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New Alzheimer’s drugs offer hope. One Louisiana woman heard a rare word: ‘remission’

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New Alzheimer’s drugs offer hope. One Louisiana woman heard a rare word: ‘remission’


Staring at her golf gear in her garage in Destrehan three years ago, Diane Roussel couldn’t understand why she couldn’t find a pair of gloves.

She rifled through her golf bag. There were no right-hand gloves. How could she have a dozen left-hand gloves and not a single pair? Her husband found her there, searching.

“You never had pairs,” he told her, gently. “Golfers wear one glove.”

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Of course, Roussel knew that. She had been a golfer for decades.

Later that year, her whole extended family celebrated Christmas and her birthday. It was the biggest gathering they’d had as a family to celebrate, “just an amazing day,” Roussel said.

Three days later, a friend texted. “How was your Christmas?”







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Diane Roussell and her husband, Black, at home in Destrehan on Monday, December 15, 2025. After seeking care for escalating memory lapses, Diane Roussel received a devastating Alzheimer’s diagnosis. She began infusions of Lecanemab, a newly approved drug for Alzheimer’s disease. Thirty-six infusions later, she has seen her biomarkers return to healthy ranges and her cognitive function improve. Her doctor calls it a remission from Alzheimer’s and is previously unheard of. (Photo by Chris Granger, The Times-Picayune)




Roussel couldn’t remember. There “was just a hole” where the memory should have been. She sought out a doctor to understand what might be wrong. After cognitive testing and a spinal tap, Roussel, then 66, learned she had biological signs of early Alzheimer’s disease.

She pleaded with God for it to be something else. “I’d rather you give me every kind of cancer you have in the book than this,” Roussel said. “I don’t want to lose who I am.”

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But there was a sliver of hope. She qualified for a newly approved drug, lecanemab, that was shown to slow down the progression of the disease.

Eighteen months later, Roussel had a follow-up brain scan. The biomarkers that typically indicate Alzheimer’s had normalized. She felt a brain fog lift and hasn’t had any more dramatic losses in memory. In a conversation with her doctor, Dr. James Rini at Ochsner Health, she heard a word rarely associated with the irreversible disease, which for decades has had no treatment shown to alter its course.

“Remission,” she said.

Remission and Alzheimer’s

Rini described Roussel as an uncommon but instructive case in the transforming fight against Alzheimer’s disease.

Since it was first identified more than a century ago, Alzheimer’s was viewed as a one-way decline, treated with medications that eased symptoms but did not change its course until the recent approval of anti-amyloid drugs in 2023 and 2024. 

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Roussel is one of a small number of patients treated early enough that both imaging and biomarker evidence of Alzheimer’s pathology have receded to undetectable levels.

“From all objective ways that we have to measure this disease right now — our serum biomarkers or PET scans or MRIs or cognitive testing — there is no evidence that it’s there,” Rini said. “If she came to my clinic right now, I’d say, ‘You don’t have this.’”

At the same time, he knows that Roussel did have it. So he borrowed language from oncology, calling it a partial remission, like you might for stage 4 cancer.

Rini said this example is not a promise of what is typical for patients, but a glimpse of what may be possible when Alzheimer’s is caught and treated at exactly the right moment, in exactly the right patient.



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Diane Roussell and her medical appointment note book on Monday, December 15, 2025. One of the last entries says PET “scan negative” and “remission.” After seeking care for escalating memory lapses, Diane Roussel received a devastating Alzheimer’s diagnosis. She began infusions of Lecanemab, a newly approved drug for Alzheimer’s disease. Thirty-six infusions later, she has seen her biomarkers return to healthy ranges and her cognitive function improve. Her doctor calls it a remission from Alzheimer’s and is previously unheard of. (Photo by Chris Granger, The Times-Picayune)




The promise and limits of Alzheimer’s drugs

Alzheimer’s is caused by a buildup of abnormal proteins, known as amyloid and tau, that slowly disrupt and kill brain cells, breaking the communication networks needed for memory, thinking and daily function.

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Dr. Demetrius Maraganore, a neurologist at Tulane University and LCMC Health, explains it to patients by comparing it to the roots of oak trees and the cement used to patch New Orleans sidewalks.

Brain cells are shaped like trees, with branching extensions that allow them to communicate. In Alzheimer’s, amyloid accumulates between brain cells, as if cement was poured around the roots of trees to fix sidewalk cracks. If cement is poured at the base of the tree, it weakens the tree, interfering with its ability to receive nutrients.

