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Experimental Alzheimer’s drug could reduce alcohol withdrawal damage, researchers say

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Experimental Alzheimer’s drug could reduce alcohol withdrawal damage, researchers say

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An investigational dementia drug may also ease alcohol withdrawal by calming the brain inflammation linked to addiction and relapse.

That’s according to researchers at the University of Kentucky, who studied an experimental medication called MW150 that targets a brain inflammation pathway known as p38α MAPK.

The drug, which has not yet been approved, is designed to treat mild to moderate Alzheimer’s disease.

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Scientists believe neuroinflammation may contribute to relapse risk and long-term neurological damage in people with alcohol use disorder.

In laboratory and animal-model experiments, MW150 was found to reduce certain inflammatory markers during alcohol withdrawal.

An investigational dementia drug may also ease alcohol withdrawal by calming the brain inflammation linked to addiction and relapse. (iStock)

The work, which was published in the journal Alcohol, came from the University of Kentucky’s Sanders-Brown Center on Aging, led by neuroinflammation researcher Linda Van Eldik.

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Caleb Bailey, Ph.D., co-author of the study and a researcher in Van Eldik’s lab, said the study provides “biological plausibility” that MW150 could mitigate neuroinflammation arising from alcohol withdrawal.

Alcohol use disorder is difficult to treat because of high relapse rates, especially during withdrawal, according to Bailey.

Alcohol use disorder is difficult to treat because of high relapse rates, especially during withdrawal, according to the researchers. (iStock)

“If follow-up experiments reveal similar anti-inflammatory effects of MW150 in animal models of alcohol use disorder, it would provide a strong rationale for development of MW150 as a treatment for those struggling with chronic alcohol relapse due to alcohol withdrawal,” he told Fox News Digital.

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Along with a related drug called Neflamapimod, MW150 is already being investigated in clinical trials as a potential therapy for dementia and other neurodegenerative conditions, the researchers noted.

“That gives this work added significance,” Bailey said. “Because these compounds are already further along in development for other neurological diseases, it raises the possibility that they could someday be repurposed more efficiently for alcohol-related conditions if future studies continue to show promise.”

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There were some important caveats to the research, including that it was conducted in cell culture and animal models.

“Because they are ‘dish’-based models, they provide limited information regarding what happens in the full organism – or even the full brain for that matter,” Bailey said.

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MW150, along with a related drug called Neflamapimod, is already being investigated in clinical trials as a potential therapy for dementia and other neurodegenerative conditions. (iStock)

“A series of follow-up studies in living animals is required to more fully understand how future MW150 treatment in alcohol use and withdrawal affects systemic health and/or alcohol consumption.”

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Dr. Amy Swift, deputy chief medical officer at Silver Hill Hospital in Connecticut, was not involved in the study but shared her reactions to the findings.

“Although detoxification using tapering doses of medication has long been considered the evidence-based first step in treating alcohol use disorder, its impact on the long-term trajectory of a person’s drinking behavior has been limited,” she told Fox News Digital.

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“Minimizing alcohol consumption … is the best strategy for staying healthy.”

“Put simply, detoxification does not treat alcohol use disorder itself; rather, it prevents the potentially fatal complications of alcohol withdrawal.”

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Adding supportive medications — especially those intended to improve overall brain health — could address an important gap in early treatment of detoxification, according to Swift.

“It is worthwhile to investigate whether reducing neuroinflammation could improve a patient’s ability to engage in treatment earlier in recovery and, in turn, meaningfully alter their long-term relationship with alcohol,” an expert said. (iStock)

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“Given the profound inflammatory effects alcohol has across multiple organ systems, it is worthwhile to investigate whether reducing neuroinflammation could improve a patient’s ability to engage in treatment earlier in recovery and, in turn, meaningfully alter their long-term relationship with alcohol,” she added.

Bailey emphasized that no amount of alcohol consumption is good from a physical health standpoint.

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“We don’t currently have robust pharmacological treatments to mitigate damage caused by chronic alcohol consumption,” he said. “Minimizing alcohol consumption, therefore, is the best strategy for staying healthy.”

As the MW150 compound continues to be studied for dementia patients, Bailey saud, “information regarding the interaction between these drugs and alcohol — for better or for worse — will be important for patient outcomes.”

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One walking habit could signal a healthier brain after 80, scientists say

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One walking habit could signal a healthier brain after 80, scientists say

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Older adults identified as “super movers” are about half as likely to develop cognitive impairment than their peers.

That’s according to a recent study led by Stony Brook Medicine in New York, which evaluated the cognitive function of 4,000 adults 80 and over who participated in multiple aging and longevity studies over several years.

Among this group, 6% to 10% were classified as super movers, which means they walk at a much faster pace than others of the same age and gender — at speeds comparable to people three decades younger.

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The super movers were found to have about half the risk of cognitive decline compared to seniors with typical gait speed.

The findings were published in the journal Neurology on June 16.

Older adults identified as “super movers” are about half as likely to develop cognitive impairment than their peers. (iStock)

“The study reinforces that mobility and brain health are closely connected,” lead study author Dr. Joe Verghese, MD, neurologist at Stony Brook Medicine, told Fox News Digital. “This suggests that preserving mobility may be an important marker of healthy brain aging and resilience.”

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The most intriguing finding, according to Verghese, was that super movers maintained cognitive function despite having similar dementia-related brain changes as their peers.

In postmortem brain analysis, there was no difference in dementia-related pathologies between the super movers and the slower walkers, the study stated.

