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New discoveries from Seattle scientists could help manage brain's aging process

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New discoveries from Seattle scientists could help manage brain's aging process


A new year marks new research on the health and well-being of the brain. On January 1, the Allen Institute published its largest study to date on aging brain cells in animals. Scientists said these discoveries could help unlock ways to keep the mind sharper, longer.

This latest study at the Allen Institute gives insight into the aging of the brain, and how diet, inflammation, and brain health are deeply interconnected. The study was funded by the National Institutes of Health (NIH).

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Scientists analyzed more than 1.2 million brain cells from mice, ages young and old. They explained they used mice because their brains are similar to humans in structure, function, genes, and cell types. The experts said older mice are considered to be the equivalent of a late middle-aged human.

The new study took a closer look at identifying specific cell types, primarily glial cells (the brain’s support system), and how those cells change as they age.

They also focused on “hot spots” when changes occur in the brain cells. Representatives said the scientists discovered an aging accelerator, saying, “In older brains, inflammation surges into overdrive while genes critical for brain structure and function decline. This imbalance sheds light on how aging increases vulnerability to disease.”

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In studying the cells, they also found the brain’s aging epicenter: the area near the third ventricle of the hypothalamus. That region of the brain is crucial in regulating food intake, metabolism, and how the body uses nutrients. That epicenter, also referred to as “hot spot,” hints at a strong connection between diet, lifestyle, brain health, and changes that can influence vulnerability to age-related brain disorders.

“Our hypothesis is that those cell types are getting less efficient at integrating signals from our environment or from things that we’re consuming,” said Kelly Jin, Ph.D., a scientist at the Allen Institute for Brain Science and lead author of the study. “And that loss of efficiency somehow contributes to what we know as aging in the rest of our body. I think that’s pretty amazing, and I think it’s remarkable that we’re able to find those very specific changes with the methods that we’re using.”

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The Allen Institute said understanding the findings in that hot spot will be key in future studies. It not only helps scientists know which cells to target, but experts said it also could lead to the development of age-related therapeutics. This includes unlocking more specific dietary or drug interventions to maintain brain health into old age.

“Aging is the most important risk factor for Alzheimer’s disease and many other devastating brain disorders. These results provide a highly detailed map for which brain cells may be most affected by aging,” said Richard J. Hodes, M.D., director of NIH’s National Institute on Aging. “This new map may fundamentally alter the way scientists think about how aging affects the brain and also provides a guide for developing new treatments for aging-related brain diseases.”

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The Allen Institute’s discoveries are now published in Nature, a weekly international journal highlighting all fields of science and technology from the finest researchers.

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Seattle Reign’s Laura Harvey says ChatGPT inspired NWSL tactics: ‘It said play a back five, so I did’

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Seattle Reign’s Laura Harvey says ChatGPT inspired NWSL tactics: ‘It said play a back five, so I did’


Seattle Reign head coach Laura Harvey says she has leaned on artificial intelligence (AI) service ChatGPT to help inspire her tactics in the NWSL this season.

The 45-year-old former Arsenal coach said she casually started testing the chatbot’s women’s soccer knowledge, before quizzing what ideas it might have for individual teams.

“One day in the offseason, I was writing things into ChatGPT like, ‘What is Seattle Reign’s identity?’ And it would spurt it out. And I was like ‘I don’t know if that’s true or not,’” Harvey told the Soccerish Podcast.

“And then I put in, ‘What formation should you play to beat NWSL teams?’ And it spurted out every team in the league and what formation you should play. And for two teams, it went ‘You should play a back five.’ So I did. No joke, that’s why I did it.”

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Harvey made the admission after being asked how she had evolved over the course of a two-decade coaching career, but she had never started playing a ‘back five’ of defenders until this season but her coaching team went on a “deep dive” to evaluate its benefits, with the tactical setup used on multiple occasions this term.

“I’d never really done a lot of research on it,” Harvey added of the formation. “I’d never really, like, invested into how it could be played in the women’s game. I’d only ever really seen it from afar, you know, watching men’s games really.

“It was always sort of talked about as a way to see games out. You know, (you go ahead) and get into a back five and stop people from scoring, was sort of how, like, a back five had been talked about for me.”

With one match remaining in the regular season, the Reign are fourth in the 14-team NWSL, in a play-off spot, with 10 wins from 25 matches. This marks a vast improvement from last season, when they finished 13th.

Harvey, who previously coached the Reign between 2013 and 2017, rejoined the club in 2021. The Brit has won three NWSL Shields with Seattle and The Women’s Cup in 2022.

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SPOG president praises new contract for SPD recruitment

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SPOG president praises new contract for SPD recruitment


The City of Seattle has worked to get Seattle Police Department (SPD) recruitment numbers back up, incentivizing a starting salary of $103,000 and a signing bonus of $7,500 for new officers.

SPD currently has 1,200 sworn officers and 631 civilian employees, according to the city’s website. That’s up from only having 424 active officers, the lowest staffing levels since at least 1957, in April 2024.

“Numbers are up. It’s a good thing. It’s amazing what a contract can do,” Seattle Police Officers Guild (SPOG) President Mike Solan told “The John Curley Show” on KIRO Newsradio Wednesday.

Earlier this month, the City of Seattle reached a new collective bargaining agreement with the SPOG, which represents all Seattle police officers.

