Health
Marijuana compound may help prevent dementia when paired with common drug
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As marijuana’s potential health benefits are under debate, new research has found that THC could have a powerful and positive effect on the brain.
Researchers at the University of Texas (UT) at San Antonio, Long School of Medicine, recently discovered that THC (tetrahydrocannabinol, the main psychoactive compound in marijuana) could prevent the development of Alzheimer’s disease – but only when paired with an anti-inflammatory drug called celecoxib.
Celecoxib is a selective COX-2 inhibitor that is commonly prescribed for arthritis and pain.
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While THC has previously been shown to have anti-inflammatory and neuroprotective properties, it’s also been linked to negative effects on the brain, particularly in learning and memory, according to a UT Health press release.
Combining THC with an anti-inflammatory drug, however, could provide the same benefits with fewer negative side effects.
THC could be powerful against cognitive decline when combined with an anti-inflammatory, a new study suggests. (iStock)
The study, which was published in the journal Aging and Disease, paired low-dose THC extract with celecoxib, which was administered to mice daily for 30 days.
The mice received the treatments before the development of memory symptoms to measure the impact on preventing or delaying Alzheimer’s.
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The results showed improved cognition, learning and memory, as well as decreased markers of neuroinflammation and reduced Alzheimer’s-related brain pathology, the release stated.
Although THC alone had the same results, it also increased inflammatory signals, while the combination dosage did not.
The THC and celecoxib combo improved cognition, learning and memory, while also decreasing markers of neuroinflammation and reduced Alzheimer’s-related brain pathology. (iStock)
“What really mattered was behavior. If cognition is not improved, then the treatment doesn’t matter. And that’s where the combination clearly worked better than THC alone,” noted lead study author Chu Chen, Ph.D., professor in the Department of Cellular and Integrative Physiology.
Years of research led Chen to connect the dots on how THC can manipulate the brain and why it’s difficult to use safely for neurological conditions, according to UT Health.
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“When THC is given, it unexpectedly increases COX-2 in the brain. That increase is closely associated with learning and memory impairment,” Chen said.
Both THC and celecoxib are FDA-approved for use in humans, which could provide a “real advantage” in moving along to clinical trials, according to UT Health.
“What really mattered was behavior. If cognition is not improved, then the treatment doesn’t matter.”
Future studies will investigate whether the drug combination can slow disease progression or reverse deficits after symptoms have appeared.
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“This work has taken many years. But now we’re at a point where basic neuroscience discoveries are pointing toward something that could realistically move into the clinic,” Chen said.
Dr. Paul Saphier, a neurosurgeon and founder of Coaxial Neurosurgical Specialists in New Jersey, called this research an “exciting breakthrough with a huge potential impact for patients and their families.”
“We know that the buildup of the plaques related to Alzheimer’s [beta-amyloid plaques] are the result of chronic inflammation.” (iStock)
“Neurocognitive deterioration has been linked to conditions that cause inflammation within the brain — prior brain bleeds, strokes, tumors and infections,” he told Fox News Digital. “We also know that the buildup of the plaques related to Alzheimer’s [beta-amyloid plaques] are the result of chronic inflammation.”
“So, it makes sense that this combination therapy [might] help limit the production of this amyloid and thereby reduce the progression of the disease.”
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Saphier said the drugs’ FDA approval status is “encouraging,” as it may “ultimately ease the availability for patients, if the trial proves successful.”
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“I look forward to the results of this trial, as well as any future trials that look at limiting the effects of chronic inflammation within the central nervous system.”
Health
Food pyramid backlash: Low-fat era may have fueled obesity, diabetes, says doctor
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The Trump administration’s January rollout of the new, inverted food pyramid has sparked some debate in nutrition circles, as it places a stronger emphasis on dairy, red meats and foods higher in fat.
The top of the pyramid, which is now the wider part of the structure, is built on meat, fats, fruits and vegetables, while whole grains are at the narrow bottom.
In an interview with Fox News Digital, Dr. Mark Hyman, co-founder of Function Health and author of the new book “Food Fix Uncensored,” commented on the backlash the new guidelines have received.
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“The pyramid is just a graphic representation of the content … and it’s really impossible to create a proper visual that’s going to satisfy everybody,” said the Massachusetts-based expert. “Could it have been better? Sure.”
Although he acknowledged there is room for improvement, Hyman, host of “The Dr. Hyman Show” podcast, praised the new model for focusing on what’s been driving obesity in America.
The new nutrition food pyramid shows previous guidance flipped in an inverted structure. (realfood.gov)
“Did it flip the script from what we used to have, which was a low-fat, high-carb set of recommendations from the government that caused the obesity, diabetes epidemic and all the resulting costs and consequences on society?” he asked. “Yeah, we needed to fix that.”
