Health
Cancer risk rises with this little-known syndrome. Here’s how to know if you have the genetic condition
As colorectal cancer continues to spike among younger patients, doctors are warning of a little-known but widespread condition that greatly increases the risk.
Lynch syndrome is a genetic disorder that makes someone more susceptible to many different kinds of cancer.
Fox News Digital spoke with two experts about what people should know about this inherited condition.
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Dr. Matthew Grossman, an interventional endoscopist and gastroenterologist with Atlantic Health System in New Jersey, explained the relationship between Lynch syndrome and human DNA.
“Think of DNA as a ladder,” he said. “Normally, errors in the rungs — called mismatches — are fixed by a repair system. In Lynch syndrome, this system is faulty, increasing the risk of mismatches.”
Lynch syndrome is a genetic disorder that makes someone more susceptible to many different kinds of cancer. (iStock)
Because of the mismatch repair defect, a person with Lynch syndrome is much more likely to develop abnormalities and defects in cells, which eventually lead to cancer, he said.
“Lynch syndrome is a type of germline mutation, meaning it’s inherited genetically, versus a somatic mutation, which can happen spontaneously to only a few cells,” said Grossman.
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Dr. Ajay Bansal, a gastroenterologist at KU Medical Center at the University of Kansas, emphasized that Lynch syndrome largely flies under the radar, as 95% of patients who have the condition don’t know about it.
“They are not aware that they are at increased risk for not only colon cancer, but also uterine, ovarian, stomach, small bowel, kidney, bladder and perhaps brain cancer,” he told Fox News Digital. “So it’s very underdiagnosed.”
In healthy DNA, errors in the rungs — called mismatches — are fixed by a repair system. In Lynch syndrome, the repair system is faulty, increasing the risk of mismatches, a doctor explained. (iStock)
One of the reasons the syndrome often goes unnoticed is because it’s a “silent” condition, Bansal said. “It doesn’t cause any symptoms until you have cancer.”
The two main cancers tied to the syndrome are colon and colorectal cancer and cancer of the uterus.
“Lynch syndrome can result from four or five different mutations,” Bansal said. “Depending on the mutation, the type of cancer risk changes.”
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For example, for those who have a mutation in a gene called MLH1, the risk of getting colorectal cancer at some point in their lifetime is 80%, Bansal warned.
Among young-onset colorectal cancers, the doctor estimated that roughly 25% are a result of Lynch syndrome.
How is Lynch syndrome detected?
Lynch syndrome can be diagnosed by either a blood test or saliva test, Bansal said.
“If a patient has a family history of multiple colon cancers or multiple other cancers in the family, or if somebody in the family had colon cancer or uterine cancer under the age of 50, we recommend genetic testing to confirm the syndrome,” he said.
Lynch syndrome can be diagnosed through either a blood test or saliva test. (iStock)
Patients who fall into these categories are typically tested for Lynch between the ages of 18 to 25, the doctor said.
Universal genetic testing is not generally performed.
“It’s not approved for the general population, mainly because of costs and insurance concerns,” Bansal noted.
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Before genetic testing was available, clinicians relied on the “3,2,1 criteria” for diagnosing Lynch syndrome, according to Grossman.
“For that criteria, if patients have three or more relatives with one of the affecting cancers on the same side of the family, and this is seen in two or more generations with at least one person under age 50, that is highly diagnostic of Lynch syndrome and they should discuss the condition with a doctor,” he said.
What happens if you’re diagnosed?
There is no treatment or “cure” for Lynch syndrome, as it’s caused by a genetic mutation.
Those who test positive should closely monitor themselves for the warning signs of cancer through regular screenings — especially colonoscopies, Bansal said.
Patients should talk to their primary care doctors about their family history, a doctor advised. (iStock)
In the general population, among people without Lynch syndrome, it is recommended to start colonoscopies at the age of 45.
In patients with Lynch syndrome — especially those with more aggressive phenotypes and genotypes — Bansal recommended starting colonoscopies at the age of 25 and repeating them every one to two years.
