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Marijuana compound may help prevent dementia when paired with common drug

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Marijuana compound may help prevent dementia when paired with common drug

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As marijuana’s potential health benefits are under debate, new research has found that THC could have a powerful and positive effect on the brain.

Researchers at the University of Texas (UT) at San Antonio, Long School of Medicine, recently discovered that THC (tetrahydrocannabinol, the main psychoactive compound in marijuana) could prevent the development of Alzheimer’s disease – but only when paired with an anti-inflammatory drug called celecoxib.

Celecoxib is a selective COX-2 inhibitor that is commonly prescribed for arthritis and pain.

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While THC has previously been shown to have anti-inflammatory and neuroprotective properties, it’s also been linked to negative effects on the brain, particularly in learning and memory, according to a UT Health press release.

Combining THC with an anti-inflammatory drug, however, could provide the same benefits with fewer negative side effects.

THC could be powerful against cognitive decline when combined with an anti-inflammatory, a new study suggests. (iStock)

The study, which was published in the journal Aging and Disease, paired low-dose THC extract with celecoxib, which was administered to mice daily for 30 days.

The mice received the treatments before the development of memory symptoms to measure the impact on preventing or delaying Alzheimer’s.

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The results showed improved cognition, learning and memory, as well as decreased markers of neuroinflammation and reduced Alzheimer’s-related brain pathology, the release stated.

Although THC alone had the same results, it also increased inflammatory signals, while the combination dosage did not.

The THC and celecoxib combo improved cognition, learning and memory, while also decreasing markers of neuroinflammation and reduced Alzheimer’s-related brain pathology. (iStock)

“What really mattered was behavior. If cognition is not improved, then the treatment doesn’t matter. And that’s where the combination clearly worked better than THC alone,” noted lead study author Chu Chen, Ph.D., professor in the Department of Cellular and Integrative Physiology.

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Years of research led Chen to connect the dots on how THC can manipulate the brain and why it’s difficult to use safely for neurological conditions, according to UT Health.

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“When THC is given, it unexpectedly increases COX-2 in the brain. That increase is closely associated with learning and memory impairment,” Chen said.

Both THC and celecoxib are FDA-approved for use in humans, which could provide a “real advantage” in moving along to clinical trials, according to UT Health.

“What really mattered was behavior. If cognition is not improved, then the treatment doesn’t matter.”

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Future studies will investigate whether the drug combination can slow disease progression or reverse deficits after symptoms have appeared.

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“This work has taken many years. But now we’re at a point where basic neuroscience discoveries are pointing toward something that could realistically move into the clinic,” Chen said.

Dr. Paul Saphier, a neurosurgeon and founder of Coaxial Neurosurgical Specialists in New Jersey, called this research an “exciting breakthrough with a huge potential impact for patients and their families.”

“We know that the buildup of the plaques related to Alzheimer’s [beta-amyloid plaques] are the result of chronic inflammation.” (iStock)

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“Neurocognitive deterioration has been linked to conditions that cause inflammation within the brain — prior brain bleeds, strokes, tumors and infections,” he told Fox News Digital. “We also know that the buildup of the plaques related to Alzheimer’s [beta-amyloid plaques] are the result of chronic inflammation.”

“So, it makes sense that this combination therapy [might] help limit the production of this amyloid and thereby reduce the progression of the disease.”

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Saphier said the drugs’ FDA approval status is “encouraging,” as it may “ultimately ease the availability for patients, if the trial proves successful.”

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“I look forward to the results of this trial, as well as any future trials that look at limiting the effects of chronic inflammation within the central nervous system.”

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‘Call a Boomer’ payphones help cure loneliness, spark friendships across generations

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‘Call a Boomer’ payphones help cure loneliness, spark friendships across generations

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Along a bustling sidewalk in Boston, a bright yellow payphone invites folks to “call a Boomer.”

Almost 3,000 miles away in Reno, Nevada, a nearly identical phone prompts residents of Sierra Manor – an apartment complex for seniors – to “Call a Zoomer.” The goal is simple: to get strangers to talk to each other.

The project, often referred to as simply “Call a Boomer,” is the latest initiative from Matter Neuroscience, a New York-based company dedicated to mapping the “biomarkers of happiness.”

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By connecting “two of the loneliest demographics” (older adults and younger adults), the project aims to prove that on a molecular level, “humans need one another in order to be happy,” according to Calla Kessler, a social strategist at Matter Neuroscience.

Along a bustling sidewalk in Boston, a bright yellow payphone invites folks to “Call a Boomer.” (Matter Neuroscience)

“Younger adults and older adults tend to experience the highest levels of loneliness of any age group,” the company wrote on its website. “So the goal of this project is to inspire generational connection through meaningful conversations, despite differences in age, lifestyle or politics.”

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The hope, according to Kessler, is that the calls will shift the brain’s focus from stress to bonding.

