen in some areas, and some rivers rose to record levels. Hundreds of people were rescued, homes were damaged and at least two people died after driving in flooded areas.

Onlookers take in the catastrophic damage to the Rapidan Dam site in Rapidan, Minn., on Monday. Debris blocked the dam, forcing the heavily backed up waters of the Blue Earth River to reroute along the bank nearest the Dam Store.

Onlookers take in the catastrophic damage to the Rapidan Dam site in Rapidan, Minn., on Monday. Debris blocked the dam, forcing the heavily backed up waters of the Blue Earth River to reroute along the bank nearest the Dam Store.

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The sheriff’s office in Monona County, near the Nebraska border, said the Little Sioux River breached levees in several areas. In neighboring Woodbury County, the sheriff’s office posted drone video on Facebook showing the river overflowing the levee and flooding land in rural Smithland. No injuries were immediately reported.

Patrick Prorok, emergency management coordinator in Monona County, described waking people at about 4 a.m. in Rodney, a town of about 45 people, to recommend evacuation. Later Tuesday morning, the water hadn’t yet washed into the community.

“People up the hill are saying it is coming our way,” Prorok said.

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Rachel Morsching sits Tuesday on the flooded porch of her father Dean Roemhildt's home in Waterville., Minn. Waters from the nearby Tetonka and Sakatah lakes have encroached on the town amid recent heavy rains.

Rachel Morsching sits Tuesday on the flooded porch of her father Dean Roemhildt’s home in Waterville., Minn. Waters from the nearby Tetonka and Sakatah lakes have encroached on the town amid recent heavy rains.

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As new areas were flooding Tuesday, some cities and towns were cleaning up after the waters receded while others downstream were piling sandbags and taking other measures to protect against the oncoming swelled currents. Some normal, unassuming tributaries ballooned into rushing rivers, damaging homes, buildings and bridges.

“Normally, this river is barely a trickle,” 71-year-old Hank Howley said as she watched the Big Sioux’s waters gush over a broken and partially sunken rail bridge in North Sioux City, South Dakota, on Monday. “Really, you could just walk across it most days.”

South Dakota state geologist Tim Cowman said that the five major rivers in the state’s southeastern corner have crested and are dropping, albeit slowly. The last of those rivers to crest, the James, did so early Tuesday.

Heavy rains in recent days have submerged farmland near Vermillion, S.D., on Tuesday. Flooding has devastated communities in several states across the Midwest.

Heavy rains in recent days have submerged farmland near Vermillion, S.D., on Tuesday. Flooding has devastated communities in several states across the Midwest.

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In a residential development along McCook Lake in North Sioux City, the devastation became clear Tuesday as floodwaters began to recede from Monday, exposing collapsed streets, utility poles and trees. Some homes had been washed off their foundations.

“Currently, there is no water, sewer, gas or electrical service in this area,” Union County Emergency Management said in a Facebook post.

President Biden approved a major disaster declaration for affected counties in Iowa on Monday, a move that paves the way for federal aid to be granted.

To the south in Sioux City and Woodbury County, Iowa, officials responded to residents’ complaints that they had received little warning of the flooding and its severity. Sioux City Fire Marshal Mark Aesoph said at a news conference Tuesday that rivers crested higher than predicted.

“Even if we would have known about this two weeks ago, there was nothing we could do at this point. We cannot extend the entire length of our levee,” Aesoph said. “It’s impossible.”

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Water had spilled over the Big Sioux River levee, and Aesoph estimated hundreds of homes likely have some internal water damage.

Homes on the south side of Spencer, Iowa, near the Little Sioux River are unlivable as water has reached the main floor, resident Ben Thomas said. A lot of people in town are facing a “double whammy,” with homes and businesses affected.

Officials in Woodbury County said around a dozen bridges over the Little Sioux River had been topped by flood water, and each would need to be inspected to see if they can reopen to traffic.

Forever Wildlife Lodge and Clinic, a nonprofit animal rescue, in northwest Iowa has answered over 200 calls since the flooding started, said licensed wildlife rehabilitator Amanda Hase.

Hase described the flooding as “catastrophic” for Iowa wildlife, which are getting washed out of dens, injured by debris and separated from each other. She and other rehabilitators are responding to calls about all kinds of species, from fawns and groundhogs to bunnies and eaglets.

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“I’ve never seen it this bad before, ever,” she said.

Floodwaters rush over a collapsed railroad bridge over the Big Sioux River near North Sioux City, S.D., on Monday.

