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New discoveries from Seattle scientists could help manage brain's aging process

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New discoveries from Seattle scientists could help manage brain's aging process


A new year marks new research on the health and well-being of the brain. On January 1, the Allen Institute published its largest study to date on aging brain cells in animals. Scientists said these discoveries could help unlock ways to keep the mind sharper, longer.

This latest study at the Allen Institute gives insight into the aging of the brain, and how diet, inflammation, and brain health are deeply interconnected. The study was funded by the National Institutes of Health (NIH).

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Scientists analyzed more than 1.2 million brain cells from mice, ages young and old. They explained they used mice because their brains are similar to humans in structure, function, genes, and cell types. The experts said older mice are considered to be the equivalent of a late middle-aged human.

The new study took a closer look at identifying specific cell types, primarily glial cells (the brain’s support system), and how those cells change as they age.

They also focused on “hot spots” when changes occur in the brain cells. Representatives said the scientists discovered an aging accelerator, saying, “In older brains, inflammation surges into overdrive while genes critical for brain structure and function decline. This imbalance sheds light on how aging increases vulnerability to disease.”

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In studying the cells, they also found the brain’s aging epicenter: the area near the third ventricle of the hypothalamus. That region of the brain is crucial in regulating food intake, metabolism, and how the body uses nutrients. That epicenter, also referred to as “hot spot,” hints at a strong connection between diet, lifestyle, brain health, and changes that can influence vulnerability to age-related brain disorders.

“Our hypothesis is that those cell types are getting less efficient at integrating signals from our environment or from things that we’re consuming,” said Kelly Jin, Ph.D., a scientist at the Allen Institute for Brain Science and lead author of the study. “And that loss of efficiency somehow contributes to what we know as aging in the rest of our body. I think that’s pretty amazing, and I think it’s remarkable that we’re able to find those very specific changes with the methods that we’re using.”

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The Allen Institute said understanding the findings in that hot spot will be key in future studies. It not only helps scientists know which cells to target, but experts said it also could lead to the development of age-related therapeutics. This includes unlocking more specific dietary or drug interventions to maintain brain health into old age.

“Aging is the most important risk factor for Alzheimer’s disease and many other devastating brain disorders. These results provide a highly detailed map for which brain cells may be most affected by aging,” said Richard J. Hodes, M.D., director of NIH’s National Institute on Aging. “This new map may fundamentally alter the way scientists think about how aging affects the brain and also provides a guide for developing new treatments for aging-related brain diseases.”

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The Allen Institute’s discoveries are now published in Nature, a weekly international journal highlighting all fields of science and technology from the finest researchers.

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Where to watch Seattle Mariners vs Chicago White Sox: TV channel, start time, streaming for May 9

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Where to watch Seattle Mariners vs Chicago White Sox: TV channel, start time, streaming for May 9


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Baseball is back and finding what channel your favorite team is playing on has become a little bit more confusing since MLB announced plans to produce and distribute broadcasts for nearly a third of the league.

We’re here to help. Here’s everything you need to know Saturday as the Seattle Mariners visit the Chicago White Sox.

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See USA TODAY’s sortable MLB schedule to filter by team or division.

What time is Seattle Mariners vs Chicago White Sox?

First pitch between the Chicago White Sox and Seattle Mariners is scheduled for 7:10 p.m. (ET) on Saturday, May 9.

How to watch Seattle Mariners vs Chicago White Sox on Saturday

All times Eastern and accurate as of Saturday, May 9, 2026, at 6:32 a.m.

Watch MLB all season long with Fubo

MLB regional blackout restrictions apply

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MLB scores, results

MLB scores for May 9 games are available on usatoday.com . Here’s how to access today’s results:

See scores, results for all of today’s games.



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Seattle Channel’s Susan Han to retire after 18 years

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Seattle Channel’s Susan Han to retire after 18 years


Susan Han, senior producer of the public affairs program City Inside/Out at the Seattle Channel, is retiring this month after nearly two decades of covering politics and community issues in Seattle.

During her tenure, Han helped lead award-winning coverage on topics including elections, police reform, homelessness, teen sex trafficking and public health issues such as safe injection sites.

“I’m most proud of my Emmy for a fentanyl documentary produced with Brian Callanan in 2023,” Han told the Northwest Asian Weekly (NWAW). “I’m grateful for all the talented hosts and hardworking crews I’ve had the good fortune to work with, and for all the guests who said YES to coming on my shows!”