“The idea here would be to monitor closely so we can prevent colon cancer by removing polyps or catching it at an early stage when we can treat it,” he said.
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Bansal, who specializes in studying vaccines for cancer prevention, is currently running a clinical trial for a new cancer vaccine. The participants are all people with Lynch syndrome.
“We felt that we had to do something to change the natural history of cancer in this high-risk population,” he told Fox News Digital.
In the trial, researchers are testing a combination of three vaccines that were initially created by a scientist at the National Cancer Institute.
“If a patient has a family history of multiple colon cancers or multiple other cancers in the family, or if somebody in the family had colon cancer or uterine cancer under the age of 50, we recommend genetic testing to confirm the syndrome,” a doctor said. (iStock)
“These vaccines attack those cells in the colorectal area that express abnormal proteins, and then it can train the immune cells to get rid of those cells in the colon — and perhaps in other organs such as the stomach, small bowel, pancreas and uterus — before they turn into cancer or polyps.”
The first two safety phases of the trial have already been completed.
Next, the researchers will perform randomized controlled trials to gauge the effectiveness of the vaccines in keeping cancer at bay.
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If the trial is successful, Bansal said he envisions the vaccine extending to other types of cancers.
Bansal’s main advice to patients is to talk to their primary care doctors about their family history.
The two main cancers tied to the syndrome are colon and colorectal cancer and cancer of the uterus. (iStock)
“In medical care, everybody’s so busy that we don’t discuss family history enough,” he said. “Patients should ask their doctor about their family history of cancers and the possibility of genetic testing, which has become much cheaper than ever before.”
Grossman agreed that it’s important to be aware of the risks associated with the genetic condition.
“Knowing you have Lynch syndrome allows for more frequent colonoscopies and additional cancer screenings that will help save lives,” he said.
“This is a great example of how our increased knowledge of genetics has improved our clinical care.”
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Collagen supplements have exploded in popularity, touted as everything from an anti-aging miracle to a muscle recovery booster.
But a sweeping new review conducted by U.K. researchers suggests that while collagen may help improve skin elasticity and ease arthritis pain, it does little for athletic performance or wrinkle reduction.
Researchers from Anglia Ruskin University analyzed 16 systematic reviews and 113 randomized controlled trials involving nearly 8,000 participants worldwide, which they say is the most extensive evaluation of collagen’s health effects to date.
The review found consistent evidence that collagen supplementation improves skin elasticity and hydration over time and provides significant relief from osteoarthritis-related joint pain and stiffness, according to findings published in Aesthetic Surgery Journal Open Forum.
A large U.K. review found that collagen supplements may improve skin elasticity and hydration over time. (iStock)
The researchers, however, did not find meaningful improvements in post-exercise muscle recovery, soreness or tendon mechanical properties (strength, springiness and stretch resistance).
“Collagen is not a cure-all, but it does have credible benefits when used consistently over time, particularly for skin and osteoarthritis,” co-author Lee Smith, professor of public health at Anglia Ruskin University, said in a statement.
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“Our findings show clear benefits in key areas of healthy aging, while also dispelling some of the myths surrounding its use,” Smith added.
Collagen, the most abundant protein in the body, supports skin, bones, tendons, cartilage and connective tissue, according to experts. Natural collagen production begins to drop in early adulthood and declines more sharply with age.
The study found that collagen supplements may help reduce joint pain and stiffness in people with osteoarthritis. (iStock)
The review found that long-term collagen supplementation was linked to improved skin firmness and hydration, but did not help skin roughness — a proxy for visible wrinkles.
Benefits appear to accumulate gradually, suggesting that collagen should not be viewed as an “anti-wrinkle ‘quick fix,’ but as a foundational dermal support for individuals seeking holistic skin maintenance,” the researchers said.
“If we define anti-aging as a product or technique designed to prevent the appearance of getting older, then I believe our findings do support this claim for some parameters,” Smith told the BBC. “For example, an improvement in skin tone and moisture is associated with a more youthful-looking appearance.”
