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UC San Francisco will be first hospital in California to offer pharmacogenetic testing

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UC San Francisco will be first hospital in California to offer pharmacogenetic testing


Starting Might 9, UC San Francisco would be the first hospital in California, and considered one of just a few nationwide, to supply pharmacogenetic testing. The check will present crucial clues a couple of affected person’s distinctive genetic make-up, enabling pharmacists to tailor medicines and dosages accordingly.

The service will end in smarter prescribing and improved medical outcomes, mentioned Bani Tamraz, PharmD, PhD, affiliate professor within the Division of Scientific Pharmacy on the UCSF College of Pharmacy and lead of the pharmacogenomics program. A affected person’s blood will likely be examined for 15 genes concerned within the metabolism of 56 medicines, together with people who deal with most cancers, transplantation, ache, coronary heart situations, infectious ailments, despair and different situations.

“Hostile drug reactions trigger an estimated 100,000 deaths every year – the fourth main reason behind loss of life in america – in addition to two million hospitalizations. With pharmacogenomic testing, adversarial drug reactions will be diminished by as much as 30%,” Tamraz mentioned.

“Pharmacogenomics will likely be a part of the medical data our pharmacists will now have the ability to use to make sure sufferers obtain the simplest treatment, and to find out the exact dose,” mentioned program co-lead Lisa Kroon, PharmD, chair of the UCSF Division of Scientific Pharmacy, and assistant chief pharmacy officer, medical innovation, training and analysis.

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“We additionally wish to guarantee equitable entry to pharmacogenomic testing and that is one thing we’ll be monitoring,” she mentioned.

Greater than 90% of the inhabitants is believed to hold a minimum of one genetic variant that will immediate a change in a medicine or dosing of sure extensively prescription drugs.

“With pharmacogenomic testing, treatment is tailor-made to a person’s genetic make-up, enhancing efficacy,” mentioned Aleksandar Rajkovich, MD, PhD, UCSF chief genomics officer and program co-lead.

Imaginative and prescient is to ship on ‘promise of precision medication’

“Bringing the most recent science into medical observe is likely one of the hallmarks of UCSF Well being,” added Russ Cucina, UCSF vice chairman of Genetic and Genomic Companies and program co-lead. “Our imaginative and prescient is to ship on the promise of precision medication for all sufferers we and our companions serve.”

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Testing will entail a single blood draw that can establish variations in 15 genes that impression dosing, effectiveness and potential unwanted side effects of the 56 medicines. The variations may end up in adversarial drug reactions or point out a distinct dosage or various medicines must be thought-about.

If sufferers comply with the testing, UCSF will invoice their insurance coverage and publish outcomes inside two weeks by way of the MyChart portal. The outcomes will stay in sufferers’ medical data to information future prescribing. As UCSF pharmacogenetic testing progresses, extra genes and medicines will likely be added. Finally, cheek swabbing could also be launched as an alternative choice to blood attracts.

Weight, age, gender, different medicine affect prescribing

Whereas a affected person’s pharmacogenetic profile will not be the one data wanted for sensible prescribing – age, gender, weight, drug interactions, being pregnant and smoking standing are different elements – it could be an important. “You are not going to double the dose if somebody is a sure age, however you probably have genetic variants that present you are a fast metabolizer, you would possibly do exactly that,” mentioned Tamraz, who has testified in Sacramento in help of a invoice to supply Medi-Cal protection for the testing. The invoice handed the Meeting Well being Committee and it’s anticipated to be in entrance of the governor later this yr.

For years, we and others have carried out analysis wherein we have recognized variants that underlie inter-individual variations in drug response. But the outcomes of that analysis have resided solely in scientific and medical journals. With the opening of the pharmacogenomics program, the analysis will profit our sufferers.

We all know one purpose for poor outcomes in minority populations is that they’re underrepresented in medical trials. The brand new program will embody main genetic variants present in all populations, permitting all of us to learn and decreasing disparities in outcomes.”

Kathy Giacomini, PhD, BSPharm, Dean of the USCF College of Pharmacy

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College of California – San Francisco



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San Francisco, CA

Atmospheric river storm causes minor flooding in San Francisco

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Atmospheric river storm causes minor flooding in San Francisco


Some San Francisco roadways and neighborhoods experienced minor flooding Friday as the atmospheric river dumped heavy rain on the city.

Matthew Coric said he was inside his restaurant when all the sudden he noticed water rising outside.

“Water was coming over the curb already and Rainbow Grocery closed for the day because they flooded or started to flood, and the next two restaurants had water in their restaurant already,” said Coric.

Two years ago during another big storm, the entire block flooded with several feet of water.

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Coric told KPIX he was determined to not let that happen again, so he and some of his employees grabbed brooms and anything else they could get their hands on and ran towards the flooding.

