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Your Hair Is Going Gray. This Glitch May Explain Why.

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Your Hair Is Going Gray. This Glitch May Explain Why.

Lots of the indicators of getting older are invisible, sluggish, and refined — modifications in cell division capability, cardiac output and kidney perform don’t precisely present up within the mirror. However grey hairs are one of the vital apparent clues that the physique isn’t working prefer it used to.

Our hair turns grey when melanin-producing stem cells cease functioning correctly. A brand new examine in mice, however with implications for individuals and revealed Wednesday within the journal Nature, offers a clearer image of the mobile glitches that flip us into silver foxes and vixens.

“It is a actually massive step towards understanding why we grey,” stated Mayumi Ito, an creator of the examine and a dermatology professor at New York College’s Grossman College of Drugs.

In contrast to embryonic stem cells, which become all kinds of various organs, grownup stem cells have a extra set path. The melanocyte stem cells in our hair follicles are answerable for producing and sustaining the pigment in our hair.

Every hair follicle retains immature melanocyte stem cells in storage. After they’re wanted, these cells journey from one a part of the follicle to a different, the place proteins spur them to mature into pigment-producing cells, giving hair its hue.

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Scientists assumed that grey hair was the results of that pool of melanocyte stem cells operating dry. Nevertheless, earlier research with mice made Dr. Ito and her co-author, Qi Solar, marvel if hair might lose its pigment even when stem cells are nonetheless current.

To be taught extra about stem cell habits all through completely different phases of hair development, the researchers spent two years monitoring and imaging particular person cells in mouse fur. To their amazement, the stem cells traveled forwards and backwards inside the hair follicle, transitioning into their mature, pigment-producing state after which out of it once more.

“We have been stunned,” stated Dr. Solar, who stated seeing one group of stem cells switching forwards and backwards between mature and younger states didn’t match up with present explanations.

However as time wore on, the melanocyte cells couldn’t sustain the double act. A hair falling out and rising again takes a toll on the follicle, and finally, the stem cells stopped making their journey, and thus, stopped receiving protein alerts to make pigment. From then on, the brand new hair development didn’t get its dose of melanin.

The researchers additional explored this impact by plucking hairs from mice, simulating a sooner hair development cycle. This “pressured getting older” led to a buildup of melanocyte stem cells caught of their storage place, not producing melanin. The mice’s fur went from darkish brown to salt-and-pepper.

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Whereas the examine was carried out with rodents, the researchers say their findings must be related to how human hair will get and loses its coloration. What’s extra, they hope their findings could possibly be a step towards stopping or reversing the graying course of.

Melissa Harris, a biologist on the College of Alabama at Birmingham who was not concerned with the examine, stated the findings assist “clinch” earlier proof she’s seen suggesting that “not all melanocyte stem cells are created equal, and even when you’ve got some left over, they is probably not helpful.”

Dr. Harris stated she takes the examine’s findings about its “pressured getting older” of mouse hair “with possibly just a little little bit of a grain of salt,” as a plucked hair won’t behave the identical as naturally aged hair. However she discovered the examine invaluable, not simply because a remedy for graying hair may be successful with the general public; the insights into stem cell habits would possibly assist researchers perceive issues like most cancers and cell regeneration.

“I believe generally individuals take the hair as a right,” she stated, “however in a way, it makes it really very easy for us to see potential methods during which getting older or different perturbations have an effect on our our bodies.”

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Kennedy’s Plan for the Drug Crisis: A Network of ‘Healing Farms’

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Kennedy’s Plan for the Drug Crisis: A Network of ‘Healing Farms’

Though Mr. Kennedy’s embrace of recovery farms may be novel, the concept stretches back almost a century. In 1935, the government opened the United States Narcotic Farm in Lexington, Ky., to research and treat addiction. Over the years, residents included Chet Baker and William S. Burroughs (who portrayed the institution in his novel, “Junkie: Confessions of an Unredeemed Drug Addict”). The program had high relapse rates and was tainted by drug experiments on human subjects. By 1975, as local treatment centers began to proliferate around the country, the program closed.

In America, therapeutic communities for addiction treatment became popular in the 1960s and ’70s. Some, like Synanon, became notorious for cultlike, abusive environments. There are now perhaps 3,000 worldwide, researchers estimate, including one that Mr. Kennedy has also praised — San Patrignano, an Italian program whose centerpiece is a highly regarded bakery, staffed by residents.

“If we do go down the road of large government-funded therapeutic communities, I’d want to see some oversight to ensure they live up to modern standards,” said Dr. Sabet, who is now president of the Foundation for Drug Policy Solutions. “We should get rid of the false dichotomy, too, between these approaches and medications, since we know they can work together for some people.”

Should Mr. Kennedy be confirmed, his authority to establish healing farms would be uncertain. Building federal treatment farms in “depressed rural areas,” as he said in his documentary, presumably on public land, would hit political and legal roadblocks. Fully legalizing and taxing cannabis to pay for the farms would require congressional action.

In the concluding moments of the documentary, Mr. Kennedy invoked Carl Jung, the Swiss psychiatrist whose views on spirituality influenced Alcoholics Anonymous. Dr. Jung, he said, felt that “people who believed in God got better faster and that their recovery was more durable and enduring than people who didn’t.”

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Children exposed to higher fluoride levels found to have lower IQs, study reveals

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Children exposed to higher fluoride levels found to have lower IQs, study reveals

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The debate about the benefits and risks of fluoride is ongoing, as RFK Jr. — incoming President Trump’s pick for HHS secretary — pushes to remove it from the U.S. water supply.

