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66-year-old HIV patient becomes the oldest person to be cured after stem cell transplant

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66-year-old HIV patient becomes the oldest person to be cured after stem cell transplant

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The oldest affected person but has been cured of HIV after receiving a stem cell transplant for leukemia, researchers reported on Wednesday.

Whereas the transplant was deliberate to deal with the now-66-year-old’s leukemia, the docs additionally sought a donor who was naturally proof against the virus that causes AIDS, a mechanism that first labored to remedy the “Berlin affected person”, Timothy Ray Brown, in 2007.

The newest affected person, the fourth to be cured on this method, is called the “Metropolis of Hope” affected person after the U.S. facility in Duarte, California, the place he was handled, as a result of he doesn’t wish to be recognized.

SOME HIV PATIENTS WITH ‘POWERFUL IMMUNE SYSTEMS’ MAY NATURALLY CLEAR HIV INFECTIONS: STUDY

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In addition to being the oldest, the affected person has additionally had HIV the longest, having been identified in 1988 with what he described as a “demise sentence” that killed lots of his associates.

He has been on antiretroviral remedy (ART) to regulate his situation for greater than 30 years.

A affected person has been cured of HIV after receding a stem cell transplant for leukemia. The affected person is the oldest particular person but to be cured on this method. Pictured: A cell contaminated with HIV particles. 

Medical doctors who introduced the information forward of the Worldwide Aids Society’s (IAS) 2022 assembly mentioned that the case opened up the potential for older sufferers with HIV and blood most cancers to entry the therapy, notably because the donor was not a member of the family.

Describing a remedy because the “holy grail”, Sharon Lewin, president-elect of the IAS, mentioned the case supplied “continued hope … and inspiration” for folks with HIV and the broader scientific group, though it was unlikely to be an possibility for most individuals with HIV because of the dangers of the process.

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Scientists assume the method works as a result of the donor particular person’s stem cells have a selected, uncommon genetic mutation which implies they lack the receptors utilized by HIV to contaminate cells.

HIV INCIDENCE DOWN 73% SINCE 1980S PEAK, CDC ESTIMATES

After the transplant three and a half years in the past, which adopted chemotherapy, the Metropolis of Hope affected person stopped taking ART in March 2021. He has now been in remission from each HIV and leukemia for greater than a 12 months, the crew mentioned.

On Wednesday, researchers in Spain additionally introduced particulars of a 59-year-old lady who’s one in all a uncommon group of what’s often known as “post-treatment controllers”. They’ll keep undetectable viral hundreds after stopping ART, and likewise present clues to a possible remedy, Lewin mentioned.

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How The Great British Bake Off Host Alison Hammond Lost 150 Lbs Naturally

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How The Great British Bake Off Host Alison Hammond Lost 150 Lbs Naturally


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Alison Hammond’s Weight Loss: How She Shed 150 Lbs | Woman’s World




















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One state leads country in human bird flu with nearly 40 confirmed cases

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One state leads country in human bird flu with nearly 40 confirmed cases

A child in California is presumed to have H5N1 bird flu, according to the San Francisco Department of Public Health (SFDPH).

As of Dec. 23, there had been 36 confirmed human cases of bird flu in the state, according to the California Department of Public Health (CDPH).

This represents more than half of the human cases in the country.

LOUISIANA REPORTS FIRST BIRD FLU-RELATED HUMAN DEATH IN US

The latest pediatric patient, who lives in San Francisco, experienced fever and conjunctivitis (pink eye) as a result of the infection.

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The unnamed patient was not hospitalized and has fully recovered, according to the SFDPH.

A child in California is presumed to have H5N1 bird flu, according to the San Francisco Department of Public Health. (iStock)

The child tested positive for bird flu at the SFDPH Public Health Laboratory. The U.S. Centers for Disease Control and Prevention (CDC) will perform additional tests to confirm the result.

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It is not yet known how the child was exposed to the virus and an investigation is ongoing.

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“I want to assure everyone in our city that the risk to the general public is low, and there is no current evidence that the virus can be transmitted between people,” said Dr. Grant Colfax, director of health, in the press release. 

BIRD FLU PATIENT HAD VIRUS MUTATIONS, SPARKING CONCERN ABOUT HUMAN SPREAD

“We will continue to investigate this presumptive case, and I am urging all San Franciscans to avoid direct contact with sick or dead birds, especially wild birds and poultry. Also, please avoid unpasteurized dairy products.” 

