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New discoveries from Seattle scientists could help manage brain's aging process

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New discoveries from Seattle scientists could help manage brain's aging process


A new year marks new research on the health and well-being of the brain. On January 1, the Allen Institute published its largest study to date on aging brain cells in animals. Scientists said these discoveries could help unlock ways to keep the mind sharper, longer.

This latest study at the Allen Institute gives insight into the aging of the brain, and how diet, inflammation, and brain health are deeply interconnected. The study was funded by the National Institutes of Health (NIH).

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Scientists analyzed more than 1.2 million brain cells from mice, ages young and old. They explained they used mice because their brains are similar to humans in structure, function, genes, and cell types. The experts said older mice are considered to be the equivalent of a late middle-aged human.

The new study took a closer look at identifying specific cell types, primarily glial cells (the brain’s support system), and how those cells change as they age.

They also focused on “hot spots” when changes occur in the brain cells. Representatives said the scientists discovered an aging accelerator, saying, “In older brains, inflammation surges into overdrive while genes critical for brain structure and function decline. This imbalance sheds light on how aging increases vulnerability to disease.”

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In studying the cells, they also found the brain’s aging epicenter: the area near the third ventricle of the hypothalamus. That region of the brain is crucial in regulating food intake, metabolism, and how the body uses nutrients. That epicenter, also referred to as “hot spot,” hints at a strong connection between diet, lifestyle, brain health, and changes that can influence vulnerability to age-related brain disorders.

“Our hypothesis is that those cell types are getting less efficient at integrating signals from our environment or from things that we’re consuming,” said Kelly Jin, Ph.D., a scientist at the Allen Institute for Brain Science and lead author of the study. “And that loss of efficiency somehow contributes to what we know as aging in the rest of our body. I think that’s pretty amazing, and I think it’s remarkable that we’re able to find those very specific changes with the methods that we’re using.”

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The Allen Institute said understanding the findings in that hot spot will be key in future studies. It not only helps scientists know which cells to target, but experts said it also could lead to the development of age-related therapeutics. This includes unlocking more specific dietary or drug interventions to maintain brain health into old age.

“Aging is the most important risk factor for Alzheimer’s disease and many other devastating brain disorders. These results provide a highly detailed map for which brain cells may be most affected by aging,” said Richard J. Hodes, M.D., director of NIH’s National Institute on Aging. “This new map may fundamentally alter the way scientists think about how aging affects the brain and also provides a guide for developing new treatments for aging-related brain diseases.”

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The Allen Institute’s discoveries are now published in Nature, a weekly international journal highlighting all fields of science and technology from the finest researchers.

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Seattle’s first homicide of 2026 is a case that began more than 50 years ago

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Seattle’s first homicide of 2026 is a case that began more than 50 years ago


In 1973, a 19-year-old man was shot near Garfield High School, a tragedy that left him paralyzed for the rest of his life. The medical examiner has now officially ruled his recent death a homicide — a rare “delayed death” directly linked to those decades-old injuries.

Prosecutors say the case is legally closed because the suspects are now dead. Still, it raises a question: What happens to cases that don’t end with an arrest?

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Local perspective:

Detective Rolf Norton has dedicated his career to finding answers in cases many assume are over. Norton refuses to call them “cold cases.” He insists they are not forgotten or “sitting on the shelf collecting dust.”

For Norton, they are not over — just unfinished.

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Norton has been with Seattle police for 31 years, including the past 24 in homicide.

What they’re saying:

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“There is no greater mission working homicides is what I wanted to do when I first got hired,” Norton said.

Waking up every day, he said, is easy. The challenge, fulfillment, significance and importance are why he doesn’t hesitate when he talks about murder investigations.

“There is no other crime that comes to the level of homicide. It’s the Fifth Commandment; it’s the foundation of society. It begins and ends with ‘We won’t kill each other,’ and to be tasked with investigating those crimes is really a great honor,” Norton said.

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A Seattle native and graduate of the University of Washington, Norton worked as a legal assistant for the King County Prosecutor’s Office before being hired by Seattle police in 1994, when the city had about 500,000 residents.