Han also co-produced Seattle Speaks, an interactive town hall series, and contributed reporting to programs including Art Zone, CityStream and Community Stories.

Colleagues and friends praised Han’s dedication and character.

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Susan Han (center) with Assunta Ng (right) and Lori Matsukawa (left). Photo from Assunta Ng.

Former KING 5 anchor Lori Matsukawa said she admired Han’s generosity, recalling that in 2006, while Han was working at KCTS, she co-chaired an Asian American Journalists Association scholarship campaign with Sanjay Bhatt that surpassed its goal ahead of schedule.

“The goal was to raise $100,000 in five years. They did it in four,” Matsukawa said.

She also praised Han’s persistence in journalism.

“She has no fear approaching politicians and other leaders to appear on her program and answer to the people. Her attitude is: That’s their job,” Matsukawa said, adding that Han “has never missed a deadline in the 500-plus shows she’s done at the Seattle Channel.”

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Assunta Ng, founder of the Northwest Asian Weekly, recalled Han’s consistent support during a difficult period in her personal life.

“What can I do?” Han asked Ng when Ng’s husband fell ill. Despite her busy schedule balancing work and family, Han began sending daily messages with humorous clips and cartoons to lift Ng’s spirits.

“Those cartoons often distract me from overthinking and being overwhelmed,” Ng said. “It brings me joy, laughter and surprises. Thank you, Susan, for being a special friend in my life.”

Han said she is looking forward to a break after a long career in television production, though the transition feels surreal.

“I’m still slightly incredulous at the idea of retiring before turning 60, but I’m excited to take a break after a productive and interesting career,” Han said.

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Over her career, Han worked at KING 5, KCTS—now Cascade PBS—and the Seattle Channel. She covered major regional developments, including the election of Gary Locke, Washington’s first Chinese American governor, the legalization of recreational marijuana, the homelessness crisis and the local impacts of the COVID-19 pandemic.

A graduate of the University of Washington, Han has received eight regional Emmy Awards and more than 30 national NATOA awards. Beyond her newsroom work, she has been active in community and nonprofit leadership, including involvement with the Asian American Journalists Association, local parent-teacher associations and the Bellevue School District Multimedia Curriculum Advisory Committee. She has also volunteered with the Make-A-Wish Foundation.



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Offseason Checklist: Seattle Kraken

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Offseason Checklist: Seattle Kraken


The offseason has arrived for half of the league’s teams that aren’t taking part in the playoffs.  Accordingly, it’s now time to examine what they will need to accomplish over the coming months.  Next up is a look at Seattle.

After another coaching change last year, the Kraken were hoping that they’d turn things around this season.  While they were technically in the race for a playoff spot in the final few games, they wound up on the outside looking in once again, resulting in the departure of Ron Francis and an organization-wide audit of their processes.  While a rebuild or roster retooling might be the more prudent move for the team, it doesn’t appear they’ll be going in that direction.  With that in mind, their checklist focuses on moves to help the team now.

Take Care Of Pending Free Agent Forwards

Since Seattle was still within striking distance of a playoff spot, they went from being likely sellers at the trade deadline to improbable buyers.  As a result, instead of moving some core rental veterans for future help, they held onto those and added another one for good measure.  Now, it’s time to figure out which ones they want to keep.

We’ll start with the newcomer Bobby McMann.  The 29-year-old was in the middle of a breakout performance with Toronto before finding a new gear following his acquisition by the Kraken.  McMann potted 10 goals in 18 games with his new team, bringing him to 29 on the season.  That puts him fourth in tallies among all pending UFAs, putting him in a position to command a long-term deal at possibly four (or more) times his current AAV of $1.35MM.  With the team carrying over $28MM in cap room for next season per PuckPedia, it certainly stands to reason that GM Jason Botterill will be trying to keep him around.

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Meanwhile, decisions need to be made on two more wingers, Jaden Schwartz and Eeli Tolvanen.  Schwartz has been with Seattle for all of its five NHL seasons and sits fifth in franchise scoring despite a long list of injuries, including this season.  He has shown flashes of top-six performance but his injury history makes him a little less likely to return, meaning he’ll need to be replaced.  Tolvanen’s case is a little less certain.  He has 35 goals and 71 points over the last two seasons but saw his role be reduced down the stretch.  Still, for a team with minimal firepower, letting a decent scorer walk would be risky.  Also up front, though Jared McCann isn’t a pending unrestricted free agent, he becomes extension-eligible in July and is someone the team should be looking to lock up to a long-term deal.

