Health
New prostate cancer medication 'shows promise' in treating aggressive disease, study finds
There may be a “promising new strategy” in combating aggressive forms of prostate cancer, according to a new study.
Researchers at Flinders University and the University of South Australia investigated how the novel drug, CDKI-73, has the potential to tackle drug-resistant prostate cancer.
This drug reportedly “defies conventional therapies,” as noted in the study findings, which were published in the British Journal of Cancer.
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Prostate cancer is the second-leading cause of cancer death in American men, following lung cancer, according to the American Cancer Society (ACS).
In 2024, around 299,010 new cases will be diagnosed and more than 35,000 men will die from the disease, per the ACS.
Prostate cancer is the second-leading cause of cancer death in American men, following lung cancer, according to the American Cancer Society. (iStock)
The disease “frequently evolves into aggressive forms that do not respond to standard hormone therapies,” according to Flinders University.
The researchers, including professors Luke Selth and Shudong Wang, targeted cyclin-dependent kinase 9 (CDK9) – a protein responsible for the growth and survival of prostate cancer cells.
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Selth, of Flinders University, confirmed in a press release that the CDKI-73 inhibitor has shown to be effective in blocking prostate cancer growth in models and tumor samples.
“Our research demonstrates that CDKI-73 potently blocks the growth of prostate cancer, even aggressive subtypes of the disease that are resistant to current treatments,” he said.
The drug being orally available may help “facilitate its use as a new treatment,” one of the researchers said. (iStock)
“Importantly, CDKI-73 targets cancer cells specifically without harming normal cells.”
In an email sent to Fox News Digital, Selth said the drug is orally available as a tablet, which could help “facilitate its use as a new treatment.”
“We still need to do a lot more work to fully understand the potential of CDK9 inhibitors and to deliver a new treatment for patients.”
Selth said he considers the study results a “significant step forward in understanding the role of CDK9 in aggressive prostate cancer.”
“Having said that, we still need to do a lot more work to fully understand the potential of CDK9 inhibitors and to deliver a new treatment for patients,” he added.
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Wang, who developed CDKI-73, said in the release that the drug is a “promising candidate for treating solid tumors, such as prostate cancer.”
“Our proof-of-principle study is an important step toward future clinical trials, and these findings will inform future studies on the use and efficacy of CDKI-73 as a prostate cancer treatment,” he went on.
One of the researchers called the drug a “promising candidate for treating solid tumors, such as prostate cancer.” (iStock)
CDKI-73 is currently being investigated in phase 2 clinical trials in patients with relapsed and therapy-resistant acute myeloid leukemia (AML), a type of blood cancer that affects the bone marrow and blood cells, according to Flinders University.
While the research is an “important step forward,” Wang said, the research team plans to complete more trials to assess the efficacy and safety of the drug before it is given to patients.
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Selth encouraged all men over the age of 50 — and those over 40 who have a family history of prostate cancer — to talk to their providers about getting screened during regular check-ups.
Dr. Marc Siegel, senior medical analyst for Fox News and clinical professor of medicine at NYU Langone Medical Center, was not involved in the study, but commented on the drug’s potential.
The new drug “shows promise in treating advanced or aggressive prostate cancer,” a doctor told Fox News Digital. (iStock)
“We know that CDK 9 is an enzyme associated with prostate cancer growth,” he told Fox News Digital.
“In this new study, an inhibitor of CDK 9 (CDKI-73) was found to inhibit growth and lead to death in human prostate cancer cells in the laboratory, and also in animals and models.”
“The drug has not been used yet in human subjects and clinical trials may be the next step,” Siegel went on. “It shows promise in treating advanced or aggressive prostate cancer.”
Fox News Digital reached out to oncologists for comment on the experimental drug.
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Stat of the week
More than 59% of women may have high blood pressure by 2050, according to a new report from the American Heart Association.
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Health
Heart disease threat projected to climb sharply for key demographic
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A new report by the American Heart Association (AHA) included some troubling predictions for the future of women’s health.
The forecast, published in the journal Circulation on Wednesday, projected increases in various comorbidities in American females by 2050.
More than 59% of women were predicted to have high blood pressure, up from less than 49% currently.
The review also projected that more than 25% of women will have diabetes, compared to about 15% today, and more than 61% will have obesity, compared to 44% currently.
As a result of these risk factors, the prevalence of cardiovascular disease and stroke is expected to rise to 14.4% from 10.7%.
The prevalence of cardiovascular disease and stroke in women is expected to rise to 14.4% from 10.7% by 2050. (iStock)
Not all trends were negative, as unhealthy cholesterol prevalence is expected to drop to about 22% from more than 42% today, the report stated.
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Dr. Elizabeth Klodas, a cardiologist and founder of Step One Foods in Minnesota, commented on these “jarring findings.”
“The fact that on our current trajectory, cardiometabolic disease is projected to explode in women within one generation should be a huge wake-up call,” she told Fox News Digital.
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“Hypertension, diabetes, obesity — these are all major risk factors for heart disease, and we are already seeing what those risks are driving. Heart disease is the No. 1 killer of women, eclipsing all other causes of death, including breast cancer.”
Cardiovascular disease is the leading cause of death for women in the U.S. and around the world. (iStock)
Klodas warned that heart disease starts early, progresses “stealthily,” and can present “out of the blue in devastating ways.”
The AHA published another study on Thursday revealing one million hospitalizations, showing that heart attack deaths are climbing among adults below the age of 55.
The more alarming finding, according to Klodas, is that young women were found more likely to die after their first heart attack than men of the same age.
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“This is all especially tragic since heart disease is almost entirely preventable,” she said. “The earlier you start, the better.”
Children can show early evidence of plaque deposition in their arteries, which can be reversed through lifestyle changes if “undertaken early enough and aggressively enough,” according to the expert.
Moving more is one part of protecting a healthy heart, according to experts. (iStock)
Klodas suggested that rising heart conditions are associated with traditional risk factors, like smoking, high blood pressure, high cholesterol, diabetes, obesity and a sedentary lifestyle.
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Doctors are also seeing higher rates of preeclampsia, or high blood pressure during pregnancy, as well as gestational diabetes. Klodas noted that these are sex-specific risk factors that don’t typically contribute to complications until after menopause.
The best way to protect a healthy heart is to “do the basics,” Klodas recommended, including the following lifestyle habits.
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Klodas especially emphasized making improvements to diet, as the food people eat affects “every single risk factor that the AHA’s report highlights.”
“High blood pressure, high blood sugar, high cholesterol, excess weight – these are all conditions that are driven in part or in whole by food,” she said. “We eat multiple times every single day, which means what we eat has profound cumulative effects over time.”
“Even a small improvement in dietary intake, when maintained, can have a massive positive impact on health,” a doctor said. (iStock)
“Even a small improvement in dietary intake, when maintained, can have a massive positive impact on health.”
The doctor also recommends changing out a few snacks per day for healthier choices, which has been proven to “yield medication-level cholesterol reductions” in a month.
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“Keep up that small change and, over the course of a year, you could also lose 20 pounds and reduce your sodium intake enough to avoid blood pressure-lowering medications,” Klodas added.
“Women should not view the AHA report as inevitable. We have power over our health destinies. We just need to use it.”
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