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“Our neuroscience angle is cannabinoids over cortisol,” Kessler told Fox News Digital. “Cannabinoids are the feel-good neurotransmitter in our brain that creates that warm feeling with a friendship — and when you activate cannabinoids, you’re counteracting the negative effects of cortisol, which is our primary stress hormone.”

“Younger adults and older adults tend to experience the highest levels of loneliness of any age group,” the company noted. (Matter Neuroscience)

This isn’t Matter’s first round of payphones. Its initial experiment connected one of the most liberal cities in the U.S. (San Francisco) with one of the most conservative (Abilene, Texas).

“We basically just wanted people to find common ground and encourage people to think beyond labels,” Kessler said.

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She noted that the negative results were “almost negligible,” with most participants enjoying their time speaking to different people.

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Now, the focus has shifted from political labels to generational divides.

The negative results have beem “almost negligible,” with most participants enjoying their time speaking to different people. (Matter Neuroscience)

As the “Call a Boomer” experiment continues, the team is busy collecting audio files of these intergenerational chats to prove that simple connections with other humans can help improve mental health.

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“Our research is essentially trying to find a non-pharmaceutical cure to depression,” Kessler added.

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Looking ahead, she said, “we’ll definitely be doing fun things that we hope get people’s attention and inspire them to learn a little more about themselves.”

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Family pleads for help as teen faces life-threatening bone marrow failure

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Family pleads for help as teen faces life-threatening bone marrow failure

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A New York City father is desperately seeking a donor to save his teenage son’s life.

Max Uribe, now 15 and a high-school freshman, has just weeks until he will need to be hospitalized with a rare blood disorder that could lead to a deadly cancer.

“Max was just 6 when we first noticed there was something wrong with his blood counts,” his father, Juan Uribe, told Fox News Digital. “At the time, we thought it was due to a viral infection, but they never fully recovered back to their normal level.”

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In December 2024, Max’s condition grew worse, and he was diagnosed with clonal cytopenia, a condition involving the blood and bone marrow.

“All three of his blood counts are low — red, white and platelets,” Uribe said. 

Max Uribe, pictured with his parents and sister, is in urgent need of a stem cell transplant to save his life. (Uribe Family)

In August 2025, another bone marrow biopsy revealed that Max is on a path to bone marrow failure, creating an urgent need for a stem cell transplant.

“The disease has continued to progress, as his blood counts continue to drop, and therefore, we have to take him to transplant in May of this year,” Uribe said.

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If left untreated, Max’s condition could lead to MDS (myelodysplastic syndrome), a type of blood cancer, and from there possibly into acute myeloid leukemia (AML).

A bone marrow match must have a specific type of HLA (human leukocyte antigen), which are proteins found on the surface of most cells in the body, according to the National Marrow Donor Program (NMDP).

Max Uribe, pictured with his parents, will be hospitalized for a transplant in May, as his blood count has been steadily decreasing. (Uribe Family)

The closer the donor’s HLA markers are to the patient’s, the more likely the body will accept the new cells without a high risk of complications.

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People from the same ethnic background are more likely to share similar HLA types, meaning a patient is most likely to find a compatible donor among individuals with similar ancestry, per the NMDP.

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Non-Hispanic White patients have a 79% chance of a perfect match. That drops to 49% for Hispanic/Latino patients, 29% for Black patients and even lower for mixed ancestries, the NMDP reports.

Because Max is a “very rare combination” of half-Colombian from his father and a mix of Italian, British and German from his mother, his path to a perfect match is proving much more difficult, Uribe noted.

“For a kid like Max, with complex, mixed heritage, the math is devastating.”

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“For a kid like Max, with complex, mixed heritage, the math is devastating,” he said. “The thinking is, we need large numbers if we’re going to have that perfect match for my son.”

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Max, who participates in competitive tennis and varsity wrestling, just had additional blood work done on Friday, which revealed that his counts continue to plummet.

“We’re at the point where this is beginning to manifest a bit more, which is why the urgency is so critical,” Uribe said.

Because Max is a “very rare combination” of half-Colombian from his father and a mix of Italian, British and German from his mother, his path to a perfect match is proving much more difficult. (Uribe Family)

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If a donor is not secured by Max’s hospitalization in May, the medical team will have to proceed with a partial match, which is not ideal for a number of reasons.

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“The survival rate is meaningfully lower with a partial match, and there’s more risk of graft versus host disease (GVHD), which could lead to complications in the process,” Uribe said. With GVHD, the donor cells begin to attack the body.

Max Uribe, an active athlete, is on a path to bone marrow failure, requiring a stem cell transplant. (Uribe Family)

To help prevent this with a partial match, Max would likely need chemotherapy and immunosuppressants for a longer period of time, which could weaken his immune system.

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Anyone interested in donating can order a free test kit on the Team Max website. The kit includes a quick cheek swab that is sent back to the lab to determine whether someone is a match.

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Eat This Before Bed To Lose Weight Overnight: ‘Second Meal Effect’ Explained

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Eat This Before Bed To Lose Weight Overnight: ‘Second Meal Effect’ Explained


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What To Eat Before Bed To Lose Weight and Burn Fat




















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