As amyloid causes brain cells to weaken, another protein, tau, tangles inside the cells themselves, accelerating their decline. Once those brain cells die, they cannot be replaced.

Now, two new drugs, lecanemab, and donanemab, which were approved by the FDA in 2023 and 2024, can remove amyloid. They aim to interrupt the chain reaction that leads to cell injury and the spread of tau tangles, which are more closely tied to cognitive decline.

Lecanemab, sold as Leqembi, is made by Eisai and Biogen. Donanemab, sold as Kisunla, is made by Eli Lilly. The drugs alone cost about $26,000 to $32,000 a year. Medicare covers them for patients with early Alzheimer’s who meet strict criteria, though access can be limited by the need for frequent scans, infusions and specialist care.

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In clinical trials, both drugs slowed cognitive and functional decline in people with very early Alzheimer’s disease. They do not cure Alzheimer’s, do not rebuild damaged brain cells and do not work for everyone.

There is an extensive screening process for who qualifies for the drug, so only about 5% of those who go through the screening process qualify, said Maraganore. Even in those people, sometimes the drugs simply don’t work. In others, they might barely slow the progression of symptoms.

Dr. Ronald Petersen, a Mayo Clinic neurologist who directs an Alzheimer’s disease treatment clinic, said it is important for patients to understand that the drugs typically do not end the memory and thinking problems that accompany Alzheimer’s. When they talk to patients about the drugs, they do so with caution. 

“One, these drugs don’t stop the disease,” Petersen said. Two, they don’t make you better, but we do think they slow down the rate of progression.”

But there could be exceptional cases. 

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“If you get to somebody who has modest amount of amyloid and maybe just a nickel’s worth of tau, that might be the perfect sweet spot,” he said.

The drugs are the only ones proven to alter the underlying biology of the disease. For decades, Alzheimer’s drugs were targeted at symptoms. And despite debate in the field over the root cause of Alzheimer’s, “the data speak for themselves” for the modest effectiveness of these drugs, Maraganore said.

‘There’s hope’

Roussel describes a before-and-after when it comes to the drug treatment: mid-conversation blankness that used to startle her, and a lifting of brain fog. The potential side effects of the drugs — brain swelling and microbleeds — were worth it for her. 

“I live life big,” said the retired IT manager. She’s got holiday lunches with friends on her schedule, and she’s babysitting her “granddog” this week for her grandson while he’s out of town. She cares for her husband, who had a cascade of health issues around the time she was diagnosed.



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Holy Water and a picture of Diane Roussell and her husband, Black, on a shelf in their home on Monday, December 15, 2025 in Destrehan. After seeking care for escalating memory lapses, Diane Roussel received a devastating Alzheimer’s diagnosis. She began infusions of Lecanemab, a newly approved drug for Alzheimer’s disease. Thirty-six infusions later, she has seen her biomarkers return to healthy ranges and her cognitive function improve. Her doctor calls it a remission from Alzheimer’s and is previously unheard of. (Photo by Chris Granger, The Times-Picayune)




In addition to the drug, Roussel also changed her lifestyle. She went to a sleep clinic, changed sleep medications and got a CPAP machine, since sleep is shown to be when the brain repairs itself. She shifted her eating toward a Mediterranean-inspired MIND diet, which emphasizes vegetables, whole grains, fish and olive oil. She also changed her cholesterol medication to one less associated with cognitive side effects.

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Under medical supervision, she began taking several supplements. She had always golfed, but added regular walking, aiming for at least 30 minutes of exercise five days a week.

She credits her faith with getting her through treatment and keeping her optimistic. Unlike decades of failed Alzheimer’s drugs, this one arrived at exactly the right moment, just as she received her diagnosis. It gave her hope.

“That was a little seed I had from the very beginning,” Roussel said. “And it just grew and grew.”

About 12% of Louisiana’s 65-plus population has Alzheimer’s disease, amounting to almost 100,000 people. A lot of them don’t talk about it because of the stigma of the disease. But Roussel sees her experience as carrying a purpose.

“I was meant to have Alzheimer’s so I could talk about it,” she said. “So I could tell people they need to get tested, and that real progress is being made.”

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‘A matter of time’

Roussel, now 69, will transition to a lower-dose maintenance injection designed to prevent amyloid from reaccumulating.

Long-term answers remain limited.

“We don’t know if it’s going to come back,” Rini said. “We monitor closely, because this is essentially ongoing clinical research in real time.”

