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Severe depression eased by single dose of synthetic ‘magic mushroom’ | CNN

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Severe depression eased by single dose of synthetic ‘magic mushroom’ | CNN



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A single dose of an artificial model of the mind-altering part of magic mushrooms, psilocybin, improved melancholy in folks with a treatment-resistant type of the illness, a brand new research discovered.

The randomized, double-blind scientific trial, which authors known as “the biggest of its variety,” in contrast outcomes of a 25-milligram dose to a 10-milligram and 1-milligram dose of an artificial psilocybin, COMP360, that was administered within the presence of skilled therapists.

Outcomes of the research, printed Wednesday in The New England Journal of Medication, discovered “an instantaneous, quick, rapid-acting, sustained response to 25 milligrams (of COMP360),” stated research coauthor Dr. Man Goodwin, a professor emeritus of psychiatry on the College of Oxford in the UK.

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“This drug might be extracted from magic mushrooms, however that isn’t the way in which our compound is generated. It’s synthesized in a purely chemical course of to provide a crystalline kind,” stated Goodwin, who’s the chief medical officer of COMPASS Pathways, the corporate that manufactures COMP360 and carried out the research.

Consultants within the subject discovered the research findings promising.

“They clearly discovered a dose impact and clinically significant enchancment in simply three weeks,” stated Dr. Matthew Johnson, a professor in psychedelics and consciousness at Johns Hopkins Medication in Baltimore. He was not concerned within the new research.

“If you happen to have been within the 25-milligram group, you have been practically thrice as prone to reply than in case you have been within the 1-milligram group,” stated Johnson, who coauthored security pointers for psychedelic analysis in 2008.

The fast response to remedy was notable as nicely.

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“The utmost impact (was) seen the day after receiving the remedy. This contrasts with customary antidepressants, which take a number of weeks to succeed in most impact,” stated Dr. Anthony Cleare, a professor of psychopharmacology and affective issues at King’s Faculty London, in a press release. He was not concerned within the research.

Nevertheless, there are a variety of points that want additional research earlier than this drug can be accessible for scientific use, consultants stated.

“The results did begin to put on off by three months, and we have to understand how greatest to forestall the melancholy returning,” Cleare stated, including that not sufficient is but identified about potential unwanted effects.

“Whereas the security profile appears encouraging total, nice care is clearly wanted when utilizing psychoactive substances comparable to psilocybin. Bigger research are on the way in which that we hope will assist reply these points,” he stated.

The scientific trial occurred at 22 websites in america, Canada, the UK and 7 nations in Europe. The research was designed to check the security of various dosages of the proprietary model of psilocybin.

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The 233 research individuals had treatment-resistant melancholy, which may solely be identified after an individual fails to reply to two programs of antidepressants. Of the 9 million folks within the US with medically handled melancholy, 3 million sufferers are immune to remedy, research have estimated. Globally, some 100 million folks have treatment-resistant melancholy, Goodwin stated.

Individuals with the situation are at a excessive threat of bodily sickness, incapacity, hospitalization and suicide, the research stated.

Any research individuals on antidepressants have been required to wean themselves from these drugs previous to the beginning of the trial. Psychedelic remedy doesn’t work on people who find themselves actively taking antidepressants — the receptors the place psychedelics connect within the mind are already flooded with serotonin from their present mood-altering medication.

“Contributors have been requested to stay off antidepressant remedy throughout the first 3 weeks after the trial-drug administration; nevertheless, these drugs may very well be began at any time throughout the trial if deemed clinically needed by a doctor investigator,” the research stated.

Melancholy severity for every particular person was assessed the day earlier than remedy utilizing a psychological scale extensively utilized by clinicians. Counselors skilled to supply psychological assist have been current throughout the psychedelic journeys, which lasted between six and eight hours. Contributors have been additionally given two extra remedy classes within the first week, the research stated.

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Melancholy ranges have been documented the day after the “journey” and one other 5 occasions over a 12-week interval. About 37% of people that took the 25-milligram dose confirmed enchancment. The truth is, 29% have been thought-about to be in remission at week three, the research discovered.

By week 12, nevertheless, the optimistic impression on depressive signs had waned and now not reached a stage of statistical significance, the research discovered.

“The incidence of sustained response at week 12 was 20% within the 25-mg group, 5% within the 10-mg group, and 10% within the 1-mg group,” wrote psychobiologist Dr. Bertha Madras, director of the laboratory of habit neurobiology at Harvard Medical College’s McLean Hospital in Belmont, Massachusetts, in an accompanying editorial. She didn’t take part within the research.

