Health
Ancient Egyptians attempted to surgically remove brain cancer from skull 4,000 years ago, study finds
Lesions found in ancient skulls suggest that cancer could have been a medical issue long before our time.
Ancient Egyptian skulls studied at the Duckworth Laboratory Collection at the University of Cambridge in the U.K. have shown signs of varying lesions, some believed to be left by malignant tumors.
The case report, published in the journal Frontiers in Medicine, found that a skull labeled E270, which belonged to a woman in her 50s, had healed cranial injuries made potentially by a sharp object.
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The evidence indicates that the woman survived, thanks to “some kind of treatment and degree of post-traumatic care,” the researchers wrote.
Skull 236, belonging to a male in his 30s, was shown to have cut marks on the bone surface that suggest a tumor had been removed.
Skull E270 is shown at the base of a microscope. The skull had healed cranial injuries potentially caused by a sharp object. (Tatiana Tondini, Albert Isidro, Edgard Camarós, 2024)
While these findings indicate “medical surgical exploration,” the researchers were unable to identify the timing of the cutting – before or after death.
“Applying scientific methodologies to archeology allows us to make new discoveries about the past.”
These surgical procedures could have been practiced during the Middle and Upper Paleolithic and Neolithic periods, the researchers concluded.
“In this context, it becomes clear that caring for others, including wound care, is a key behavior among humans that has also been observed in non-human primates,” they wrote.
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First study author Tatiana Tondini, a researcher at the University of Tübingen in Germany, discussed the results with Fox News Digital, noting that the most “remarkable finding” was the discovery of cut marks near “two secondary cancer lesions” on skull 236.
“They have been confirmed not to be taphonomic (environmental) damages, and there are two explanations for them,” she said.
Skull 236, pictured here, was shown to have two “secondary cancer lesions.” (Tatiana Tondini, Albert Isidro, Edgard Camarós, 2024)
The first possible explanation is that the ancient Egyptians attempted a surgical removal of the secondary tumors, “which would make it the first recorded cancer surgical operation in history, but we cannot confirm that,” Tondini said.
The second possibility is that the ancient Egyptians made those cut marks while examining the man after he passed away.
“Caring for others, including wound care, is a key behavior among humans.”
“This would also be remarkable, as it means that the ancient Egyptians were studying cancer,” the researcher said.
Another important discovery, according to Tondini, was the successful treatment of skull E270, which had traces of a lesion left by a sharp object like a sword or hatchet.
Skull E270, pictured here, had traces of a lesion left by a sharp object like a sword or hatchet. (Tatiana Tondini, Albert Isidro, Edgard Camarós, 2024)
“It is very unlikely that the individual would have made it without proper treatment,” she said.
“We can see that the individual survived, as the fracture has clear signs of healing, which means ancient Egyptians were able to treat severe cranial fractures.”
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An accident or act of domestic violence was the most likely cause of the woman’s head injury, according to Tondini, although the depth of the wound and the sign of brutality could point to a battle wound.
“If that is the case, we should reconsider the role of women in Ancient Egypt,” she said. “It is known that women had more rights in Ancient Egypt compared to Rome and Greece, but warfare duties have always been associated with men.”
A fragment of wall painting depicts the transport of ointments, found in the tomb of Metchetchi at Saqqara in Egypt. (DEA/G. DAGLI ORTI/De Agostini via Getty Images)
As the skulls were “very old” and “very fragile,” Tondini said it was difficult to assess the damage with the naked eye.
“But using a powerful microscope, it was possible to characterize most lesions,” she said. “For some more complex ones, the micro-CT scan allowed us to analyze the internal structure of a lesion and determine its cause.”
‘Cancer culture’
Based on the findings from skull 236, the researchers believe that cancer is not only a modern disease caused by unhealthy lifestyles and exposure to carcinogens, but that it was also present in ancient populations — though at lower rates, according to Tondini.
