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New discoveries from Seattle scientists could help manage brain's aging process

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New discoveries from Seattle scientists could help manage brain's aging process


A new year marks new research on the health and well-being of the brain. On January 1, the Allen Institute published its largest study to date on aging brain cells in animals. Scientists said these discoveries could help unlock ways to keep the mind sharper, longer.

This latest study at the Allen Institute gives insight into the aging of the brain, and how diet, inflammation, and brain health are deeply interconnected. The study was funded by the National Institutes of Health (NIH).

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Scientists analyzed more than 1.2 million brain cells from mice, ages young and old. They explained they used mice because their brains are similar to humans in structure, function, genes, and cell types. The experts said older mice are considered to be the equivalent of a late middle-aged human.

The new study took a closer look at identifying specific cell types, primarily glial cells (the brain’s support system), and how those cells change as they age.

They also focused on “hot spots” when changes occur in the brain cells. Representatives said the scientists discovered an aging accelerator, saying, “In older brains, inflammation surges into overdrive while genes critical for brain structure and function decline. This imbalance sheds light on how aging increases vulnerability to disease.”

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In studying the cells, they also found the brain’s aging epicenter: the area near the third ventricle of the hypothalamus. That region of the brain is crucial in regulating food intake, metabolism, and how the body uses nutrients. That epicenter, also referred to as “hot spot,” hints at a strong connection between diet, lifestyle, brain health, and changes that can influence vulnerability to age-related brain disorders.

“Our hypothesis is that those cell types are getting less efficient at integrating signals from our environment or from things that we’re consuming,” said Kelly Jin, Ph.D., a scientist at the Allen Institute for Brain Science and lead author of the study. “And that loss of efficiency somehow contributes to what we know as aging in the rest of our body. I think that’s pretty amazing, and I think it’s remarkable that we’re able to find those very specific changes with the methods that we’re using.”

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The Allen Institute said understanding the findings in that hot spot will be key in future studies. It not only helps scientists know which cells to target, but experts said it also could lead to the development of age-related therapeutics. This includes unlocking more specific dietary or drug interventions to maintain brain health into old age.

“Aging is the most important risk factor for Alzheimer’s disease and many other devastating brain disorders. These results provide a highly detailed map for which brain cells may be most affected by aging,” said Richard J. Hodes, M.D., director of NIH’s National Institute on Aging. “This new map may fundamentally alter the way scientists think about how aging affects the brain and also provides a guide for developing new treatments for aging-related brain diseases.”

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The Allen Institute’s discoveries are now published in Nature, a weekly international journal highlighting all fields of science and technology from the finest researchers.

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How Polanco’s departure impacts Seattle Mariners’ offseason

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How Polanco’s departure impacts Seattle Mariners’ offseason


The Seattle Mariners’ offseason will not be completed in a nice, neat, run-it-back bow, with reports Saturday morning that Jorge Polanco and the Mets are in agreement on a two-year, $40 million contract.

Drayer: Mariners’ plan for 2B and 3B coming more into focus

The number was stunning, with most industry insiders estimating Polanco would be looking at something closer to $12-15 million per year. Even ESPN’s Jeff Passan, one of the few to estimate Polanco would receive above $15 million per year, was likely to be surprised Saturday morning.

“He’s not getting $20 million a year,” Passan told Seattle Sports’ Brock and Salk on Tuesday. “I think at the end of the day, it’s probably going to be $14-17 million a year. If there are two teams duking it out at the end, maybe it goes up a million a year. It looks like it is going to be a three-year deal, but something along the lines of three (years) for $45-50 (million). I think that’s about right.”

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The one move Passan says could make Mariners the AL favorites

The estimated $17 million salary sounded outrageous to the show hosts, but a lot can change this time of year, namely the Mets losing Pete Alonso to the Orioles. In comparison, Polanco is not exactly a splash after the loss of Alonso, but his versatility and offense when healthy (an .821 OPS in 2025) were attractive to the Mets.

