Health
Vaccine protection waned this spring but boosters helped, the C.D.C. reports.
The emergence of extremely contagious Omicron subvariants this spring in the USA appeared to scale back the safety provided by vaccines in opposition to Covid hospitalizations, scientists from the Facilities for Illness Management and Prevention reported on Friday.
However first and second booster photographs helped to shore up folks’s defenses, the company discovered. The extra photographs raised folks’s ranges of safety in opposition to these Omicron subvariants and restored a number of the safety that was misplaced as time handed since their final photographs.
“Booster doses must be obtained instantly when individuals grow to be eligible,” the C.D.C. scientists wrote.
The findings, nevertheless, got here with a notable caveat: Measurements of vaccine effectiveness have been sophisticated by the variety of unvaccinated individuals who have been contaminated by the virus, particularly in the course of the wintertime surge of Omicron instances.
These prior infections give folks some safety in opposition to Covid. Because of this, in research just like the C.D.C.’s that evaluate outcomes from the virus in vaccinated and unvaccinated folks, the vaccines seem much less protecting than they are surely.
The C.D.C. scientists used what little data they’d about sufferers’ an infection histories to attempt to account for these difficulties. Utilizing information from hospitals throughout 10 states, the company’s scientists studied some 58,000 hospitalizations with a prognosis of Covid-like sickness from mid-December via mid-June. The research targeted on adults with wholesome immune techniques.
By late April, subvariants of Omicron often called BA.2 and BA.2.12.1 had outcompeted the model of Omicron that unfold throughout the nation over the winter.
After these subvariants turned dominant, the Pfizer-BioNTech and Moderna vaccines have been much less efficient in preserving folks from being admitted to the hospital with Covid than they’d been in the course of the wintertime Omicron wave, the research discovered.
Two doses of the vaccines have been 24 % efficient in opposition to hospitalizations after the variants took over, in contrast with 61 % in the course of the interval when the unique model of Omicron dominated. (These figures held for individuals who had been given their second dose at the very least 5 months earlier.)
That decline in all probability partly resulted from the flexibility of the subvariants to evade folks’s immune defenses from the vaccine, and partly from unvaccinated folks drawing some safety from earlier infections.
A booster dose helped significantly, though the advantages of these further doses appeared to wane over time. As soon as the subvariants turned the primary sources of an infection, a 3rd dose of Pfizer or Moderna raised the vaccines’ effectiveness in opposition to hospitalization to 69 % initially, and 52 % after 4 months or extra.
The third doses had been much more protecting in the course of the wintertime surge of the unique model of Omicron.
Second boosters have been licensed in late March for folks 50 and older with wholesome immune techniques, and people further boosters appeared to assist folks climate the subvariant surge, the C.D.C. discovered.
Not less than per week after a fourth dose, the vaccines have been 80 % efficient in opposition to hospitalizations with Covid, the company stated. That was a substantial carry from the 55 % effectiveness provided by three doses after 4 months in that age group.
It was not clear how shortly the safety provided by that fourth dose would diminish. The research additionally didn’t measure the vaccines’ efficiency in opposition to BA.5, the newest Omicron subvariant, which seems to be driving a recent surge of instances and hospitalizations. That subvariant has grow to be dominant amongst new U.S. instances and seems to be essentially the most evasive type of Omicron to unfold within the nation.
With hospital admissions rising, federal well being officers have urged eligible folks to get booster doses as quickly as potential, saying that these photographs wouldn’t forestall folks from getting an extra dose of an up to date, variant-specific vaccine within the fall or winter. The newest outcomes strengthened the necessity for booster photographs, the company stated.
“Given latest will increase in deaths and hospitalizations related to the BA.5 variant,” the C.D.C. stated on Friday, “everybody ought to keep updated with really useful Covid-19 vaccinations, together with further booster doses for many who are reasonably to severely immunocompromised and adults over 50.”
Health
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Health
One state leads country in human bird flu with nearly 40 confirmed cases
A child in California is presumed to have H5N1 bird flu, according to the San Francisco Department of Public Health (SFDPH).
As of Dec. 23, there had been 36 confirmed human cases of bird flu in the state, according to the California Department of Public Health (CDPH).
This represents more than half of the human cases in the country.
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The latest pediatric patient, who lives in San Francisco, experienced fever and conjunctivitis (pink eye) as a result of the infection.
The unnamed patient was not hospitalized and has fully recovered, according to the SFDPH.
