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Ozempic, the happy drug? Study suggests weight-loss medications could reduce depression, anxiety

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Ozempic, the happy drug? Study suggests weight-loss medications could reduce depression, anxiety

For the millions of people who take Ozempic and Wegovy, weight loss is the best-known outcome — but a new study suggests the medications could also help squash depression.

Investigators from Epic Research, a health analytics firm based in Verona, Wisconsin, found that patients with diabetes who were prescribed glucagon-like peptide-1 receptor agonist (GLP-1) medications were less likely to develop depression compared to people who are not taking the drugs.

GLP-1 medications include semaglutide (Ozempic or Wegovy), tirzepatide (Mounjaro), dulaglutide (Trulicity) and exenatide (Byetta and Bydureon).

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“The likelihood of anxiety in diabetic patients is lower for those on all five GLP-1 medications studied,” the researchers wrote in a release on Epic’s website.

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For those without diabetes, semaglutide was linked to a lower likelihood of depression and anxiety, while liraglutide did not show any statistically significant benefit.

Weight loss is the best-known perk of Ozempic and Wegovy, but a new study suggests the medications could also help to reduce depression. (iStock)

The study analyzed the GLP-1 medications and mental health diagnoses of 3,081,254 diabetic patients and 929,174 non-diabetic patients.

Dr. Brett Osborn, a Florida neurologist and founder of the longevity company Senolytix, was not surprised to hear of the Epic Research study findings.

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“Ozempic’s potential antidepressive effects are garnering interest, both from the scientific community and those seeking holistic ways to manage their mental health alongside physical conditions,” he told Fox News Digital.

Weight loss often leads to a boost in mood and overall outlook in Osborn’s patients, he noted.

GLP-1 medications include semaglutide (Ozempic or Wegovy), tirzepatide (Mounjaro), dulaglutide (Trulicity) and exenatide (Byetta and Bydureon). (Getty Images)

“Losing weight can significantly impact an individual’s self-esteem and overall mood, leading to a more positive outlook on life,” the doctor said. 

“The confidence boost that comes with achieving weight loss goals can be transformative, reducing feelings of depression and enhancing mental well-being.”

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OZEMPIC AND WEGOVY COULD LEAD TO MUSCLE LOSS, EXPERTS SAY, BUT PREVENTION IS POSSIBLE

Dr. Jennifer Bourgeois, PharmD, a Dallas-based pharmacy and health expert with SingleCare, a prescription discount service, said none of the companies that produce GLP-1 medications studied the effect on depression in the original clinical trials.

“At this time, none of the GLP-1 medications used to improve glycemic control in adults with type 2 diabetes or in chronic weight management claim to curb depression and anxiety,” she told Fox News Digital.

That doesn’t mean it’s not possible, however, the expert said.

Physical and mental mood-lifters

In previous research, Ozempic and other GLP-1 drugs were shown to have antidepressant-like effects in diabetic mice with type 2 diabetes, suggesting that the drugs have direct effects on brain chemistry and connectivity, Osborn said.

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“It is thought that this results from GLP-1’s influence on the release of neurotransmitters, such as norepinephrine and serotonin, in a deep brain region known as the hypothalamus,” Osborn said.

Weight loss often leads people to adopt healthier lifestyle habits, such as regular exercise and improved dietary choices, an expert pointed out.  (iStock)

GLP-1 drugs also modify the release of dopamine in the amygdala, the “emotional center” of the brain, Osborn said, which is involved in mood regulation. 

While Bourgeois agrees that these medications may impact mood via brain changes, she said the likelier reason for the reduced depression and anxiety is the positive mental and physical health effects of weight loss.

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Weight loss induced by GLP-1 medications triggers biological changes that positively impact mood regulation, Bourgeois said. 

“As excess adipose tissue (body fat) decreases, the production of inflammatory cytokines reduces, leading to a decrease in systemic inflammation,” she said. 

“Research suggests that chronic inflammation may disrupt neurotransmitters like serotonin and dopamine as well as the balance of gut bacteria, potentially leading to mood imbalances.”