“Fluoride is an industrial waste associated with arthritis, bone fractures, bone cancer, IQ loss, neurodevelopmental disorders and thyroid disease,” RFK wrote in a post on X in November.

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A new study published in JAMA Pediatrics on Jan. 6 found another correlation between fluoride exposure and children’s IQs.

RFK JR. CALLS FOR REMOVAL OF FLUORIDE FROM DRINKING WATER, SPARKING DEBATE

Study co-author Kyla Taylor, PhD, who is based in North Carolina, noted that fluoridated water has been used “for decades” to reduce dental cavities and improve oral health.

Fluoride exposure has been linked to a variety of negative health effects, yet benefits oral health. (iStock)

“However, there is concern that pregnant women and children are getting fluoride from many sources, including drinking water, water-added foods and beverages, teas, toothpaste, floss and mouthwash, and that their total fluoride exposure is too high and may affect fetal, infant and child neurodevelopment,” she told Fox News Digital.

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The new research, led by scientists at the National Institute of Environmental Health Sciences (NIEHS), analyzed 74 epidemiological studies on children’s IQ and fluoride exposure.

FEDERAL JUDGE ORDERS EPA FURTHER REGULATE FLUORIDE IN DRINKING WATER DUE TO CONCERNS OVER LOWERED IQ IN KIDS

The studies measured fluoride in drinking water and urine across 10 countries, including Canada, China, Denmark, India, Iran, Mexico, Pakistan, New Zealand, Spain and Taiwan. (None were conducted in the U.S.)

The meta-analysis found a “statistically significant association” between higher fluoride exposure and lower children’s IQ scores, according to Taylor.

“[It showed] that the more fluoride a child is exposed to, the more likely that child’s IQ will be lower than if they were not exposed,” she said.

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Little girl drinking water from a glass

Scientists found a “statistically significant association” between higher fluoride exposure and lower children’s IQ scores. (iStock)

These results were consistent with six previous meta-analyses, all of which reported the same “statistically significant inverse associations” between fluoride exposure and children’s IQs, Taylor emphasized.

The research found that for every 1mg/L increase in urinary fluoride, there was a 1.63-point decrease in IQ. 

‘Safe’ exposure levels

The World Health Organization (WHO) has established 1.5mg/L as the “upper safe limit” of fluoride in drinking water.

“There is concern that pregnant women and children are getting fluoride from many sources.”

Meanwhile, the U.S. Public Health Service recommends a fluoride concentration of 0.7 mg/L in drinking water.

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“There was not enough data to determine if 0.7 mg/L of fluoride exposure in drinking water affected children’s IQs,” Taylor noted.

FDA BANS RED FOOD DYE DUE TO POTENTIAL CANCER RISK

Higher levels of the chemical can be found in wells and community water serving nearly three million people in the U.S., the researcher noted.

She encouraged pregnant women and parents of small children to be mindful of their total fluoride intake.

little boy filling fresh water from water tap in sports bottle

Nearly three million people have access to wells and community water with fluoride levels above the levels suggested by the World Health Organization. (iStock)

“If their water is fluoridated, they may wish to replace tap water with low-fluoride bottled water, like purified water, and limit exposure from other sources, such as dental products or black tea,” she said.

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“Parents can use low-fluoride bottled water to mix with powdered infant formula and limit use of fluoridated toothpaste by young children.”

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While the research did not intend to address broader public health implications of water fluoridation in the U.S., Taylor suggested that the findings could help inform future research into the impact of fluoride on children’s health.

Dental health expert shares cautions

In response to this study and other previous research, Dr. Ellie Phillips, DDS, an oral health educator based in Austin, Texas, told Fox News Digital that she does not support water fluoridation.

Mother and her toddler drinking a glass with water from the tap

The study researcher encouraged parents of small children to be mindful of their total fluoride intake. (iStock)

“I join those who vehemently oppose public water fluoridation, and I question why our water supplies are still fluoridated in the 21st century,” she wrote in an email.

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“There are non-fluoridated cities and countries where the public enjoy high levels of oral health, which in some cases appear better than those that are fluoridated.”

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Phillips called the fluoride debate “confusing” even among dentists, as the American Dental Association (ADA) advocates for fluoride use for cavity prevention through water fluoridation, toothpaste and mouthwash — “sometimes in high concentrations.”

mother checks son's brushed teeth

Fluoride is used in water, toothpaste and mouthwash to help prevent cavities. (iStock)

“[But] biologic (holistic) dentists generally encourage their patients to fear fluoride and avoid its use entirely, even if their teeth are ravaged by tooth decay,” she said.

“Topical fluoride is beneficial, while systemic consumption poses risks.”

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Phillips encouraged the public to consider varying fluoride compounds, the effect of different concentrations and the “extreme difference” between applying fluoride topically and ingesting it.

“Topical fluoride is beneficial, while systemic consumption poses risks,” she cautioned. 

“Individuals must take charge of their own oral health using natural and informed strategies.”

The study received funding from the National Institute of Environmental Health Sciences (NIEHS), the National Institutes of Health (NIH) and the Intramural Research Program.

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Treating Other Diseases With Ozempic? Experts Weigh In | Woman's World

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Treating Other Diseases With Ozempic? Experts Weigh In | Woman's World


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Treating Other Diseases With Ozempic? Experts Weigh In | Woman’s World




























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