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COVID-flu combo vaccine shows ‘positive’ results in phase 3 trials, Moderna says: A 'two-for' option

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COVID-flu combo vaccine shows ‘positive’ results in phase 3 trials, Moderna says: A 'two-for' option

A combination COVID-influenza vaccine is apparently one step closer to hitting the market.

Moderna, which is developing the experimental vaccine, announced Monday that in phase 3 clinical trials, mRNA-1083 achieved a better immune response than other vaccines.

The combination vaccine includes mRNA-1010 (Moderna’s vaccine candidate for seasonal influenza) and mRNA-1283 (the company’s “next-generation COVID-19 vaccine candidate”), according to a press release from the company.

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“This data serves as a milestone for the industry’s pursuit of a flu and COVID-19 combination vaccine, which could change the way we manage the respiratory illness season,” Francesca Ceddia, chief medical affairs officer at Moderna, said in a statement to Fox News Digital. 

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A combination COVID-influenza vaccine is one step closer to hitting the market with this new announcement from Moderna. (iStock)

“With mRNA-1083, we may be able to not only offer the convenience of dual protection in a single shot, but we also may offer enhanced immunity compared to today’s standalone vaccines against the two respiratory diseases with the largest burden on health care systems,” she continued.

“Our hope is that with improved convenience comes improved compliance — helping to advance public health and lower rates of severe outcomes related to COVID-19 and flu.”

Moderna is the only company with a positive phase 3 flu and COVID combination vaccine, according to the company’s press release.

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Moderna’s phase 3 trial was a randomized, double-blinded study that included two independent groups, each consisting of 4,000 adults.

One group included adults age 65 and older, who compared the experimental vaccine to Fluzone HD, an enhanced influenza vaccine, and Spikevax, Moderna’s currently licensed COVID-19 vaccine, the release stated.

Moderna sign

Moderna announced Monday that in phase 3 clinical trials, mRNA-1083 achieved a better immune response than other vaccines. (REUTERS/Brian Snyder)

The second group, which included adults 50 to 64 years old, compared mRNA-1083 to Fluarix, a standard dose influenza vaccine, and Spikevax.

In both groups, mRNA-1083 resulted in “statistically significantly higher immune responses against three influenza virus strains (H1N1, H3N2, and B/Victoria) and against SARS-CoV-2,” according to the release.

“One can never predict rare adverse events.”

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Amrie Grammer, a Virginia-based immunologist who previously worked with the National Institutes of Health, was not involved in the trial or the vaccine development but commented on the findings.

“Moderna’s results from their Ph3 NCT06097273 trial indicate that the dual SARS-CoV-2/influenza immunization is no less effective than two single shots,” Grammer told Fox News Digital.

COVID and flu viruses

In both groups, mRNA-1083 resulted in “statistically significantly higher immune responses against three influenza virus strains (H1N1, H3N2, and B/Victoria) and against SARS-CoV-2.” (iStock)

“This makes it simpler for more Americans to protect themselves from these two serious infections, especially those 65 and older who are most at risk for COVID- and flu- related deaths,” she continued.

“Ninety percent of deaths from COVID and 70% to 85% of deaths from the flu in 2023 were in those 65 and older.”

“This is especially good news for people who are wary of too many vaccines, even if they believe in them.”

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Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center and a Fox News medical contributor, was also not involved in the trial but shared insights. 

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“Moderna has been working on combining a vaccine to fight both the latest coronavirus subvariant and the year’s flu strain,” he told Fox News Digital. 

“The phase 3 clinical trials look excellent — safe and effective, with more antibodies made against both than when either immunization is given alone.”

COVID clinical trials

Overall, the experimental vaccine showed an “acceptable tolerability and safety profile,” Moderna stated.  (iStock)

The effectiveness is likely due to the vaccine “waking up” the immune system to both viruses at the same time, causing a stronger, more varied and more durable response, according to Siegel.

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“This is especially good news for people who are wary of too many vaccines, even if they believe in them,” he said.

