Health
‘Smart mask’ could detect asthma, COPD and other medical conditions, researchers say
Your breath could hold clues to your health, researchers say — and they have developed a “smart mask” to tap into them.
Wei Gao, professor of medical engineering at the California Institute of Technology (Caltech) in Pasadena, led the team that created the EBCare, a mask that analyzes the chemicals in someone’s breath to detect any existing health issues.
The mask is designed to screen for medical conditions like respiratory infections, COPD (chronic obstructive pulmonary disease), asthma and post-COVID infections, according to a press release from Caltech.
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EBCare works by cooling the breath to convert it into a liquid, then transports it to sensors to be analyzed for specific biomarkers.
Researchers have developed a “smart mask” (pictured at left) to detect signs of medical conditions. (Caltech/Wei Gao and Wenzheng Heng; iStock)
In an email to Fox News Digital, lead researcher Gao noted the mask’s ability to enable “continuous, real-time monitoring of exhaled breath condensate (EBC) in a non-invasive and wearable format.”
“This technology has the potential to revolutionize the way we monitor respiratory health by providing valuable insights into conditions like asthma, COPD and other metabolic disorders,” Gao said, noting that it could be a path to more personalized health care.
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“It can also be applied to pandemic management by monitoring respiratory infections on a wide scale,” he added.
The ultimate goal is for the EBCare technology to go beyond respiratory diseases, Gao noted.
“As research progresses, we envision that the smart mask can be adapted to detect a wider range of biomarkers, including those related to metabolic, cardiovascular and infectious diseases,” he said.
This schematic shows the process by which the smart mask can detect chemicals in the breath, such as nitrite, which is an indicator of airway inflammation. (Caltech/Wei Gao and Wenzheng Heng)
A study of the mask’s capabilities included 31 healthy adults who wore the EBCare in real-life settings over a 14-hour span, according to Caltech. They only removed the mask for three-minute intervals to eat.
Ten of the participants were smokers, 10 had asthma, nine had COPD and 12 had recently recovered from COVID-19.
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The masks accurately detected the biomarker for asthma and COPD in participating patients. They also successfully detected signs of kidney disease.
EBCare also produced accurate readings of blood alcohol levels.
“Monitoring alcohol levels in real time offers a non-invasive and continuous alternative to breathalyzers or blood tests,” Gao said.
“We would need to see at least a few clinical studies demonstrating that the masks can diagnose better — or more rapidly or with more sensitivity — than the standard of care.”
The research — which was funded by the National Institutes of Health, the National Science Foundation, the Tobacco Related Disease Research Program, and the U.S. Army Medical Research Acquisition Activity — was published in the journal Science on Aug. 29.
The idea is not for the smart mask to replace traditional medical diagnosis, but to provide “early warning” through continuous health monitoring during daily activities and to “bridge the gap” between doctor’s visits, Gao said.
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“The goal is to identify subtle physiological changes before they develop into more severe conditions, giving individuals the opportunity to take proactive steps in managing their health,” he said.
This is especially important for those who need regular monitoring, such as patients with chronic conditions or those recovering from respiratory infections like COVID-19, according to Gao.
The mask (not pictured) is designed to screen for medical conditions like respiratory infections, COPD (chronic obstructive pulmonary disease), asthma and post-COVID infections. (iStock)
“I recommend that health care providers consider integrating real-time EBC analysis technology into their diagnostic and monitoring practices, especially for chronic conditions like asthma and COPD,” he said.
“For individuals, the ability to monitor one’s health non-invasively through a wearable device offers the opportunity to be more proactive in managing personal health, which can lead to early intervention and better health outcomes.”
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MarkAlain Déry, DO, MPH, infectious disease doctor and chief innovation officer at Access Health Louisiana, who was not involved with the development of the smart mask, agreed that it is an “exciting concept.”
“Could it work? Sure,” he told Fox News Digital.
Wei Gao, professor of medical engineering at the California Institute of Technology in Pasadena, led the team that created the EBCare mask. (Caltech)
“However, we would need to see at least a few clinical studies demonstrating that the masks can diagnose better — or more rapidly or with more sensitivity — than the standard of care,” he went on.
“Then, we would need studies that demonstrate clinical improvement.”
Potential limitations
Some external doctors not involved in the mask’s development questioned whether this mode of data collection is beneficial.
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“While the mask introduces an innovative method to monitor exhaled breath condensate (EBC), we need to ask an important question: Do these continuous, real-time measurements genuinely make a difference in everyday life?” said Dr. Brett Osborn, a Florida neurosurgeon, in a conversation with Fox News Digital.
“For the average person, the biomarkers it detects — ammonium, pH, nitrite and alcohol — do not need constant monitoring, especially when routine blood tests can provide this information more accurately and with greater relevance.”
“For the average person, the biomarkers it detects … do not need constant monitoring, especially when routine blood tests can provide this information more accurately and with greater relevance,” a doctor said. (iStock)
Osborn believes that the concept of the EBCare mask is better suited for “specific, high-stakes environments,” such as real-time monitoring of toxic gases in military or industrial settings.
