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Marijuana compound may help prevent dementia when paired with common drug

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Marijuana compound may help prevent dementia when paired with common drug

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As marijuana’s potential health benefits are under debate, new research has found that THC could have a powerful and positive effect on the brain.

Researchers at the University of Texas (UT) at San Antonio, Long School of Medicine, recently discovered that THC (tetrahydrocannabinol, the main psychoactive compound in marijuana) could prevent the development of Alzheimer’s disease – but only when paired with an anti-inflammatory drug called celecoxib.

Celecoxib is a selective COX-2 inhibitor that is commonly prescribed for arthritis and pain.

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While THC has previously been shown to have anti-inflammatory and neuroprotective properties, it’s also been linked to negative effects on the brain, particularly in learning and memory, according to a UT Health press release.

Combining THC with an anti-inflammatory drug, however, could provide the same benefits with fewer negative side effects.

THC could be powerful against cognitive decline when combined with an anti-inflammatory, a new study suggests. (iStock)

The study, which was published in the journal Aging and Disease, paired low-dose THC extract with celecoxib, which was administered to mice daily for 30 days.

The mice received the treatments before the development of memory symptoms to measure the impact on preventing or delaying Alzheimer’s.

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The results showed improved cognition, learning and memory, as well as decreased markers of neuroinflammation and reduced Alzheimer’s-related brain pathology, the release stated.

Although THC alone had the same results, it also increased inflammatory signals, while the combination dosage did not.

The THC and celecoxib combo improved cognition, learning and memory, while also decreasing markers of neuroinflammation and reduced Alzheimer’s-related brain pathology. (iStock)

“What really mattered was behavior. If cognition is not improved, then the treatment doesn’t matter. And that’s where the combination clearly worked better than THC alone,” noted lead study author Chu Chen, Ph.D., professor in the Department of Cellular and Integrative Physiology.

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Years of research led Chen to connect the dots on how THC can manipulate the brain and why it’s difficult to use safely for neurological conditions, according to UT Health.

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“When THC is given, it unexpectedly increases COX-2 in the brain. That increase is closely associated with learning and memory impairment,” Chen said.

Both THC and celecoxib are FDA-approved for use in humans, which could provide a “real advantage” in moving along to clinical trials, according to UT Health.

“What really mattered was behavior. If cognition is not improved, then the treatment doesn’t matter.”

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Future studies will investigate whether the drug combination can slow disease progression or reverse deficits after symptoms have appeared.

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“This work has taken many years. But now we’re at a point where basic neuroscience discoveries are pointing toward something that could realistically move into the clinic,” Chen said.

Dr. Paul Saphier, a neurosurgeon and founder of Coaxial Neurosurgical Specialists in New Jersey, called this research an “exciting breakthrough with a huge potential impact for patients and their families.”

“We know that the buildup of the plaques related to Alzheimer’s [beta-amyloid plaques] are the result of chronic inflammation.” (iStock)

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“Neurocognitive deterioration has been linked to conditions that cause inflammation within the brain — prior brain bleeds, strokes, tumors and infections,” he told Fox News Digital. “We also know that the buildup of the plaques related to Alzheimer’s [beta-amyloid plaques] are the result of chronic inflammation.”

“So, it makes sense that this combination therapy [might] help limit the production of this amyloid and thereby reduce the progression of the disease.”

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Saphier said the drugs’ FDA approval status is “encouraging,” as it may “ultimately ease the availability for patients, if the trial proves successful.”

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“I look forward to the results of this trial, as well as any future trials that look at limiting the effects of chronic inflammation within the central nervous system.”

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Katie Couric couldn’t remember the year or the president during frightening brain episode

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Katie Couric couldn’t remember the year or the president during frightening brain episode

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Journalist Katie Couric is sharing a scary medical episode that she experienced on June 27.

In a post on Substack titled “The Day I’ll Never Remember,” she detailed a sudden episode that left her unable to recall the current month, year and president.

“I thought it was 2024. And I believed Joe Biden was president,” she wrote.

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The event occurred while Couric was attending the Aspen Ideas Festival in Colorado, during which she participated in two public panels — one on AI and one on journalism — both of which she cannot remember at all.

“I have no idea what we talked about, or of what occurred when the panels ended,” she said.

Journalist Katie Couric is sharing a scary medical episode that she experienced on June 27. (Getty Images)

John Molner — Couric’s husband, who was in attendance at the festival and the two panels — also shared his account.

After the event, someone told Molner that Katie wasn’t feeling well. When he reached her, an EMT and a doctor were tending to her. “I could tell something was off,” he wrote. “It could have been altitude sickness, but Katie was definitely not all there.”

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At the hospital, when Couric struggled to recall the year, the president and her grandchildren’s names, doctors began checking for a stroke.

An MRI revealed no signs of stroke, which was a relief, but “Katie’s ‘fog’ became a lot more apparent,” Molner wrote.

John Molner, Couric’s husband, who was in attendance at the festival and the two panels, also shared his account. (Getty Images)

“She repeatedly asked me the same questions: ‘What was I doing before we got to the hospital?’ ‘Why am I at the hospital?’”

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Couric was ultimately diagnosed with transient global amnesia, a sudden, temporary episode of memory loss that prevents a person from forming new memories and may also erase some recent memories, according to Mayo Clinic.

“The cause seems to be as mysterious as the brain itself.”

It is not caused by a stroke, seizure or head injury, and it usually resolves completely within 24 hours.

“[It’s] just a very weird neural episode that’s pretty uncommon and, at least in most cases, is a ‘one and done’ experience,” Molner said.

