Health
AI blood test could detect Parkinson's disease up to 7 years before symptoms: 'Particularly promising'
A new blood test could reveal Parkinson’s diagnoses up to seven years before symptoms emerge.
Researchers from University College London and University Medical Center Goettingen in Germany used artificial intelligence to develop the test.
The study, which was published in the journal Nature Communications, included 72 patients with rapid eye movement behavior disorder (iRBD), a condition that has been linked to a higher risk of Alzheimer’s.
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When the researchers used machine learning to analyze blood samples from the patients, they discovered that 79% of them had the same biomarkers as people with Parkinson’s.
A new blood test could reveal Parkinson’s diagnoses up to seven years before symptoms emerge, according to recent research. (iStock)
Over a 10-year follow-up period, the researchers confirmed that 16 of the patients went on to develop Parkinson’s, a movement disorder that affects nearly one million people in the U.S.
“By determining eight proteins in the blood, we can identify potential Parkinson’s patients several years in advance,” said co-first-author Dr. Michael Bartl from the University Medical Center Goettingen in a press release.
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“This means that drug therapies could potentially be given at an earlier stage, which could possibly slow down disease progression or even prevent it from occurring.”
“We have not only developed a test, but can diagnose the disease based on markers that are directly linked to processes such as inflammation and degradation of non-functional proteins. So these markers represent possible targets for new drug treatments.”
When the researchers used machine learning to analyze blood samples from the patients, they discovered that 79% of them had the same biomarkers as people with Parkinson’s. (iStock)
Blood tests provide a less invasive alternative to a lumbar puncture (also known as a spinal tap), which has been used more often to diagnose Parkinson’s in clinical research, according to professor David Dexter, director of research at Parkinson’s UK.
“This research, co-funded by Parkinson’s UK, represents a major step forward in the search for a definitive and patient friendly diagnostic test for Parkinson’s,” Dexter said in the release.
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Looking ahead, the researchers plan to follow the participants to confirm the accuracy of the test, and will also analyze samples from others in the population who have a genetic mutation that puts them at a higher risk of developing Parkinson’s.
“The findings add to an exciting flurry of recent activity toward finding a simple way to test for and measure Parkinson’s.”
“With more work, it may be possible that this blood-based test could distinguish between Parkinson’s and other conditions that have some early similarities, such as multiple systems atrophy or Lewy body dementia,” Dexter said in the release.
“The findings add to an exciting flurry of recent activity toward finding a simple way to test for and measure Parkinson’s.”
Dr. Harvey Castro, a Dallas, Texas-based board-certified emergency medicine physician and national speaker on AI in health care, said the blood test could serve as a model for other diseases. (Dr. Harvey Castro)
Dr. Harvey Castro, a Dallas, Texas-based board-certified emergency medicine physician and national speaker on AI in health care, was not involved in the blood test but spoke to Fox News Digital about its potential impact.
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“As an ER physician deeply involved in AI applications in health care, I find this development particularly promising,” Castro said.
“It exemplifies the potential of AI to diagnose and predict serious health conditions, allowing for earlier and potentially more effective interventions.”
Nearly one million people in the U.S. are living with Parkinson’s disease, according to the Parkinson’s Foundation. (iStock)
This approach could serve as a model for other diseases, Castro suggested.
“Having a tool that provides more time before significant nerve cell damage occurs offers a substantial opportunity to address diseases at very early stages, where traditional diagnostic methods might not detect them,” the doctor said.
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“This early intervention capability could significantly slow the disease progression.”
Although knowing about a disease in advance can help patients prepare mentally and emotionally, Castro warned that it could be a “double-edged sword.”
“Having a tool that provides more time before significant nerve cell damage occurs offers a substantial opportunity to address diseases at very early stages,” one doctor said. (iStock)
“While some patients may benefit from early knowledge and the ability to plan their lives accordingly, others might prefer not to know about a potential future illness due to the psychological burden it could impose,” he said.
Overall, Castro said, this AI-powered blood test represents a “paradigm shift” in the approach to neurodegenerative diseases like Parkinson’s.
“It underscores the importance of integrating advanced technologies into medical practice to enhance patient outcomes and transform health care delivery,” he said.
Fox News Digital reached out to the study researchers for additional comment.
Health
Diabetes surge among Americans could be driven by ‘healthy’ breakfasts, doctor warns
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Americans consume foods every day that are marketed as “healthy,” when they could be quietly destroying their health, one doctor warns.
Dr. Mark Hyman, physician and co-founder of Function Health in California, says that much of America’s daily diet is filled with unhealthy ingredients.
“The amount of refined starches and sugars that are everywhere is just staggering to me, given what we know about how harmful they are,” he shared in an interview with Fox News Digital. “I don’t think people really understand.”
Hyman, author of the new book “Food Fix Uncensored,” said he’s “astounded” by what people are eating, especially for breakfast.
“People just eat sugar for breakfast,” he said. “They have muffins, they have bagels, they have croissants, they have sugar-sweetened coffees and teas.”
Dr. Mark Hyman is the author of the new book “Food Fix Uncensored.” (Function Health; Little, Brown Spark)
In addition to the traditionally sweet options for breakfast, some cereal brands and breakfast staples have adopted new “protein-packed” menu items and products, following health trends that encourage eating more protein.
“Highly processed food is not food.”