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Tondini admitted that she and her fellow researchers did not expect these findings before investigating these two “very rare” pieces of history.
“I remember I was analyzing skull 236 with the microscope to characterize its lesions,” she told Fox News Digital. “When I got to the first lesion that had those cut marks, I initially was a bit unsure of what I was looking at.”
A lesion inside skull 236 shows cut marks identified under the microscope. (Tatiana Tondini, Albert Isidro, Edgard Camarós, 2024)
“I asked my colleague, Dr. Camaros, who was also very surprised about the discovery,” she continued. “We characterized the cut marks and confirmed they were manmade and occurred before or immediately after the death of the individual.”
Within a few minutes, Tondini said, the laboratory was “filled with other researchers, technicians and professors, who were all around the microscope looking at the lesions and could not believe their eyes.”
Neurosurgeon’s take
Dr. Paul Saphier, M.D., a neurosurgeon and founder of Coaxial Neurosurgical Specialists in New Jersey, commented that while this new research is interesting, there has been similar evidence of neurosurgical procedures dating back to the Mesolithic period, around 6000 B.C.
“These early surgeries [known as trepanning] were usually small holes in the skull with limited surgical extent,” Saphier, who was not involved in the skull research at hand, told Fox News Digital.
A medieval surgeon performs a “trepanning” operation on a patient’s skull, circa 1350. (Hulton Archive/Getty Images)
“Clearly, our ability to perform complex neurosurgical procedures was limited by technology, mostly radiographic (CT/MRI imaging) and direct surgical visualization.”
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The neurosurgeon added, “With these advances, as well as anesthesia and critical care medicine, we have been able to tackle more sophisticated cases, large in scope and extent.”
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In an “ironic twist,” he said, recently there’s been a “tremendous reversal toward a more minimally invasive approach” in cranial neurosurgery.
“This has been heralded by newer tech and an outspoken group of advanced cranial neurosurgeons championing these advances, of which I am proud to be a member of,” Saphier added.
Skull 236, at left, and skull E270, right, revealed interesting findings about ancient medicine. (Tatiana Tondini, Albert Isidro, Edgard Camarós, 2024)
“So ironically, what is old may … actually be new again.”
Tondini said she hopes the study findings will inspire more research on “cancer cases in antiquities using non-destructive techniques.”
“For other researchers and the public, applying scientific methodologies to archeology allows us to make new discoveries about the past,” she said.
Today, you’re going to do perhaps the single best thing for your brain.
When I asked neurologists about their top behaviors for brain health, they all stressed the importance of physical activity.
“Exercise is top, No. 1, when we’re thinking about the biggest bang for your buck,” said Dr. Gregg Day, a neurologist at the Mayo Clinic.
Numerous studies have shown that people who exercise regularly tend to perform better on attention, memory and executive functioning tests. There can be a small cognitive boost immediately after a workout, and the effects are sustained if people exercise consistently. And while staying active can’t guarantee you won’t develop dementia, over the long term, it is associated with a lower risk of it.
Researchers think that moving your muscles benefits your brain in part because of special signaling molecules called exerkines. During and after a workout, your muscles, fat and other organs release these molecules into the bloodstream, some of which make their way up to the brain. There, those exerkines go to work, helping to facilitate the growth of new connections between neurons, the repair of brain cells and, possibly, the birth of new neurons.
Exercise also appears to improve blood flow in the brain. That ramps up the delivery of good things to brain cells, like oxygen, glucose and those amazing exerkines. And it helps remove more bad things, namely toxic proteins, like amyloid, that can build up and damage brain cells, increasing the risk for Alzheimer’s.
All of the changes brought on by exercise are “essentially allowing your brain to age more slowly than if you’re physically inactive,” said Kirk Erickson, the chair of neuroscience at the AdventHealth Research Institute.
The benefits are particularly pronounced in the hippocampus, a region critical for learning and memory. In older adults, the hippocampus shrinks 1 to 2 percent a year, and it is one of the main areas affected by Alzheimer’s. Researchers think physical activity helps to offset some of that loss.