“These two drains right here on either side of the street, we literally couldn’t see them. This was up above the curb. We were just blindly scraping trying to get it unclogged until we could see the little tornado start,” said Coric.

He said they were able to unclog the drain just in time to stop the water from flooding his restaurant, and that it took about 30 minutes for the water to fully recede. 

While he is happy they were able to avoid another crisis, he said he wishes the city would have been monitoring the area so that he and his employees didn’t have to fix it on their own.

“It flooded two years ago, and then last year the city was like high alert. They would park their trucks out here and make sure nothing happened. But now it’s been two years, they forgot about us again and same thing happened,” said Coric.

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He said, from now on when it rains, he’s going to monitor the drains himself and step in anytime he sees them getting clogged.

He recommends that others in areas where flooding happens do the same.

“If you’re out on the street, anybody right, and you see the drain overflowing, I know if you can wait for the city that’s great, but it might not come. Just clean it yourself or get somebody that can just to save everybody a bunch of headaches,” said Coric.



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San Francisco, CA

San Francisco D.A. announces conviction in 2015 quadruple murder

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San Francisco D.A. announces conviction in 2015 quadruple murder


Nearly 10 years after a quadruple murder, drive-by shooting shocked the San Francisco Hayes Valley neighborhood, District Attorney Brooke Jenkins on Friday announced the conviction of the San Francisco man responsible. 

The D.A.’s office issued a news release that said Lee Farley, 36, was found guilty by a jury on four counts of first-degree murder with special circumstances when he opened fire on an occupied vehicle on the night of January 9, 2015.  

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According to evidence and testimony, four men were ambushed from behind on Laguna Street just south of Page Steet at around 10 p.m.

The jury found that Farley committed this act as a participant of a criminal street gang and that he was a felon in possession of a firearm. 

Police arrested Farley in the summer of 2016. He was already serving time at a federal prison in Atwater on unrelated weapons charges when he was taken into custody. 

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The slayings of Manuel O’Neal, David Saucier II, Harith Atchan and Yalani Chinyamurindi left the victims’ families in turmoil as they waited for justice. 

“I would like to thank the jury for their service in this trial,” said District Attorney Jenkins. “I would also like to thank the mothers and families of the murdered men for their patience, faith and trust in my office to get justice for their families. Our strong legal team fought hard, understanding that while nothing we do can bring back their loved ones, that hopefully this verdict brings them some comfort.”

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The D.A. thanked her team and the San Francisco Police Department’s homicide unit for their work on this case. 

Farley’s sentencing will be scheduled after a bench trial on priors. That date is set for Dec. 16, 2024. 



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San Francisco Giants Seen as Top Trade Partner for Chicago Cubs Superstar

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San Francisco Giants Seen as Top Trade Partner for Chicago Cubs Superstar


The San Francisco Giants are expected to swing big this offseason as they look to get themselves back into playoff contention.

A pitch to superstar slugger Juan Soto is considered to be that first big swing, although they are not expected to end up landing him.

Assuming the Giants end up missing on Soto, there are plenty of other fallback options that they could consider.

Pete Alonso and Anthony Santander are two other free agents that the Giants have been connected to. However, there is also a potential trade target that has been linked to San Francisco.

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Looking at the needs the Giants have, they could use more starting pitching, especially if Blake Snell ends up leaving town in free agency. But San Francisco could also use more offensive firepower. They need a big bat to plug into their lineup.

With that in mind, Chicago Cubs star outfielder and first baseman Cody Bellinger has come up as a potential option.

Zach Pressnell of Newsweek has named the Giants as one of the top potential trade suitors for Bellinger if the Cubs end up trading him. Reports have come out that Chicago would like to trade their star this offseason. With new leadership in San Francisco, after the hiring of Bustery Posey as president of baseball operations, there is a chance the former All-Star catcher would listen on a deal for the slugger.

“San Francisco has to chase the Los Angeles Dodgers and the San Diego Padres in its own division before it can worry about coming home with the World Series title,” Pressnell wrote. “A move for Bellinger would push the Giants in the right direction without breaking the bank.”

Bellinger would certainly be an intriguing option for San Francisco. He’s set to make $27.5 million in 2025 and then will have another choice to make before the 2026 season, as his current deal has another option year. There is a chance that he could opt into another year of his deal at $25 million.

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During the 2024 MLB season, Bellinger produced lower numbers than expected. However, he dealt with some injury issues and the Cubs as a whole played under expectations.

He played in 130 total games, hitting 18 home runs to go along with 78 RBI. Bellinger also recorded a slash line of .266/.325/.426.

Just one year previously in 2023, Bellinger had a much stronger season. He hit .307/.356/.525 to go along with 26 home runs and 97 RBI. He was also named the National League Comeback Player of the Year award winner.

All of that being said, the former National League MVP would be an excellent addition for the Giants. Depending on what Chicago is asking for in return, San Francisco should strongly consider making a push to acquire him.



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