Connect with us

Health

Study discovers 'trigger gene' in IBD as researchers look for drugs to prevent the bowel disease

Published

on

Study discovers 'trigger gene' in IBD as researchers look for drugs to prevent the bowel disease

Join Fox News for access to this content

Plus special access to select articles and other premium content with your account – free of charge.

By entering your email and pushing continue, you are agreeing to Fox News’ Terms of Use and Privacy Policy, which includes our Notice of Financial Incentive.

Please enter a valid email address.

Having trouble? Click here.

Inflammatory bowel disease (IBD) — which includes Crohn’s disease and ulcerative colitis — affects around 3.1 million U.S. adults.

The disease can cause debilitating symptoms such as diarrhea, abdominal pain and cramping, blood in the stool and more. 

Advertisement

Now, researchers at the U.K.’s Francis Crick Institute, working with UCL and Imperial College London, have discovered a genetic component — referred to as a “weak spot” in the DNA — that is present in 95% of those living with the disorder.

FIRST-EVER AUGMENTED REALITY ABDOMINAL SURGERY PERFORMED IN CHILE: ‘A REVOLUTION’

The study, published in the journal Nature earlier this month, identified a section of DNA that boosts the activity of a gene called ETS2

ETS2 has been linked to inflammatory functions that increase the chances of IBD.

Inflammatory bowel disease (IBD) can cause debilitating symptoms such as diarrhea, abdominal pain and cramping, blood in the stool and more.  (iStock)

Advertisement

Rosario Ligresti, M.D., chief of the Division of Gastroenterology at Hackensack University Medical Center in New Jersey, was not involved in the research but called the findings “quite important.”

CANCER PREVENTION IN THE ESOPHAGUS COULD BE JUST A PILL AWAY, DOCTOR SAYS: ‘TREMENDOUS BENEFIT’

“The researchers finally showed that all autoimmune and inflammatory disease — including IBD — appear to be caused by a single gene, ETS2,” he told Fox News Digital.

“The research identified this gene as a central regulator of a type of inflammatory cell called the macrophage, which is the main inflammatory cell in all these processes.”

“IBD usually develops in young people and can cause severe symptoms that disrupt education, relationships, family life and employment.”

Advertisement

“The more the gene was ‘turned on’ or amplified, the greater the risk of inflammation. Without this gene, these cells do not ‘turn on’ and there is no IBD.”

While diet and stress have long been suspected to worsen IBD, the exact “‘molecular switch’ that activates inflammatory bowel disease has been unknown until now,” Ligresti noted.

Inflammatory bowel disease (IBD) — which includes Crohn’s disease and ulcerative colitis — affects around 3.1 million U.S. adults. (iStock)

“This discovery is so exciting and significant because it only gives us a better understanding of the inner workings of the disease, and it will allow researchers to adapt existing drugs to finally treat it,” added Ligresti. 

The research team is now investigating drugs that could reduce the activity of the ETS2 gene, thus reducing the occurrence of IBD.

Advertisement

HERE’S WHY YOU’RE BLOATED — AND WHAT TO DO ABOUT THE COMMON DIGESTIVE CONDITION

They found that a group of existing anti-inflammatory medications called MEK inhibitors could do the trick.

“Although there have been many factors suggested as risks for IBD, there is currently no way to prevent the onset of IBD,” Ligresti said. 

“The researchers finally showed that all autoimmune and inflammatory disease — including IBD — appear to be caused by a single gene, ETS2,” a researcher (not pictured) told Fox News Digital. (iStock)

“We do know, however, that inflammatory pathways in the body are likely activated at least five years before the onset of symptoms of IBD.”

Advertisement

Ideally, he said, patients at increased risk could be given a drug during this window of time that could “nip IBD in the bud.”

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

While more research is needed to find ways to deliver these MEK inhibitors to the target cells, Ligresti noted that this finding opens a “tantalizing door” to the future of very effective therapies to “shut off” inflammatory bowel disease.

The research team is now investigating drugs that could reduce the activity of the ETS2 gene, thus reducing the occurrence of IBD. (iStock)

James Lee, group leader of the Genetic Mechanisms of Disease Laboratory at the Crick, who led the research, agreed that better treatments are “urgently needed.”

Advertisement

“IBD usually develops in young people and can cause severe symptoms that disrupt education, relationships, family life and employment,” Lee said in a Crick press release. 

                                                               

“Using genetics as a starting point, we’ve uncovered a pathway that appears to play a major role in IBD and other inflammatory diseases,” he said.