Make A Decision On Wright

When the Kraken selected Shane Wright with the fourth overall selection in 2022, they hoped that he could be their future top center or at least a core second liner.  Four years later, that outcome doesn’t seem quite as certain.  The team evidently felt the same way as back in January, they reportedly made the youngster available if they were going to land the impactful forward they were seeking.

Unfortunately for Seattle, that move didn’t materialize and Wright’s value has likely dipped since then.  After putting up a very respectable 19 goals and 25 assists in 79 games in his first full season in 2024-25, his sophomore numbers took a turn in the wrong direction.  Wright managed just 12 goals and 15 helpers in 74 appearances last season and struggled considerably after the Olympic break, notching just one goal and four assists in 18 outings.

On the one hand, it seems as if he’s trending in the wrong direction.  On the other, he’s a young center who is signed for one more year on his entry-level deal at a cap charge not far above the minimum salary.  He still has five seasons of team control remaining, too.  Even if his value isn’t as high as it once was, there would still be plenty of suitors for his services.

On top of that, the Kraken are well-stocked down the middle.  Matty Beniers is entrenched as one of their top two middlemen while Berkly Catton, an eighth-overall selection, is a natural center, as is prospect Jake O’Brien, a number pick himself.  Meanwhile, veteran Chandler Stephenson is still signed long-term and bottom-sixer Frederick Gaudreau has a couple of years left as well.  While there is no elite piece (at least at the moment), they’re not in bad shape depth-wise and could afford to part with Wright.

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Botterill will need to decide if he’s better off giving Wright another look in the hopes of him rebounding or at least helping his trade value at the risk of a slow start further lowering his value.  But if the team is still open to moving him, Wright is one of their better trade chips.

Add More Firepower

Over the years, the Kraken have tried more of a by-committee approach with their offense.  Several of the players from that approach are still around but more often than not, that hasn’t worked out well.  In three of their five seasons, they have been in the bottom five of the league in terms of goals scored, including 2025-26 when they were 28th.  (They were fourth and 16th the other two seasons.)

This is why they were willing to pay a significant premium in terms of salary to try to land Artemi Panarin from the Rangers in the hopes of making him the centerpiece of their offense.  They’re believed to have tried to make some big offers in the past to free agents as well but haven’t had a ton of success on that front and the market this year isn’t likely to bring significant improvements up front.

That’s where the idea of moving Wright makes some sense.  With Brandon Montour in the fold, perhaps Vince Dunn could be a trade chip to add a core forward.  They could also pull from their prospect pool (though that’s risky for a non-playoff team).  But with three subpar offensive seasons from this core group, Botterill needs to find a way to add at least one if not two more threats up front.

Upgrade Defensive Depth

Seattle has one other unrestricted free agent of consequence this summer in veteran Jamie Oleksiak.  However, with Dunn, Ryan Lindgren, and Ryker Evans in the fold, they should be able to fill his spot without too much difficulty so they don’t necessarily need to get into a bidding war to try to keep him.

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However, they could stand to upgrade on their depth options.  If they want to give their prospects a bit more time in the minors with Coachella Valley, their internal replacements for Oleksiak are Josh Mahura and Cale Fleury.  Both players have been around the NHL for a few years now but are better seventh options than a full-time sixth.

Fortunately, there will be better options available on the open market.  While there aren’t a ton of top-four players set to reach free agency, there are a lot of third-pairing pieces who have had more success than Mahura and Fleury.  Ideally, the addition would be a right-shot option to balance out the pairings but an upgrade is an upgrade.  They likely only need a short-term player with Ty Nelson, Tyson Jugnauth, Caden Price, and Ville Ottavainen having some success in the minors with the Firebirds and presumably, one of them could break through to full NHL readiness within a year.

But while that prospect depth is promising, a short-term veteran addition to replace Oleksiak and be an improvement on Mahura and Fleury would be worthwhile.  More importantly, it’s one that should be realistic to achieve, unlike their forward needs which will be much harder to accomplish.

Photo courtesy of Charles LeClaire-Imagn Images.

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