“The most commonly solicited adverse reactions were injection site pain, fatigue, myalgia and headache.”

“This shot creates a ‘two-for’ option and should be a useful tool, especially if primary care physicians have ready access to it.”

Overall, the experimental vaccine showed an “acceptable tolerability and safety profile,” Moderna stated. 

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“The most commonly solicited adverse reactions were injection site pain, fatigue, myalgia and headache,” per the release.

As Grammer pointed out, Moderna’s phase 3 trial included thousands of people with a “modest adverse event profile, but one can never predict rare adverse events.”

Child receives vaccines

As of May 2022, only some 23% of U.S. adults are up-to-date on COVID vaccines, according to data from the CDC. (Julian Stratenschulte/dpa)

Siegel also chimed in on the vaccine’s safety profile.

“Contrary to some public pronouncements, this has been shown to be an overall very safe technology, though it does cause short-term side effects, like sore arm and, rarely, something more pronounced or long-lasting,” he told Fox News Digital.

         

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As of May 2022, only some 23% of U.S. adults are up-to-date on COVID vaccines, according to data from the Centers for Disease Control and Prevention (CDC).

Flu vaccine coverage for adults was around 47% as of January 2024, per the CDC.

COVID vaccine

The effectiveness is likely due to the vaccine “waking up” the immune system to both viruses at the same time, a doctor noted. (iStock)

Looking ahead, Moderna plans to present the phase 3 clinical data and submit it for publication.

“Moderna plans to present the Phase 3 clinical data for mRNA-1083 at an upcoming medical conference as well as submit it for publication,” the release stated. “The company will engage with regulators on next steps.” 

For more Health articles, visit www.foxnews/health 

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Both Novavax and Pfizer-BioNTech also have ongoing clinical trials of SARS-CoV-2/influenza vaccines, Grammer pointed out.

“Our Phase 3 COVID-19-influenza combination study is on track to start in the second half of this year,” a spokesperson from Novovax told Fox News Digital. 

“A single combination vaccine visit creates a convenience that we believe can translate into improved vaccination rates, especially in older adults, who are most at risk.”

Fox News Digital reached out to Pfizer for comment.

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Saunas have health benefits, but overuse is linked to dangerous health risks

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Saunas have health benefits, but overuse is linked to dangerous health risks

Taking time to sit in a sauna can be a great way to decompress after a grueling workout or even a stressful day. 

While in a sauna, you can add to the relaxation by reading your favorite book, listening to a motivational podcast or just by closing your eyes, taking deep breaths and sweating the stress away. 

Saunas are commonly found at gyms and spas, but you can buy one for your home. 

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A sauna offers health benefits, but it’s also important to be mindful of risks. 

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  1. What are the different types of saunas?
  2. What are the health benefits that come from sauna use?
  3. How long is it safe to go in the sauna?
  4. Are there any risks of sauna use I should be aware of?

A sauna is full of health benefits, but it also poses risk if not used properly or if used with certain underlying health conditions.  (iStock)

1. What are the different types of saunas?

A sauna is “a specific room heated to about 150 to 195 (F) degrees, and where the temperature and humidity of the room can be controlled with sprinkling water on the rocks in the heater/stove,” according to the North American Sauna Society’s website. 

Some of the most commonly found saunas are wood-burning saunas, electrically heated saunas, manufactured sauna rooms, smoke saunas, steam rooms and infrared rooms. 

For the most part, many of the health benefits are consistent no matter what type of sauna you use. 

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“While many benefits overlap, steam may be better for respiratory issues, far infrared for weight loss and recovery,” Dr. Brooke Jeffy, a board-certified dermatologist from Scottsdale, Arizona, and founder of youth skin care brand BTWN, told Fox News Digital via email. 

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2. What are the health benefits that come from sauna use?

There are several different health benefits that come along with sauna use. 

“Both steam and dry saunas can have beneficial effects on respiratory conditions, cardiovascular disease and dementia,” Jeffy said. 

