Health
C.D.C. Site Restores Some Purged Files After ‘Gender Ideology’ Ban Outcry
On Friday, the Centers for Disease Control and Prevention purged from its website thousands of pages that included terms such as “transgender,” “L.G.B.T.” and “pregnant person,” to comply with an executive order barring any material that promoted “gender ideology.”
By Monday, some of the pages had reappeared, in part in response to intense media coverage, backlash from the scientific community and concern for the public’s health, according to a senior official with knowledge of the matter.
The purge had also swept up vaccine information statements, which must be given to patients before they can be immunized; guidelines for contraception; and several pages on how race and racism affect health outcomes. Also removed was a database containing 20 years of H.I.V. data that doctors rely on to determine whether a pregnant woman lives in an area of high H.I.V. prevalence and should be tested for the virus in her third trimester.
Some of these resources were also reinstated, but the return was not entirely smooth. Charts and tables in the H.I.V. database could be reached through a Google search, for instance, but the C.D.C.’s own portal remained broken.
C.D.C. employees are “fully and completely implementing the executive order,” said a senior official who spoke on condition of anonymity for fear of retaliation. But “historical data, articles, and clinical guidelines continue to be available,” the official said. “That essentially is how this is being applied.”
The shake-up accompanied two other directives also aimed at expunging information on certain topics. C.D.C. scientists were ordered late on Friday to withdraw any pending publications, at any scientific journal, that mention the forbidden terms, according to an email viewed by The New York Times.
Separately, a directive prohibiting C.D.C. employees from holding scientific meetings or communicating with other organizations or the public was indefinitely extended on Saturday, when it was expected to lapse, according to another email obtained by The Times.
“I am very fearful and I am very angry about what is happening right now,” said Dr. Ina Park, an expert in H.I.V. and other sexually transmitted infections at the University of California, San Francisco.
The directive also targeted pages on other government websites, including a webpage on Section 1557 of the Affordable Care Act, under the aegis of the Health and Human Services Department. That provision forbids “discrimination on the basis of race, color, national origin, age, disability, or sex (including pregnancy, sexual orientation, gender identity, and sex characteristics), in covered health programs or activities.” It, too, was back online on Monday.
The C.D.C.’s recommendations are the bedrock of clinical practice in the United States. Every hospital’s procedural manuals are filled with the agency’s documents, and clinicians regularly refer to the recommendations, on the website or through the agency’s app.
Now, however, searching for some terms leads to a dead link or to pages that have been stripped of key details, or the search yields a suggestion to explore another topic instead. For instance, a search for the word “abortion” suggests that the user “also try: adoption.”
Some pages — for instance, those on transgender health — were expected to remain absent because they might promote “gender ideology.”
“I have no idea what that term means,” said Dr. Richard Besser, who served as acting director of the C.D.C. in 2009.
“We’re not talking here about ideology — we’re talking about public health,” he added. “We’re talking about people whose lives are being put at risk.”
The disappearance of the pages is already affecting medical care. In Washington State, Dr. Tim Menza, a medical director for King County’s sexual health clinic, worried that hard-won progress against early syphilis in gay and bisexual men would be lost.
Dr. Jessica Weyer, an obstetrician-gynecologist in Concord, N.H., said she could not guide her patients’ choice of contraception without access to the complex eligibility criteria. For instance, the guidelines for birth control include recommendations for patients with various medical conditions. They also list drug interactions that must be taken into account and give providers information on newer methods like vaginal rings.
“If a patient has high blood pressure or migraine headaches, I need to know what’s safe for her,” Dr. Alison Stuebe, an obstetrician-gynecologist in North Carolina, said.
The C.D.C. website is ostensibly being altered to comply with Mr. Trump’s executive orders on diversity, equity, inclusion, accessibility and “defending women.” But vaccine information statements and contraception guidelines are unrelated to those orders, Dr. Weyer said.
“This just seems like a purposeful removal of important information providing safe contraception, which I view as terrifying,” she said. “It sounds like they want to control women, not defend women.”
Although the executive orders did not mention race, several resources on structural racism and health disparities in certain communities also disappeared on Friday.
In the United States, race and ethnicity are strongly linked to health. Black and Native American women are two to three times as likely as white women to die during pregnancy and after childbirth, and their babies face roughly twice the risk of dying before their first birthday. Diabetes, obesity and other chronic diseases are also much more prevalent, and life expectancy is lower, among racial and ethnic minority groups.
Information on racial disparities is crucial for helping health care providers to focus on the groups most at risk, said Linda Goler Blount, president of the Women’s Black Health Imperative, an advocacy group. During the Covid pandemic, she noted, health researchers discovered that pulse oximeter devices, which measure blood oxygen levels, “didn’t work on people with dark skin.” That disparity might have contributed to higher death rates among communities of color.