“Excitingly, we’ve shown that this can be targeted therapeutically, and we’re now working on how to ensure this approach is safe and effective for treating people in the future.”

Inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, often occur early in life, experts say. (iStock)

Advertisement

Lauren Golightly, 27, was diagnosed with Crohn’s disease in 2018 after experiencing stomach cramps, bleeding and irregular bowel habits, according to the release. 

“I’ve had a rocky road since diagnosis, with many hospital admissions, several different medications and even surgery to have a temporary stoma bag,” she said in the release.

For more Health articles, visit www.foxnews/health 

“I still experience flare-ups and can still spend quite a bit of time in hospital.”

She also said, “Learning about this research is so exciting and encouraging. I am hopeful this could potentially make a difference for myself and so many other hundreds of thousands of people living with IBD.”

Advertisement

Fox News Digital reached out to the researchers for additional comment.

Health

Deaths from one type of cancer are surging among younger adults without college degrees

Published

on

Deaths from one type of cancer are surging among younger adults without college degrees

NEWYou can now listen to Fox News articles!

Colorectal cancer, once considered a disease of older age, is becoming a crisis for younger adults. New research shows one group getting hit the hardest – those without a college degree.

A recent study from the American Cancer Society analyzed data from over 101,000 adults aged 25 to 49 who died from colorectal cancer between 1994 and 2023.

While death rates remained stable for college graduates, they climbed significantly for those without a bachelor’s degree, the findings showed.

WIDESPREAD HABIT MAY RAISE COLORECTAL CANCER RISK MORE THAN YOU THINK

Advertisement

For young adults with a high school education or less, the mortality rate rose from 4.0 to 5.2 per 100,000 people, while the rate for those with at least a bachelor’s degree stayed flat, at approximately 2.7 per 100,000.

This does not mean that a degree offers some kind of biological protection, researchers cautioned.

Colorectal cancer, once considered a disease of older age, is becoming a crisis for younger adults. (iStock)

The difference is likely driven by the conditions in which people live and work, which often correlate with education levels, the researchers noted.

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

Advertisement

The study suggests that the higher death rates are likely driven by differences in the prevalence of risk factors, including obesity, physical inactivity, smoking and diet, which are “known to be elevated among children and young adults with lower [socioeconomic status].”

Because the study relied on death certificates, researchers couldn’t say exactly why college graduates had better outcomes.

Because the researchers didn’t have the patients’ actual medical records, they couldn’t see things like frequency of screenings or treatment options, which would impact survival outcomes. (iStock)

Certificates typically list the cause of death, age, race and education level, but they do not include a person’s full medical history.

RED FLAGS FOR COLORECTAL CANCER THAT WARRANT SCREENINGS BEFORE 45 YEARS OF AGE

Advertisement

Because the researchers didn’t have the patients’ actual medical records, they couldn’t see things like frequency of screenings or treatment options, which would impact survival outcomes.

CLICK HERE FOR MORE HEALTH STORIES

Colorectal cancer is now the leading cause of cancer death for men under 50 and the second leading cause for women in the same age group, according to recent statistics.

While colorectal cancer death rates remained stable for college graduates, they climbed significantly for those without a bachelor’s degree, the findings showed. (iStock)

Because the disease is highly treatable when caught early, the U.S. Preventive Services Task Force (USPSTF) lowered the recommended screening age from 50 to 45 in 2021.

Advertisement

TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ

Common signs and symptoms of colorectal cancer can include a change in bowel habits, such as diarrhea, constipation or narrowing of the stool, that lasts for more than a few days, according to the American Cancer Society.

CLICK HERE TO DOWNLOAD THE FOX NEWS APP

Other signs that warrant seeing a doctor include blood in the stool or a persistent feeling of needing to go to the bathroom but being unable to go.

The research was published in JAMA Oncology.

Advertisement

Continue Reading

Health

Cancer tied to woman’s vaping habit since age 15 as she’s now given just months to live

Published

on

Cancer tied to woman’s vaping habit since age 15 as she’s now given just months to live

NEWYou can now listen to Fox News articles!

A young woman who started vaping at the age of 15 has been given just 18 months to live — after being diagnosed with lung cancer in her early 20s. 

Kayley Boda, 22, of Manchester, in the United Kingdom, was engaging in heavy vaping on a regular basis when she started coughing up a brown substance with “grainy bits” in it in January 2025, news agency SWNS reported. 

The retail assistant said doctors turned her away eight times, telling her she had a chest infection — until she began coughing up blood.    