Collagen supplementation was linked to reduced pain and stiffness in people with osteoarthritis, with stronger benefits seen over longer periods of use, and showed modest improvements in muscle mass and tendon structure that may support healthy aging.
Collagen did not significantly improve skin roughness, a marker of visible wrinkles. (iStock)
However, it did not show meaningful results when used as a fast-acting sports performance supplement, and evidence for benefits related to cholesterol, blood sugar, blood pressure and oral health was mixed or inconclusive.
Dr. Daniel Ghiyam, a California-based physician and longevity specialist, said the findings align with what he sees in clinical practice.
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“Collagen is a targeted support tool, not a foundation of health or performance,” Ghiyam, who was not involved in the study, told Fox News Digital. “When marketed that way, it makes sense. When marketed as a cure-all, it doesn’t hold up to the data.”
The authors noted that while many previous collagen studies have received financial support from the supplement industry, the current review did not receive industry funding.
Experts say collagen supplements may offer modest benefits for skin hydration and joint comfort, but they are not a cure-all. (iStock)
The team called for more high-quality clinical trials examining long-term outcomes, optimal dosages and differences between collagen sources, such as marine, bovine and plant-based alternatives.
Among its limitations, the review could not determine whether certain forms of collagen work better than others or what the optimal regimen should be.
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While the review included randomized controlled trials, the quality of the studies varied, with newer research generally showing stronger results.
Experts say more data and studies are needed to build on the findings. They also noted that diet plays a crucial role in skin health.
Collagen supplements, often sold as powders or pills, may improve skin elasticity and ease joint pain, experts say. (iStock)
Dr. Erum Ilyas, a Pennsylvania-based dermatologist and chair of dermatology at Drexel University College of Medicine, noted that the review analyzed previously published meta-analyses rather than generating new primary data.
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“At this time, I have not seen sufficiently strong independent evidence to routinely recommend collagen supplements to my patients,” Ilyas, who was not involved in the review, told Fox News Digital.
“Although some studies show modest improvements in markers such as hydration and elasticity, there remains limited independent, biopsy-confirmed evidence demonstrating sustained increases in dermal collagen content,” she added.
Fox News Digital has reached out to the researchers for comment.
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As colorectal cancer (CRC) is now the leading cause of cancer death in adults under 50, a new report reveals some surprising shifts in the incidence of the disease.
Although rates of CRC have been declining among seniors, those 65 and under are facing a rise in diagnoses, according to a report titled Colorectal Cancer Statistics, 2026, from the American Cancer Society.
Adults 65 and younger comprise nearly half (45%) of all new colorectal cancer cases — a significant increase from 27% in 1995, states the report, which was published in CA: A Cancer Journal for Clinicians.
The disease is rising fastest among adults 20 to 49 years old, at a rate of 3% per year.
Colorectal cancer is now the leading cause of cancer death in adults under 50. (iStock)
Among adults 50 and under, 75% of colorectal cancers are diagnosed at an advanced stage. Half of the diagnoses in that age range are made between the ages of 45 and 49. Although that age group is eligible to receive routine screenings, just 37% do so.
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The report also revealed that rectal cancer is on the rise, now accounting for about one-third (32%) of all CRC cases — an increase from 27% in the mid-2000s.
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“After decades of progress, the risk of dying from colorectal cancer is climbing in younger generations of men and women, confirming a real uptick in disease because of something we’re doing or some other exposure,” said Rebecca Siegel, senior scientific director, surveillance research at the American Cancer Society and lead author of the report, in a press release.
Among adults 50 and under, 75% of colorectal cancers are diagnosed at an advanced stage. Half of the diagnoses in that age range are made between the ages of 45 and 49. (iStock)
“We need to redouble research efforts to understand the cause, but also circumvent deaths through earlier detection by educating clinicians and the general public about symptoms and increasing screening in people 45-54 years.”