“If we can’t collect data by race, ethnic identity and gender identity, we’re going to see mortality rates increase,” Ms. Blount said.
Mr. Trump’s orders purged more than 8,000 web pages across more than a dozen U.S. government websites. In some cases, the executive orders also targeted the work of private citizens.
A memo to the federal Agency for Healthcare Research and Quality, which publishes papers from both government and academic researchers, gave employees until 5 p.m. on Friday to scrub the agency’s publication, Patient Safety Network, of terms including “transgender,” “nonbinary,” “L.G.B.T.” and “gender identity.”
Among the roughly 20 research papers that were taken down was one from 2022 detailing how clinicians can better identify emergency room patients at risk of suicide. The paper’s lead author, Dr. Gordon Schiff, is the director of quality and safety for the Harvard Medical School Center for Primary Care; he is not a government scientist. The paper was flagged for a single line: “High risk groups include male sex, being young, veterans, Indigenous tribes, lesbian, gay, bisexual, transgender, queer/questioning (L.G.B.T.Q.).”
Dr. Schiff said he was shocked by the new administration’s “extreme censorship.” “This whole idea that the risk factors or commentary should be based on political ideology rather than data and truth is a pretty scary prospect,” he said.
Some experts are exploring the legality of the administration’s deleting content from federal websites and papers written by C.D.C. scientists. But in the case of Dr. Schiff’s paper, the administration clearly crossed the line, said Larry Gostin, director of the World Health Organization Center on Global Health Law.
“To me, that’s classic viewpoint censorship in violation of the First Amendment,” Mr. Gostin said.
“While the administration may be able to silence government health officials carrying out their official duties, it cannot drag private scientists into its web of censorship,” he added. “And all that censorship for expressing a single word with which the government objects.”
Health
Aging process could accelerate due to ‘forever chemicals’ exposure, study finds
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A new study suggests that middle-aged men may be more vulnerable to faster biological aging, potentially linked to exposure to “forever chemicals.”
The research, published in the journal Frontiers in Aging, examined how perfluoroalkyl and polyfluoroalkyl substances, more commonly known as PFAS, could impact aging at the cellular level.
PFAS are synthetic chemicals commonly used in nonstick cookware, food packaging, water-resistant fabrics and other consumer products, the study noted.
Their chemical structure makes them highly resistant to breaking down, allowing them to accumulate in water, soil and the human body.
Chinese researchers analyzed blood samples from 326 adults enrolled in the U.S. National Health and Nutrition Examination Survey between 1999 and 2000.
A new study suggests that middle-aged men could face accelerated biological aging at the cellular level due to exposure to PFAS. (iStock)
The researchers measured levels of 11 PFAS compounds in participants’ blood and used DNA-based “epigenetic clocks” — tools that analyze chemical changes to DNA to estimate biological age — to determine how quickly their bodies were aging at the cellular level, the study stated.
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Two compounds, perfluorononanoic acid (PFNA) and perfluorooctanesulfonamide (PFOSA), were detected in 95% of participants.
Higher concentrations of those chemicals were associated with faster biological aging in men of certain age groups, but not in women.
“People should not panic.”
The compounds most strongly linked to accelerated aging were not the PFAS chemicals that typically receive the most public attention, the researchers noted.
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“The associations were strongest in adults aged 50 to 64, particularly in men,” Dr. Xiangwei Li, professor at Shanghai Jiao Tong University School of Medicine and the study’s corresponding author, told Fox News Digital.
“While this does not establish that PFAS cause aging, it suggests that these widely present ‘forever chemicals’ may be linked to molecular changes related to long-term health and aging.”
The study found that two of the compounds were detected in 95% of participants, and higher levels were linked to faster biological aging in men ages 50–64. (iStock)
Midlife may represent a more sensitive biological period, when the body becomes more vulnerable to age-related stressors, according to the researchers.
Lifestyle factors, such as smoking, may influence biological aging markers, potentially increasing vulnerability to environmental pollutants.
While Li said “people should not panic,” she does recommend looking for reasonable ways to reduce exposure.
That might mean checking local drinking water reports, using certified water filters designed to reduce PFAS, and limiting the use of stain- or grease-resistant products when alternatives are available.
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Meaningful reductions in PFAS exposure will likely depend on broader regulatory action and environmental cleanup efforts, Li added.
The researchers noted that midlife could be a particularly sensitive stage, when the body is more susceptible to stressors associated with aging. (iStock)
Study limitations
The researchers outlined several important limitations of the research, including that the findings show an association, but do not prove that PFAS directly causes accelerated aging.
“The study is cross-sectional, meaning exposure and aging markers were measured at the same time, so we cannot determine causality,” Li told Fox News Digital.