SMOKING AND VAPING MAY BE BANNED AT ONE STATE’S MOST POPULAR BEACHES AND PARKS: HERE’S WHY

Advertisement

After seven biopsies, Boda was diagnosed with lung cancer. She underwent surgery to remove the lower lobe of her right lung, as well as chemotherapy — and in February 2026, got the all-clear, the same source reported.

Two months later, though, doctors said the cancer had come back in the pleural lining. Now she’s been given 18 months to live.

Kayley Boda, 22, is shown in the hospital. She started coughing up a brown substance with “grainy bits” in January 2025, she said. She had been vaping since the age of 15.  (SWNS)

The young woman has now issued a warning to others to be aware of the dangers of vaping.

Boda said she smoked a bit as a young teenager. She took up vaping after that. 

Advertisement

Then, “a few months after I switched from reusable vapes to disposable ones, I started coughing up brown, grainy mucus,” as SWNS reported.

TOURISTS MAY FACE STEEP FINES AND JAIL TIME FOR VAPES AT THIS VACATION HOT SPOT

“Doctors turned me away eight times with a chest infection. … Then I started coughing up blood, so they did an X-ray and found a shadow on my lung,” she added.

“They told me they were 99% sure, [since I was] so young, that it wasn’t cancer, so not to worry about it. When I got the results back, and they told me it was lung cancer, it felt so surreal.”

Boda said she was “very naive” before her diagnosis and thought that “something like this would never happen to me.”

Advertisement

She said that she had surgery to remove half of her right lung.

“After the surgery, I started chemo and I had a terrible reaction to it. I couldn’t lift my head up. I was throwing up blood. I was urinating blood. I couldn’t eat. I couldn’t sleep.”

VACATION HOT SPOT CRACKS DOWN ON VAPING WITH JAIL THREATS AND HEFTY FINES

She said that when she got the “all clear [in Feb. 2026], it felt amazing, but just two months later I was told the cancer had come back, and I have 18 months to live.”

She added, “I’m 22. This isn’t meant to happen to somebody my age.”

Advertisement

“Stay off the vapes because they will catch up with you.”  

She blames her cancer on vaping, she said.  

“My symptoms started a few months after I started disposable vapes, and there’s no lung cancer in my family,” she said. “I haven’t vaped for three months, I’ve made my partner stop, I’ve made my mom stop, I’m urging all my friends to stop. Stay off the vapes,” she continued, “because they will catch up with you.”  

When doctors did an X-ray, they found a shadow on Boda’s right lung. She was later diagnosed with lung cancer and has undergone surgery to remove the lower lobe of her right lung, as well as chemotherapy. (SWNS)

She said she’d been using reusable vapes since the age of 15 and began using disposable vapes a few months before her cancer symptoms started.

Advertisement

DISPOSABLE VAPES MORE TOXIC AND CARCINOGENIC THAN CIGARETTES, STUDY SHOWS

In November 2024, when she developed a rash all over her body, doctors said it could have been due to shingles, chicken pox or scabies, she told SWNS.    

‘Nothing worked’

“I got treated for all three, and nothing worked,” Boda said. “It got to the point where I was cutting myself from scratching so hard.” 

A few months after that, she began coughing up a dark brown mucus, with “grainy bits, the consistency of sugar, in it,” she said. When the coughing continued, she visited the doctor’s office, but was told it could be scarring from pneumonia or a chest infection, she also said.    

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

Advertisement

It wasn’t until March 2025 that she began coughing up bright red blood. At that point, doctors gave her a chest X-ray and told her they’d found a shadow on her lower right lung.    

Over the next four months, she had seven biopsies as doctors took samples from the “shadow.” In August, when she went to get the results, she was told she had stage one lung cancer.

Boda is shown in the hospital. She was diagnosed with lung cancer and had surgery to remove the lower lobe of her right lung, as well as chemotherapy. (SWNS)

In September 2025, she had surgery to remove the lower lobe of her right lung, and the surrounding lymph nodes. During the surgery, doctors upstaged her cancer from stage one to stage three after finding cancer in six surrounding lymph nodes, she said.  

Following the surgery, Boda was unable to breathe properly and had to learn to walk all over again.  

Advertisement

“The oncologist said this is so rare.”

After finishing chemotherapy in February 2026, Kayley was given the all clear, leaving her feeling elated. 

TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ

However, just a month after that, she began experiencing extreme chest pains and was told by doctors she had a pleural effusion — a build-up of fluid in the lungs. She had the fluid removed, but when doctors tested it, they discovered her cancer had returned to the pleural lining of her lungs, giving her 18 months to live.  