Samuel Scarpino, director of AI and life sciences and professor of health sciences at Northeastern University in Boston, is calling for “decisive action” to protect individuals who may be in contact with infected livestock and also to alert the public about the risks associated with wild birds and infected backyard flocks. 

Chick bird flu test

An infectious diseases expert called for “decisive action” to alert the public about the risks associated with wild birds and infected backyard flocks.  (iStock)

“While I agree that the risk to the broader public remains low, we continue to see signs of escalating risk associated with this outbreak,” he told Fox News Digital.

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Experts have warned that the possibility of mutations in the virus could enable person-to-person transmission.

     

“While the H5N1 virus is currently thought to only transmit from animals to humans, multiple mutations that can enhance human-to-human transmission have been observed in the severely sick American,” Dr. Jacob Glanville, CEO of Centivax, a San Francisco biotechnology company, told Fox News Digital.

Split image of cows and bird flu vial

As of Jan. 10, there have been a total of 707 infected cattle in California, per reports from the California Department of Food and Agriculture. (iStock)

“This highlights the requirement for vigilance and preparation in the event that additional mutations create a human-transmissible pandemic strain.”

As of Jan. 10, there have been a total of 707 infected cattle in California, per reports from the California Department of Food and Agriculture (CDFA).

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In the last 30 days alone, the virus has been confirmed in 84 dairy farms in the state.

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Chronic Pain Afflicts Billions of People. It’s Time for a Revolution.

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Chronic Pain Afflicts Billions of People. It’s Time for a Revolution.

“In the beginning, everyone thought they were going to find this one breakthrough pain drug that would replace opioids,” Gereau said. Increasingly, though, it’s looking like chronic pain, like cancer, could end up having a range of genetic and cellular drivers that vary both by condition and by the particular makeup of the person experiencing it. “What we’re learning is that pain is not just one thing,” Gereau added. “It’s a thousand different things, all called ‘pain.’”

For patients, too, the landscape of chronic pain is wildly varied. Some people endure a miserable year of low-back pain, only to have it vanish for no clear reason. Others aren’t so lucky. A friend of a friend spent five years with extreme pain in his arm and face after roughhousing with his son. He had to stop working, couldn’t drive, couldn’t even ride in a car without a neck brace. His doctors prescribed endless medications: the maximum dose of gabapentin, plus duloxetine and others. At one point, he admitted himself to a psychiatric ward, because his pain was so bad that he’d become suicidal. There, he met other people who also became suicidal after years of living with terrible pain day in and day out.

The thing that makes chronic pain so awful is that it’s chronic: a grinding distress that never ends. For those with extreme pain, that’s easy to understand. But even less severe cases can be miserable. A pain rating of 3 or 4 out of 10 sounds mild, but having it almost all the time is grueling — and limiting. Unlike a broken arm, which gets better, or tendinitis, which hurts mostly in response to overuse, chronic pain makes your whole world shrink. It’s harder to work, and to exercise, and even to do the many smaller things that make life rewarding and rich.

It’s also lonely. When my arms first went crazy, I could barely function. But even after the worst had passed, I saw friends rarely; I still couldn’t drive more than a few minutes, or sit comfortably in a chair, and I felt guilty inviting people over when there wasn’t anything to do. As Christin Veasley, director and co-founder of the Chronic Pain Research Alliance, puts it: “With acute pain, medications, if you take them, they get you over a hump, and you go on your way. What people don’t realize is that when you have chronic pain, even if you’re also taking meds, you rarely feel like you were before. At best, they can reduce your pain, but usually don’t eliminate it.”

A cruel Catch-22 around chronic pain is that it often leads to anxiety and depression, both of which can make pain worse. That’s partly because focusing on a thing can reinforce it, but also because emotional states have physical effects. Both anxiety and depression are known to increase inflammation, which can also worsen pain. As a result, pain management often includes cognitive behavioral therapy, meditation practice or other coping skills. But while those tools are vital, it’s notoriously hard to reprogram our reactions. Our minds and bodies have evolved both to anticipate pain and to remember it, making it hard not to worry. And because chronic pain is so uncomfortable and isolating, it’s also depressing.

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