It is projected that 158,850 new cases of colorectal cancer will be diagnosed this year, and that the disease will cause 55,230 deaths, per the report.
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More than half of CRC cases can be linked to high-risk behaviors, the researchers said. Those include lack of nutrition, high alcohol consumption, smoking, lack of exercise and obesity.
“These findings further underscore that colorectal cancer is worsening among younger generations and highlight the immediate need for eligible adults to begin screening at the recommended age of 45,” said Dr. William Dahut, chief scientific officer at the American Cancer Society.
When the disease is caught at a local (early) stage, the five-year survival rate is 95%. (iStock)
“The report also shines a light on the crucial importance of continued funding for research to help discover new therapies to treat the disease and advance patient care.”
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When the disease is caught at a local (early) stage, the five-year survival rate is 95%, the report stated.
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A new study suggests that middle-aged men may be more vulnerable to faster biological aging, potentially linked to exposure to “forever chemicals.”
The research, published in the journal Frontiers in Aging, examined how perfluoroalkyl and polyfluoroalkyl substances, more commonly known as PFAS, could impact aging at the cellular level.
PFAS are synthetic chemicals commonly used in nonstick cookware, food packaging, water-resistant fabrics and other consumer products, the study noted.
Their chemical structure makes them highly resistant to breaking down, allowing them to accumulate in water, soil and the human body.
Chinese researchers analyzed blood samples from 326 adults enrolled in the U.S. National Health and Nutrition Examination Survey between 1999 and 2000.
A new study suggests that middle-aged men could face accelerated biological aging at the cellular level due to exposure to PFAS. (iStock)
The researchers measured levels of 11 PFAS compounds in participants’ blood and used DNA-based “epigenetic clocks” — tools that analyze chemical changes to DNA to estimate biological age — to determine how quickly their bodies were aging at the cellular level, the study stated.
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Two compounds, perfluorononanoic acid (PFNA) and perfluorooctanesulfonamide (PFOSA), were detected in 95% of participants.
Higher concentrations of those chemicals were associated with faster biological aging in men of certain age groups, but not in women.
“People should not panic.”
The compounds most strongly linked to accelerated aging were not the PFAS chemicals that typically receive the most public attention, the researchers noted.
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“The associations were strongest in adults aged 50 to 64, particularly in men,” Dr. Xiangwei Li, professor at Shanghai Jiao Tong University School of Medicine and the study’s corresponding author, told Fox News Digital.
“While this does not establish that PFAS cause aging, it suggests that these widely present ‘forever chemicals’ may be linked to molecular changes related to long-term health and aging.”
The study found that two of the compounds were detected in 95% of participants, and higher levels were linked to faster biological aging in men ages 50–64. (iStock)
Midlife may represent a more sensitive biological period, when the body becomes more vulnerable to age-related stressors, according to the researchers.
Lifestyle factors, such as smoking, may influence biological aging markers, potentially increasing vulnerability to environmental pollutants.
While Li said “people should not panic,” she does recommend looking for reasonable ways to reduce exposure.
That might mean checking local drinking water reports, using certified water filters designed to reduce PFAS, and limiting the use of stain- or grease-resistant products when alternatives are available.
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Meaningful reductions in PFAS exposure will likely depend on broader regulatory action and environmental cleanup efforts, Li added.
The researchers noted that midlife could be a particularly sensitive stage, when the body is more susceptible to stressors associated with aging. (iStock)
Study limitations
The researchers outlined several important limitations of the research, including that the findings show an association, but do not prove that PFAS directly causes accelerated aging.
“The study is cross-sectional, meaning exposure and aging markers were measured at the same time, so we cannot determine causality,” Li told Fox News Digital.
The study was also relatively small, limited to 326 adults age 50 or older, which means the findings may not apply to younger people or broader populations.
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Researchers measured PFAS levels using data collected between 1999 and 2000, and today’s exposure patterns may differ.
Li added that while PFAS is known to persist in the environment and the body, these results should be validated through larger, more recent studies that follow participants over time.
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