Floodwaters rush over a collapsed railroad bridge over the Big Sioux River near North Sioux City, S.D., on Monday.

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Further to the east in Humboldt, Iowa, a record crest of 16.5 feet was expected Wednesday at the west fork of the Des Moines River. Amid high temperatures and humidity, nearly 68,000 sandbags have been laid, according to county emergency manager Kyle Bissell.

Bissell told reporters Tuesday that there was no water on the streets yet, but flooding had begun in some backyards and was reaching up to foundations. Humboldt is home to nearly 5,000 residents.

More severe weather was forecast to move into the region Tuesday, potentially bringing large hail, damaging winds and even a brief tornado or two in parts of western Iowa and eastern Nebraska, according to the National Weather Service. Showers and storms were also possible in parts of South Dakota and Minnesota, the agency said.

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In Michigan, more than 150,000 homes and businesses were without power Tuesday morning after severe thunderstorms barreled through, less than a week after storms left thousands in the dark for days in suburban Detroit.

The weather service also predicted more than two dozen points of major flooding in southern Minnesota, eastern South Dakota and northern Iowa, and flood warnings are expected to continue into the week.

Many streams, especially with additional rainfall, may not crest until later this week as the floodwaters slowly drain down a web of rivers to the Missouri and Mississippi. The Missouri will crest at Omaha on Thursday, said Kevin Low, a weather service hydrologist.

North of Des Moines, Iowa, the lake above the Saylorville Dam was absorbing river surge and expected to largely protect the metro area from flooding, according to the Polk County Emergency Management Agency. The U.S. Army Corps of Engineers projected Tuesday that water levels at Saylorville Lake will rise by more than 30 feet by the Fourth of July.

Jared Gerlock (left) and his son, Robbie, carry a bin of water-logged stuffed animals out of the flood-damaged basement of their home on East Second Street in Spencer, Iowa, on Tuesday. Officials said about 40% of properties in the city were affected after the Little Sioux River flooded.

Jared Gerlock (left) and his son, Robbie, carry a bin of water-logged stuffed animals out of the flood-damaged basement of their home on East Second Street in Spencer, Iowa, on Tuesday. Officials said about 40% of properties in the city were affected after the Little Sioux River flooded.

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Outside Mankato, Minnesota, the local sheriff’s office said Monday that there was a “partial failure” of the western support structure for the Rapidan Dam on the Blue Earth River after the dam became plugged with debris. Flowing water eroded the western bank, rushed around the dam and washed out an electrical substation, causing about 600 power outages.

Eric Weller, emergency management director for the Blue Earth County sheriff, said the bank would likely erode more, but he didn’t expect the concrete dam itself to fail. The two homes downstream were evacuated.

Minnesota Gov. Tim Walz on Tuesday cautioned against rebuilding too fast, instead emphasizing more sustainable repairs that could prevent or mitigate future flooding.

“Nature doesn’t care whether you believe in climate change or not,” Walz said. “The insurance companies sure believe in it. The actuarials sure believe in it, and we do.”

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WikiLeaks gadfly: the Julian Assange saga

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WikiLeaks gadfly: the Julian Assange saga

Julian Assange had already been ruffling feathers for several years when, in 2010, the Australian hacker and publisher released leaked footage of a US helicopter crew gunning down unarmed Iraqis on a Baghdad street.

The video, dubbed Collateral Murder, was among thousands of classified US military documents that the WikiLeaks website published at the time. As much as any, it put its founder on a collision course with America that only this week — 14 years later — is reaching some form of resolution.

Assange this week walked free from Belmarsh high-security prison in London, where he has been incarcerated since 2019, fighting extradition to the US on espionage charges.

He was on his way by plane to the US-controlled Northern Mariana Islands in the Pacific where, in return for a sentence of time served, he will plead guilty to one charge of conspiracy to obtain and disseminate classified information. Other charges relating to the publication of the material have been dropped.

Assange will then be free to return to his native Australia, without whose patience and diplomatic support some allies believe he might never have seen this day.

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A screen grab taken from the X account of WikiLeaks of Julian Assange following his release from prison © @WikiLeaks/PA Wire

“It’s debatable whether this is a victory for freedom or not,” said Vaughan Smith, founder of the Frontline Club, the group for journalists in Paddington where Assange stayed in the months that he was first polarising global opinion.

At the time, supporters saw him as a fearless warrior for press freedom, exposing double standards at the heart of power. Detractors were forming a different view: they saw a dangerous gadfly, disclosing information regardless of the consequences.

