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New discoveries from Seattle scientists could help manage brain's aging process

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New discoveries from Seattle scientists could help manage brain's aging process


A new year marks new research on the health and well-being of the brain. On January 1, the Allen Institute published its largest study to date on aging brain cells in animals. Scientists said these discoveries could help unlock ways to keep the mind sharper, longer.

This latest study at the Allen Institute gives insight into the aging of the brain, and how diet, inflammation, and brain health are deeply interconnected. The study was funded by the National Institutes of Health (NIH).

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Scientists analyzed more than 1.2 million brain cells from mice, ages young and old. They explained they used mice because their brains are similar to humans in structure, function, genes, and cell types. The experts said older mice are considered to be the equivalent of a late middle-aged human.

The new study took a closer look at identifying specific cell types, primarily glial cells (the brain’s support system), and how those cells change as they age.

They also focused on “hot spots” when changes occur in the brain cells. Representatives said the scientists discovered an aging accelerator, saying, “In older brains, inflammation surges into overdrive while genes critical for brain structure and function decline. This imbalance sheds light on how aging increases vulnerability to disease.”

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In studying the cells, they also found the brain’s aging epicenter: the area near the third ventricle of the hypothalamus. That region of the brain is crucial in regulating food intake, metabolism, and how the body uses nutrients. That epicenter, also referred to as “hot spot,” hints at a strong connection between diet, lifestyle, brain health, and changes that can influence vulnerability to age-related brain disorders.

“Our hypothesis is that those cell types are getting less efficient at integrating signals from our environment or from things that we’re consuming,” said Kelly Jin, Ph.D., a scientist at the Allen Institute for Brain Science and lead author of the study. “And that loss of efficiency somehow contributes to what we know as aging in the rest of our body. I think that’s pretty amazing, and I think it’s remarkable that we’re able to find those very specific changes with the methods that we’re using.”

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The Allen Institute said understanding the findings in that hot spot will be key in future studies. It not only helps scientists know which cells to target, but experts said it also could lead to the development of age-related therapeutics. This includes unlocking more specific dietary or drug interventions to maintain brain health into old age.

“Aging is the most important risk factor for Alzheimer’s disease and many other devastating brain disorders. These results provide a highly detailed map for which brain cells may be most affected by aging,” said Richard J. Hodes, M.D., director of NIH’s National Institute on Aging. “This new map may fundamentally alter the way scientists think about how aging affects the brain and also provides a guide for developing new treatments for aging-related brain diseases.”

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The Allen Institute’s discoveries are now published in Nature, a weekly international journal highlighting all fields of science and technology from the finest researchers.

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Seattle teens arrested after shooting up Portland gas station, carjacking rideshare driver

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Seattle teens arrested after shooting up Portland gas station, carjacking rideshare driver


Four Seattle juveniles were arrested in connection with a series of armed crimes in Portland, including a convenience store robbery in which an employee was shot multiple times and critically injured, Portland police said.

The investigation began after a robbery and shooting at about 4:46 a.m. Friday at a gas station convenience store in the 400 block of Northeast Martin Luther King Jr. Boulevard.

Multiple armed suspects threatened a store clerk before another employee entered the store, prompting a struggle during which multiple shots were fired, Police said.

An image of one of the guns that was used, according to police. (PPB)

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The employee was struck at least five times — four times in the abdomen and once in the leg. Bullets also hit the store’s walls and shattered a window.

Officers arrived less than four minutes after being dispatched, secured the scene, and summoned emergency medical responders.

The victim was taken to a hospital, where he underwent extensive surgery. Police said he is expected to survive.

Detectives with the Major Crimes Unit, patrol officers, forensic specialists, and analysts linked the robbery to several other crimes earlier in the week, including a rideshare driver’s carjacking at gunpoint on Tuesday, a menacing incident involving armed suspects attempting to steal from a vehicle, and an armed robbery at another gas station convenience store in which an employee was struck in the head with a handgun.

Hours before Friday’s shooting, officers responded to a report of masked suspects attempting to enter another convenience store. After the suspects left, officers searched the area, anticipating another robbery.

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Later Friday, investigators identified suspect vehicles and tracked possible suspects to a residence in Northeast Portland.

A search warrant was served with assistance from the Portland Police Bureau’s Special Emergency Reaction Team, Crisis Negotiation Team, and East Metro SWAT. Twelve people were detained, and multiple handguns were seized.

Police said three juveniles, ages 15, 16, and 17, all from Seattle, were charged in connection with Friday’s robbery. Additional charges tied the juveniles to the earlier robberies and menacing case.

A fourth 17-year-old from Seattle was charged in the Tuesday robbery. An adult Portland man was arrested on unrelated outstanding warrants.

