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Alzheimer’s blood test achieves faster diagnoses, high accuracy at Mayo Clinic

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Alzheimer’s blood test achieves faster diagnoses, high accuracy at Mayo Clinic

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With nearly seven million Americans currently living with Alzheimer’s disease — and 13 million projected to have the illness by 2050 — early diagnosis and treatment are more urgent than ever.

To help address this, Mayo Clinic has announced a new, non-invasive blood test that detects a protein in the brain that signals Alzheimer’s.

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The goal, doctors say, is for this test to offer a convenient, less invasive alternative to traditional diagnostic methods.

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Fox News Digital spoke to Dr. Alicia Algeciras-Schimnich, professor of laboratory medicine and pathology at Mayo Clinic Rochester in Minnesota, about the new test and what it means for Alzheimer’s patients and their families.

“This is the first Alzheimer’s disease blood test offered at Mayo Clinic Laboratories,” said Algeciras-Schimnich, who led the clinical validation study to gauge how well the test performed.

A new, non-invasive blood test detects a protein in the brain that signals Alzheimer’s, Mayo Clinic (not pictured) announced. (iStock)

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“While there are other commercial blood tests for Alzheimer’s disease, the uniqueness of our test is its high accuracy rate.”

How does it work?

One of the hallmark features in the brains of patients with Alzheimer’s disease is the formation of plaque containing a protein known as beta amyloid.  

“The pTau217 assay assesses the accumulation of beta amyloid in the brain by measuring the amount of phosphorylated Tau 217 (p-Tau217) in the test sample,” said Algeciras-Schimnich.

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Accumulation of beta amyloid in the brain can also be evaluated by imaging techniques, such as PET scans or cerebrospinal fluid (CSF) biomarkers, the doctor noted — but those methods have some limitations. 

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“The PET scan to evaluate beta amyloid is expensive and not a widely available technology,” said Algeciras-Schimnich. 

Mayo Clinic

The Mayo Clinic is a nonprofit medical practice and medical research group based in Rochester, Minnesota. Mayo Clinic has announced a new, non-invasive blood test to help determine if patients have Alzheimer’s. (iStock)

“And the CSF collection requires an invasive technique to remove spinal fluid, so it is also not widely used.”

The Alzheimer’s disease blood biomarkers serve as a non-invasive tool that can improve access for patients who need answers, she said.

How accurate is it?

In patients with symptoms of cognitive decline, the blood test has a sensitivity of 92% and a specificity of 96%. 

“Sensitivity measures the ability of the test to correctly identify patients with the disease, while specificity measures the ability of the test to correctly identify those without the disease,” Algeciras-Schimnich explained.

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“A blood-based test not only offers convenience, but could help transform Alzheimer’s disease research.”

Patients who take the test are classified as positive or negative for the presence of the accumulation of beta amyloid. 

“In a small number of patients, the test will not be able to differentiate between the presence or absence of beta amyloid,” said Algeciras-Schimnich.  

Woman blood draw

Patients who take the test are classified as positive or negative for the presence of the accumulation of beta amyloid.  (iStock)

“These patients will need additional tests to determine if they are positive or negative for the accumulation of beta amyloid.”

The test is purposely designed to minimize the number of false positive results as compared to other tests, the doctor said.

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“The test has been validated at Mayo Clinic through a rigorous quality process backed by scientific experts and clinicians,” Algeciras-Schimnich said.

The test is currently available for clinicians to order through Mayo Clinic Laboratories. 

Alzheimer’s disease

Evidence of Alzheimer’s disease is seen on PET scans at the Center for Alzheimer Research and Treatment (CART) at Brigham and Women’s Hospital in Boston, Massachusetts, March 2023. (REUTERS/Brian Snyder/File Photo)

“Since it is a blood test, it requires a blood draw by a phlebotomist, so anyone who is averse to blood should be aware,” said Algeciras-Schimnich.

At this point, the test is only recommended for individuals 50 years of age and older who have symptoms of mild cognitive impairment or mild dementia.

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“We don’t yet have enough data to support how the test performs in younger individuals,” Algeciras-Schimnich said.

Michelle Rankine, PhD, a certified dementia practitioner in Texas, is not associated with Mayo Clinic but shared her comments on the test’s potential.

A PET scan in Washington, D.C.

Accumulation of beta amyloid in the brain can also be evaluated by imaging techniques, such as PET scans or cerebrospinal fluid (CSF) biomarkers, the doctor noted — but those methods have some limitations.  (Michael Robinson Chávez/The Washington Post)

“As the global burden of Alzheimer’s continues to rise, a blood-based test not only offers convenience, but could help transform Alzheimer’s disease research,” Rankine told Fox News Digital. 

“This could make screening more efficient in averting the clinical onset of Alzheimer’s disease.”

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For more Health articles, visit www.foxnews/health 

“This innovation addresses a growing need and could accelerate development of new treatments, improve patient evaluation and care, and potentially even allow for early intervention before symptoms become worse,” Rankine added.

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How The Great British Bake Off Host Alison Hammond Lost 150 Lbs Naturally

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How The Great British Bake Off Host Alison Hammond Lost 150 Lbs Naturally


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One state leads country in human bird flu with nearly 40 confirmed cases

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One state leads country in human bird flu with nearly 40 confirmed cases

A child in California is presumed to have H5N1 bird flu, according to the San Francisco Department of Public Health (SFDPH).