The child tested positive for bird flu at the SFDPH Public Health Laboratory. The U.S. Centers for Disease Control and Prevention (CDC) will perform additional tests to confirm the result.
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It is not yet known how the child was exposed to the virus and an investigation is ongoing.
“I want to assure everyone in our city that the risk to the general public is low, and there is no current evidence that the virus can be transmitted between people,” said Dr. Grant Colfax, director of health, in the press release.
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“We will continue to investigate this presumptive case, and I am urging all San Franciscans to avoid direct contact with sick or dead birds, especially wild birds and poultry. Also, please avoid unpasteurized dairy products.”
Samuel Scarpino, director of AI and life sciences and professor of health sciences at Northeastern University in Boston, is calling for “decisive action” to protect individuals who may be in contact with infected livestock and also to alert the public about the risks associated with wild birds and infected backyard flocks.
“While I agree that the risk to the broader public remains low, we continue to see signs of escalating risk associated with this outbreak,” he told Fox News Digital.
Experts have warned that the possibility of mutations in the virus could enable person-to-person transmission.
“While the H5N1 virus is currently thought to only transmit from animals to humans, multiple mutations that can enhance human-to-human transmission have been observed in the severely sick American,” Dr. Jacob Glanville, CEO of Centivax, a San Francisco biotechnology company, told Fox News Digital.
“This highlights the requirement for vigilance and preparation in the event that additional mutations create a human-transmissible pandemic strain.”
As of Jan. 10, there have been a total of 707 infected cattle in California, per reports from the California Department of Food and Agriculture (CDFA).
For more Health articles, visit www.foxnews.com/health
In the last 30 days alone, the virus has been confirmed in 84 dairy farms in the state.
Health
Chronic Pain Afflicts Billions of People. It’s Time for a Revolution.
“In the beginning, everyone thought they were going to find this one breakthrough pain drug that would replace opioids,” Gereau said. Increasingly, though, it’s looking like chronic pain, like cancer, could end up having a range of genetic and cellular drivers that vary both by condition and by the particular makeup of the person experiencing it. “What we’re learning is that pain is not just one thing,” Gereau added. “It’s a thousand different things, all called ‘pain.’”
For patients, too, the landscape of chronic pain is wildly varied. Some people endure a miserable year of low-back pain, only to have it vanish for no clear reason. Others aren’t so lucky. A friend of a friend spent five years with extreme pain in his arm and face after roughhousing with his son. He had to stop working, couldn’t drive, couldn’t even ride in a car without a neck brace. His doctors prescribed endless medications: the maximum dose of gabapentin, plus duloxetine and others. At one point, he admitted himself to a psychiatric ward, because his pain was so bad that he’d become suicidal. There, he met other people who also became suicidal after years of living with terrible pain day in and day out.
The thing that makes chronic pain so awful is that it’s chronic: a grinding distress that never ends. For those with extreme pain, that’s easy to understand. But even less severe cases can be miserable. A pain rating of 3 or 4 out of 10 sounds mild, but having it almost all the time is grueling — and limiting. Unlike a broken arm, which gets better, or tendinitis, which hurts mostly in response to overuse, chronic pain makes your whole world shrink. It’s harder to work, and to exercise, and even to do the many smaller things that make life rewarding and rich.
It’s also lonely. When my arms first went crazy, I could barely function. But even after the worst had passed, I saw friends rarely; I still couldn’t drive more than a few minutes, or sit comfortably in a chair, and I felt guilty inviting people over when there wasn’t anything to do. As Christin Veasley, director and co-founder of the Chronic Pain Research Alliance, puts it: “With acute pain, medications, if you take them, they get you over a hump, and you go on your way. What people don’t realize is that when you have chronic pain, even if you’re also taking meds, you rarely feel like you were before. At best, they can reduce your pain, but usually don’t eliminate it.”
A cruel Catch-22 around chronic pain is that it often leads to anxiety and depression, both of which can make pain worse. That’s partly because focusing on a thing can reinforce it, but also because emotional states have physical effects. Both anxiety and depression are known to increase inflammation, which can also worsen pain. As a result, pain management often includes cognitive behavioral therapy, meditation practice or other coping skills. But while those tools are vital, it’s notoriously hard to reprogram our reactions. Our minds and bodies have evolved both to anticipate pain and to remember it, making it hard not to worry. And because chronic pain is so uncomfortable and isolating, it’s also depressing.
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