“That is not a spectacular response fee for a psychiatric remedy … and we’d solely anticipate this to worsen over an extended follow-up interval,” stated Dr. Ravi Das, an affiliate professor of academic psychology analysis strategies and statistics at College Faculty London by way of e mail. He who was not concerned with the research.

As well as, “there have been an uneven variety of severely depressed sufferers in every group; with considerably fewer severely depressed folks within the obvious ‘efficient’ (25mg) dose group,” Das stated in a press release. “This doesn’t look like acknowledged within the paper.”

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Headache, nausea, fatigue and dizziness plagued 77% of the research individuals and occurred in any respect dosage ranges, which consultants say is a typical response on the day of psilocybin administration.

A small variety of folks in all three dosage teams skilled suicidal ideas or injured themselves over the 12-week follow-up interval, the research discovered. Throughout the first three weeks alone, two folks within the 25-milligram group thought of suicide and two deliberately injured themselves. Two folks within the 10-milligram group have been suicidal, one self-injured and one was hospitalized for extreme melancholy, the research reported.

These behaviors are “frequent in treatment-resistant melancholy research — most instances occurred greater than per week after the COMP360 psilocybin session,” the corporate stated.

“Do not forget that that is in individuals who have been assessed to not be at vital threat of suicide after they entered the trial. The numbers have been pretty small, however that is one thing that may have to be taken fastidiously into consideration in any later-stage trials,” stated Kevin McConway, professor emeritus of utilized statistics at The Open College, a British public analysis college.

The research outcomes are promising, however many questions stay and it’s unknown if this drug would achieve success for several types of melancholy, stated McConway, who was not concerned within the research.

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“They’ll’t inform us how efficient this psilocybin plus remedy remedy is compared with different current drug or non-drug therapies for melancholy,” stated McConway, noting that as a subsequent step for follow-up trials.

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Trump’s crypto embrace overshadows new EU digital assets rules

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Trump’s crypto embrace overshadows new EU digital assets rules

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Donald Trump’s embrace of cryptocurrencies risks undermining Europe’s incoming rules on digital assets as companies overlook the continent in favour of a friendlier US market, industry executives have warned.

Companies such as Binance, the world’s largest cryptocurrency exchange, have indicated they will look to refocus their attention on the US after Trump promised to make the country “the crypto capital of the planet”.

Top executives and analysts say a crypto-friendly White House will exert a strong pull that compares favourably to the European Union’s new landmark rules, which come into force from December 30.

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The bloc’s rules, known as the Markets in Crypto-Assets Regulation (MiCA), will set guardrails for the public following the collapse of companies like exchange FTX and lenders including Genesis and Celsius. The standards have in the past been praised by the industry as a potential benchmark for global crypto asset regulation.

“In the previous US administration . . . MiCA certainly seemed like it was a good way of trying to think about the crypto industry without completely killing off innovation,” said Eswar Prasad, senior fellow at the Brookings Institution. 

But in the wake of Trump’s win, “we’re going to see a migration of crypto-related activities away from Europe in any form because things are going to be much easier in the US,” he added. “[MiCA] is going to be seen as very stringent.”

Trump’s victory has helped propel bitcoin to a record high of $108,000 this year, more than double its price a year ago. Retail and institutional investors have warmed to Trump’s pledge that he will end the US’s tough regulatory crackdown of recent years.

He has also nominated Paul Atkins, a crypto advocate, to head the Securities and Exchange Commission, and appointed David Sacks, a venture capitalist, to advise the president on crypto and AI policy. “We’re going to do something great with crypto,” he said last week.

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The EU’s MiCA rules will regulate the issuance of crypto coins including stablecoins, as well as digital asset services like custody and trading by demanding that companies providing those services are authorised in the EU.

Yulia Makarova, special counsel at law firm Cooley, said complying with MiCA “increases the costs for start-up firms” in particular. “Ongoing compliance costs can be such that the business gets to the brink of viability,” she added, warning that crypto start-ups may choose to launch in the US rather than the EU.

Some companies, such as US cryptocurrency exchange Coinbase and Circle, operator of the stablecoin USDC, have secured their EU licences. However others, such as Tether, the world’s largest stablecoin, will not be compliant with the new rules and are being delisted by local regulated exchanges.

“The new administration might take a bit of shine and a bit of edge off MiCA,” said Denzel Walters, head of Luxembourg at market maker B2C2. “But I still think MiCA here presents a really great opportunity for the digital assets market,” he added.

Executives are betting that Trump, as well as a new cohort of pro-crypto politicians in Washington, will also make headway with new legislation for crypto assets, which will in turn pave the way for traditional financial institutions to plough money into crypto.