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In his new book, Hyman writes that a central component of America’s dietary policy is what Americans are told to eat — and why.
“I think it was a good step in the right direction.”
The doctor highlighted key updates to U.S. dietary guidance, including a stronger emphasis on whole foods, limits on highly processed products and sugar-sweetened beverages, and revised protein recommendations to “reflect the current science.”
“This is revolutionary,” Hyman said.
Dr. Mark Hyman is the author of the new book “Food Fix Uncensored.” (Function Health; Little, Brown Spark)
The updated pyramid also recommends consuming whole grains, while previous guidance green-lit white flour in portions, which the doctor says is not optimal for human health.
The guidelines are “a bit more protein-forward” than before, Hyman noted, with less of an emphasis on low-fat and non-fat dairy. The expert called the low-fat movement “problematic.”
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“The data didn’t support it,” he said. “It was maybe even the opposite — there was some evidence that kids who had low-fat or non-fat milk actually had more obesity issues because it’s not as satisfying.”
The doctor highlighted key updates to U.S. dietary guidance, including a stronger emphasis on whole foods, limits on highly processed products and sugar-sweetened beverages, and revised protein recommendations to “reflect the current science.” (iStock)
“On the whole, I think [the guidelines are] a big improvement,” Hyman said. “Are they perfect? No. Were there problems? Yes. But it’s a radical departure from what was, and I think it was a good step in the right direction.”
Many Americans struggle with a variety of health conditions that may require specialized diets, such as high cholesterol, inflammation or lactose intolerance.
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Hyman noted that if he had written the guidelines himself, he would have specified that dairy is not a mandatory recommendation.
“There’s no scientific evidence that humans require it,” he said. “It’s a perfectly fine choice if you want to make it.”
Dairy consumption should be a “personalized choice” based on how it affects a person, the doctor said. (iStock)
Dairy consumption should be a “personalized choice” based on how it affects a person, said the doctor, adding that it would be “problematic” guidance to tell Americans they must choose three servings per day.
“It should be understood that 75% of the population is lactose-intolerant, that many people have inflammatory or other issues as a result of consuming dairy — and it should be a personalized choice based on how it affects them.”
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Consuming protein also requires a level of personalization, the expert said, particularly for those who have certain medical conditions, like kidney failure.
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“[The government] could have made more nuanced statements around aging and longevity … and [around] higher protein needs when you’re older, when you are sick, and so forth,” Hyman added. “I think there’s some nuance there that could have been underscored.”
Health
Simple food combo may outperform omega-3 supplements for reducing inflammation
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A simple dietary pairing could offer broader immune benefits than omega-3s alone.
Researchers at the University of Nottingham found that pairing kefir with a prebiotic fiber mix led to greater reductions in inflammation markers than omega-3 supplements or fiber alone.
The findings, published in the Journal of Translational Medicine, suggest that supporting gut bacteria may play an important role in immune and metabolic function.
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Kefir is a fermented milk drink similar to yogurt that contains live bacteria and yeast.
Drinking kefir and taking fiber together may help lower inflammation more effectively than omega-3 supplements. (iStock)
When kefir was combined with prebiotic fiber, researchers observed a stronger effect. Prebiotic fiber feeds healthy bacteria in the gut, helping them grow and function more effectively, the study explained.
As those beneficial bacteria thrive, they produce natural substances that help calm inflammation in the body.
In the six-week study, people who took the kefir-and-fiber combination showed the biggest drop in markers linked to whole-body inflammation.
Those who took omega-3 supplements or fiber alone also improved, but not to the same degree, the study suggested.
Over six weeks, those taking kefir and fiber saw the largest drop in inflammation markers, while omega-3 or fiber alone produced smaller reductions. (iStock)
“Our study shows that while all three dietary approaches reduced inflammation, the synbiotic — combining fermented kefir with a diverse prebiotic fiber mix — had the most powerful and wide-ranging effects,” said Amrita Vijay, a gut microbiome scientist who led the research.
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The researchers measured systemic inflammatory markers, which indicate inflammation occurring throughout the body.
Inflammation is a normal immune response, but chronic, low-level inflammation that persists over time has been linked to conditions such as heart disease and metabolic conditions, according to Cleveland Clinic.
Throughout the study, researchers monitored blood markers to track changes in whole-body inflammation. (iStock)
The findings suggest that combining probiotics and prebiotics may provide broader support than relying on a single supplement.
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“This suggests that the interaction between gut microbes and dietary fiber may be key to supporting immune balance and metabolic health,” Vijay said.
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The team plans to further investigate how synbiotic supplementation may affect individuals with chronic inflammatory disorders.
