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Clinical trial suggests aerobic exercise helps prevent brain fog caused by chemotherapy

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Clinical trial suggests aerobic exercise helps prevent brain fog caused by chemotherapy
Credit: CC0 Public Domain

Many women who receive chemotherapy experience a decreased ability to remember, concentrate, and/or think—commonly referred to as “chemo-brain” or “brain fog”—both short- and long-term.

In a clinical trial of women initiating chemotherapy for breast cancer, those who simultaneously started an aerobic exercise program self-reported greater improvements in cognitive function and quality of life compared with those receiving standard care.

The findings are published online in the journal Cancer.

The study, called the Aerobic exercise and CogniTIVe functioning in women with breAsT cancEr (ACTIVATE) trial, included 57 Canadian women in Ottawa and Vancouver who were diagnosed with stage I–III breast cancer and beginning chemotherapy. All women participated in 12–24 weeks of aerobic exercise: 28 started this exercise when initiating chemotherapy and 29 started after chemotherapy completion.

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Cognitive function assessments were conducted before chemotherapy initiation and after chemotherapy completion (therefore, before the latter group started the exercise program).

Women who participated in the aerobic exercise program during chemotherapy self-reported better cognitive functioning and felt their mental abilities improved compared with those who received standard care without exercise. Neuropsychological testing—a performance-based method used to measure a range of mental functions—revealed similar cognitive performance in the two groups after chemotherapy completion, however.

“Our findings strengthen the case for making exercise assessment, recommendation, and referral a routine part of cancer care; this may help empower women living with and beyond cancer to actively manage both their physical and mental health during and after treatment,” said lead author Jennifer Brunet, Ph.D., of the University of Ottawa.

Dr. Brunet noted that many women undergoing chemotherapy for breast cancer remain insufficiently active, and there are limited exercise programs tailored to their needs.

“To address this, we advocate for collaboration across various sectors—academic, health care, fitness, and community—to develop exercise programs specifically designed for women with breast cancer,” she said.

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“These programs should be easy to adopt and implement widely, helping to make the benefits of exercise more accessible to all women facing the challenges of cancer treatment and recovery.”

More information:
Aerobic exercise and Cognitive functioning in women with breast cancer (ACTIVATE): a randomized controlled trial, Cancer (2024). DOI: 10.1002/cncr.35540

Citation:
Clinical trial suggests aerobic exercise helps prevent brain fog caused by chemotherapy (2024, October 21)
retrieved 21 October 2024
from https://medicalxpress.com/news/2024-10-clinical-trial-aerobic-brain-fog.html

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Fitness

How much should you exercise to actually lose weight?

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How much should you exercise to actually lose weight?

Two and a half hours of physical exercise per week may be essential for achieving any significant reduction in body weight, a new review of studies has found.

The review, published in the journal JAMA Network Open on Thursday, analysed previously conducted clinical trials probing the effect of exercise on weight loss.

It found that doing about 30 minutes of exercise a week was linked to only a modest reduction in body weight, body fat measures, and waist circumference among adults with obesity.

However, aerobic exercise exceeding 150 minutes per week, at moderate intensity or greater, was more likely to achieve clinically important reductions in weight-loss parameters.

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Adult with obesity practicing running
Adult with obesity practicing running (University Of Granada)

Aerobic exercise is any type of physical activity that raises a person’s heart rate and gets them moving and sweating for a sustained period of time.

Previous studies have shown this type of cardio exercise provides a range of benefits when coupled with a healthy diet, enabling people to think more clearly, and even protect against cognitive decline with age.

Some previous studies have estimated the optimal minimum period of exercise at between 30 and 45 minutes.

As little as 30 minutes of aerobic exercise has been linked to significantly better performance on cognitive quizzes.

One study showed that about 30 minutes of treadmill walking for 10 consecutive days may significantly reduce depression.

But the exact amount of optimal exercise needed for weight loss has been unclear.

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Health guidelines suggest that at least 150 minutes a week of aerobic exercise at moderate intensity is key to achieving meaningful weight loss of about 2 to 3kg. Some studies suggest a moderate intensity physical activity of about 225 to 420 minutes per week is required for weight loss of 5 to 7.5 kg.

Being overweight surpasses smoking as Australia’s leading health risk

The new study assessed data from over 100 clinical trials examining the effect of exercise over a duration of at least eight weeks on overweight or obese adults.

Researchers found that 30 minutes of aerobic exercise per week may enable adults who are overweight or have obesity to “slightly reduce” body weight.

However, they found the “greatest, clinically important” improvement from aerobic exercise of over 150 minutes per week.

“Aerobic training at least 150 minutes per week may be needed to achieve important reductions in waist circumference and body fat,” they said in the review.

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“Longer durations of aerobic exercise may be associated with more beneficial weight or waist circumference outcomes.”

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Why you should do strength training at 70: try these exercises

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Why you should do strength training at 70: try these exercises

A decline in health and fitness isn’t inevitable once you cross into your seventies. Just take look at the recent snaps of Pierce Brosnan — age 70 — shirt off in the wilds of Yellowstone National Park. Or think of Angela Rippon, 79, high-kicking it on Strictly; Helen Mirren, 78, on the red carpet; or the verve of Bruce Springsteen, playing a three-hour set in Hyde Park, London, in the summer at the age of 73. These are just four examples of a host of septuagenarians and octogenarians who have demonstrated that vitality is possible at any age — if you’re prepared to work for it.

Skeletal muscle mass and strength decline more rapidly as we age and can affect physical performance, but this

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Running heel taps to warm up for your workout – Today's Tip

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Running heel taps to warm up for your workout – Today's Tip
  • Today’s Tip

Fit this workout into your day!

By6abc Digital Staff

Thursday, December 26, 2024 12:34PM

Fitness Tip: Running heel taps to warm up for your workout

Shoshana shows us how running heel taps can quickly bring your heart rate up!

PHILADELPHIA (WPVI) — Shoshana shows us how running heel taps can quickly bring your heart rate up!

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