“The oncologist said this is so rare, and usually something they see in patients that are 80 years old,” she said, as SWNS reported.  

Advertisement

Increasingly, vacation hot spots are enforcing strict bans on the use of e-cigarettes in public venues.  (iStock)

Boda claimed that doctors were unable to pin her cancer to a specific cause — but told her that smoking and vaping definitely didn’t help.

Since her diagnosis, she has stopped and is urging others to stop, too.    

CLICK HERE TO DOWNLOAD THE FOX NEWS APP

She’s hoping to raise the thousands of dollars needed for treatment to try to prolong her life, she said.  

Advertisement

Last year, Fox News Digital reported on the case of a Pennsylvania woman, 26, who said she vaped for just one year before her lungs collapsed. She was 22 when she took up the habit, she said in an interview. 

“Everybody warned me about it, but I didn’t listen — I wish that I did,” she said.

CLICK HERE FOR MORE HEALTH ARTICLES

Dr. David Campbell, clinical director and program director at Recover Together Bend in Oregon, told Fox News Digital at that time that signs of collapsed lungs include sharp chest or shoulder pain, shortness of breath and difficulty breathing.

Lung issues are just one of the many health issues linked to vaping, he warned. The habit can also increase the risk of heart disease and stroke, as well as exposure to harmful heavy metals.

Advertisement

Melissa Rudy of Fox News Digital contributed reporting. 

Continue Reading

Health

Experts reveal why ‘nonnamaxxing’ trend may improve mental, physical health

Published

on

Experts reveal why ‘nonnamaxxing’ trend may improve mental, physical health

NEWYou can now listen to Fox News articles!

The key to feeling better in a fast, overstimulated world might be surprisingly simple: Live a little more like your grandparents.

A growing social media trend, dubbed “nonnamaxxing,” draws inspiration from the slower, more intentional rhythms associated with an Italian grandmother.

The lifestyle is often linked to activities like preparing home-cooked meals, spending time outdoors and making meaningful connections.

MARTHA STEWART SHARES 7 TIPS FOR AGING WELL: ‘LOOK GOOD, FEEL GOOD, BE GOOD’

Advertisement

“Nonnamaxxing is a 2026 trend that embraces the slower, more intentional lifestyle of an Italian grandmother (a Nonna). Think cooking from scratch, long family meals, daily walks, gardening and less screen time,” Erin Palinski-Wade, a New Jersey-based registered dietitian, told Fox News Digital.

Nonnamaxxing, derived from the name for an Italian grandmother, is a trend that incorporates lifestyle habits hundreds of years in the making. (iStock)

Stepping away from screens and toward real-world interaction can have measurable benefits, according to California-based psychotherapist Laurie Singer.

“We know that interacting with others in person, rather than spending time on screens, significantly improves mental health,” she told Fox News Digital, adding that social media often fuels comparison and lowers self-esteem.

LONELINESS MAY BE SILENTLY ERODING YOUR MEMORY, NEW RESEARCH REVEALS

Advertisement

Living more like previous generations isn’t purely driven by nostalgia. Cooking meals from scratch, for example, has been linked to better nutrition and more mindful eating patterns.

Adopting traditional mealtime habits can improve diet quality and support both physical and mental health, especially when meals are shared regularly with others, Palinski-Wade noted.

One longevity expert stresses that staying healthy isn’t just about food — it’s also about joy and community. (iStock)

There’s also a psychological benefit to slowing down and focusing on one task at a time. Anxiety often stems from unfinished or avoided tasks, Singer noted, and engaging in hands-on activities can counteract that.

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

Advertisement

“Nonnamaxxing encourages us to be present around a task, like gardening, baking or knitting, or just taking a mindful walk, that delivers something ‘real,’” she said.

CLICK HERE FOR MORE HEALTH STORIES

Palinski-Wade cautions against turning the trend into another source of pressure, noting that a traditional “nonna” lifestyle often assumes a different pace of life.

The key, she said, is adapting the mindset, not replicating it perfectly.

Nonnamaxxing, derived from the name for an Italian grandmother, is a trend that incorporates lifestyle habits hundreds of years in the making. (iStock)

Advertisement

The goal is to reintroduce small, intentional moments that make you feel better.

TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ

That might mean prioritizing a few shared meals each week, taking a walk without your phone or setting aside time for a simple hobby, the expert recommended.

CLICK HERE TO DOWNLOAD THE FOX NEWS APP

Singer added, “Having a positive place to escape to, through whatever activities speak to us and make us happy, isn’t generational – it’s human.”

Advertisement

Continue Reading
Advertisement

Trending