But the future is bright for a field that just a few years ago had almost nothing to offer patients. Lecanemab and donanemab have been shown to slow the progression of the disease 27% to 35%.

“There’s a place for these drugs,” Maraganore said. “But I also know that better things are going to come.”

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Maraganore pointed to an oral drug in development, taken once daily, that he said has shown 50% to 75% slowing of disease progression at one year in clinical trials and is now being reviewed by regulators in Europe.

“Right now we’re peddling in Kitty Hawk trying to fly across the ocean, but soon we’re going to be sitting in first class in jumbo jets,” he said. “It’s just a matter of time.”



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Louisiana State Police arrest 18-year-old in Vidalia crash t…

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Louisiana State Police arrest 18-year-old in Vidalia crash t…


VIDALIA, La. — Louisiana State Police arrested 18-year-old Gregory Steele early Sunday morning on two counts of vehicular homicide, one count of underage operating a motor vehicle while intoxicated, one count vehicular negligent injuring and one count careless operation, according to Concordia Parish Jail records.

Steele, 18, a white male, was arrested in connection with an accident that occurred at approximately 1:54 a.m. on Sunday morning on Minorca Road in Vidalia. Two passengers in the vehicle were killed. Steele and another passenger were able to escape the vehicle.



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On this Mother’s Day, three Louisiana mothers grieve the deaths of eight of their children, seven killed by their own father | CNN

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On this Mother’s Day, three Louisiana mothers grieve the deaths of eight of their children, seven killed by their own father | CNN


Christina Snow bends down and whispers something in her daughter’s ear as the 11-year-old lies in a white casket, eyes closed as if she were simply asleep.

On the morning before Mother’s Day, Sariahh Snow’s small, lifeless body is one of eight – all children – lined in open white caskets along the front of a church hall in Shreveport, Louisiana.

Except for the low murmur of church organ music drifting through the sanctuary, Snow’s muffled sobs momentarily silence an audience of hundreds who have gathered to grieve alongside the three mothers whose children were all fatally shot by the same man: the father of seven of the eight killed and an uncle to the eighth.

The shocking act of violence, which also left two of the mothers seriously wounded, marked the nation’s deadliest mass shooting in more than two years, a catastrophe so staggering it forced an already grief-stricken country to once again confront the deadly collision of a mental health crisis and America’s unrelenting access to guns.

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“This is not a Shreveport mourning,” Congressman Cleo Fields said in his tribute. “This is a nation mourning.”

Now remembered as the “Eternal 8,” Jayla Elkins, 3; Shayla Elkins, 5; Kayla Pugh, 6; Layla Pugh, 7; Mar’Kaydon Pugh, 10; Sariahh Snow, 11; Khedarrion Snow, 6; and Braylon Snow, 5, were killed in the April 19 shooting.

As grieving attendees lined up to pay respects to the children, one woman shut her eyes after peering at one of the children, Kayla, who wore a white dress, her fingernails carefully painted pink. Just behind her body stood a photograph from when she was still alive, her sweet, wide eyes impossible to reconcile with the stillness of the tiny body in the casket.

Inside the funeral pamphlet, Kayla is described by her family as “K-Mae,” a sweetheart with a big smile who never asked for much, but when she did, melted hearts. She loved “going to school, playing with her sisters, brothers, and cousins, and being outside running, jumping and even wrestling with those she loved.”

The seven other entries read as sweetly. Sarriah was described as “sunshine,” a creative, smart, and loving girl. Khedarrion loved helping his family and adored his principal. Braylon was sweet and gentle. Mar’Kaydon, or “K-Bug,” was a cheerful child who loved telling his grandmother what he learned at school every day. Jayla, also known as her family’s “little J-Bae,” taught her family “more about unconditional love, strength and resilience than words could ever express.” Shayla was warm and quiet. Layla adored her siblings and cousins so much she “would stand up for them no matter how big the other person was.”

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It’s a tragedy that sends chills racing down your spine and leaves a lump in your throat. Throughout the hall, people clung tightly to one another, wiping away each other’s tears. Children filled the pews — sweet, innocent and suddenly feeling even more precious to everyone there.

The Saturday funeral service was carried by the reverberating melody of gospel music that rattled through the hall like waves, sending prayer hands into the air and tears spilling from the eyes of loved ones and strangers alike.

But there were smiles too; and white, pink, blue, and purple bloomed in the crowd of black funereal clothes, woven among bright dresses, pressed shirts, ribbons and flowers.