The best exercise you can do for your brain is the one you’ll do consistently, so find something that you enjoy and that fits easily into your life.
Walking is one option; two neurologists I spoke to said they got their exercise in by walking at least part of the way to their offices. Recent research suggests that just a few thousand steps a day can reduce the risk of dementia. It’s important to get your heart rate up, though, so “walk as though you’re trying to get somewhere on time,” said Dr. Linda Selwa, a clinical professor of neurology at the University of Michigan Medical School.
Or you could try swimming, cycling, Pilates, weight lifting, yoga, pickleball, dancing, gardening — any type of physical exertion can be beneficial.
If the thought of working out feels like a drag, try pairing it with something else you enjoy doing, like listening to an audiobook. This is a trick that Katherine Milkman, a professor who studies habits at The Wharton School of the University of Pennsylvania, calls “temptation bundling.”
For Day 3, we’re asking you to spend at least 20 minutes exercising for your brain. Go for a walk with your accountability partner if they’re nearby. (If not, call them and do a walk-and-talk.) Or let us find you a new workout to try, using the tool below. As usual, we can all meet in the comments to catch up and check in.
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Recent studies continue to support a decades-old drug as an alternative means of reducing alcohol consumption.
The prescription opioid pill, called naltrexone, was first approved by the FDA to treat opioid dependence in 1984. A decade later, it was approved for alcohol use disorder.
In addition to the daily pill version, naltrexone is also available as a monthly injectable therapy, which was approved for alcohol use disorder in 2006 and opioid use disorder in 2010.
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How it works
Naltrexone works by blocking opioid receptors in the brain. For those dependent on opioids, it blocks the “euphoric” effects of the drugs and also curbs cravings for alcohol, according to experts.
The prescription opioid pill, called naltrexone, was first approved by the FDA to treat opioid dependence in 1984. A decade later, it was approved for alcohol use disorder. (iStock)
“Naltrexone can be used to assist with reducing alcohol cravings and reduce the pleasurable effects from alcohol ingestion, which can help those prone to binge-drinking to consume less volume,” Dr. David Campbell, clinical director and program director at Recover Together, a behavioral health and addiction treatment facility in Bend, Oregon, told Fox News Digital.
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The medication is useful for people who experience strong cravings, often drink to excess once they start, or drink primarily due to reward or relief as opposed to habit, according to Campbell.
“Naltrexone affects the rewards center of the brain, which blocks the rewarding effects of alcohol.”
Jessica Steinman, chief clinical officer at No Matter What Recovery in Los Angeles, calls naltrexone “an incredibly helpful and life-saving tool” for people who struggle with alcohol use disorder.
“Currently, in our society, many people are looking to get medication-assisted help from overconsumption of certain things or behaviors, including food, cigarettes and now alcohol,” she told Fox News Digital.
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“Naltrexone affects the rewards center of the brain, which blocks the rewarding effects of alcohol and cravings to be minimized. It can assist in telling the brain that alcohol isn’t wanted.”
The drug can also help if someone has a “healthy” relationship with alcohol and is looking to cut back on their drinking behaviors, Steinman added.
“We do not suggest moderation in any way for people struggling with alcohol use disorder or any type of dependence to alcohol or other substances,” she noted. “We do not believe drinking ‘less’ is a solution.”
Side effects
Common side effects of naltrexone can include nausea and vomiting, headache, sleep disturbances, dizziness, fatigue, anxiety, loss of appetite, and joint or muscle pain, according to the Substance Abuse and Mental Health Services Administration (SAMHSA).
These effects are generally mild and may improve as the body adjusts to the medication.
The medication is useful for people who experience strong cravings, often drink to excess once they start, or drink primarily due to reward or relief as opposed to habit. (iStock)
In rare cases, patients may experience more severe effects, such as liver issues, allergic reactions, trouble breathing and mental health effects.