Polanco going elsewhere was certainly a possibility – perhaps established as a good possibility when he failed to sign quickly, unlike the Mariners’ No. 1 target of the offseason, Josh Naylor. They were well aware of this with president of baseball operations Jerry Dipoto recently admitting the odds were technically against them with numerous teams involved. The Mariners valued Polanco but were outbid by a team that needed to make a move. So they must move on.

While the Mariners remained engaged in talks with free agents this week, it is the trade market where the most attractive candidates reside, with the Cardinals expected to trade Brendan Donovan and the Diamondbacks making Ketel Marte available.

Donovan and Marte would be great fits on the field and on the salary spreadsheet for Seattle, but they would come at the cost of prospect capital with the Cardinals, and to a lesser extent Diamondbacks, dealing from a position of leverage.

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The Cardinals do not have to deal Donovan, who has two years remaining under club control, but his value presents new president of baseball operations Chaim Bloom the opportunity to make a significant early organizational mark.

In the case of Marte, the leverage he brings the Diamondbacks is short-lived as he will become a 10-and-5 player in the first weeks of the season, meaning he will be able to veto any trades at that point.

Can the M’s give up what Arizona wants for a Ketel Marte trade?

On the free agent market, despite reports that agent Scott Boras reached out to the Mariners about third baseman Alex Bregman having some interest in the team, the big-ticket players appear to remain off limits for the Mariners. They have maintained that the door would be open for Eugenio Suárez in the right circumstances. Assuming that would be a one-year deal, that signing seems unlikely to happen. The remaining free agent infielders appear to be more stopgap options of the take-a-chance variety with names like Willi Castro, Luis Rengifo or even Adam Frazier available.

The loss of Polanco and his production at the plate put Dipoto and general manager Justin Hollander in the position where they are going to have to make a gamble. They have a track record of making trades that end up requiring lower-ranked prospects than expected. If that is not the norm this winter, then do they make that painful prospect trade, or trade a starter from the big league roster? Does ownership decide it can make a gamble in expanding the budget for a higher-priced free agent, or does it take the gamble of making smaller moves, essentially staying where they are, seeing how it plays out and attempting to make big moves at the trade deadline once again?

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The Mariners and Mariners fans have just been hit with a large dose of uncertainty. In the uncertainty are opportunities, however, and the remainder of the offseason should not be quiet.

More Seattle Mariners offseason coverage

• Backup catcher target emerges for Seattle Mariners, per reports
• Salk: What we know and think about Seattle Mariners’ offseason needs
• Why Nolan Arenado could make sense as a Seattle Mariners trade target
• Seattle Mariners pick two, lose one in minor league phase of Rule 5 draft
• With a tweak, Jose Ferrer could be special in Seattle Mariners’ bullpen






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Seattle Kraken fall to Mammoth 5-3 for 7th loss in 8 games

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Seattle Kraken fall to Mammoth 5-3 for 7th loss in 8 games


SALT LAKE CITY (AP) — Dylan Guenther scored a go-ahead power-play goal in the third period and the Utah Mammoth beat the Seattle Kraken 5-3 on Friday night to snap a three-game losing streak.

Utah Mammoth 5, Seattle Kraken 3: Box score

Nick Schmaltz had a goal and two assists, and Kailer Yamamoto, JJ Peterka, and Lawson Crouse also scored for the Mammoth. Kevin Stenlund had three assists and Karel Vejmelka stopped 32 shots.

Mason Marchment had two goals and Ben Meyers also scored for the Kraken in their seventh loss in eight games. Phillipp Grubauer had 26 saves.

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After a scoreless first period, Marchment put Seattle on the board with a backhand shot at 3:35 of the second.

Schmaltz tied it at 8:09 with an unassisted goal. He attacked off a breakaway and chipped the puck over Grubauer’s shoulder from close range.