As of Dec. 23, there had been 36 confirmed human cases of bird flu in the state, according to the California Department of Public Health (CDPH).

This represents more than half of the human cases in the country.

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The latest pediatric patient, who lives in San Francisco, experienced fever and conjunctivitis (pink eye) as a result of the infection.

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The unnamed patient was not hospitalized and has fully recovered, according to the SFDPH.

A child in California is presumed to have H5N1 bird flu, according to the San Francisco Department of Public Health. (iStock)

The child tested positive for bird flu at the SFDPH Public Health Laboratory. The U.S. Centers for Disease Control and Prevention (CDC) will perform additional tests to confirm the result.

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It is not yet known how the child was exposed to the virus and an investigation is ongoing.

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“I want to assure everyone in our city that the risk to the general public is low, and there is no current evidence that the virus can be transmitted between people,” said Dr. Grant Colfax, director of health, in the press release. 

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“We will continue to investigate this presumptive case, and I am urging all San Franciscans to avoid direct contact with sick or dead birds, especially wild birds and poultry. Also, please avoid unpasteurized dairy products.” 

Samuel Scarpino, director of AI and life sciences and professor of health sciences at Northeastern University in Boston, is calling for “decisive action” to protect individuals who may be in contact with infected livestock and also to alert the public about the risks associated with wild birds and infected backyard flocks. 

Chick bird flu test

An infectious diseases expert called for “decisive action” to alert the public about the risks associated with wild birds and infected backyard flocks.  (iStock)

“While I agree that the risk to the broader public remains low, we continue to see signs of escalating risk associated with this outbreak,” he told Fox News Digital.

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Experts have warned that the possibility of mutations in the virus could enable person-to-person transmission.

     

“While the H5N1 virus is currently thought to only transmit from animals to humans, multiple mutations that can enhance human-to-human transmission have been observed in the severely sick American,” Dr. Jacob Glanville, CEO of Centivax, a San Francisco biotechnology company, told Fox News Digital.

Split image of cows and bird flu vial

As of Jan. 10, there have been a total of 707 infected cattle in California, per reports from the California Department of Food and Agriculture. (iStock)

“This highlights the requirement for vigilance and preparation in the event that additional mutations create a human-transmissible pandemic strain.”

As of Jan. 10, there have been a total of 707 infected cattle in California, per reports from the California Department of Food and Agriculture (CDFA).

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In the last 30 days alone, the virus has been confirmed in 84 dairy farms in the state.

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Chronic Pain Afflicts Billions of People. It’s Time for a Revolution.

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Chronic Pain Afflicts Billions of People. It’s Time for a Revolution.

“In the beginning, everyone thought they were going to find this one breakthrough pain drug that would replace opioids,” Gereau said. Increasingly, though, it’s looking like chronic pain, like cancer, could end up having a range of genetic and cellular drivers that vary both by condition and by the particular makeup of the person experiencing it. “What we’re learning is that pain is not just one thing,” Gereau added. “It’s a thousand different things, all called ‘pain.’”

For patients, too, the landscape of chronic pain is wildly varied. Some people endure a miserable year of low-back pain, only to have it vanish for no clear reason. Others aren’t so lucky. A friend of a friend spent five years with extreme pain in his arm and face after roughhousing with his son. He had to stop working, couldn’t drive, couldn’t even ride in a car without a neck brace. His doctors prescribed endless medications: the maximum dose of gabapentin, plus duloxetine and others. At one point, he admitted himself to a psychiatric ward, because his pain was so bad that he’d become suicidal. There, he met other people who also became suicidal after years of living with terrible pain day in and day out.

The thing that makes chronic pain so awful is that it’s chronic: a grinding distress that never ends. For those with extreme pain, that’s easy to understand. But even less severe cases can be miserable. A pain rating of 3 or 4 out of 10 sounds mild, but having it almost all the time is grueling — and limiting. Unlike a broken arm, which gets better, or tendinitis, which hurts mostly in response to overuse, chronic pain makes your whole world shrink. It’s harder to work, and to exercise, and even to do the many smaller things that make life rewarding and rich.

It’s also lonely. When my arms first went crazy, I could barely function. But even after the worst had passed, I saw friends rarely; I still couldn’t drive more than a few minutes, or sit comfortably in a chair, and I felt guilty inviting people over when there wasn’t anything to do. As Christin Veasley, director and co-founder of the Chronic Pain Research Alliance, puts it: “With acute pain, medications, if you take them, they get you over a hump, and you go on your way. What people don’t realize is that when you have chronic pain, even if you’re also taking meds, you rarely feel like you were before. At best, they can reduce your pain, but usually don’t eliminate it.”

A cruel Catch-22 around chronic pain is that it often leads to anxiety and depression, both of which can make pain worse. That’s partly because focusing on a thing can reinforce it, but also because emotional states have physical effects. Both anxiety and depression are known to increase inflammation, which can also worsen pain. As a result, pain management often includes cognitive behavioral therapy, meditation practice or other coping skills. But while those tools are vital, it’s notoriously hard to reprogram our reactions. Our minds and bodies have evolved both to anticipate pain and to remember it, making it hard not to worry. And because chronic pain is so uncomfortable and isolating, it’s also depressing.

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