Seattle, WA
New discoveries from Seattle scientists could help manage brain's aging process
SEATTLE – A new year marks new research on the health and well-being of the brain. On January 1, the Allen Institute published its largest study to date on aging brain cells in animals. Scientists said these discoveries could help unlock ways to keep the mind sharper, longer.
This latest study at the Allen Institute gives insight into the aging of the brain, and how diet, inflammation, and brain health are deeply interconnected. The study was funded by the National Institutes of Health (NIH).
Scientists analyzed more than 1.2 million brain cells from mice, ages young and old. They explained they used mice because their brains are similar to humans in structure, function, genes, and cell types. The experts said older mice are considered to be the equivalent of a late middle-aged human.
The new study took a closer look at identifying specific cell types, primarily glial cells (the brain’s support system), and how those cells change as they age.
They also focused on “hot spots” when changes occur in the brain cells. Representatives said the scientists discovered an aging accelerator, saying, “In older brains, inflammation surges into overdrive while genes critical for brain structure and function decline. This imbalance sheds light on how aging increases vulnerability to disease.”
In studying the cells, they also found the brain’s aging epicenter: the area near the third ventricle of the hypothalamus. That region of the brain is crucial in regulating food intake, metabolism, and how the body uses nutrients. That epicenter, also referred to as “hot spot,” hints at a strong connection between diet, lifestyle, brain health, and changes that can influence vulnerability to age-related brain disorders.
“Our hypothesis is that those cell types are getting less efficient at integrating signals from our environment or from things that we’re consuming,” said Kelly Jin, Ph.D., a scientist at the Allen Institute for Brain Science and lead author of the study. “And that loss of efficiency somehow contributes to what we know as aging in the rest of our body. I think that’s pretty amazing, and I think it’s remarkable that we’re able to find those very specific changes with the methods that we’re using.”
The Allen Institute said understanding the findings in that hot spot will be key in future studies. It not only helps scientists know which cells to target, but experts said it also could lead to the development of age-related therapeutics. This includes unlocking more specific dietary or drug interventions to maintain brain health into old age.
“Aging is the most important risk factor for Alzheimer’s disease and many other devastating brain disorders. These results provide a highly detailed map for which brain cells may be most affected by aging,” said Richard J. Hodes, M.D., director of NIH’s National Institute on Aging. “This new map may fundamentally alter the way scientists think about how aging affects the brain and also provides a guide for developing new treatments for aging-related brain diseases.”
The Allen Institute’s discoveries are now published in Nature, a weekly international journal highlighting all fields of science and technology from the finest researchers.
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CHICAGO (AP) — The struggling New York Mets placed former Seattle Mariners second baseman/designated hitter Jorge Polanco on the 10-day injured list on Saturday with a right wrist contusion.
Mariners Injury Update: Latest on Robles, Vargas and more
The move was made retroactive to Wednesday, a day after Polanco went 0 for 4 with two strikeouts in a 2-1 loss at the Los Angeles Dodgers. The 32-year-old Polanco is batting .179 (10 for 56) with a homer and two RBIs in his first season with New York, which has lost nine straight.
“When doctors first took a look at him, it looked like he got hit by a pitch when he didn’t,” manager Carlos Mendoza said. “In talking to him, it was just a couple of swings that he took that night. … He didn’t think much of it, but just got worse the following day.
“So you just got to let it calm down a little bit and then we’ll go from there. But we don’t have a timetable for how long this is going to last.”
Polanco, who signed a two-year, $40 million contract with the Mets in December, also has been dealing with an ankle issue.
“He was trending in the right direction,” Mendoza said of the ankle injury. “It’s definitely going to help, obviously now with him being shut down. But the biggest thing now is that we’ve got to take care of that wrist.”
Polanco spent the previous two seasons with the Mariners, who acquired him in a February 2024 trade with the Minnesota Twins.
Polanco struggled during his first season with Seattle in 2024, hitting just .213 with 16 homers in 118 games while playing through a knee injury that didn’t become public knowledge until after the season.
But after the Mariners somewhat surprisingly brought him back for a one-year contract in 2025, Polanco rebounded to hit .265 with 26 homers and an .821 OPS in 138 games last season. He then added three homers during Seattle’s playoff run, along with a 15th-inning walkoff single in Game 5 of the American League Division Series that sent the Mariners to their first ALCS in 24 years.
Seattle Sports staff made additions to this post.
Mariners RHP Bryce Miller to begin rehab assignment
Seattle, WA
Brandon Nimmo hits leadoff homer, Jacob deGrom works 4 scoreless as Rangers beat Seattle Mariners 5-0
SEATTLE, WASHINGTON – APRIL 17: Corey Seager #5 of the Texas Rangers tags out Dominic Canzone #8 of the Seattle Mariners during the fourth inning at T-Mobile Park on April 17, 2026 in Seattle, Washington. (Steph Chambers / Getty Images)
SEATTLE – Brandon Nimmo hit a leadoff home run, Jacob deGrom threw four shutout innings and Gavin Collyer earned his first career win as the Texas Rangers beat the Seattle Mariners 5-0 on Friday night.
Seattle lost its fourth straight game, and was shut out for the fourth time in 21 games, falling to 8-13. The Mariners were shut out six times during the 2025 season. Texas won its third straight game.
Nimmo led off the game with a 372-foot shot to right field off Mariners starter Logan Gilbert (1-3). It was Nimmo’s 16th career leadoff homer and second of the season. He also hit a leadoff home run on April 11 in a 6-3 loss to the Los Angeles Dodgers.
DeGrom effectively maneuvered through Seattle’s lineup, and worked out of a one out, bases-loaded jam in the first inning. The two-time Cy Young Award winner recorded two of his three strikeouts after walking Josh Naylor to load the bases. Randy Arozarena fanned on a curveball, and Luke Raley swung through a fastball.
Texas added to its lead after Nimmo’s homer. Wyatt Langford’s single to left scored Corey Seager, who led off the third inning with a double. The Rangers stretched the lead to 3-0 on an RBI single from Jake Burger in the seventh.
The Mariners’ best scoring chance came in the sixth after Collyer (1-0), who worked 1 1/3 scoreless innings, left the game.
J.P. Crawford singled to left off Tyler Alexander with two out, and Mariners third base coach Carlos Cardoza sent Naylor from second base, but he was thrown out by Langford.
Texas added two more runs in the ninth on a sacrifice fly by Andrew McCutchen and an RBI double by Josh Jung.
Seattle third baseman Brendan Donovan left the game early due to a left hip issue.
Mariners right-hander Bryce Miller, who started the year on the injured list with a left oblique injury, was at T-Mobile Park for the first time this season. He will begin a rehab assignment with Triple-A Tacoma on Saturday.
Up next
Mariners RHP George Kirby (2-2, 3.25) will face Rangers righty Nathan Eovaldi (2-2, 5.40) on Saturday afternoon.
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FIFE, Wash. – A portion of southbound I-5 will be closed overnight in Fife Friday and Saturday night, according to WSDOT.
The Washington State Department of Transportation says the purpose of the closure is to install a new electronic sign and will need two nights to do it.
Crews will close southbound I-5 from 54th Avenue to Port of Tacoma Road starting at 11 p.m. Friday night until 7:30 a.m. Saturday morning. Closures will resume Saturday night starting at 11 p.m. as well, and lanes will reopen Sunday morning at 8:30 a.m.
WSDOT says the closure will include the 54th Avenue ramps to southbound I-5.
Detours for weekend I-5 closure in Fife, WA
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The Source: Information in this story comes from the Washington State Department of Transportation.
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