Health
Smoking shrinks the brain and drives up Alzheimer’s risk, new study finds
Smoking is notorious for causing damage to the lungs — but a recent study confirmed that it’s also harmful to the brain.
Researchers from the Washington University School of Medicine (WashUMed) in St. Louis, Missouri, analyzed the brain scans, smoking history and genetic risk of 32,094 participants of European descent from the UK Biobank database.
Those who smoked one pack daily were found to have decreased brain volume compared to those who never smoked or had smoked fewer than 100 total cigarettes.
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With each additional year of smoking, the shrinkage was greater.
The study, published in the January 2024 issue of Biological Psychiatry: Global Open Science, helps to explain why older people who smoke are at a higher risk of Alzheimer’s disease and other dementias, according to the researchers.
Smoking is notorious for causing damage to the lungs, but recent research confirmed that it is also harmful to the brain. (iStock)
“People who smoke are more likely to have deterioration in gray and white matter, which provides a possible explanation as to why 14% of global Alzheimer’s disease cases could be attributable to cigarette smoking,” they wrote in the study findings.
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“Up until recently, scientists overlooked the effects of smoking on the brain, in part because we were focused on all the terrible effects of smoking on the lungs and the heart,” said senior author Laura J. Bierut, M.D., the Alumni Endowed Professor of Psychiatry, in a press release from WashUMed.
“But as we’ve started looking at the brain more closely, it’s become apparent that smoking is also really bad for your brain.”
Those who smoked one pack daily were found to have decreased brain volume compared to those who never smoked or had smoked fewer than 100 total cigarettes. (iStock)
It has long been known that aging is linked to a gradual reduction in brain volume, and this study shows that smoking speeds up that process, the researchers noted.
“This is important as our population gets older, because aging and smoking are both risk factors for dementia,” noted Bierut.
“There’s one thing you can change to stop aging your brain and putting yourself at increased risk of dementia, and that’s to quit smoking.”
One positive finding was that kicking the habit can prevent the loss of additional brain tissue — but the shrinkage can’t be reversed.
“You can’t undo the damage that has already been done, but you can avoid causing further damage,” said first author Yoonhoo Chang, a graduate student at WashUMed.
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“Smoking is a modifiable risk factor. There’s one thing you can change to stop aging your brain and putting yourself at increased risk of dementia, and that’s to quit smoking.”
Fox News Digital reached out to the study authors for additional comment.
Impact of toxins on aging
Dr. Brett Osborn, neurosurgery section chief at St. Mary’s Medical Center in West Palm Beach, Florida, was not involved in the WashUMed study but shared his reaction to the findings.
While aging — and some age-related diseases — can’t be prevented, Osborn noted that our lifestyle choices can accelerate or decelerate the process.
Dr. Brett Osborn, neurosurgery section chief at St. Mary’s Medical Center in West Palm Beach, Florida, shared his reaction to the study findings. (Dr. Brett Osborn)
“We can age gracefully in part by choosing to avoid toxins such as alcohol and smoking, both of which increase the production of toxic free radicals, also known as oxidative stress,” he told Fox News Digital.
When someone smokes, the doctor explained, the person’s blood vessel linings are “bombarded” by free radicals, which are electrons that cause cell damage. That impacts not only the heart and lungs, but also the brain.
“When you smoke, the brain takes a hit due to the induced vascular damage,” Osborn said. “Over time, the brain shrinks, and this is evident on MRI.”
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The new study confirms not only the correlation between reduced global brain volume, but also causation, said Osborn.
“It is not that those with reduced global brain volume tend to smoke from a genetic standpoint, but it is that those who smoke cause their brains to atrophy,” he said.
“Smoking does terrible things not only to the body but also to the brain, and in some parts, disproportionately more than others.”
“Smoking does terrible things not only to the body but also to the brain, and in some parts, disproportionately more than others,” a neurologist told Fox News Digital. (iStock)
The regions most affected by smoking are the frontal cortex (involved in executive function, memory input and mood), cerebellum (coordination), corpus callosum (information bridge between the two hemispheres), and amygdala (emotional response and memory), Osborn pointed out.
“It is also well-established that hippocampal volume, or the volume of our primary center, is reduced in daily smokers,” he said. “It should be no surprise, therefore, that there is an increased incidence of Alzheimer’s disease in smokers.”
“Smoking does terrible things not only to the body but also to the brain.”
While other organs, such as the lungs, can recover after a person quits smoking, there are no subsequent increases in brain volume, said Osborn.
“The brain demonstrates a lower capacity for recovery, so the best you can hope for is a deceleration in induced damage when you stop,” he said. “So, the sooner you quit, the better.”
The study helps to explain why older people who smoke are at a higher risk of Alzheimer’s disease and other dementias, according to the researchers. (REUTERS/Brian Snyder/File Photo)
“Remember, staying healthy lifelong is about making the right choices to mitigate the cellular damage that is the hallmark of the disease we call aging, to which no one is immune,” Osborn added.