A pharmacist holds boxes of Eli Lilly & Co. Mounjaro brand tirzepatide medication at a pharmacy in Provo, Utah, on Monday, Nov. 27, 2023.  (Getty Images)

The boost to self-esteem and body image can also curb depression and anxiety, Bourgeois noted, leading to an overall more positive outlook. 

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“Individuals who achieve weight loss through GLP-1 receptor agonists may experience a sense of accomplishment and empowerment, which can positively influence their mental health,” she said.

There may also be a “trickle-down” effect, with weight loss often leading people to adopt healthier lifestyle habits — such as regular exercise and improved dietary choices, the expert pointed out. 

“These lifestyle changes can have profound effects on mental health,” she said.  

The boost to self-esteem and body image that comes with weight loss can also curb depression and anxiety, experts say. (iStock)

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“Physical activity is known to stimulate the release of endorphins, which promote feelings of happiness and euphoria, and a nutrient-rich diet can provide essential vitamins and minerals that support brain function and mood regulation.”

More research needed

While the Epic data is “promising,” said Bourgeois, “more research is needed to determine if the medication itself is responsible for the reduction in depression and anxiety diagnoses.”

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“Other factors like physical activity, diet and sleep were not controlled and could be contributing to the mood-altering effects.”

Osborn added, “I’m not saying that Ozempic will become a first-line treatment for depression, but it certainly highlights the interconnectedness of physical and mental health.”

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Experts reveal why ‘nonnamaxxing’ trend may improve mental, physical health

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Experts reveal why ‘nonnamaxxing’ trend may improve mental, physical health

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The key to feeling better in a fast, overstimulated world might be surprisingly simple: Live a little more like your grandparents.

A growing social media trend, dubbed “nonnamaxxing,” draws inspiration from the slower, more intentional rhythms associated with an Italian grandmother.

The lifestyle is often linked to activities like preparing home-cooked meals, spending time outdoors and making meaningful connections.

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“Nonnamaxxing is a 2026 trend that embraces the slower, more intentional lifestyle of an Italian grandmother (a Nonna). Think cooking from scratch, long family meals, daily walks, gardening and less screen time,” Erin Palinski-Wade, a New Jersey-based registered dietitian, told Fox News Digital.

Nonnamaxxing, derived from the name for an Italian grandmother, is a trend that incorporates lifestyle habits hundreds of years in the making. (iStock)

Stepping away from screens and toward real-world interaction can have measurable benefits, according to California-based psychotherapist Laurie Singer.

“We know that interacting with others in person, rather than spending time on screens, significantly improves mental health,” she told Fox News Digital, adding that social media often fuels comparison and lowers self-esteem.

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Living more like previous generations isn’t purely driven by nostalgia. Cooking meals from scratch, for example, has been linked to better nutrition and more mindful eating patterns.

Adopting traditional mealtime habits can improve diet quality and support both physical and mental health, especially when meals are shared regularly with others, Palinski-Wade noted.

One longevity expert stresses that staying healthy isn’t just about food — it’s also about joy and community. (iStock)

There’s also a psychological benefit to slowing down and focusing on one task at a time. Anxiety often stems from unfinished or avoided tasks, Singer noted, and engaging in hands-on activities can counteract that.

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“Nonnamaxxing encourages us to be present around a task, like gardening, baking or knitting, or just taking a mindful walk, that delivers something ‘real,’” she said.

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Palinski-Wade cautions against turning the trend into another source of pressure, noting that a traditional “nonna” lifestyle often assumes a different pace of life.

The key, she said, is adapting the mindset, not replicating it perfectly.

Nonnamaxxing, derived from the name for an Italian grandmother, is a trend that incorporates lifestyle habits hundreds of years in the making. (iStock)

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The goal is to reintroduce small, intentional moments that make you feel better.

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That might mean prioritizing a few shared meals each week, taking a walk without your phone or setting aside time for a simple hobby, the expert recommended.

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Singer added, “Having a positive place to escape to, through whatever activities speak to us and make us happy, isn’t generational – it’s human.”

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Loneliness may be silently eroding your memory, new research reveals

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Loneliness may be silently eroding your memory, new research reveals

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Feeling lonely may take a toll on older adults’ memory — but it may not speed up cognitive decline, according to a new study.