“Lord, we ask right now a special prayer for Summer Grove School. Lord God, we pray for Lynnwood Public Charter School,” Pastor Al George said during his tribute, praying for the two schools the children had attended.

“We pray for all of those teachers, those principals; Lord, they need you right now. Those students need you right now. They’re going to school and see empty desks; Lord God, they need you right now.”

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Some of the funeral attendees were family, friends and teachers, and many were complete strangers – people who drove more than 12 hours just to stand witness to the unimaginable loss of children they had never met.

“I had to get here,” Kelvin Gadson told CNN. He had arrived a day earlier, having driven from South Carolina, and attended an open viewing of the caskets at a funeral home – the first time the mothers were able to see their children’s bodies.

But Gadson wasn’t just there to honor the children lost. He came for the children still here, the ones now carrying images no child should ever have to carry. With him were two costumes: Minnie and Mickey Mouse. The kids could pose with them as a distraction from what they’d just witnessed.

“They come out scared. But I’m really here because this violence has to stop. It’s killing our children, our precious babies,” Gadson, the founder of Giving a Child a Dream Foundation, told CNN. “My mission is about preventing gun violence.”

Little ones who came out of the casket viewing with their parents wore expressions of confusion and shock after witnessing eight bodies that didn’t look so different from their own.

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One of the children was Micheal Thomas.

“I’m kind of scared of funerals. I’m scared of the dead bodies, and they were pretty kids,” the 10-year-old said, sounding wiser than his years. “They were little. I wish I knew them, we would’ve been playing basketball, football, it would’ve been so fun.”

His friends at school don’t talk about the children as much as he does, he said. Then he points to his little brother, who hides behind his legs and clings tightly to him. “I care because imagine that was your kid. If it was my brother, I would be dying; I would be down bad.”

One day, he said, he will meet them in heaven and tell them, “Hey! How you doing? I’m doing good. You broke my heart, but I was talking about you.”

He hasn’t cried about seeing their bodies but he knows he will. The tears “don’t want to come,” but when they do, he promised he won’t push them back.

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Plastic trucks and ribbon-wrapped dolls

Days after the shooting stunned Shreveport, a whirlwind of police lights, camera crews and grieving relatives swarmed the neighborhood where the killings unfolded, the streets vibrating with sirens, the air shrouded in questions and disbelief.

But today, the home sits almost unbearably silent.

The main road leading to the Cedar Grove house where the children were killed is under construction. Jagged pieces of cement push through the dirt as orange and white caution cones warn drivers of danger. While less than half a mile away, innocent children received no warning at all before encountering the worst danger imaginable.

Eight balloons sway weakly in the wind above a makeshift memorial – eight crosses staked into the damp ground, covered in handwritten messages. Toys cover the lawn: stuffed animals, plastic trucks, dolls still wrapped in ribbons, left behind for children who will never come outside to claim them.

Besides the permanent stain the massacre has left on the neighborhood, it remains, in many ways, still beautiful — homes resting in the midst of lush green grass, children playing on porches, and neighbors blasting Michael Jackson as a family gathers around a table outside.

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A young girl sits slouched in a chair, chin in her hands, bored. It is a neighborhood that, in quieter moments, feels almost like childhood nostalgia made real — fragile, ordinary, and proof of how quickly innocence can be shattered.

In front of the memorial, a small gray cat sits in the rain before wandering to the front door of the gray and white home, curling near the entrance where blood had been spattered just weeks earlier. The gunman was identified as 31-year-old Shamar Elkins. Shreveport Police Cpl. Chris Bordelon told CNN affiliate KSLA the shootings were “domestic in nature.”

As the shooting unfolded, some of the children tried to escape out the back, a state representative said at an earlier news conference. Bullet holes could be seen in the back door of one of the homes.

Every now and then, a car slows to a crawl before pulling over beside the memorial, the people inside sitting silently behind fogged windows, perhaps reminiscing, perhaps praying, perhaps simply trying to make sense of a loss too enormous to truly understand.

Not far from the now empty home, stripped of the laughter and the innocent chaos of excited children that once filled every room and hallway with life, the three mothers, dressed in all white, sit side by side before the eight caskets.

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Keosha Pugh — sister of Shaneiqua Pugh, the gunman’s wife — walked into the funeral leaning on a cane, a painful reminder of the injuries she suffered after jumping from a roof with her daughter, Mar’Kianna, while fleeing the gunfire. The fall shattered her pelvis and hip. Shaneiqua Pugh escaped physically unharmed, but Snow was shot in the face during the attack.