Yamamoto then gave Utah its first lead with 6:36 left in the middle period.

Seattle had several shots at an equalizer during a two-man advantage lasting nearly two minutes, but the Kraken came up empty.

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Marchment then got his second goal of the night and fourth of the season at 7:50 of the third, slapping the puck home from long distance to tie it.

Guenther gave Utah a 3-2 lead with 7:05 remaining, successfully converting a power play.

Peterka and Crouse added empty netters over the final three minutes, and Meyers scored for Seattle with 43 seconds to go for the final margin.

Up next

Kraken: Host Buffalo on Sunday.

Mammoth: At Pittsburgh on Sunday.

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Seattle Kraken dealt another tough blow on the injury front



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Brock: How rookie DL can fit in Seattle Seahawks’ defense

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Brock: How rookie DL can fit in Seattle Seahawks’ defense


The Seattle Seahawks focused heavily on their offense during the draft this past spring, using nine of their 11 selections to pick players on that side of the ball.

Just two of their picks were defenders: safety Nick Emmanwori and defensive lineman Rylie Mills.

Seattle Seahawks waive 2 players, have options to fill their roster spots

After returning from an injury suffered in the season opener that forced him to miss three games (and essentially four since he played on four snaps in Week 1), Emmanwori is making his case to be in consideration for NFL Defensive Rookie of the Year.

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Mills, on the other hand, has yet to play a snap while recovering from an ACL tear suffered last December during his final season at Notre Dame. But the fifth-round pick appears to be nearing his NFL debut. Mills, who was designated to return to practice from injured reserve Nov. 26, was a full participant in practice for the first time last Friday. He was ruled out of Sunday’s game against Atlanta, but practiced in full on Wednesday and Thursday as Seattle prepares for a matchup with Indianapolis this Sunday.

The Seahawks have until next Wednesday to decide if they will activate Mills to the 53-man roster or place him on IR for the rest of the season. So it may be another week until he makes his debut, and it’s no guarantee that he will play this season. If he is activated to the 53-man roster, how will he fit the Seahawks’ standout defense? Former NFL quarterback Brock Huard shared his insight about the role the Notre Dame product could play during his Blue 88 segment on Seattle Sports’ Brock and Salk on Thursday.

“I do remember watching him a number of times and just, gosh, he was a good college football player,” Huard said. “He’s big now. He’s 6-5, 290 (pounds), and to be honest with you, you know where he fits a little bit more? He would fit a little bit more in a traditional, kind of old school Pittsburgh Steelers 3-4 defense. He would be that five-technique defensive end that could play that spot and be very stout.”

Mills is similar in size to star Seahawks defensive lineman Leonard Williams, who measures in at 6-5 and 310 pounds. But one key difference is Williams has more length, which is a concern Huard has about Mills.

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“The challenge and what I’m anxious to kind of see in how they utilize him eventually is he’s not real long (Mills had 32 5/8 inch arms at the draft combine)” Huard said. “He’s not like Leonard Williams with that length. He’s not necessarily like a (Quinton) Bohanna and a (Brandon) Pili at 330-plus pounds either. (He’s) 6-5, 290, fairly athletic, super smart, super savvy, but he’s a little different than all the rest of these D-linemen.

“He’s certainly not an edge player and he doesn’t have some of the size or the length of some of the interior (linemen).”

However, Huard is confident the Seahawks can figure out the best way to utilize Mills’ skills just like they have with another player on their defensive line who lacks some of the ideal measurables: 2024 first-round pick Byron Murphy II.

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“Like they’ve done with Murphy, who also is not prototypical in some of the size, they will play to his skill set,” Huard said. “(Mills’) greatest skill set, frankly, might just be his brain.”

Hear the full conversation at this link or in the audio player near the top of this story. Listen to Brock and Salk weekdays from 6-10 a.m. or find the podcast on the Seattle Sports app. 

Seattle Seahawks coverage

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