“However, for the average person, especially in a post-pandemic world, the idea of wearing a mask like this is counterproductive,” he said.
Dr. John W. Ayers, PhD, vice chief of innovation in the Division of Infectious Diseases and Global Public Health at the University of California San Diego, also questioned the idea of having patients with asthma or COPD — who already experience breathing difficulties — wear the masks.
“For the average person, especially in a post-pandemic world, the idea of wearing a mask like this is counterproductive.”
The lead researcher, Gao, responded to some of these comments.
“While routine blood tests are indeed reliable, they are typically periodic and require a clinical setting, which limits their ability to capture dynamic, day-to-day physiological changes,” he told Fox News Digital.
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“The real innovation of the EBCare mask lies in its ability to continuously monitor health in real time, offering insights that might not be detectable with intermittent tests.”
For individuals managing chronic conditions like asthma, COPD or metabolic disorders, fluctuations in certain biomarkers can provide early warning signs, according to the researchers. (iStock)
For individuals managing chronic conditions like asthma, COPD or metabolic disorders, fluctuations in certain biomarkers can provide early warning signs before symptoms worsen, allowing for timely intervention, according to the researcher.
Gao, however, did acknowledge some limitations with the EBCare device.
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“One limitation was the relatively small sample size in some of the clinical trials, particularly for conditions like COPD and asthma,” he told Fox News Digital.
“Future studies with larger and more diverse populations will help to further validate the device’s performance across a broader range of conditions and environments.”
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A highly contagious digestive virus is surging across the U.S., experts warn.
Rotavirus, a double-stranded RNA virus, causes acute gastroenteritis — inflammation of the stomach and intestines — which can lead to severe diarrhea, vomiting, fever and stomach pain.
The virus primarily affects infants and young children, but there have also been outbreaks in elderly populations, such as nursing homes.
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Data from the Centers for Disease Control and Prevention shows that in the week ending April 4, out of 2,329 rotavirus tests, 7.3% were positive for the infection. Last year’s highest infection rate was 6.77% as of the week ending April 19.
Rotavirus, a double-stranded RNA virus, causes acute gastroenteritis — inflammation of the stomach and intestines — which can lead to severe diarrhea, vomiting, fever and stomach pain. (iStock)
“We’re seeing a lot of rotavirus in the wastewater right now,” Dr. Marc Siegel, Fox News senior medical analyst, confirmed to Fox News Digital. “Testing for rotavirus is way down, but the percentage of positive tests is up.”
While the virus typically peaks in the spring, it is not currently slowing down, he noted.
Why cases may be rising
Patricia Pinto-Garcia, M.D., a medical editor at GoodRx who is based in California, said there are several possible reasons for the rotavirus spike.
“Vaccine rates are down overall among young children, as they decreased during COVID,” she told Fox News Digital. “This means there’s a growing number of infants and young children who are vulnerable to infection.”
The rotavirus vaccine series must be completed by the time a child is 8 months old, she noted.
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As a result of the declining vaccinations, herd immunity isn’t protecting vulnerable children, according to Pinto-Garcia. “Children who haven’t finished the vaccine series yet, are too young to get vaccinated, or can’t get the vaccine due to medical illness are more likely to get exposed to the illness because other children aren’t vaccinated,” she said.
Siegel noted that before the vaccine became available, rotavirus resulted in 55,000 to 70,000 in the U.S. per year.
“Vaccine rates are down overall among young children, as they decreased during COVID,” a doctor told Fox News Digital. “This means there’s a growing number of infants and young children who are vulnerable to infection.” (iStock)
“I am concerned that the vaccination rate has been declining over the past seven years and is continuing to decline in the current climate of vaccine skepticism,” he said.
Surveillance methods are also much better than they used to be, Pinto-Garcia noted, which means public health experts are able to pick up and track cases better than ever before.
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“But we see that rotavirus-related healthcare visits are also up, so improved detection is not the only reason we are seeing this spike,” she said.
The COVID pandemic also disrupted the pattern of infections, according to Pinto-Garcia, so it’s “tricky” to compare the current levels against older cycles.
“It’s possible that what we are seeing is still some post-pandemic rebound, but it’s unlikely that this year’s pattern is fully explained by just this factor,” she added.
Transmission and risk
Dr. Zachary Hoy, a pediatric infectious disease specialist at Pediatrix Medical Group based in Nashville, Tennessee, often sees young patients with rotavirus.
“Rotavirus is spread via the fecal-oral route, meaning that a person comes into contact with virus droplets from contact with other children or adults, or from contact with objects such as toys that have been contaminated with the virus from someone who is sick,” he told Fox News Digital. “This can lead to outbreaks, especially at schools where many young children share the same toys.”
“It’s possible that what we are seeing is still some post-pandemic rebound, but it’s unlikely that this year’s pattern is fully explained by just this factor.”
Rotavirus is associated with many dehydration cases in the hospital due to the degree of diarrhea, according to Hoy.
In some severe cases, the virus can lead to seizures due to electrolyte imbalances from dehydration and loss of electrolytes in the stool.
