A newly identified muscle protein may help explain why people who stay active as they age often remain stronger and healthier for longer, according to new research.

Scientists found that a protein called NOX4 naturally declines with age and inactivity. As levels dropped, researchers observed signs of frailty, muscle loss, insulin resistance and liver disease in mice.

The findings were published in the journal Science Advances.

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Researchers believe NOX4 helps muscles repair themselves and adapt to the physical demands of exercise.

When NOX4 was removed from the muscles of mice, the animals became weaker, lost muscle mass and developed health problems commonly associated with aging.

The researchers also found that exercise helped restore NOX4 levels in older mice.

Josephine Hunt, an educational leader, former group fitness instructor and founder of The Resilience Revolution based in New Jersey, who was not involved in the study, told Fox News Digital that the findings help explain why exercise benefits so many aspects of health.

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“Movement is medicine,” Hunt said.

“The emerging NOX4 research is exciting because it helps explain something exercise scientists have observed for decades. Physical activity does far more than strengthen muscles.”

Hunt said many people view exercise as a way to improve appearance or fitness, but its effects reach much deeper.

“Exercise appears to activate biological signaling pathways that help the body adapt, repair and become more resilient over time,” she said.

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She said one of the study’s biggest takeaways is that physical activity helps the body maintain its ability to recover from challenges.

“Exercise does not simply help us look younger or stay physically fit,” Hunt said. “It appears to help the body maintain its ability to adapt, repair and respond to stress.”

Hunt added that healthy aging is about more than simply living longer.

“Healthy aging is not just about adding years to life,” she said. “It is about preserving strength, function, independence, cognitive health and overall quality of life.”

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Researchers stressed that additional studies are needed, but the findings may help explain why regular physical activity remains one of the most effective tools for maintaining health as people age.

The study was conducted in mice, meaning the findings do not necessarily translate directly to humans.

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While the team also examined muscle samples from younger and older men and found similar declines in NOX4, additional research is needed to better understand the protein’s role in human aging.

Sticking to a resistance or strength training routine for a certain amount of time may extend your life, according to a new study.

Research published in the British Journal of Sports Medicine analyzed whether workouts involving weightlifting and weight machines are linked to a lower risk of death over time.

The study followed more than 147,000 U.S. adults who participated in three large health studies spanning up to 30 years. More than 35,000 died during the study period.

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Participants reported their exercise habits, including the number of minutes per week spent on resistance training and on aerobic activity, like walking, biking or swimming.

Resistance training levels were then compared with later death from any cause, as well as from cardiovascular disease, cancer, respiratory disease and neurological disease, according to a press release.

Doing a moderate amount of resistance training was linked with a lower risk of death, according to study results. This outcome persisted even after researchers adjusted for other factors like age, smoking, diet quality, alcohol intake, family history and aerobic activity.

The clearest benefit was seen at around 90 to 119 minutes per week of resistance training.

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People who stuck to this interval of training per week had a 13% lower risk of all-cause death, 19% lower risk of death from heart disease and 27% lower risk of death from neurological disease.

More than 120 minutes of resistance training per week did not appear to add extra benefit to the overall death risk, according to the findings.

A lower risk of cancer death was seen at even small amounts of resistance training — 30 to 59 minutes per week was associated with a 12% decreased risk.

The lowest overall death risk was found in people who did both higher aerobic activity and moderate to high resistance training.

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The study shows only an association between resistance training and lower death risk, not a direct cause, the researchers noted.

Other limitations were that participants reported their own exercise habits, which may not have been completely accurate, and the study did not measure how intensely they exercised.

30 to 59 minutes per week of strength training was associated with a 12% decreased risk of cancer death.

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The authors reflected in the study that engaging in “sufficient aerobic or resistance training alone is linked to lower mortality, with a stronger effect from aerobic activity.”

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The lowest risk was seen among people who did high levels of both aerobic exercise and resistance training. However, for people already doing a very high amount of aerobic exercise (roughly five to six hours of jogging or 11 hours of brisk walking per week), adding resistance training did not appear to lower the risk any further, they noted.

In a previous interview with Fox News Digital, Kenny Santucci, fitness trainer, gym owner and host of the “Strong New York” podcast, shared the importance of pairing general movement with a focus on muscle building.

For a better fitness outcome, Santucci encourages gym-goers to add more strength training to their routines and to lift “a little bit heavier.”

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“Strength training should be the basis of what you do,” he said. “I don’t have anything against cycling … but if you’re telling me that’s the basis of your training, and your goal is aesthetics, then you are not really helping yourself get to that point any easier.”

“Hard doesn’t necessarily mean it’s a better workout.”

Santucci recommends working at about 60% to 80% of capacity, pushing to a point of fatigue with moderate intensity.

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“There’s a science behind muscle growth, and if there’s no external force pushing against the muscle tissue, and you’re not fueling yourself with protein, then you’re probably not going to build muscle,” he said.

“Hard doesn’t necessarily mean it’s a better workout … If you’re training at levels of intensity, then you’re reproducing good outcomes.”

A vaccine created using artificial intelligence that could potentially provide broader protection against multiple coronaviruses and help prepare for future outbreaks has passed its first human clinical trial.

Researchers from the Universities of Cambridge and Southampton developed a “universal vaccine” designed to protect against multiple Sarbeco coronaviruses, which the university explained in a news release is “the large group of viruses that occur in nature, including SARS-CoV-2, which caused the COVID pandemic.”

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Traditional vaccines must constantly be updated as viruses mutate, and the process is “like a dog chasing its tail,” said University of Southampton professor Saul Faust, the trial’s chief investigator.

“Viruses like Influenza, coronaviruses and the Ebola group are evolving continuously, and by the time vaccines are rolled out, they may be poorly matched — the current ‘reactive’ vaccine system struggles to keep pace,” Faust said.

An antigen is the active ingredient in a vaccine meant to trigger an immune-system response and fight off infection. According to the release, the university scientists logged all the available genetic sequence data for Sarbeco coronaviruses and used AI used to design a “super-antigen” that contains the antigen features “common to this whole group of viruses – including ones that haven’t emerged yet.”

The trial of the vaccine proved safe and triggered an immune response in 39 healthy volunteers, marking “the first time that a vaccine whose active component was designed entirely by computer simulations has been tested in humans,” the release said.

The trial vaccine was administered through a micro-fluid jet that delivers the immunization through the skin using a tiny, high-pressure stream of liquid and does not require a needle. The researchers said this method could make it “faster and easier to carry out in large numbers of people.”

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“This new class of universal vaccines are future-proofed,” Faust said. “They not only protect against many variants simultaneously, but potentially against related viruses that haven’t yet emerged and spilt over to humans. If we can develop and clinically advance this new class of vaccines before a virus outbreak begins, millions of lives could be saved, lockdowns avoided and the economy preserved.”

Some experts have raised broad concerns about using AI in medicine, primarily when it comes to making clinical decisions, not developing vaccines. Certain groups of people may be underrepresented in the data AI relies on, resulting in biased outcomes, some said.

AI also sometimes produces erroneous information, called “hallucinations,” and determining who is liable for medical failings in such situations is a complex matter.

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Others have expressed concern over patient privacy, as well as the need for human judgment that takes into account the scope of a patient’s health history, rather than a single dataset.

The universal-vaccine researchers said that a larger trial involving “a wider and more diverse population” is needed. They published their findings in Journal of Infection.