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BA.5 omicron variant may lead to higher risk for reinfection and severe outcomes, compared to other variants

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BA.5 omicron variant may lead to higher risk for reinfection and severe outcomes, compared to other variants

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The next is a abstract of some latest research on COVID-19. They embody analysis that warrants additional research to corroborate the findings and that has but to be licensed by peer evaluation.

Reinfections, extreme outcomes could also be extra frequent with BA.5.

In contrast with the sooner Omicron BA.2 subvariant, at present dominant Omicron BA.5 is linked with larger odds of inflicting a second SARS-COV-2 an infection no matter vaccination standing, a research from Portugal suggests.

A nurse administers a dose of the “Cominarty” Pfizer-BioNTech coronavirus illness (COVID-19) vaccine to a affected person at a vaccination middle in Ancenis-Saint-Gereon, France, November 17, 2021.
(REUTERS/Stephane Mahe/File Picture/File Picture)

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From late April by means of early June, researchers there studied 15,396 adults contaminated with the BA.2 variant and 12,306 contaminated with BA.5. Vaccines and boosters have been equally efficient towards each sublineages, in keeping with a report posted on Monday on medRxiv forward of peer evaluation. Nonetheless, 10% of BA.5 circumstances have been reinfections, in comparison with 5.6% of BA.2 circumstances, which suggests a discount in safety conferred by earlier an infection towards BA.5 in comparison with BA.2, the researchers mentioned. Furthermore, the vaccines seemed to be much less efficient in decreasing the chance of extreme outcomes for BA.5 in contrast with BA.2.

AS THE BA.5 OMICRON SUBVARIANT SURGES, VACCINE EXPERTS URGE HIGH RISK PEOPLE TO GET COVID-19 BOOSTER NOW

“Amongst these contaminated with BA.5, booster vaccination was related to 77% and 88% discount in threat of COVID-19 hospitalization and demise, respectively, whereas larger threat discount was discovered for BA.2 circumstances, with 93% and 94%, respectively,” the researchers wrote. Whereas “COVID-19 booster vaccination nonetheless gives substantial safety towards extreme outcomes following BA.5 an infection,” they mentioned, their findings present “proof to regulate public well being measures throughout the BA.5 surge.”

Virus spike protein damages coronary heart muscle cells

The spike protein on its floor that the coronavirus makes use of to interrupt into coronary heart muscle cells additionally triggers a dangerous assault from the immune system, in keeping with new analysis.

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Eric Aviles, 6, receives the Pfizer COVID-19 vaccine from pharmacist Sylvia Uong at a pediatric vaccine clinic for children ages 5 to 11 set up at Willard Intermediate School in Santa Ana, Calif., on Nov. 9.

Eric Aviles, 6, receives the Pfizer COVID-19 vaccine from pharmacist Sylvia Uong at a pediatric vaccine clinic for youngsters ages 5 to 11 arrange at Willard Intermediate College in Santa Ana, Calif., on Nov. 9.
(AP/Jae C. Hong)

The SARS-CoV-2 spike protein interacts with different proteins in cardiac myocytes to trigger irritation, researchers mentioned on Wednesday in a presentation on the American Coronary heart Affiliation’s Fundamental Cardiovascular Sciences Scientific Classes 2022. In experiments with mice hearts, evaluating the results of SARS-CoV2 spike proteins and spike proteins from a special, comparatively innocent coronavirus, the researchers discovered that solely the SARS-CoV-2 spike protein brought on coronary heart dysfunction, enlargement, and irritation. Additional, they discovered, in contaminated coronary heart muscle cells solely the SARS-CoV-2 spike interacted with so-called TLR4 proteins (Toll-like receptor-4) that acknowledge invaders and set off inflammatory responses. In a deceased affected person with COVID-19 irritation, the researchers discovered the SARS-CoV-2 spike protein and TLR4 protein in each coronary heart muscle cells and different cell sorts. Each have been absent in a biopsy of a wholesome human coronary heart.