“They also help stiff muscles and joints and increase circulation to the skin. Both steam and infrared saunas have beneficial effects on blood pressure. Infrared saunas may improve weight loss when combined with exercise and improve muscle recovery.” 

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The time at which you use a sauna doesn’t matter, according to Jeffy. Either a morning sweat or a relaxing sit in the sauna before bed can boast health benefits. 

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Many people also choose to hop in a sauna after a workout. 

“Post-workout sessions help improve weight control and muscle recovery,” Jeffy said. 

A woman sitting in the sauna

It’s common to sit in a sauna after completing a workout. (iStock)

3. How long is it safe to go in the sauna?

When in a sauna, make sure you keep track of how long you’ve been inside. 

Many gym saunas have a clock, so you don’t have to take your phone inside, potentially causing it to overheat. 

If there isn’t a timer or clock available, make sure to bring one with you or set an alarm to sound so you know when it’s time to exit. 

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“The maximum time to spend in the dry sauna or steam room is about 15-20 minutes,” Jeffy said. “Infrared sauna can be used longer, anywhere from 20-40 minutes.”

4. Are there any risks of sauna use I should be aware of?

While sauna use does include benefits, there are also risks you should be aware of if you decide to add it to your routine. 

The risks include dehydration, heat exhaustion and stroke, according to Jeffy. 

Woman drinking water

Make sure to drink water to keep yourself hydrated while in a sauna.  (iStock)

To avoid potential dehydration, bring a bottle of water into the sauna with you.

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If you aren’t a regular sauna user already, consider a slow progression to allow your body to adjust and slowly begin increasing the time you sit inside. 

 

Lastly, if you are pregnant, sick, intoxicated or prone to dizziness, you should not use a sauna, according to Jeffy. 

“Saunas should not be used if you have had a recent heart attack, or history of angina, aortic stenosis or congestive heart failure,” Jeffy added. 

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‘Is it bad to skip breakfast if I’m not hungry?’: Ask a doctor

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‘Is it bad to skip breakfast if I’m not hungry?’: Ask a doctor

You’ve likely heard the old adage that breakfast is the most important meal of the day, but what if you’re just not hungry in the morning?

Is it OK to consistently skip the morning meal and hold off until lunch?

Fox News Digital asked some nutritionists about the potential ramifications of bypassing breakfast on a regular basis and their recommendations for optimizing metabolism with a healthy morning routine.

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While most experts agree it’s OK to skip breakfast once in a while, it’s generally beneficial to eat something within an hour or two of waking up.

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While most experts agree it’s OK to skip breakfast once in a while, it’s generally beneficial to eat something within an hour or two of waking up. (iStock)

“Skipping breakfast regularly could lead to some unwanted side effects,” Shelley Balls, registered dietitian and owner at Fueling Your Lifestyle in Smoot, Wyoming, told Fox News Digital.

“It can lead to an overconsumption of foods in the following meals throughout the day. You may think you’re eating fewer calories, but you might actually be binging at lunch or dinner,” she said.

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Never eating breakfast can also affect energy levels, she warned, as the body isn’t getting the carbohydrates and nutrients it needs to perform optimally.

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There could also be a long-term effect of slowing down the metabolism, the expert said.

“Breakfast is meant to break the overnight fast, and can help jump-start your metabolism. So, over time, not eating breakfast could decrease your metabolism, as your body becomes more efficient with fewer calories,” Balls said. 

Bacon eggs toast

Protein in the morning usually leads to a higher calorie burn and helps to reduce hunger later in the day, experts say. (iStock)

Breakfast has been associated with a bevy of benefits, including better weight management, better cognitive function, increased metabolism, improved energy and reduced hunger, according to Vanessa King, registered dietitian nutritionist and media spokesperson for the Academy of Nutrition and Dietetics in Oahu, Hawaii. 

“Breakfast gives you an energy boost to power-start your day,” King told Fox News Digital. 

“Not eating breakfast could decrease your metabolism, as your body becomes more efficient on fewer calories.”