The study was also relatively small, limited to 326 adults age 50 or older, which means the findings may not apply to younger people or broader populations.
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Researchers measured PFAS levels using data collected between 1999 and 2000, and today’s exposure patterns may differ.
Li added that while PFAS is known to persist in the environment and the body, these results should be validated through larger, more recent studies that follow participants over time.
Health
Melissa Joan Hart, 49, Opens up About Weight Loss in Perimenopause
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Health
Alzheimer’s prevention breakthrough found in decades-old seizure drug
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A drug that has long been used to treat seizures has shown promise as a potential means of Alzheimer’s prevention, a new study suggests.
The anti-seizure medication, levetiracetam, was first approved by the FDA in November 1999 under the brand name Keppra as a therapy for partial-onset seizures in adults. The approval has since expanded to include children and other types of seizures.
Northwestern University researchers recently found that levetiracetam prevented the formation of toxic amyloid beta peptides, which are small protein fragments in the brain that are commonly seen in Alzheimer’s patients.
The medication was found to prevent the formation of amyloid-beta 42 in both animal models and cultured human neurons, according to the study findings, which were published in Science Translational Medicine.
The effect was also seen in post-mortem human brain tissue obtained from individuals with Down syndrome, who are at high risk for Alzheimer’s disease.
The medication was found to prevent the formation of amyloid-beta 42 in both animal models and cultured human neurons. (iStock)
“While many of the Alzheimer’s drugs currently on the market, such as lecanemab and donanemab, are approved to clear existing amyloid plaques, we’ve identified this mechanism that prevents the production of the amyloid‑beta 42 peptides and amyloid plaques,” said corresponding author Jeffrey Savas, associate professor of behavioral neurology at Northwestern University Feinberg School of Medicine, in a press release.
“Our new results uncovered new biology while also opening doors for new drug targets.”
HIDDEN BRAIN CONDITION MAY QUADRUPLE DEMENTIA RISK IN OLDER ADULTS, STUDY SUGGESTS
The brain is better able to avoid the pathway that produces toxic amyloid‑beta 42 proteins in younger years, but the aging process gradually weakens that ability, Savas noted.
“This is not a statement of disease; this is just a part of aging. But in brains developing Alzheimer’s, too many neurons go astray, and that’s when you get amyloid-beta 42 production,” he said.
The effect was also seen in post-mortem human brain tissue obtained from individuals with Down syndrome, who are at high risk for Alzheimer’s disease. (iStock)
That then leads to tau (“tangles”) — abnormal clumps of protein inside brain neurons — which can kill brain cells, trigger neuroinflammation and lead to dementia.
In order for levetiracetam to function as an Alzheimer’s blocker, high-risk patients would have to start taking it “very, very early,” Savas said — up to 20 years before elevated amyloid-beta 42 levels would be detected.
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“You couldn’t take this when you already have dementia, because the brain has already undergone a number of irreversible changes and a lot of cell death,” the researcher noted.
The researchers also did a deep dive into previous human clinical data to determine whether Alzheimer’s patients who were taking the anti-seizure drug had slower cognitive decline. They reported that the patients in that category had a “significant delay” in the span from cognitive decline to death compared to those not taking the drug.
“This analysis supports the positive effect of levetiracetam to slow the progression of Alzheimer’s pathology,” the researcher said. (iStock)
“Although the magnitude of change was small (on the scale of a few years), this analysis supports the positive effect of levetiracetam to slow the progression of Alzheimer’s pathology,” Savas said.
Looking ahead, the research team aims to find people who have genetic forms of Alzheimer’s to participate in testing, Savas said.
Limitations and caveats
The study had several limitations, including that it relied on animal models and cultured cells, with no human trials conducted.
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Because the study was observational in nature, it can’t prove that the medication caused the prevention of the toxic brain proteins, the researchers acknowledged.
Savas noted that levetiracetam “is not perfect,” cautioning that it breaks down in the body very quickly.
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The team is currently working to create a “better version” that would last longer in the body and “better target the mechanism that prevents the production of the plaques.”
“You couldn’t take this when you already have dementia, because the brain has already undergone a number of irreversible changes and a lot of cell death.”
The medication’s common documented side effects include drowsiness, weakness, dizziness, irritability, headache, loss of appetite and nasal congestion.
It has also been linked to potential mood and behavior changes, including anxiety, depression, agitation and aggression, according to the prescribing information. In rare cases, it could lead to severe allergic reactions, skin reactions, blood disorders and suicidal ideation.
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Funding for the study was provided by the National Institutes of Health and the Cure Alzheimer’s Fund.
Fox News Digital reached out to the drug manufacturer and the researchers for comment.
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