“Do everything in your power to slow it down, rather than accelerating the process by smoking.”
One out of every five U.S. deaths can be attributed to smoking, per the Centers for Disease Control and Prevention (CDC).
Tips for kicking the habit
Dr. David Seitz, a New York-based physician with a specialty in addiction medicine, previously shared with Fox News Digital some tips for kicking the habit.
The first step is to remove all traces of cigarettes and other forms of smoking.
It’s also important to have a strong support system in place, the doctor said.
Some people find that it’s easier to gradually wean themselves off smoking instead of quitting cold turkey. (iStock)
He also suggested seeking out healthier activities to fill the gap, such as walking or jogging, listening to a relaxing playlist, meditating or going to a yoga class.
Some people find that it’s easier to gradually wean themselves off smoking instead of quitting cold turkey.
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“This could involve gradually reducing the number of cigarettes smoked each day until eventually giving up completely, cutting back to a certain number of cigarettes per week or focusing on specific dates when you need to be completely smoke-free,” Seitz said.
For those who are unable to stop smoking on their own, Seitz recommended seeing a doctor for assistance.
“Your doctor can provide helpful information about how to quit smoking, prescribe medications that may help, and also monitor your progress along the way.”
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One woman’s uncomfortable reaction to alcohol led to a grave discovery.
Hollie Thursby, 28, a mother of two from the U.K., told Kennedy News and Media that after giving birth to her second son, Jack, she began experiencing unusual symptoms.
At a checkup for her son, who was a couple of months old, Thursby mentioned that she was experiencing “unbearably itchy skin,” which is known to be a post-partum symptom. The doctor suggested it was due to changing hormones.
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Thursby added that she occasionally drank a couple glasses of wine. Although she kept the drinking to a minimum, she described having “a lot of pain” down the side of her neck.
“Really quite painful and uncomfortable,” she said, according to the report.
A U.K. mom reported experiencing pain in her neck after drinking a glass or two of wine, which turned out to be one of the first signs that she had cancer. (Kennedy News and Media)
The mother also reported feeling extremely exhausted, which she assumed was due to caring for her children throughout the day.
“I also felt like when I got to bed that someone was sitting on my chest,” she shared.
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In July 2025, Thursby discovered a lump on the side of her neck that she described as “really quite big,” but wasn’t painful, Kennedy News and Media reported.
“It was hard, it didn’t move, but it was there,” she said. “When I turned my neck to the side, you could see it.”
Thursby reportedly began chemotherapy for Stage 2 Hodgkins lymphoma. (Kennedy News and Media)
Thursby’s symptoms turned out to be a form of blood cancer — Stage 2 Hodgkins lymphoma, which means it is in two or more lymph nodes, according to Cancer Research U.K.
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Common symptoms include swelling of the lymph nodes, heavy sweating, weight loss, itching, persistent cough or shortness of breath, high temperatures, and pain in the stomach or lymph nodes after drinking alcohol.
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“Pain when you drink alcohol is actually a known side effect of Hodgkin lymphoma,” she said, per the report. “It’s something about the acidity in the wine and not when you drink other alcohol.”
While alcohol-related pain in Hodgkins lymphoma patients has been “an accepted scientific consensus” since the 1950s, cases are rare, Healthline confirmed.
Hollie Thursby, 28, and her two sons are pictured above. The mother reported feeling extremely exhausted, which she assumed was due to caring for her children throughout the day. (Kennedy News and Media)
Thursby reportedly began chemotherapy in November, noting that the hardest part is not being able to care for her kids after losing her own mother to a blood disorder called myelodysplasia.
“I grew up without a mum, and it was horrendous. I can’t do that to the boys,” she told Kennedy News and Media. “We’re all devastated, but we all know now, and we’ve got a treatment plan, which is what we need.”
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“I’m just doing everything I can to get better for them. I keep telling myself this is only temporary, I just need to keep going.”
Anyone experiencing pain or other concerning symptoms after consuming alcohol should consult a doctor for guidance.
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Red light therapy has been shown to reduce brain inflammation, protecting people who experience head trauma from long-term health consequences, a University of Utah study has shown.
Brain damage from repeated impact over the years is known to cause cognitive symptoms, ranging from memory issues to full-blown dementia, particularly affecting soldiers and athletes.
Chronic traumatic encephalopathy (CTE) is a progressive, degenerative brain disease linked to repeated head impacts rather than a single injury, according to Mayo Clinic.
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More than 100 former NFL football players have been posthumously diagnosed with CTE, according to the new study, which was published in the Journal of Neurotrauma.
Other research has shown that military personnel in active combat suffer from similar issues, as do first responders and veterans.
The treatment was administered three times a week for 20 minutes using specialized headsets and intranasal devices designed to penetrate the skull. (iStock)
In the new study, the researchers recruited 26 current football players to understand more about the impact of red-light therapy on brain injuries.
The participants received either red light therapy delivered by a light-emitting headset and a device that clips into the nose, or a placebo treatment with an identical device that doesn’t produce light. Players self-administered the therapy three times a week, 20 minutes each time, for 16 weeks.