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Under the agreement, police officers will receive a retroactive pay increase of 6% for 2024 and 4.1% for 2025. Officers will get an additional 2.7% increase in 2026, and the 2027 increase will range from 3% to 4%, depending on the Consumer Price Index.

Solan told KIRO host John Curley the two typically go without a contract for around three years, but this time it was over 12 years before a deal was made.

“To me, it’s unacceptable. But I credit the Harrell administration for recognizing that we’re in a public safety quagmire, as I usually refer to it, and they thought outside the box, and they got serious at the table. And we did as well, our contract team, and we put a deal together that I think the constituents across the city will want to have more cops,” he said.

Watch the full discussion in the video above. 

Listen to John Curley weekday afternoons from 3 – 7 p.m. on KIRO Newsradio, 97.3 FM. Subscribe to the podcast here.

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Mayor Harrell Advances Legislation to Ban Trump’s Obstructive Face Coverings for Law Enforcement – Office of the Mayor

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Mayor Harrell Advances Legislation to Ban Trump’s Obstructive Face Coverings for Law Enforcement – Office of the Mayor


New ordinance will also require officers to clearly display badges or emblems of agency, increasing transparency and accountability

Seattle – Today, Mayor Bruce Harrell proposed a new ordinance to prohibit the use of face coverings by law enforcement, with limited exceptions, and require all law enforcement officials to have visible emblems and badges that identify their agency while performing enforcement duties in Seattle.

This legislation puts Seattle on track to be the first city in Washington and one of the first major cities in the country to adopt a mask ban to increase transparency and accountability around federal law enforcement activity, including immigration enforcement operations.

“Federal law enforcement officials operating in Seattle are not above the laws of our city,” said Mayor Harrell. “The Trump administration’s tactic of using masked, unidentified agents to carry out their inhumane deportation agenda with impunity not only erodes accountability but also sows fear in our communities and creates a dangerous possibility for copycat actors. In the face of Trump’s tyrannical militarization of American cities, this ordinance is a concrete step we can take to uphold our local values and protect our immigrant and refugee communities from these unjust actions. My administration remains committed to using every tool at our disposal to protect the safety and dignity of our residents from federal overreach.”

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Face coverings include any mask, garment, helmet, headgear, or other item that conceals or obscures the facial identity of an individual, including a balaclava, tactical mask, gator, and ski mask. The ordinance includes exemptions, including medical or surgical masks to protect against transmission of disease, and respirators to protect against toxins or other environmental hazards.

A willful and knowing violation of the ordinance by a law enforcement officer or agency can result in a civil violation and penalty of $5,000. The ordinance will be enforced by the Office for Civil Rights (OCR).

“Accountability is not punishment, it is a promise kept,” said Derrick Wheeler-Smith, Director of the Seattle Office for Civil Rights. “This legislation strengthens civil rights by ensuring that masked or unidentified federal agents, and those pretending to be, are seen, documented, and addressed rather than swept aside. By holding every officer and agency to the same standard, we protect the rights of our immigrant and refugee neighbors and affirm a simple truth: justice is not selective, it is shared.”

The legislation follows the two Executive Orders the mayor signed earlier this month on preparedness and coordination in the event of unilateral troop deployment to Seattle and protecting immigrant and refugee communities from unjust immigration enforcement actions. The second order reaffirms that the City has no role in civil immigration enforcement, which is solely the responsibility of the federal government.

Additionally, the Seattle Police Department (SPD) is currently developing guidance for officers responding to emergency calls where masked or unidentified individuals are detaining people. The increased use of masks and plainclothes officers has led to multiple arrests across the country of civilians impersonating federal immigration enforcement officials, posing a real public safety threat to communities.

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“Our officers’ appearance will be consistent when someone calls 9-1-1 for help and Seattle police officers are dispatched. They will show up ready to serve the public with their faces uncovered and their SPD badge and name proudly displayed,” said Seattle Police Chief Shon Barnes. “At our core, we are peace officers, and our goal is to protect people and keep the peace.” 

“For our client communities to truly feel welcome, it is essential to have protections in place that promote trust and safety for all,” said Malou Chavez, Executive Director of the Northwest Immigrant Rights Project. “This legislation is an example of the City of Seattle’s leadership seeking to protect all communities, and we hope that other jurisdictions follow suit.”

The City is also developing an ordinance to prohibit staging and operations of federal immigration activities on City-owned properties. This is intended to prevent federal immigration enforcement from using parking lots and similar spaces for staging, which has occurred in other cities like Chicago.

Since the beginning of Trump’s second term, Seattle has advanced multiple legal and legislative steps to protect residents from his administration’s unlawful actions and funding cuts. Efforts include passing legislation that strengthens local protections for people seeking gender-affirming and reproductive health care; a lawsuit over DEI and gender ideology Executive Orders and unlawful conditioning of funds; a lawsuit challenging threats to cities with sanctuary policies; and a lawsuit over frozen counterterrorism funds through the Securing the Cities program.

Additionally, Mayor Harrell’s 2026 proposed budget also includes a $27.6 million investment plan to safeguard essential services threatened by federal funding cuts, including shelter, rental assistance, and food access programs, and a 70% increase in funding for immigrant and refugee services including legal supports, Know Your Rights trainings, and workforce development.  

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