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Already, crypto companies that dropped US services for fear of being hit by regulators, or were banned, are planning to return. “We are closer than ever to restoring US dollar services and our plan is to achieve this important milestone in early 2025,” said Norman Reed, interim chief executive of crypto exchange Binance US. “It is not a matter of if, but when,” he added.

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Bird flu has killed 20 big cats including cougars at a U.S. wildlife sanctuary

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Bird flu has killed 20 big cats including cougars at a U.S. wildlife sanctuary

A cougar is seen in a forest in autumn. The Wild Felid Advocacy Center of Washington says bird flu has killed 20 of its big cats, including cougars, in the past month.

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An animal sanctuary in Shelton, Wash., is under quarantine after a bird flu outbreak killed 20 big cats at the facility over the past month.

The Wild Felid Advocacy Center of Washington called the deaths “heartbreaking,” confirming the virus has claimed more than half its animals, including four cougars and a half-Bengal tiger, since late November.

“Our sanctuary is under quarantine to protect our remaining animals and prevent further spread,” the center said in a statement, adding it will remain closed to the public until further notice.

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The sanctuary said the outbreak may have been caused by respiratory secretions passed from infected birds to the cats or by contaminated meat fed to the cats. It said bird flu poses a serious risk to felines, often progressing from mild symptoms to fatal pneumonia within 24 hours.

The first cat, a cougar, died on Nov. 23 after showing signs of the illness. The virus then quickly sickened many other animals across the sanctuary. While some of the cats shared a wall between their habitats, they did not have direct contact.

The sanctuary’s 17 surviving animals — cougars, bobcats, servals, and tigers — remain under close observation.

In response, the sanctuary removed 8,000 pounds of food from storage and began deep cleaning, but the nonprofit says the measures have strained its finances. “The mounting medical costs, even at discounted rates, are significant,” it said, appealing for donations to cover expenses.

The outbreak comes amid rising concerns over bird flu in the U.S.

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Earlier this month, California Gov. Gavin Newsom declared a state of emergency due to its spread among dairy cattle, and outbreaks have been reported in wild and domestic bird populations across multiple states.

A brand of cat food also said it was recalling a line of its products after authorities linked the death of a cat to a batch of feed contaminated with bird flu.

The brand, Northwest Naturals, said it was advising people to throw out two-pound bags of its Feline Turkey Recipe that have a best-by date between May 21, 2026, and June 23, 2026, after the bags tested positive for virulent bird flu.

Experts warn that highly pathogenic avian influenza (HPAI) is becoming more prevalent, driven by migratory bird patterns.

While the virus primarily affects birds, it has shown the capacity to infect mammals, including domestic pets and wildlife, under certain conditions.

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Earlier this month, the Centers for Disease Control and Prevention confirmed the first severe human case of bird flu in the U.S. — a Louisiana resident who was hospitalized after being exposed to backyard flocks.

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India’s former prime minister Manmohan Singh dies

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India’s former prime minister Manmohan Singh dies

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India’s former prime minister Manmohan Singh, who liberalised the economy and then led the country through a period of strong economic growth, has died.

Singh, 92, was being treated for age-related medical conditions, the All India Institute of Medical Sciences in New Delhi said, as it announced his death on Thursday.

The Oxford university-educated economist set India on a path to becoming a fast-growing economy as finance minister from 1991 to 1996, when he opened up the country to more foreign trade and private investment.

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Considered a political lightweight by some in India at that time, Singh was a surprise choice by the Congress party to be prime minister after it won parliamentary elections in 2004.

Alongside a growth rate of almost 7 per cent, Singh’s decade as premier was marred by allegations of widespread corruption against his party’s leaders, although his personal integrity was rarely questioned.

Singh was accused of inaction and opposition parties claimed he was subservient to Congress’s chief at that time, Sonia Gandhi.

Shortly before Congress lost elections to Narendra Modi’s Bharatiya Janata party in 2014, Singh said in a speech to parliament that “history would be kinder to me than the contemporary media, or for that matter opposition parties”.

Prime Minister Modi on Thursday described Singh as one of India’s most distinguished leaders, saying he left a “strong imprint on our economic policy over the years” and had “made extensive efforts to improve people’s lives” as premier.

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Rahul Gandhi, a senior member of the Congress party, paid tribute to Singh, saying he had lost a “mentor and guide” whose “humility and deep understanding of economics inspired the nation”.

A member of parliament for more than three decades, Singh retired from active politics earlier this year.

The mild-mannered Singh, who belonged to India’s minority Sikh community, was born to a humble family in 1932 in a village in India’s Punjab prior to the country’s independence, which is now part of Pakistan.

Singh rose to become one of India’s most successful economists, serving the government in various capacities, including as head of the country’s central bank in the 1980s.

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