Smith, who has remained a loyal friend, said that whichever way you look at it, Assange has been through a terrible ordeal.

Facing allegations of rape in Sweden, which he denied, he spent seven years holed up in the Ecuadorean embassy in London, attracting support outside the gates from a diverse crew of celebrities including Pamela Anderson, Lady Gaga and the former Greek finance minister Yanis Varoufakis.

Once the Ecuadoreans had tired of him, he was arrested and sent to Belmarsh. “It’s pretty sobering the way he has been made to suffer,” said Smith.   

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WikiLeaks founder Julian Assange, second left, and Frontline Club founder Vaughan Smith, second from right, attend a press conference at the Frontline Club in London on January 17 2011
Julian Assange, second left, and Frontline Club founder Vaughan Smith, second from right, attend a press conference at the Frontline Club in London on January 17 2011. Smith says of Assange: ‘He doesn’t necessarily fit in’ © Ben Stansall/AFP/Getty Images

Collateral Murder was published in 2010 alongside a trove of classified US military documents relating to the Iraq and Afghan wars. These were obtained from Chelsea Manning, the former US army intelligence analyst, who served seven years of a 35 year sentence for her part in the saga.   

Shot from an Apache helicopter gunship, the footage exposed casual rules of engagement by US troops, along with a loose relationship with the truth on the part of commanders who had portrayed victims of the 2007 incident as armed.

It was one explosive element in a huge data dump that was highly damaging to the reputation of the US military. Two of the 11 civilians killed were employees of the Reuters news agency.

At first the information from WikiLeaks was published in careful collaboration with The Guardian, New York Times, Der Spiegel, El País and Le Monde newspapers, redacted to protect the identities of sources and personnel involved.

But later — after Assange had fallen out with some of the newspapers he had worked with, and a German hacker had accessed the files — WikiLeaks released the raw documents en masse, along with more than 250,000 US diplomatic cables.

Alan Rusbridger, former editor of The Guardian, said the advent of WikiLeaks, which started life in 2006 exposing corruption in Kenya, marked the beginning of a “new era of transparency”.

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At the same time, journalists are enduring a sustained backlash as western intelligence agencies come down hard on anyone touching classified information.

“The stuff on Iraq and Afghanistan needed to come out,” Rusbridger said. The diplomatic cables were less impactful, he argued, in part because many of them made for “sensible” reading: “It does make you reconsider why all this stuff has to be so secret.”

For the Americans, some of the less-than-diplomatic language used in the cables damaged relations with allies.

Worse, they claimed, it brought sources who were exposed into harm’s way.

At the time of Assange’s indictment in 2019, John Demers, the then-top justice department national security official, said: “No responsible actor, journalist or otherwise, would purposely publish the names of individuals he or she knew to be confidential human sources in war zones, exposing them to the gravest of dangers.”

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Julian Assange speaks to media and supporters from a balcony at the Ecuadorian embassy in London in May 2017
Julian Assange speaks to media and supporters from a balcony at the Ecuadorean embassy in London in May 2017 © Luke MacGregor/Bloomberg

Assange first honed his skills as a teenage hacker in Australia where he also had his first brush with the law. Smith said some of Assange’s later problems were the result of being “different”.

His character, as well as his work, has divided opinion.

“He doesn’t necessarily fit in. From time to time, people who are different have something to say, and humans are inclined to turn on them,” Smith said. The rape allegations, which have passed the point at which they can be prosecuted under Swedish law, had “diminished him and poisoned him in the public eye”, he added.

Others who met Assange along the way were less generous. One described him as “a mercurial guy — sometimes he would behave like a CEO, strategic and efficient. Other times he would be like a badly behaved child.”

UK district judge Michael Snow, who convicted Assange in 2019 for jumping bail in 2012, described him as “a narcissist who cannot get beyond his own selfish interests”.

Even in confinement, Assange remained a potent force, playing a tumultuous role in the 2016 US elections when WikiLeaks released a tranche of emails from the Democratic party. Federal prosecutors said these were originally stolen by Russian intelligence operatives.

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Donald Trump, at first a fan, eventually turned on him too.  

Assange’s treatment during the extradition process in the UK has also proved controversial. For champions of press freedom, it has shown the UK in a poor light, pandering to US interests.

Nick Vamos, an expert in extradition law, disagrees. He suggested that a High Court decision this year to allow Assange to appeal may have been instrumental in securing his release.

“Our extradition laws are generous in terms of allowing people to argue different points,” he said. “That is ultimately what has brought everyone to the negotiating table.”

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