“Flash me back to 1994 — I take a look, and then take the blindfold off. In 2026, I’ll look around, and I won’t recognize it,” Norton said.

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Policing has changed, too — no body cameras then, no doorbell cameras, and certainly no security footage on every block.

“If the Green River Killer had been active in 2026 instead of 1983, we would have had him after number one or number two, because we would have had him on camera,” Norton said, referring to the serial killer who terrorized the region in the 1980s.

Dig deeper:

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DNA technology has also evolved dramatically over the past two decades, from limited testing in the late 1990s to breakthroughs in genetic genealogy that help identify suspects decades later.

“In the past, it’s been more about, ‘We have this result. What can we do with it? How can we interpret it? How can we make it better?’ Now it’s — we go back to the start, starting from scratch. It’s crazy, and I’m excited with the optimism that all this brings,” Norton said.

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Even with new tools, not every case has an ending.

“I’m on a one-person mission to change the vernacular. I can’t stand the word ‘cold case,’” Norton said. “I don’t call them cold cases because I’m working them.”

He says they are not binders that have sat untouched for decades at the bottom of a vault.

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“If you walked into my office, I probably have 100 case files, and they’re all piled up in a very organized manner for me,” Norton said.

These are not just files — they are the names of someone’s loved one. Norton says he takes them home mentally and, at times, physically.

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“There’s been some cases where I’ve printed out the original follow-up that the initial detectives produced, and have left them at every sleeping area in my house, and sometimes just pick it up and start reading saying, ‘What did I miss?’” Norton said.

Why you should care:

One of the cases he has carried for a decade is the killing of 14-year-old Tanya Frazier, who was kidnapped, sexually assaulted and murdered in 1994. An arrest was finally made last year, more than 30 years later.

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“I’m pleased we got to where we are today, that we have made an arrest, but the process isn’t done,” Norton said.

Another case is “Baby Boy Doe,” found dead in November 1997 in a north Seattle gas station trash can after his mother delivered him and left him to die. Despite police sharing images of the mother walking toward the restroom, the case remained unsolved for years.

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“I come to the photos of Baby Doe in a garbage can and it’s mind-blowing. Frankly, it’s life-changing, you see something that you immediately want to file away and never go back to, but you can’t because you have a job, a mission, and no one is looking out for baby doe, except for us,” Norton said, describing the crime scene photos publicly for the first time.

The mother, Christine Warren, was convicted in January 2023, but for years many believed the case would never be solved.

“It’s important to know that this child wasn’t forgotten,” said Casey McNerthney of the King County Prosecuting Attorney’s Office.

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McNerthney said the same goes for the case of Joseph Garrett, even though it cannot be prosecuted.

Garrett was 19 when, according to a brief three-paragraph article in the Seattle Post-Intelligencer, he was shot in the shoulder during a fight with another teen near Garfield High School. The bullet lodged in his spine, paralyzing him.

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“It’s encouraging to see that Ralph Norton would see how police was on top of this one,” McNerthney said. “Many of the cases that people assume aren’t being looked at are actually on his desk.”

He also offered a warning.

“If somebody thinks they’ve gotten away with it because it’s a few years, or even a few decades in the past, they’re wrong. If you never know when that knock on the door will come, and at some point it will come,” McNerthney said.

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For families, he added, time feels different.

“We know that for the surviving family members in these cases, every day is like the day they found out,” McNerthney said.

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Norton acknowledges that being the face of that pain is not easy.

“You’re the face of the worst thing that ever happened to them and the family members, and you don’t always have good news,” Norton said.

When asked how he moves forward in each case knowing many remain unsolved for families, Norton said, “I think you need to focus on the process and not the result, and you need to be cognizant of what you can address today.”

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The odds are not always in his favor.

“It’s tough. These cases are unsolved not because of a lack of effort. They’re unsolved because they’re difficult,” Norton said.

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When asked what he would say to families still waiting for answers, Norton did not pause.