“Which means as soon as the center is contaminated with SARS-CoV-2, it can activate the TLR4 signaling,” Zhiqiang Lin of the Masonic Medical Analysis Institute in Utica, New York mentioned in a press release. “We supplied direct proof that spike protein is poisonous to the center muscle cells and narrowed down the underlying mechanism as spike protein straight inflames the center muscle cells,” he instructed Reuters. “Extra work is being executed in my lab to check whether or not and the way spike protein kills coronary heart muscle cells.”

Omicron-targeted antibody combo nears human trials

A brand new monoclonal antibody mixture can forestall and deal with Omicron infections in monkeys, researchers reported on Monday in Nature Microbiology.

The antibodies, known as P2G3 and P5C3, acknowledge particular areas of the spike protein the SARS-CoV-2 virus makes use of to enter cells. “P5C3 alone can block all SARS-CoV-2 variants that had dominated the pandemic as much as Omicron BA.2,” mentioned Dr. Didier Trono of the Swiss Institute of Know-how in Lausanne. “P2G3 then involves the rescue because it not solely can neutralize all earlier SARS-CoV-2 variants of concern, however it might probably additionally block BA.4 and BA.5,” he mentioned. “P2G3 is even efficient towards some BA.2 or BA.4/BA.5 mutants able to escaping (Eli Lilly’s) bebtelovimab, the one antibody authorised for the clinics nonetheless displaying exercise towards the at present dominant BA.4/BA.5 subvariants.”

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OMICRON BA.5 SPIKES TO 82% OF COVID CASES IN US, SAYS CDC

In lab experiments, mutations which may make SARS-CoV-2 variants immune to P2G3 didn’t enable escape from P5C3, and P5C3 escape mutants have been nonetheless blocked by P2G3, Trono mentioned. “In essence, the 2 antibodies cowl for one another, one filling in for the lapses of the opposite and vice versa.”

Aerium Therapeutics plans to start out testing the mixture in people subsequent month, mentioned Trono, who’s among the many firm’s founders. If bigger trials finally affirm its effectiveness, the P5C3/P2G3 mixture might be given by injection each three-to-six months to people who find themselves immunocompromised and would not have a powerful response to COVID-19 vaccines, the corporate has mentioned.

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How The Great British Bake Off Host Alison Hammond Lost 150 Lbs Naturally

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How The Great British Bake Off Host Alison Hammond Lost 150 Lbs Naturally


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Alison Hammond’s Weight Loss: How She Shed 150 Lbs | Woman’s World




















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One state leads country in human bird flu with nearly 40 confirmed cases

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One state leads country in human bird flu with nearly 40 confirmed cases

A child in California is presumed to have H5N1 bird flu, according to the San Francisco Department of Public Health (SFDPH).

As of Dec. 23, there had been 36 confirmed human cases of bird flu in the state, according to the California Department of Public Health (CDPH).

This represents more than half of the human cases in the country.

LOUISIANA REPORTS FIRST BIRD FLU-RELATED HUMAN DEATH IN US

The latest pediatric patient, who lives in San Francisco, experienced fever and conjunctivitis (pink eye) as a result of the infection.

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The unnamed patient was not hospitalized and has fully recovered, according to the SFDPH.

A child in California is presumed to have H5N1 bird flu, according to the San Francisco Department of Public Health. (iStock)

The child tested positive for bird flu at the SFDPH Public Health Laboratory. The U.S. Centers for Disease Control and Prevention (CDC) will perform additional tests to confirm the result.

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It is not yet known how the child was exposed to the virus and an investigation is ongoing.

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“I want to assure everyone in our city that the risk to the general public is low, and there is no current evidence that the virus can be transmitted between people,” said Dr. Grant Colfax, director of health, in the press release. 

BIRD FLU PATIENT HAD VIRUS MUTATIONS, SPARKING CONCERN ABOUT HUMAN SPREAD

“We will continue to investigate this presumptive case, and I am urging all San Franciscans to avoid direct contact with sick or dead birds, especially wild birds and poultry. Also, please avoid unpasteurized dairy products.” 