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“Younger children do not have the reserves that older children and adults have, so they can become more dehydrated quicker and develop more severe electrolyte imbalances, leading to more severe infections,” Hoy said.
“Patients with problems with their immune systems or on medications that can decrease their immune systems can have more severe and prolonged infections, too.”
Treatment and care
Because rotavirus is a viral infection, antibiotics are not effective against it. There is no specific antiviral treatment for the condition, with doctors typically recommending supportive care.
“The mainstay of treatment is hospitalization for rehydration via intravenous (IV) fluids,” Hoy told Fox News Digital. “Sometimes it can take up to two to three days of IV fluids to help get patients rehydrated.”
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Blood draws are often necessary to evaluate patients’ electrolyte levels, such as sodium, potassium, calcium and magnesium, according to the doctor.
“If these electrolyte levels are significantly low, sometimes patients need special IV solutions or individual electrolyte medications,” he added.
“The mainstay of treatment is hospitalization for rehydration via intravenous (IV) fluids,” a doctor told Fox News Digital. (iStock)
Dr. Daniel Park, medical director of the Pediatric Emergency Department at UNC Health in Chapel Hill, North Carolina, noted that most children recover with supportive care, but parents should seek medical attention if a child shows signs of dehydration. Those include decreased urination, lethargy or inability to keep fluids down.
“While rare, rotavirus can be life-threatening in vulnerable populations, especially very young infants or children with underlying medical conditions,” Park told Fox News Digital.
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Prevention strategies
Given the lack of antiviral medications for rotavirus, doctors emphasize the importance of prevention, primarily the vaccine.
There are two rotavirus vaccines – Rotateq (a three-dose series) and Rotarix (a two-dose series). They are given starting at age 2 months as oral drops, not injections, according to Hoy.
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“It’s important to get the rotavirus vaccines on schedule, because these younger infants are at greatest risk if they get rotavirus,” he advised.
Other recommended prevention methods include handwashing with soap and water.
Every day we’re faced with a zillion small choices: Go to sleep early, or watch one more episode of that Netflix drama. Call an old friend to catch up, or cruise social media. Of course, no single action will guarantee a long, healthy life or doom you to an early grave. But those little daily decisions do add up, and over the long term they can make a difference when it comes to both your longevity and your health span, the amount of life spent in relatively good health.
Scroll through this theoretical “day in the life” and select the option that best fits your typical day. Not every situation will apply perfectly, but think about which choice you’d be most likely to make. This isn’t a formal scientific assessment. The goal here isn’t to assign you a “good” or “bad” score, but to help you understand the central factors that shape the way we age and how long we live.
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A study from Harvard Medical School indicates natural selection has favored the red hair gene, resulting in a potential increase in the number of redheaded people as humanity continues to evolve.
By analyzing nearly 16,000 ancient genomes spanning 10,000 years, researchers identified a list of traits that nature is actively pushing forward. Among the most prominent were the genetic variants for red hair.
“Perhaps having red hair was beneficial 4,000 years ago, or perhaps it came along for the ride with a more important trait,” the authors noted.
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The study, published in the journal Nature, relied on a large database of ancient DNA from West Eurasia. Using new computing methods, the team was able to filter out random fluctuations in DNA to identify what it called “directional selection.”
Directional selection happens when a particular version of a gene gives an organism a strong survival or reproductive advantage, causing it to become more common in a population faster than it would by chance, according to experts.
Directional selection is when a specific gene provides such significant benefits that it rises in frequency across a population much faster than random chance. (iStock)
Prior to this study, scientists only knew of about 21 such instances in human history, one of which was lactose tolerance. This new research uncovered hundreds more.
“With these new techniques and a large amount of ancient genomic data, we can now watch how selection shaped biology in real time,” Ali Akbari, first author of the study and senior staff scientist in the lab of Harvard geneticist David Reich, said in a press release.
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The data showed that genetic markers for red hair are among 479 gene variants that have been strongly favored over the past 10,000 years. One likely explanation, the researchers said, is a major shift in human history: the transition to farming.
Scientists have long pointed to vitamin D synthesis as a likely driver for the rise of traits like fair skin and light hair. (iStock)
As humans moved away from hunting and gathering and settled into agricultural societies, their environment and behavior changed radically, triggering an evolutionary “acceleration.”
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While the Harvard study provides the first definitive statistical proof that red hair was actively selected during the rise of farming, the researchers noted that the exact prehistoric benefit still requires more study.
However, scientists have long pointed to vitamin D synthesis as a likely driver for the rise of these light-pigmented traits in northern climates.
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While redheads remain a minority of the global population today, the Harvard study’s analysis suggests that they may not be an evolutionary accident.
While redheads remain a minority of the global population today, the Harvard study’s analysis suggests they may not be an evolutionary accident. (iStock)
Instead, the red hair trait was “boosted” by natural selection as humans adapted to the challenges of a modern world, according to the researchers.
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The researchers urged caution in how these findings are interpreted.
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“What a variant is associated with now is not necessarily why an allele propagated,” the authors noted.
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