“I remember, we remember, I won’t quit. We won’t quit,” Norton said.

Norton has reviewed more than 600 unsolved cases dating from 1907 to 2020. During a recent interview, he shared a list of 13 names — cases for which he is the lead detective and continues to update families.

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He is waiting for DNA technology to keep improving, hoping it will one day give families closure. While he does not promise resolutions, he wants families to know their loved ones are not far from his reach.

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The Source: Information in this story comes from original reporting by FOX 13 Seattle reporter Alejandra Guzman.

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Paul Allen’s estate begins process to sell Seattle Seahawks

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Paul Allen’s estate begins process to sell Seattle Seahawks


SEATTLE — The Seattle Seahawks are going up for sale in accordance with the wishes of late team owner Paul Allen.

Allen’s estate announced Wednesday that it has begun the process of selling the team, which is just coming off its second Super Bowl victory in franchise history.

Investment bank Allen & Company and law firm Latham & Watkins will lead the sales process, which is estimated to continue through the offseason. NFL owners must then ratify a final purchase agreement.

The estate said the sale is consistent with Allen’s directive to eventually sell his sports holdings and direct all estate proceeds to philanthropy.

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The Seahawks have been in the Allen family since 1997, when Paul bought the Seahawks for $194 million from then-owner Ken Behring.

Since Allen, co-founder of Microsoft, died in 2018 from complications of non-Hodgkin lymphoma at 65, the Seahawks and NBA’s Trail Blazers have been owned by his sister, Jody. The estate agreed in September to sell the Trail Blazers to an investment group led by Carolina Hurricanes owner Tom Dundon.

–By Andrew Destin/The Associated Press



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Burien, WA cold weather shelter expected to hit capacity as temperatures fall

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Burien, WA cold weather shelter expected to hit capacity as temperatures fall


With a wintry mix of precipitation falling in parts of the Seattle metro area Tuesday, many of those experiencing homelessness were trying to figure out where they could go to stay warm overnight.

Frost On The Ground in Burien

“For the most part, there are a lot of resources with churches, but not so much with the city,” said Matthew McMillen, who lives in an RV.

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McMillen spent the day in Kent. Though he has an RV, it’s not heated.

“You have got a shell that’s metal, so inside it’s probably another 10 – 20 degrees colder inside,” McMillen said.

He says there is no guarantee he won’t be forced to move from its parking spot.

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“They treat you like a criminal, having a motorhome. Mine is licensed and insured, and I still get chased around,” McMillen said.

“They are just getting aggressive. I get it, homelessness brings crime, but not everyone out here is like that,” said Thomas Arviso of Kent, who was hoping to stay with a family member overnight. “For the most part, just trying to get by.”

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At the Highline United Methodist Church in Burien, Pastor Jenny Partch and other volunteers were stepping in to help get a cold weather shelter ready inside the church.

“When we open, the word spreads pretty fast,” Partch said.

“There is a 9-bed women’s shelter here in Burien, and that’s it in terms of shelter in the area. So, the need is great,” Partch said.

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They expected 50–60 people overnight at the church’s cold weather shelter based on the number of people who needed help in January. There were people waiting outside on Tuesday night when the doors opened, eager to get out of the cold weather.

“We believe in what Jesus told us. When we feed someone or clothe someone or give them shelter, we are doing it to Jesus himself,” said Partch.

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 She says the need is great in South King County since the unhoused population has “exploded” over the past five years.

“It gives them a space where they start to feel like somebody cares and they want to make changes in their lives, so it’s that first step of what could come next for them,” said Partch.

Highline United Methodist Church in Burien

Shelter beds at Highline United Methodist Church in Burien (FOX 13 Seattle)

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The church will be open from 7 p.m. to 9 a.m. starting Tuesday and running through Friday morning. Pets and couples are allowed.

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Download the free FOX LOCAL app for mobile in the Apple App Store or Google Play Store for live Seattle news, top stories, weather updates and more local and national news.

The Source: Information in this story came from original FOX 13 Seattle reporting and interviews.

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