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“This suggests they may possess resilience mechanisms that help preserve brain function even in the presence of age-related changes,” he said. “Understanding these resilience factors could lead to new strategies for promoting healthy brain aging.”

As the study was observational, there were some limitations, and it does not prove that walking faster prevents dementia, the researchers noted.

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Super movers were found to have about half the risk of cognitive decline compared to seniors with typical gait speed. (iStock)

“Other factors, such as cardiovascular health, physical fitness or genetics, may also contribute to both faster walking and better cognitive outcomes,” Verghese said.

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This study adds to growing evidence that what’s good for the heart and muscles also benefits the brain, he noted, adding that “staying physically active remains one of the most effective, evidence-based ways to support healthy aging.”

“Walking speed is best viewed as a marker of overall health, not a treatment.”

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“The broader message is that physical activity is important at any age,” Verghese said. “Walking is an easy step-up point because you don’t need any special equipment. You can do it inside or outdoors, and you can do it on a regular basis. You can walk with a dog, you can walk with a friend.”

Any activity is beneficial if it’s done regularly and with the right intensity, he added.

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Rather than just trying to walk faster, the neurologist recommends that seniors focus on maintaining mobility through regular physical activity, strength training, balance exercises and good cardiovascular health.

“Walking speed is best viewed as a marker of overall health, not a treatment,” Verghese noted.

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Major public health guidelines from the CDC and U.S. Physical Activity Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity each week, such as brisk walking.

Major public health guidelines from the CDC and U.S. Physical Activity Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity each week, such as brisk walking. (iStock)

This can be achieved by walking 30 minutes a day, five days a week, or about 20 to 25 minutes most days. Another option is to engage in shorter sessions that add up over the day.

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“You have to do it within your health limitations and medical conditions,” Verghese advised. “So if there are any medical concerns, I would get your physician to clear you before starting exercise.” The good thing about walking, he added, is that you can start at a slow pace and then gradually build up to a brisker pace.

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“And then adding on strength and balance training, whatever age you are, I think is also important.”

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I Tried the Viral Gelatin Weight-Loss Recipe—Here’s My Honest Take

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I Tried the Viral Gelatin Weight-Loss Recipe—Here’s My Honest Take


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I Tried the Viral Gelatin Weight-Loss Recipe: Does It Really Work?




















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Dr Oz warns Medicare scammers are stealing billions — and your personal information could be next

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Dr Oz warns Medicare scammers are stealing billions — and your personal information could be next

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Medicare fraud is a multibillion-dollar problem that government officials say threatens both taxpayer dollars and Americans’ personal identities.

In a July 6 interview with Fox News Digital at the Great American State Fair in Washington, D.C., Dr. Mehmet Oz warned that every dollar stolen through Medicare fraud is a dollar taxpayers lose – a problem that has worsened since the COVID pandemic.

“If I had to just pick one thing to focus on to make healthcare more affordable in America, I’d go to health fraud and all the waste and abuse that accompanies it,” said Oz, who is the administrator of the Centers for Medicare & Medicaid Services. “And just to put this in perspective, we think it’s about $100 billion a year.”

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Medicare fraud can include billing for services that were never provided, overcharging for medical equipment, using stolen patient or doctor information, or performing unnecessary procedures, according to the U.S. Government Accountability Office.

CMS administrator Dr. Mehmet Oz is pictured on stage at the Great American State Fair in Washington, D.C., on July 6, 2026. (Angelica Stabile/Fox News Digital)

As the Trump administration ramped up efforts to combat fraud, CMS reported $41.9 billion in Medicare program integrity savings in 2025, up 59% from $26.3 billion in 2024.

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Medicare fraud not only harms the federal budget and steals from taxpayers, but exposes seniors to identity theft, unnecessary care, higher premiums and reduced access, Oz cautioned.

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Removing corruption from the healthcare system will have the greatest impact among seniors, since “so much of the fraud is perpetrated against them,” the administrator said.

“I’m talking about people tricking seniors to give up their Medicare beneficiary numbers, which is like a credit card basically,” he said. “These scammers can take those numbers and use them for all kinds of illegitimate purposes.”

“If I had to just pick one thing to focus on to make healthcare more affordable in America, I’d go to health fraud and all the waste and abuse that accompanies it,” said Oz. (Fox News Digital)

“People are stealing from you by pretending to send you drugs you don’t want, wheelchairs you don’t need, [and] services you never asked for or don’t benefit from,” Oz added.

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To prevent this, he shared his top advice for seniors: Do not give your Medicare beneficiary number to anybody, do not answer questions on a phone call from an unknown person and do not give away personal information.

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“These scammers are calling seniors, tricking them, and once they have key information, they can steal it,” he said. “And I won’t know it and you won’t know it.”

“We want to protect people who need these programs the most,” Oz went on. “You do that by making sure scoundrels don’t corrupt the systems and steal money out of the till that is designed to help folks in dire straits when they’re vulnerable and in need of services.”

Seniors should never share their Medicare information with unknown people, the administrator advised. (iStock)

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Removing fraud could “double the life expectancy of the trust fund that makes all this possible,” Oz predicted.

“If you’re worried about Medicare being there when you’re ready to retire in a couple decades, depending on how old you are, and you’re concerned that it might not last because of all the fraud that’s hitting it … you’ve got a good [reason to] worry,” he said.

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“If we take the fraud out, we could double the life expectancy, which means you, your kids, your kids’ kids … they could all benefit from this beautiful safety net program.”

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