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Couric said she finally began feeling “like herself” again around 9 p.m. and went to sleep at 2 a.m.

As TGA leaves a “permanent gap in memory” for the duration of the episode and for hours beforehand, Couric said that from around noon on that day until at least 7 p.m. will remain a “big, black hole.”

As TGA leaves a “permanent gap in memory” for the duration of the episode and for hours beforehand, Couric said that from around noon on that day until at least 7 p.m. will remain a “big, black hole.” (Getty Images)

Data shows that approximately three to eight people per 100,000 will have an episode of transient global amnesia, with people 50 years of age and older at higher risk.

The specific cause of TGA is not known, but some experts believe it stems from a “temporary dysfunction in the brain’s hippocampus — the area responsible for creating new memories,” Couric shared.

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“Doctors believe this is driven by brief interruptions in blood or oxygen flow, or microscopic spasm in the blood vessels.”

Episodes could potentially be triggered by intense physical exertion, emotional distress, extreme temperature changes or migraines, experts say.

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Approximately 15% of patients will have a recurrence 10 years later.

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“Why did this happen to me? Was the altitude an issue? Was I dehydrated? Tired? Stressed? The literature doesn’t seem to indicate that these are contributing factors, but the cause seems to be as mysterious as the brain itself,” Couric wrote.

Anyone who experiences sudden memory loss, confusion, difficulty speaking, weakness, numbness, vision changes, severe headache or other stroke-like symptoms should seek immediate medical attention or call 911, doctors advise. (iStock)

“All I know is that those hours will be forever lost. Someone described it as my brain failing to hit the ‘record button.’”

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“While this was a freaky occurrence, it could have been much more serious. So ultimately, I’m relieved — even though several hours of a Saturday in June will always be missing for me.”

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Anyone who experiences sudden memory loss, confusion, difficulty speaking, weakness, numbness, vision changes, severe headache or other stroke-like symptoms should seek immediate medical attention or call 911, doctors advise.

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One walking habit could signal a healthier brain after 80, scientists say

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One walking habit could signal a healthier brain after 80, scientists say

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Older adults identified as “super movers” are about half as likely to develop cognitive impairment than their peers.

That’s according to a recent study led by Stony Brook Medicine in New York, which evaluated the cognitive function of 4,000 adults 80 and over who participated in multiple aging and longevity studies over several years.

Among this group, 6% to 10% were classified as super movers, which means they walk at a much faster pace than others of the same age and gender — at speeds comparable to people three decades younger.

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The super movers were found to have about half the risk of cognitive decline compared to seniors with typical gait speed.

The findings were published in the journal Neurology on June 16.

Older adults identified as “super movers” are about half as likely to develop cognitive impairment than their peers. (iStock)

“The study reinforces that mobility and brain health are closely connected,” lead study author Dr. Joe Verghese, MD, neurologist at Stony Brook Medicine, told Fox News Digital. “This suggests that preserving mobility may be an important marker of healthy brain aging and resilience.”

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The most intriguing finding, according to Verghese, was that super movers maintained cognitive function despite having similar dementia-related brain changes as their peers.

In postmortem brain analysis, there was no difference in dementia-related pathologies between the super movers and the slower walkers, the study stated.

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“This suggests they may possess resilience mechanisms that help preserve brain function even in the presence of age-related changes,” he said. “Understanding these resilience factors could lead to new strategies for promoting healthy brain aging.”

As the study was observational, there were some limitations, and it does not prove that walking faster prevents dementia, the researchers noted.

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Super movers were found to have about half the risk of cognitive decline compared to seniors with typical gait speed. (iStock)

“Other factors, such as cardiovascular health, physical fitness or genetics, may also contribute to both faster walking and better cognitive outcomes,” Verghese said.

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This study adds to growing evidence that what’s good for the heart and muscles also benefits the brain, he noted, adding that “staying physically active remains one of the most effective, evidence-based ways to support healthy aging.”

“Walking speed is best viewed as a marker of overall health, not a treatment.”

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“The broader message is that physical activity is important at any age,” Verghese said. “Walking is an easy step-up point because you don’t need any special equipment. You can do it inside or outdoors, and you can do it on a regular basis. You can walk with a dog, you can walk with a friend.”

Any activity is beneficial if it’s done regularly and with the right intensity, he added.

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Rather than just trying to walk faster, the neurologist recommends that seniors focus on maintaining mobility through regular physical activity, strength training, balance exercises and good cardiovascular health.

“Walking speed is best viewed as a marker of overall health, not a treatment,” Verghese noted.

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Major public health guidelines from the CDC and U.S. Physical Activity Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity each week, such as brisk walking.

Major public health guidelines from the CDC and U.S. Physical Activity Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity each week, such as brisk walking. (iStock)

This can be achieved by walking 30 minutes a day, five days a week, or about 20 to 25 minutes most days. Another option is to engage in shorter sessions that add up over the day.

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“You have to do it within your health limitations and medical conditions,” Verghese advised. “So if there are any medical concerns, I would get your physician to clear you before starting exercise.” The good thing about walking, he added, is that you can start at a slow pace and then gradually build up to a brisker pace.

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“And then adding on strength and balance training, whatever age you are, I think is also important.”

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I Tried the Viral Gelatin Weight-Loss Recipe—Here’s My Honest Take

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I Tried the Viral Gelatin Weight-Loss Recipe—Here’s My Honest Take


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I Tried the Viral Gelatin Weight-Loss Recipe: Does It Really Work?




















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