“The most important thing when taking naltrexone for alcohol use is to ensure that there is no concurrent use of opioids, as taking naltrexone when using opioids can induce precipitated withdrawal, a very uncomfortable event,” Campbell cautioned.
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More than 50% of U.S. adults drink alcohol, about 17% are classified as binge-drinkers and about 6% drink heavily, according to CDC data.
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Each year, around 178,000 deaths in the country are linked to excessive alcohol use.
“Heavy alcohol consumption and binge-drinking can lead to many health problems and make chronic health conditions worse, so reducing alcohol intake can really improve health,” Donita Robinson, Ph.D., an associate professor of psychiatry at the UNC School of Medicine in North Carolina, told Fox News Digital.
More than 50% of U.S. adults drink alcohol, about 17% are classified as binge-drinkers and about 6% drink heavily. (iStock)
“Naltrexone helps many people reduce their drinking – it’s an effective medication to reduce alcohol craving and heavy drinking, and it works best in combination with counseling or other therapy.”
Robinson reiterated that people who are on opioid medications, including some painkillers, shouldn’t take naltrexone, as it can block their effectiveness and cause opioid withdrawal.
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Naltrexone is available with a prescription from a licensed healthcare provider, such as a primary care doctor, addiction medicine specialist or psychiatrist.
Health officials warn against purchasing the drug online or without a prescription, as it may be counterfeit and unsafe.
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Those interested in exploring whether naltrexone is an option for them should see a doctor, who can assess the safety of the drug based on the patient’s medical status and history.
They should also “make sure they have their goals and intentions in line before using a medication like this,” according to Steinman.
Welcome to Day 2 of the Brain Health Challenge. Today, we’re talking about food.
Your brain is an energy hog. Despite comprising about 2 percent of the average person’s body mass, it consumes roughly 20 percent of the body’s energy. In other words, what you use to fuel yourself matters for brain health.
So what foods are best for your brain?
In a nine-year study of nearly 1,000 older adults, researchers at Rush University in Chicago found that people who ate more of nine particular types of food — berries, leafy greens, other vegetables, whole grains, beans, nuts, fish, poultry and olive oil — and who ate less red meat, butter and margarine, cheese, sweet treats and fried food had slower cognitive decline.
Based on these findings, the researchers developed the MIND diet.
Large studies encompassing thousands of people have since shown that following the MIND diet corresponds with better cognitive functioning, a lower risk of dementia and slower disease progression in people with Alzheimer’s. People benefit from the diet regardless of whether they start it in midlife or late life.
Experts think the foods included in the MIND diet are especially good for the brain because they contain certain macro and micronutrients.
Berries and leafy greens, for example, are rich in polyphenols and other antioxidants, said Jennifer Ventrelle, a dietitian at Rush and a co-author of “The Official Mind Diet.” Many of these compounds can cross the blood-brain barrier and help to fight inflammation and oxidative stress, both of which can damage cells and are linked to dementia.
Nuts and fatty fishes, like salmon and sardines, contain omega-3 fatty acids, which are important for building the insulating sheaths that surround the nerve fibers that carry information from one brain cell to another.
Whole grains and beans both contain a hefty dose of fiber, which feeds the good microbes in the gut. Those microbes produce byproducts called short-chain fatty acids that experts think can influence brain health via the gut-brain axis.
You don’t have to revamp your whole diet to get these nutrients. Instead, think about “MIND-ifying” whatever you already tend to eat, said Dr. Joel Salinas, a neurologist at NYU Langone Health and the founder and chief medical officer of the telehealth platform Isaac Health. For instance, add a handful of nuts or berries to your breakfast.
Today’s activity will help you MIND-ify your own meals. Share your choices with your accountability partner and in the comments, and I’ll discuss the ways I’m adjusting my diet, too. For added inspiration, check out these MIND-approved recipes from New York Times Cooking.
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