Seattle, WA
New discoveries from Seattle scientists could help manage brain's aging process
SEATTLE – A new year marks new research on the health and well-being of the brain. On January 1, the Allen Institute published its largest study to date on aging brain cells in animals. Scientists said these discoveries could help unlock ways to keep the mind sharper, longer.
This latest study at the Allen Institute gives insight into the aging of the brain, and how diet, inflammation, and brain health are deeply interconnected. The study was funded by the National Institutes of Health (NIH).
Scientists analyzed more than 1.2 million brain cells from mice, ages young and old. They explained they used mice because their brains are similar to humans in structure, function, genes, and cell types. The experts said older mice are considered to be the equivalent of a late middle-aged human.
The new study took a closer look at identifying specific cell types, primarily glial cells (the brain’s support system), and how those cells change as they age.
They also focused on “hot spots” when changes occur in the brain cells. Representatives said the scientists discovered an aging accelerator, saying, “In older brains, inflammation surges into overdrive while genes critical for brain structure and function decline. This imbalance sheds light on how aging increases vulnerability to disease.”
In studying the cells, they also found the brain’s aging epicenter: the area near the third ventricle of the hypothalamus. That region of the brain is crucial in regulating food intake, metabolism, and how the body uses nutrients. That epicenter, also referred to as “hot spot,” hints at a strong connection between diet, lifestyle, brain health, and changes that can influence vulnerability to age-related brain disorders.
“Our hypothesis is that those cell types are getting less efficient at integrating signals from our environment or from things that we’re consuming,” said Kelly Jin, Ph.D., a scientist at the Allen Institute for Brain Science and lead author of the study. “And that loss of efficiency somehow contributes to what we know as aging in the rest of our body. I think that’s pretty amazing, and I think it’s remarkable that we’re able to find those very specific changes with the methods that we’re using.”
The Allen Institute said understanding the findings in that hot spot will be key in future studies. It not only helps scientists know which cells to target, but experts said it also could lead to the development of age-related therapeutics. This includes unlocking more specific dietary or drug interventions to maintain brain health into old age.
“Aging is the most important risk factor for Alzheimer’s disease and many other devastating brain disorders. These results provide a highly detailed map for which brain cells may be most affected by aging,” said Richard J. Hodes, M.D., director of NIH’s National Institute on Aging. “This new map may fundamentally alter the way scientists think about how aging affects the brain and also provides a guide for developing new treatments for aging-related brain diseases.”
The Allen Institute’s discoveries are now published in Nature, a weekly international journal highlighting all fields of science and technology from the finest researchers.
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Seattle, WA
Fast Start for Kraken Win, Homestand | Seattle Kraken
That stretch begins with five more home games: A skilled and successful Carolina squad Monday, followed by St. Louis (for the second time in a week) Wednesday, Ottawa next Saturday, then Nashville (just behind Seattle in the West wild-card race) on March 10 and then finishing with Western Conference leader Colorado March 12.
Stars Shine and Star-Crossed Hat Trick
Vince Dunn opened the scoring in his 600th NHL game. Jordan Eberle topped the best Kraken-season goals mark with his 21st and 22nd goals of the year, with 23 games left to flirt with his first 30-plus goals on the year since his sophomore season in 2011-12. Joey Daccord registered 27 saves on the victorious night, including nine high-danger chances in the first 40 minutes alone.
To the fans’ disappointment, the slick-stickhandling Daccord missed a historic goalie goal by inches. But the sellout crowd was rewarded when Eberle cashed in on the Vancouver empty net. Eberle now has four two-goal games this season.
In a bizarre twist, when Eberle scored that empty-netter, Kraken fans rightfully cheered and tossed headwear for what was presumed to be a hat-trick score. But after Eberle scored, the scoring change on the Kraken’s power play goal was announced when off-ice officials realized Eberle’s shot had just ever-so-slightly deflected off Matty Beniers’ skate. So no hat trick for the second time this season. Linemate Jared McCann and hat-tossing fans thought the Kraken’s all-time leading scorer had notched a hat trick earlier this season, only to have it reversed when an offside infraction by, wait for it, Beniers, erased the goal.
Eberle joked post-game that maybe fans deserved some hats. The Kraken captain also said when Daccord missed by inches on his goalie goal, he was on the bench saying, “he got it, he got it.” Post-game, Eberle said, “It’s just a matter of time before he gets one” because he greatly admires the goaltender’s puck-handling skills.
The Kraken came out fast Saturday night with two goals, a couple of near-misses, lots of scoring attempts and pucks on net during the first 20 minutes. One near-miss was a hard wrist shot from Jordan Eberle that clanged off the far post. But no matter, Eberle scored a pivotal goal in the second period, getting in front of a Vancouver shot and chasing his own ricochet to create a breakaway with his still-elite speed. The 35-year-old Seattle captain went to his lethal backhand to beat Canucks goalie Kevin Lankinen. Eberle’s tally re-upped the two-goal lead.
Good night for Kraken special teams as well. The penalty killer snuffed an early third period Canucks power play to keep the two-score cushion. Later third period, Matty Beniers scored on the power play, deflecting an Eberle shot, to push the score to 4-1. Chandler Stephenson earned his second point of the night with the primary assist. Same for Dunn, who notched the second assist. The Kraken needed just 10 seconds to score the man-advantage marker.
