Health
For diabetes patients, inhaled insulin is shown just as effective as injections and pumps
Most of the 38 million people living with diabetes in the U.S. use daily injections or insulin pumps to keep glucose at safe levels — but new research suggests that a third option could be just as effective.
In a study led by Dr. Irl B. Hirsch, M.D., medical director of the Diabetes Care Center of the University of Washington Medical Center, an inhaled form of insulin — similar to an asthma inhaler — worked just as well as injections or pumps to control type 1 diabetes.
The research was presented last week at the American Diabetes Association (ADA)’s 84th Scientific Sessions in Orlando, Florida.
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The clinical trial tested a product called Afrezza, an inhaled insulin made by MannKind Corporation in California.
Afrezza, the only inhaled insulin on the market, has been available since getting FDA approval in June 2014.
Benefits of a third option
“In those with type 1 diabetes, insulin is required for survival,” Hirsch told Fox News Digital in an interview.
“With continuous glucose sensing, glucose control has been dramatically improved — but not everyone reaches the target with multiple injections or pumps, and there are many pros and cons with each therapy,” he said.
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With pumps, people must wear the device, which can lead to skin problems.
They also have to purchase extra accessories.
Blood glucose levels can also drop with exercise, Hirsch warned, which can be problematic.
“Injections overall can be more convenient for some, but they don’t do as well as pump patients,” he said.
With Afrezza, the product is inhaled into the lungs before meals, and the fast-acting insulin minimizes the glucose spike often seen after eating, Hirsch noted.
“Patients with type 1 diabetes should consider this as another option for their mealtime insulin, and talk to their doctor about this choice.”
During the 17-week study, researchers evaluated the results of 141 adults who were assigned to either use the Afrezza inhaler or continue with traditional methods of injection or pump delivery.
At the 17-week mark, all participants switched to the inhaler for another 13 weeks.
All groups were assessed with continuous glucose monitoring at the start of the study, at 17 weeks and again at 30 weeks.
Among the inhaled insulin group, 30% of participants reached their target glucose levels (less than 7% blood sugar) compared to 17% of the people using injections and pumps.
There was no difference in hypoglycemia (low blood sugar) between the groups.
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“In general, there was no difference in our primary endpoint, HbA1c, a reflection of average blood sugar,” Hirsch said.
“But that alone is misleading — many patients did better with their glucose control, while others did worse.”
“The point is, inhaling insulin isn’t for everyone, but some did better than they did on their pumps.”
The people who saw the best results inhaled insulin between meals and at bedtime, Hirsch added.
At the end of the study, more than half of the participants said they would opt to stay on the inhaled insulin therapy.
“The biggest takeaway is that patients with type 1 diabetes should consider this as another option for their mealtime insulin, and talk to their doctor about this choice,” he recommended.
‘Adds value’
The American Diabetes Association acknowledged the promise of the study findings in an email to Fox News Digital.
“We look forward to our Scientific Sessions every year to see data like the INHALE-3 study’s findings, which have the potential to expand diabetes care,” Raveendhara Bannuru, M.D., PhD, the ADA’s vice president of medical affairs and quality improvement outcomes in Boston, Massachusetts, told Fox News Digital via email.
“We are hopeful for the continuous development of alternative insulin delivery methods that could offer options for people living with diabetes,” the group also said in the statement.
“The INHALE-3 trial demonstrated that inhaled insulin, combined with insulin degludec, effectively reduces A1c levels without increasing hypoglycemia or weight gain in people with type 1 diabetes. This adds value to the options in insulin therapy.”
Potential risks and limitations
While more people met their glycemic targets with Afrezza, some subjects saw worse readings when switching from usual methods to inhaled insulin — “potentially due to missing doses of inhaled insulin during the day and/or underdosing going into bedtime,” the researchers wrote.
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“We didn’t see any concerns,” Hirsch said when asked about side effects.
“As expected, a few people coughed immediately when dosing their insulin, but no major concerns were seen and everyone continued on their inhaled insulin.”
The most common side effects noted in the study were hypoglycemia, cough and throat pain or irritation.
Afrezza has been linked to a risk of acute bronchospasm in patients with chronic lung disease, such as asthma or COPD, according to the manufacturer.
“Inhaling insulin isn’t for everyone, but some did better than they did on their pumps.”
Before starting Afrezza, patients should see a doctor for a physical examination and testing to measure lung function.
Patients who smoke or who recently quit smoking should not take the inhaled medication.
For more Health articles, visit www.foxnews/health
Fox News Digital reached out to MannKind requesting additional comment.
Health
'For better sleep, how can I reduce nighttime bathroom trips?': Ask a doctor
One in three Americans over 30 wake up at least twice each night to use the restroom, studies show.
These frequent interruptions can wreak havoc on your sleep, but there are some practical ways to manage them.
Dr. Hana Patel, resident sleep expert at Mattress Online, who is based in London, provides the following tips to cut down on nightly bathroom trips to improve your rest.
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1. Train your bladder with Kegels and exercise
Patel recommends doing Kegel exercises — also known as pelvic floor muscle training — as a means of strengthening the muscles that support the bladder.