Health
Doctor shares 3 simple changes to stay healthy and independent as you age
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Living longer isn’t just about making it to 100 anymore, experts say. It’s about feeling your best once you get there.
Dr. Mary Claire Haver, a certified menopause specialist and founder of The ‘Pause Life, said it’s possible to optimize health for a longer life with simple lifestyle changes.
“Hormone therapy can be a tool in the toolkit, but we can’t ignore nutrition, strength training and getting adequate sleep,” she told Fox News Digital. “Focusing on those core pillars of health will provide the whole package so she can age well.”
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The expert, who is also an associate professor of obstetrics and gynecology at the University of Texas Medical Branch, dove into the following three adjustments to improve energy, weight and overall well-being.
No. 1: Prioritize sleep
Sleep is Haver’s top priority for improving well-being and energy.
“If you’re not sleeping, everything else tends to fall apart,” she said.
“If you’re not sleeping, everything else tends to fall apart,” the expert told Fox News Digital. (iStock)
The health expert recommends sleeping in a cool, dark room and using an eye mask or blackout curtains if necessary.
It’s also best to stop using phones and other electronics before bed, including the TV. “Your bed should be for intimacy and for sleeping — that’s it,” Haver said.
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Sleep is a “core pillar of health,” she noted, adding research has shown that inconsistent rest can exacerbate certain neurological conditions like dementia.
“If you’re not sleeping, everything else tends to fall apart.”
“We cycle in and out of different sleep stages, so we have REM sleep where we’re dreaming, [and] we have deep sleep,” Haver said. “Deep sleep is when your brain, it’s like a washing machine … It’s washing out all those negative proteins.
“So, if you’re not hitting that deep sleep, you’re missing that opportunity for your brain to reset, and that is where we see the increasing risk of dementia.”
No. 2: Eat a nutritious diet
Following a nutritious diet is another essential component of good health. In particular, Haver’s “top tip” is to add fiber to a balanced diet.
“Most women get 10 to 12 grams per day,” she said. “You need 25 plus, 35 plus [grams] for heart health.”
“Fibermaxxing” has become a popular nutrition trend, which encourages the addition of more fiber into a daily diet.
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Nutrition experts agree this approach can boost gastrointestinal and heart health, while helping with weight management and the prevention of diabetes and certain cancers. More fiber can also help people feel fuller throughout the day, while minimizing cravings.
Experts recommend introducing fiber slowly because, for some people, adding too much right away can cause cramping, bloating and constipation.
“Fibermaxxing” has become a popular nutrition trend, encouraging the addition of more fiber into the daily diet. (iStock)
No. 3. Incorporate regular movement
Moving your body throughout the day and getting intentional exercise is key to living longer and staying healthy, per various research and experts.
While walking is a great way to boost wellness and help with weight loss, Haver noted that it may not be enough for some individuals with certain conditions.
“A lot of women, most of my patients, are walking,” she said. “I love walking, but you really need to protect your bones and muscles, and strength training is the quickest and easiest way to do that.”
Haver encourages women to hit the gym and lift heavy weights, as it’s “actually going to serve you as you age.”
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The independence gap
Although lifespan has been increasing, Haver noted that women tend to struggle more as they age.
“Women by and large are having a rougher go in that last decade and losing their independence,” she told Fox News Digital.
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The doctor, who only sees menopausal patients, shared that “not one woman” has come into her office saying she wants to live to be 120 years old.
As many women have witnessed their mothers and aunts lose their own independence with age, Haver said her patients’ priorities have shifted from “help me live longer” to “keep me out of a nursing home.”
Many women have witnessed their mothers and grandmothers lose their independence with age, the expert shared. (iStock)
Women are being diagnosed more often with conditions that hinder their ability to care for themselves at home. The two most common drivers of that, Haver said, are dementia and frailty.
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“Loss of muscle mass leads to such weakness that you can’t do your activities of daily living, [and] loss of cognitive ability [means] you cannot take care of yourself,” she said.
“What’s the point of living to 120 if you are in a bed and can’t take care of yourself?”
“That’s what is driving women to make these changes — not to look a certain way or weigh a certain weight,” Haver said. “They care about staying as healthy and independent as long as possible. … I mean, what’s the point of living to 120 if you are in a bed and can’t take care of yourself?”
Stimulating the brain and getting regular movement can boost overall well-being. (iStock)
The expert reiterated the importance of stimulating the brain for longevity, perhaps by reading a book, learning a new skill or playing a challenging game rather than watching TV or scrolling on a phone.
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“Do something fun with your time when your brain is constantly being interactive,” she suggested. “Also, don’t isolate yourself. So often, we see the older generation tend to become more isolated.
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“Be active in your community. Join a cooking class. Do something that is going to foster your relationships so that you have a higher chance of being happier, healthier and more active as you age.”
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