Captaining His Best Kraken Season…
It is Eberle’s 21st goal of the season. The next one he scores will set a new high as a Kraken for the teammate everyone calls “Ebs.” That makes it three of five seasons that Eberle has scored 20 or more goals. Eberle almost scored again later second period when matching cross-checking penalties on SEA forward Kaapo Kakko and VAN defenseman Filip Hronek. The ensuing 4-on-4 play was dominated by the Kraken quartet of Eberle, Matty Beniers, Brandon Montour and Ryker Evans. Beniers stood with some moves and an improv that had future Hall of Fame play-by-play man John Forslund saying, “Beniers did everything but score.” It was heartening to see Seattle flexing its offensive chops with a 3-1 lead.
The Kraken scored twice in an opening 20 minutes played to order, returning to the hard forechecking game they exhibited on a heater 10-game streak before the Olympic break. The starting goalie did his part, stopping all nine of Vancouver’s shots in the first 20 minutes to bring confidence to the first-intermission home locker room.
Jumping Out of the Starting Blocks
The Kraken faithful were mega-decibel loud during the announcement of the starting lineups, welcoming back Olympian bronze medalists Kaapo Kakko and Eeli Tolvanen, as well as Seattle teammates. This week’s two road losses forgotten, replaced by rousing cheers for starters and fourth-liners Freddy Gaudreau, centering Jacob Melanson and Ben Meyers (on the wing for the first since a road matchup in LA right before the winter holiday break).
Defenseman Cale Fleury and Ryker Evans rounded out the skaters in front of Joey Daccord. It’s not a stretch to think head coach Lane Lambert was sending a message with his fourth line and third pair getting the first shift after losing two games in the Midwest by a composite score of 9-2.
Saturday morning, both defenseman Vince Dunn and Lambert both talked about what would be the ideal first 10 to 20 minutes in this Pacific Division showdown with rival Vancouver.
“We need to play simple and hard and direct,” said Dunn, who was playing in his 600th NHL game, 333 with Seattle. “I think we’re very connected when we can get our forecheck going. I think the way we play as a five-man unit is that we slow teams down and don’t get scrambled in our own end. We’re more patient in our own end and letting guys accept their positions and roles and areas that they need to defend in.
“Right away, we need to start shooting pucks … the past two games, the shot count hasn’t been where we wanted it to be in the first 10 minutes. So let’s get some looks and see what happens. Let’s see if we can get the other team scrambling.”
Seattle, WA
Two local soccer scribes to discuss Seattle’s road to 2026
From miners, lumberjacks and seamen to the world arriving on our shores this summer, Folio Seattle will host a program Monday night, with two local soccer scribes detailing the region’s collective footy history in “Seattle’s Road to the 2026 World Cup.”
Matt Pentz, a former soccer reporter for The Seattle Times and The Athletic, is teaming with historian Frank MacDonald, executive director for Washington State Legends of Soccer and occasional Sounder at Heart contributor. The program goes from 6-8 PM at the Folio location in Pike Place Market. Donations of any amount are accepted.
Pentz and MacDonald will dive into the state’s century-plus adoration of the game and highlight what’s changed in the last generation, since Seattle failed to land matches for the 1994 FIFA World Cup.
Seattle, WA
Seattle Torrent put Olympic captain Hilary Knight on long-term IR – Seattle Sports
Olympians Hilary Knight, Kendall Coyne Schofield and Erin Ambrose have all been placed on long-term injured reserve by their PWHL clubs after sustaining injuries during the Milan Cortina Games.
Kraken sign forwards Ben Meyers, Ryan Winterton to extensions
Knight, a five-time Olympian and captain of the United States team that won gold, will be out of the lineup for the Seattle Torrent indefinitely after sustaining a lower-body injury in Italy, the team announced Friday.
Knight had three goals and three assists for the U.S. at Milan Cortina including a goal in the 2-1 overtime win over Canada in the final. She has three goals and seven assists during the current PWHL season.
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“While we’re eager to be at full strength and recognize the anticipation of Hilary’s return, we’re focused on putting her and our team in the best position for a playoff push,” Torrent general manager Meghan Turner said in a statement.
Minnesota Frost captain Coyne Schofield was placed on long-term injured reserve on Friday retroactive to Feb. 19 with an upper-body injury. Coyne Schofield scored three goals for the United States during the Olympics.
“I am incredibly proud of all our Frost Olympians who demonstrated true excellence on the world stage,” general manager Melissa Caruso said in a statement. “We are fully committed to supporting Kendall throughout her recovery, and our medical team will be working diligently to help her prepare for her return to the ice.”
The moves by the Torrent and Frost came a day after the Montreal Victoire announced that Ambrose has been placed on long-term injured reserve retroactive to Feb. 19 for a lower‑body injury suffered while representing Canada in the gold medal game. Ambrose had a pair of assists at the Olympics.
The Victoire’s Marie-Philip Poulin, Canada’s captain in Italy, was listed as day-to-day with an Olympics-related injury.
Victoire general manager Daniele Sauvageau said of the team’s Olympians “we are confident that they will be back in the lineup in the near future.”
PWHL influence apparent at Olympics with OT medal games
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