“Now, we’re seeing this halo of protein in certain things,” Hyman said, mentioning that many protein smoothies are “full of sugar.”
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The doctor also noted that some popular cereals are now marketed as having protein in them. “My joke is, if it has a health claim on the label, it’s definitely bad for you,” he said.
Instead of starting the day with a “quick fix” or processed food, Hyman suggests choosing whole sources of protein and fat for breakfast, adding that “if there’s a little carbohydrate in there, it’s fine.”
More products marketed as “high protein” have cropped up on supermarket shelves. (iStock)
For his own breakfast, Hyman said he has a protein shake with whey protein, avocado and frozen berries. Eggs and avocados are also a great protein-and-fat combo option, he added.
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“It’s not that complicated — people need to just think about their breakfast not being dessert,” he said. “No wonder we’re in this cycle of obesity and diabetes. One in three teenage kids now has type 2 diabetes or pre-diabetes. That’s just criminal.”
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Instead of counting calories and being in a caloric deficit as a way to lose weight and stay healthy, Hyman instead suggests focusing on how certain foods make you feel and how they impact your health.
“When you look at the way in which different types of calories affect your biology, you can just choose what you’re eating, and then you don’t have to worry about how much,” he told Fox News Digital.
In addition to the traditionally sweet options for breakfast, some cereal brands and breakfast staples have adopted new “protein-packed” menu items and products. (iStock)
“For example, if you eat a diet that doesn’t cause your insulin to spike — which is low in starch and sugar, higher in protein and fat — you won’t develop those swings in blood sugar, you won’t develop the spikes in insulin, you won’t deposit hungry fat … You will break that cycle.”
People are more likely to “self-regulate when they eat real food” instead of processed foods, which “bypasses the normal mechanisms of satiety, fullness and brain chemistry,” according to Hyman.
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“Ultraprocessed food and junk food or highly processed food is not food,” he said. “It doesn’t support the health and well-being of an organism. It doesn’t do that. It does the opposite.”
Health
Scientists make startling discovery when examining prostate cancer tissue
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Small fragments of plastic were found in the tumors of most prostate cancer patients, according to a new study from NYU Langone Health.
In past studies, microplastics have been found in almost every human organ and in bodily fluids, but their impact on human health still isn’t fully understood.
The researchers analyzed tissue samples from 10 patients with prostate cancer who underwent surgery to remove the entire organ.
Using visuals of both benign samples and tumor samples, as well as specialized equipment, the scientists identified plastic particles in 90% of the tumor samples and 70% of benign tissue samples, according to the study press release.
In past studies, microplastics were found in almost every single human organ along with bodily fluids, even the placenta. (iStock)
The cancerous tissue contained on average more than double the amount of plastic as healthy prostate tissue samples, the study found. This equates to about 40 micrograms of plastic per gram of tissue compared to 16 micrograms.
Researchers avoided contaminating the samples with other plastics by substituting standard tools with those made of aluminum, cotton and other non-plastic material, the release noted.
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The scientists say this is the first direct evidence linking microplastics to prostate cancer.
“By uncovering yet another potential health concern posed by plastic, our findings highlight the need for stricter regulatory measures to limit the public’s exposure to these substances, which are everywhere in the environment,” said senior study author Vittorio Albergamo, assistant professor in the department of pediatrics at NYU Grossman School of Medicine, in the release.
Using visuals of both benign samples and tumor samples, as well as specialized equipment, the scientists identified plastic particles in 90% of the tumor samples and 70% of benign tissue samples. (iStock)
The study findings were presented during the American Society of Clinical Oncology’s Genitourinary Cancers Symposium in San Francisco on Feb. 26.
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“What is most striking is not that microplastics were detected, but that they were found embedded within tumor tissue itself,” Dr. David Sidransky, oncologist and medical advisor at SpotitEarly, a startup that offers an at-home breath-based test to detect early-stage cancer, told Fox News Digital.
“While complete avoidance is unrealistic, people can take practical steps to reduce exposure.”
“We already know microplastics are present in water, air, blood and even placental tissue. Their detection in prostate tumors suggests systemic distribution and long-term bioaccumulation,” added Maryland-based Sidransky, who was not involved in the study.
Study limitations
Albergamo cautioned that a larger sample is needed to confirm the findings. Additionally, Sidransky noted that the presence of microplastics alone does not prove they cause cancer.
“Tumors can act as ‘biologic sinks,’ meaning they may accumulate circulating particles simply because of altered vasculature and permeability,” he said.
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A key unanswered question, according to the doctor, is whether microplastics are biologically active in ways that “promote DNA damage, immune modulation or chronic inflammation within the prostate.”
About one in eight men in the U.S. will be diagnosed with prostate cancer at some point in their lifetime, according to the Centers for Disease Control and Prevention.
The most actionable step men can take is appropriate screening and early detection, according to doctors. (iStock)
For those concerned about microplastics, Sidransky offered some insights.
“I believe the appropriate response is curiosity, not panic, and a commitment to understand more,” he said.
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“While complete avoidance is unrealistic, people can take practical steps to reduce exposure, such as minimizing heating food in plastic containers, reducing bottled water consumption when possible, and favoring glass or stainless steel alternatives.”
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The most actionable step men can take, however, is getting appropriate screenings to help ensure early detection, according to the doctor. Screening discussions should be individualized based on age, family history and other risk factors.
Health
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