Researchers from Colombia, Spain and Sweden analyzed data from more than 10,000 adults ages 65 to 94 across 12 European countries and found those who reported higher levels of loneliness did worse on memory tests at the start of the study, according to research published this month in the journal Aging & Mental Health.

Over a seven-year period, however, memory decline occurred at a similar rate regardless of how lonely participants felt.

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“The finding that loneliness significantly impacted memory, but not the speed of decline in memory over time was a surprising outcome,” lead author Dr. Luis Carlos Venegas-Sanabria of the School of Medicine and Health Sciences at the Universidad del Rosario said in a statement.

Loneliness may be linked to memory performance in older adults, a new study suggests. (iStock)

“It suggests that loneliness may play a more prominent role in the initial state of memory than in its progressive decline,” Venegas-Sanabria said, adding that the findings highlight the importance of addressing loneliness as a factor in cognitive performance.

The findings add to debate about whether loneliness contributes to dementia risk. While loneliness and social isolation are often considered risk factors for cognitive decline, research results have been mixed.

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The study looked at data from the long-running Survey of Health, Ageing and Retirement in Europe (SHARE), which tracked 10,217 older adults between 2012 and 2019. Participants were asked to recall words immediately and after a delay to measure memory performance.

Social isolation and loneliness could play a surprising role in cognitive health among seniors. (iStock)

Loneliness was assessed using three questions about how often participants felt isolated, left out or lacking companionship.

About 8% of participants reported high levels of loneliness at the outset. That group tended to be older, more likely to be female and more likely to have conditions such as depression.

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Researchers found that those with higher loneliness had lower scores on both immediate and delayed memory tests at baseline. Still, all groups — regardless of loneliness level — experienced similar declines in memory over time.

The results suggest loneliness may not directly accelerate the progression of memory loss, though it remains linked to poorer cognitive performance overall.

Researchers look at a brain scan at the National Institutes of Health in Bethesda, Maryland. (Saul Loeb/AFP/Getty Images)

Experts warn, however, that the findings should not be interpreted to mean loneliness is harmless.

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“The finding that lonely older adults start with worse memory but don’t decline faster is actually the most interesting part of the paper, and I think it’s easy to misread,” said Jordan Weiss, Ph.D., a scientific advisor and aging expert at Assisted Living Magazine and a professor at NYU Grossman School of Medicine.

“It likely means loneliness does its damage earlier in life, well before people show up in a study like this at 65-plus,” Weiss told Fox News Digital.

By older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold, an aging expert says. (iStock)

He suggested that by older age, long-term social patterns may already be established, making it harder to detect when the effects of loneliness first took hold.

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“By the time you’re measuring someone in their late 60s, decades of social connection patterns are already baked in,” he said.

Weiss, who was not involved in the research, added that loneliness may coincide with other health conditions, and noted that participants who felt more isolated also had higher rates of depression, high-blood pressure and diabetes. The link, he said, may reflect a cluster of health risks rather than a direct cause.

“While they can go hand-in-hand, it’s not clear that loneliness contributes to dementia,” a psychotherapist says. (iStock)

Amy Morin, a Florida-based psychotherapist and author, said the findings reflect a broader pattern in research on loneliness and brain health, and that the relationship may be more complex than it appears.

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“The evidence shows there’s a link between loneliness and cognitive decline but there’s no direct evidence of a cause and effect relationship,” she said. “So while they can go hand-in-hand, it’s not clear that loneliness contributes to dementia.”

Morin added that loneliness, which can fluctuate, may not be the root of the problem, but rather a symptom of other underlying mental or physical health issues.

Researchers suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging. (iStock)

She said staying socially and mentally engaged is crucial for overall brain health.

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“It’s important to be proactive about social activities,” Morin said. “Joining a book club, having coffee with a friend, or attending faith-based services can be a powerful way to maintain connections in older age.”

The researchers also suggested screening for loneliness be incorporated into routine cognitive assessments as one way to support healthy aging.

Fox News Digital reached out to the researchers for comment.

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Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day

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Eat More To Lose Weight? She Dropped 55 Pounds by Having 5 Meals a Day


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Eat More To Lose Weight? How Small Meals Boost Fat Burn




















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