“When done right, Kegels can strengthen pelvic muscles, cutting down on the urge to go at night,” she told Fox News Digital.
The doctor also emphasized the importance of staying active overall.
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“Simple preventive measures, like regular exercise, can significantly lower the need for nighttime bathroom visits,” she said.
Exercises that involve the lower abdomen are particularly effective, the expert noted.
2. Say no to triggering beverages
Cutting back on certain drinks can help reduce the need for nighttime bathroom trips.
“Caffeine, alcohol, artificially sweetened and fizzy drinks are diuretics, meaning they’ll increase urine production, so I advise avoiding them where you can,” Patel said.
To reduce nighttime disruptions, she recommends either enjoying these beverages earlier in the day or switching to less irritating alternatives, like decaffeinated or non-alcoholic drinks.
3. Ease up on evening salt and protein
Adjusting your meal timing and composition can help reduce the need to visit the bathroom overnight, Patel said.
“Salty and protein-rich meals can boost urine production, especially close to bedtime,” she told Fox News Digital.
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Eating these types of meals earlier in the evening or at lunch instead of dinner can prevent increased nighttime trips to the bathroom without having to give up those foods entirely, the doctor added.
4. Limit the TV, and keep your feet up
Health
Drinking alcohol is linked to six types of cancer, experts say: ‘It’s toxic’
It’s long been known that no amount of alcohol is good for the body — and now new research spotlights the potential harm it can cause.
More than 5% of all cancer cases are caused by drinking alcohol, according to the Cancer Progress Report 2024 from the American Association for Cancer Research (AACR).
Among the modifiable risk factors for cancer, alcohol is the third biggest, behind obesity (7.6% of cases) and cigarette smoking (19.3%).
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“Excessive levels of alcohol consumption increase the risk for six different types of cancer, including certain types of head and neck cancer, esophageal squamous cell carcinoma, and breast, colorectal, liver and stomach cancers,” said Rajarshi Sengupta, PhD, lead author of the AACR Cancer Progress Report 2024, in a statement sent to Fox News Digital.
“Further, research shows that alcohol intake at an early age can increase the risk of cancer later in life.”
Based on these findings, limiting or eliminating alcohol can reduce the risk of developing alcohol-related cancers by 8% and the risk of all cancers by 4%, the report noted.
Addiction expert warns of risks
There has been a “roller coaster of information” about whether alcohol is harmful, according to addiction psychiatrist Dr. Adam Scioli of Caron Treatment Centers in Pennsylvania.
“There have even been reports for years that it could be beneficial for one’s health — but we know now that alcohol ingestion is one of the modifiable risk factors for cancer,” Scioli, who is not affiliated with AACR, told Fox News Digital.
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Around 75,000 Americans each year are diagnosed with a cancer that is linked in some way to alcohol use, according to Scioli.
The more someone drinks — both in volume and frequency — the higher the risk, he warned.
“Alcohol is a toxin,” Scioli said.
“We’ve long known that it impacts any number of organs, essentially starting with the brain and working its way down to the colorectal system.”
Is there a ‘safe’ amount?
Moderate alcohol use is defined as one drink or less in one day for women.
For men, it is two drinks or fewer per day, according to the Centers for Disease Control and Prevention (CDC).
“We’ve long known that alcohol impacts any number of organs, starting with the brain and working its way down to the colorectal system.”
“Drinking alcohol in moderation may increase your overall risks of death and chronic disease,” the agency stated on its website.
“Even low levels of alcohol use (less than one drink per day) can raise the risk of certain cancers.”
Scioli agreed, emphasizing that “we can definitely say there’s no added health benefit to ingestion of alcohol.”
“The line between safety and danger is debatable, and is different for each person.”
While risk factors like tobacco use are widely known, public awareness about the link between alcohol and cancer is still low, according to Sengupta.
Most Americans (51%) are not aware that alcohol increases cancer risk, per AACR data.
“It’s been flying under the radar for far too long — especially given the number of Americans who have met the criteria for alcohol use disorder, which is around 29 million Americans in 2023,” said Scioli.
What needs to change?
The good news, according to Scioli, is that with modifiable risk factors like alcohol, reducing the intake decreases the risk.
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As the report stated, those who are successful in decreasing their drinking or abstaining below those moderate risk levels will see a risk reduction in overall cancers, he noted.
“We need to do a much better job of making the public aware of the risks inherent in drinking — particularly moderate to heavy drinking,” Scioli said.
“And we need to make the public aware that there are mechanisms by which they can access help if they are unable to moderate their drinking or quit on their own.”
For more Health articles, visit www.foxnews.com/health
To help raise awareness, Sengupta of the AACR called for public messaging campaigns, “such as cancer-specific warning labels displayed on alcoholic beverages.”
Along with that, she told Fox News Digital, “effective clinical strategies that reduce or eliminate alcohol consumption must be considered to reduce the burden of alcohol-related cancers.”
Health
Intermittent Fasting + Walking: The Science-Backed Combo That Helped This Grandma Lose 3X the Weight
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