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“My first reaction was, ‘There’s no way this can be real,’” said first author Hannah Lindsey, Ph.D., in the university press release. “That’s how striking it was.”
Specific wavelengths of light are believed to enter the brain and reduce molecules that trigger inflammation, potentially halting the path toward dementia and other cognitive conditions. (iStock)
Players using the placebo treatment experienced increased brain inflammation over the course of the season. Magnetic resonance imaging (MRI) scans taken at the end of the season showed significantly more signs of inflammation than at the beginning of the season, the study found.
For players who used red-light therapy during the season, their brain inflammation didn’t increase at all.
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Previous studies have shown that red light, if powerful enough, can penetrate the skull and reach the brain, where it may reduce inflammation-related molecules.
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“When we first started this project, I was extremely skeptical,” said Elisabeth Wilde, Ph.D., the senior author on the study. “But we’ve seen consistent results across multiple of our studies, so it’s starting to be quite compelling.”
Study limitations
The study was conducted using a small sample size, which led to different levels of inflammation in the treatment and control groups, the researchers acknowledged.
While the placebo group showed increased brain inflammation during the football season, those receiving red light therapy showed no increase in inflammatory markers. (iStock)
Future large randomized clinical trials will be “crucial to back up the results” in larger populations, they noted.
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“We’ve been trying to figure out how to make sports safer, so that our kids, friends and family can participate in sports safely for the long term while they’re involved in activities that give them happiness and joy,” Carrie Esopenko, Ph.D., second author of the study, said in the release.
“And this really feels like part of the hope for protecting the brain that we’ve been searching for.”
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The team plans to recruit 300 people with persistent symptoms from TBI or concussion for a randomized controlled trial in 2026, with a focus on first responders, veterans and active-duty service members.
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Drinking heavily and consistently over an adult’s lifetime could lead to a higher risk of colorectal cancer, according to a study published in the journal Cancer by the American Cancer Society (ACS).
The study analyzed 20 years of data from more than 88,000 U.S. adults to determine how long-term drinking impacted the risk of developing colorectal cancer (CRC) or precancerous colorectal adenomas (polyps).
The participants reported their average weekly intake of beer, wine and liquor intake during four age periods — 18 to 24, 25 to 39, 40 to 54, and 55 and older.
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“Heavy drinkers” were identified as having more than 14 drinks per week and “moderate drinkers” had between seven and 14 drinks per week.
The observational research revealed that consistent heavy drinking over adulthood was linked to a higher risk of colorectal cancer, especially rectal cancer.
Researchers found a major association between colorectal cancer diagnosis and heavy lifetime drinking. (iStock)
Heavy lifetime drinking was associated with a 25% higher overall CRC risk and nearly double the risk of rectal cancer. Moderate lifetime drinking had a lower overall CRC risk.
Compared to light drinkers, the consistently heavy drinkers had about a 91% higher risk of CRC.
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For colorectal adenomas (precancerous polyps), higher current lifetime drinking did not show a strong pattern, although former drinkers showed a significantly lower risk of non-advanced adenoma compared to current light drinkers.
Out of the 88,092 participants, 1,679 were diagnosed with colorectal cancer.
Out of the 88,092 participants in the study, 1,679 were diagnosed with colorectal cancer. (iStock)
The authors noted that the research was limited, as it was observational and not based on a clinical trial. It also hinged on self-reported alcohol use.
The findings suggest that consistently heavy alcohol intake and higher average lifetime consumption “may increase CRC risk, whereas cessation may lower adenoma risk,” the researchers stated. Associations “may differ by tumor site,” they added.
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The link between drinking alcohol and cancer is not a new discovery, according to health experts.
In a recent episode of the podcast “The Dr. Mark Hyman Show,” Dr. Mark Hyman, chief medical officer of Function Health in California, detailed how even moderate drinking can impact “nearly every organ system in the body,” due to metabolic stress, inflammation, impaired detoxification and its effect on hormones.
The link between drinking alcohol and cancer is not a new discovery, according to health experts. (iStock)
Drinking has been found to increase the risk of many cancers, metabolic dysfunction, gut microbiome disturbances and mitochondrial toxins, Hyman said.
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“Bottom line, alcohol taxes every major system in your body, especially your liver, your brain, your gut, your hormones,” he warned.
Reducing or eliminating alcohol can lower the risk of several cancers, according to medical experts. (Getty Images)
In a previous interview with Fox News Digital, Dr. Pinchieh Chiang, a clinician at Circle Medical in San Francisco, shared that taking a break from drinking alcohol for longer periods of time can “reshape health more profoundly.”
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“Over months to a year, we see sustained improvements in blood pressure, liver function and inflammation,” she said. “Those changes directly affect long-term heart disease and stroke risk.”
Chiang added, “Reducing or eliminating alcohol lowers the risk of several cancers, including breast and colorectal, over time.”
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Fox News Digital reached out to the study researchers for comment.
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