Samuel Scarpino, director of AI and life sciences and professor of health sciences at Northeastern University in Boston, is calling for “decisive action” to protect individuals who may be in contact with infected livestock and also to alert the public about the risks associated with wild birds and infected backyard flocks. 

Chick bird flu test

An infectious diseases expert called for “decisive action” to alert the public about the risks associated with wild birds and infected backyard flocks.  (iStock)

“While I agree that the risk to the broader public remains low, we continue to see signs of escalating risk associated with this outbreak,” he told Fox News Digital.

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Experts have warned that the possibility of mutations in the virus could enable person-to-person transmission.

     

“While the H5N1 virus is currently thought to only transmit from animals to humans, multiple mutations that can enhance human-to-human transmission have been observed in the severely sick American,” Dr. Jacob Glanville, CEO of Centivax, a San Francisco biotechnology company, told Fox News Digital.

Split image of cows and bird flu vial

As of Jan. 10, there have been a total of 707 infected cattle in California, per reports from the California Department of Food and Agriculture. (iStock)

“This highlights the requirement for vigilance and preparation in the event that additional mutations create a human-transmissible pandemic strain.”

As of Jan. 10, there have been a total of 707 infected cattle in California, per reports from the California Department of Food and Agriculture (CDFA).

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In the last 30 days alone, the virus has been confirmed in 84 dairy farms in the state.

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Chronic Pain Afflicts Billions of People. It’s Time for a Revolution.

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Chronic Pain Afflicts Billions of People. It’s Time for a Revolution.

“In the beginning, everyone thought they were going to find this one breakthrough pain drug that would replace opioids,” Gereau said. Increasingly, though, it’s looking like chronic pain, like cancer, could end up having a range of genetic and cellular drivers that vary both by condition and by the particular makeup of the person experiencing it. “What we’re learning is that pain is not just one thing,” Gereau added. “It’s a thousand different things, all called ‘pain.’”

For patients, too, the landscape of chronic pain is wildly varied. Some people endure a miserable year of low-back pain, only to have it vanish for no clear reason. Others aren’t so lucky. A friend of a friend spent five years with extreme pain in his arm and face after roughhousing with his son. He had to stop working, couldn’t drive, couldn’t even ride in a car without a neck brace. His doctors prescribed endless medications: the maximum dose of gabapentin, plus duloxetine and others. At one point, he admitted himself to a psychiatric ward, because his pain was so bad that he’d become suicidal. There, he met other people who also became suicidal after years of living with terrible pain day in and day out.

The thing that makes chronic pain so awful is that it’s chronic: a grinding distress that never ends. For those with extreme pain, that’s easy to understand. But even less severe cases can be miserable. A pain rating of 3 or 4 out of 10 sounds mild, but having it almost all the time is grueling — and limiting. Unlike a broken arm, which gets better, or tendinitis, which hurts mostly in response to overuse, chronic pain makes your whole world shrink. It’s harder to work, and to exercise, and even to do the many smaller things that make life rewarding and rich.

It’s also lonely. When my arms first went crazy, I could barely function. But even after the worst had passed, I saw friends rarely; I still couldn’t drive more than a few minutes, or sit comfortably in a chair, and I felt guilty inviting people over when there wasn’t anything to do. As Christin Veasley, director and co-founder of the Chronic Pain Research Alliance, puts it: “With acute pain, medications, if you take them, they get you over a hump, and you go on your way. What people don’t realize is that when you have chronic pain, even if you’re also taking meds, you rarely feel like you were before. At best, they can reduce your pain, but usually don’t eliminate it.”

A cruel Catch-22 around chronic pain is that it often leads to anxiety and depression, both of which can make pain worse. That’s partly because focusing on a thing can reinforce it, but also because emotional states have physical effects. Both anxiety and depression are known to increase inflammation, which can also worsen pain. As a result, pain management often includes cognitive behavioral therapy, meditation practice or other coping skills. But while those tools are vital, it’s notoriously hard to reprogram our reactions. Our minds and bodies have evolved both to anticipate pain and to remember it, making it hard not to worry. And because chronic pain is so uncomfortable and isolating, it’s also depressing.

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