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“Breaking an overnight fast with a balanced breakfast significantly impacts well-being and overall health,” she added. “It’s important for everyone. And for children and teens, eating breakfast has been associated with better behavior and academic performance.”

If you’re not hungry within an hour or two of waking up, King suggests looking at your eating pattern.

“Are you snacking at night and it’s leaving you full in the morning? Try lighter snacks and allow more time between your last meal and sleep,” she advised.

The fasting factor

For people who are following a plan of intermittent fasting or time-restricted feeding, eliminating breakfast is a common way to maintain a shorter eating window and a longer fasting stretch, according to Dr. Jennie Stanford, an obesity medicine physician in Pennsylvania and medical contributor for Drugwatch. 

“One main determinant here is how someone feels later in the day,” she told Fox News Digital. 

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If skipping breakfast makes you feel ravenous later in the day, ultimately causing you to overconsume at other meals, this is not recommended, the doctor said. 

“However, if not eating breakfast doesn’t impact the calories and other macronutrients they consume as the day progresses, it may represent an opportunity to decrease overall calorie intake,” Stanford added.

Lighter options for when you’re not hungry

“If you’re not ready for a full meal, begin with something small within 30 to 60 minutes of waking,” recommends Chloë Ward, a functional diagnostic nutrition practitioner and certified integrative nutrition health coach in Santa Barbara, California.

“Even a light snack can help signal to your body that it’s time to start burning energy.”

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Woman eating breakfast

“Breakfast gives you an energy boost to power-start your day,” an expert told Fox News Digital.  (iStock)

Ward offers the following breakfast suggestions for someone who’s not generally hungry in the morning but wants to kick-start metabolism.

   

  1. Smoothies: A nutrient-dense smoothie with ingredients like spinach, a small amount of fruit, protein powder and healthy fats (like avocado or nut butter) can be a light yet satisfying option.
  2. Greek yogurt with berries: Greek yogurt is rich in protein and can be paired with a handful of berries and a sprinkle of nuts or seeds for added fiber and healthy fats.
  3. Overnight Oats: Preparing oats the night before with milk, chia seeds and a dash of cinnamon can create a light and easy-to-digest breakfast that’s ready when you wake up.
  4. Protein-rich snack: A hard-boiled egg, a piece of turkey or chicken, or a small serving of cottage cheese can be a quick and light protein boost.
  5. A piece of fruit with nut butter: Slices of apple or banana with a spoonful of almond or peanut butter offer a balance of carbs, protein and healthy fats without being too heavy.
Strawberries and blueberries

Greek yogurt is rich in protein and can be paired with a handful of berries and a sprinkle of nuts or seeds for added fiber and healthy fats, a nutritionist said. (iStock)

Overall, experts agree that healthy options like fruits, whole grains, dairy, protein and vegetables provide the biggest benefit.

“Protein has a higher thermogenic effect than other macronutrients, meaning it requires more energy (heat) to break it down than either fats or carbohydrates,” Stanford told Fox News Digital. 

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“As such, having protein in the morning usually leads to a higher calorie burn, at least temporarily.”

Protein also helps to reduce hunger later in the day, Stanford said.

For more Health articles, visit www.foxnews/health

“Protein doesn’t have to mean meat, if it sounds too heavy in the morning,” she noted. 

“Other good protein sources include low-sugar Greek yogurt, eggs, low-carb breakfast wraps, cheese, protein oats, protein shakes or clean protein bars.”

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“Even a light snack can help signal to your body that it’s time to start burning energy.”

If you really can’t tolerate food in the morning, Ward suggests starting the day with a glass of warm water, possibly with lemon. 

“Warm water helps wake up your digestive system, aids in hydration and can boost your metabolism after a night of fasting,” she said.

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Hit a Weight Loss Plateau? A Dietitian Reveals 3 Ways To Break It

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Hit a Weight Loss Plateau? A Dietitian Reveals 3 Ways To Break It


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Weight Loss Plateau: How To Tell if You’ve Hit One and How To Break It | Woman’s World




















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