The investigation remains ongoing, and additional or modified charges are possible, police said.

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‘Imagine you crushed a raccoon like a can’: Curley describes viral deformed ‘mutant’ Jimothy – MyNorthwest.com

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‘Imagine you crushed a raccoon like a can’: Curley describes viral deformed ‘mutant’ Jimothy – MyNorthwest.com


Jimothy, a raccoon who may have short-spine syndrome, has gone viral overnight after being spotted around Seattle.

KIRO host John Curley tried to describe the uniquely shaped animal, who has quickly become a local celebrity, on “The John Curley Show” on KIRO Newsradio.

“Just imagine a raccoon for a moment,” Curley said. “Normal raccoon in your mind. There’s a raccoon. He has the black around his eyes. You know why that is? That’s to cut down on glare, so he can see better. Like a football player has the black eye shade on there. So, a normal raccoon. Now, just imagine if you took the raccoon and you put one hand on his like snout, and you put the other hand on his backside there, and you had superhuman strength, and you were able to kind of crush him like a can, without killing him.

“No, then you kill him and throw him in the garbage. No, you just squish him a little bit, and you crush him up,” he continued. “Imagine if he’s made out of clay. Then all of a sudden, like, OK, you know he’s got this kind of bump on his back. Well, that’s what this thing looks like. Took me a long way to get to it.”

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Jimothy seen on porches, wandering through Ballard

In one video, Jimothy is seen dipping his hands into a bowl on a porch. Curley debunked the common myth that raccoons wash their food, explaining that water actually stimulates nerve endings in their fingers, helping them feel what they’re eating better.

“The raccoon will dip the food, if they find food, in water all the time, and people like, ‘Oh, they’re always washing their food. They got hygiene on their mind.’ No, it helps to stimulate the end of their fingers so that the nerve endings are more sensitive,” he said. “So they do that, and even when they can’t find water, they’ll turn it like they’re spinning it to put it in water. It’s to create more sensitivity, so they have a better idea of what they’re eating.”

Ballard residents have reported seeing Jimothy wandering across backyard decks, drinking from a dog’s water bowl, and sitting in neighborhood trees.

Watch the full discussion in the video above.

Listen to John Curley weekday afternoons from 3 – 7 p.m. on KIRO Newsradio, 97.3 FM. Subscribe to the podcast here.

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Seattle real estate owner sentenced to prison for $4.7 million tax evasion scheme – MyNorthwest.com

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Seattle real estate owner sentenced to prison for .7 million tax evasion scheme – MyNorthwest.com


A 70-year-old Seattle real estate owner was sentenced to prison for tax evasion and filing false tax returns.

Steven Loo was convicted following a nine-day trial and ordered to spend 20 months in prison for his $4.7 million tax evasion scheme, according to the U.S. Attorney’s Office.

“Mr. Loo made a sustained, willful decision to evade taxes. The only thing that explains that is greed,” First Assistant U.S. Attorney Neil Floyd stated. “A man who amasses $43 million in wealth can afford to pay his taxes — just like the 85% of us who pay our taxes fully and on time.”

Loo owned and operated multiple commercial real estate properties in western Washington and California, according to records filed in the case. He hired property management companies to manage the properties, and had the companies send profit from the properties to two bank accounts in the name of shell companies he controlled.

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Loo hid real estate profits through shell companies, claimed zero tax for 20 years

Loo spent the money for his benefit and for his friends and family. He also re-invested funds in various businesses he controlled. However, Loo did not declare that income— over $4.7 million — on his tax returns. He used shell companies and repeated transfers of funds to conceal the income from the IRS, according to records filed in the case.

“At trial, the government presented evidence detailing the eight properties operated by Loo via various limited liability companies (LLCs),” the attorney’s office stated. “The income from the LLCs was funneled into bank accounts associated with two specific inactive entities that were established in Washington in 1999. Loo did not report this income to the IRS. Loo failed to inform his tax return preparer of these funds that were income from his properties.”

Loo claimed he owed no tax at all over 20 years and even claimed a net refund from the IRS.

“Loo is living the American dream yet believes he has no obligation to pay the taxes that support our nation,” prosecutors said in asking for a 51-month sentence. “Loo was not content with merely failing to report his income. Instead, he contrived a plan to hide his wealth from the IRS using shell companies and money-routing schemes. When Loo’s luck ran out, and an IRS criminal investigator knocked on his door, he continued his deception by trotting out a fairy tale about using imaginary losses to offset his income.”

Along with serving prison time, Loo must also pay a $250,000 fine and serve three years of supervised release following his prison term. The attorney’s office noted Loo has already paid back taxes to the IRS of $1,603,686.

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Follow Julia Dallas on X. Read her stories here. Submit news tips here.




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