All three mothers carried the visible weight of trauma throughout the service. Their legs trembled beneath them, their hands and heads shook with anxiety, and at times Snow, in tears, curled into the arms of friends and loved ones.

Prayers were recited over the bodies of their babies after horse-drawn carriages carried the children slowly into the cemetery as mourners followed behind, some arms carrying flowers and others carrying young children.

Roses were gently laid across the caskets before eight white doves were released into the sky, their wings unfurling into the clouds — a cruel irony beside the eight young lives below, cut short before their stories ever had the chance to unfurl at all.

Among the mourners was Dollie Sims, who had met the children when their father brought them to her community programs. She recalls being struck by how deeply loved they were. When she learned of their killing, she said she was stunned and retraumatized.

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“This was reliving the gun violence of my son, who was shot 15 times walking down the street. This is surreal, and as a parent, I think all of us out here are just devastated because what makes this situation so traumatic is that it was by their father, who struggled with mental illness,” Sims said, donning a white fur coat and dress as she waited for the family to arrive at the cemetery.

Her son, who survived, was 19 years old at the time of the shooting.

“This should open the eyes to Shreveport, Louisiana, and Louisiana period, about gun violence and its seriousness, and what we need to do to help this situation to make it safer … We need to advocate and support other families and show up and try to find a way to make it better to keep the next family safe.”

Sims believes the full impact of the tragedy has not fully hit the mothers who have not yet been given time to grieve, she said.

“Mother’s Day is just going to be the beginning of them realizing that those babies aren’t there anymore.”

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A few blocks away from the cemetery, Sharon Pouncy had up a folding table beside the road to sell Mother’s Day gift baskets. She lost her own child years ago, she said, after he became sick.

“I want these mamas to know that every mother is holding them in their hearts today,” Pouncy said from the driver’s seat of her truck. She’s wearing a Minnie Mouse shirt – unbeknownst to her, the character is a favorite of the children she had come to honor.

“We know your pain. Once you feel that loss, it never really goes away, you just …” She pauses, and a sad smile flickers across her face. “Well, you just find a way to live with it forever.”

At the same time three mothers lay their babies into the earth; another mother, years into her own journey of grief, finds herself thinking of her baby too.

A man pulls over and points to a basket he’s interested in buying. A card pokes out from a pile of teddy bears: “I love you, Mom.”

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Officials say Louisiana’s black bear bounty could boost hunting this year

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Officials say Louisiana’s black bear bounty could boost hunting this year


BATON ROUGE, La. (Louisiana Illuminator) – Louisiana is set to once again nearly double the number of black bears hunters can legally bag starting later this year.

The number of bear tags issued to hunters will increase from 26 in 2025 to 42 this year, according to the Louisiana Wildlife and Fisheries Commission announced Thursday. Hunters are still limited to one bear each, so the increased count clears the way for more people to pursue the animals.

Black bear hunting season, which resumed in Louisiana two years ago, is scheduled for Dec. 6-20 this year.

The number of black bear tags could change based on continuously updated population counts, said John Hanks, large carnivore program manager for the Louisiana Department of Wildlife and Fisheries, during the meeting. This, in part, is because the commission also ratified an expansion to where black bears can be hunted. Once restricted to only about a third of the state, hunting tags are being made available across more of Louisiana.

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Most tags will be available in Bear Management Area 4 in the northeast corner of the state, where 20 will be awarded through a hunter lottery. The area encompasses all of Madison, Franklin, Tensas, West Carroll and East Carroll parishes and smaller portions Catahoula and Richland parishes.

Other parts of the state will have fewer tags, ranging from two to eight per bear management area.

A map of the Bear Management Areas in Louisiana.(Louisiana Department of Wildlife and Fisheries)

The state brought back black bear hunting in 2024 after banning the practice in 1987, citing successful conservation efforts. The Louisiana black bear was listed as a federally threatened species in 1992 and taken off the list in 2016 as its population grew.

The first season saw 11 bear tags issued, and hunters took 10 bears, eight males and two females. The state increased its tag count to 26 last year, when hunters took 10 males and six females.

Wildlife and Fisheries estimates there are roughly 1,500 black bears in the state.

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There are three types of black bear hunting permits in Louisiana: general permits, for people hunting on private lands with the owner’s permission; wildlife management area permits, for those hunting in public areas the state manages; and private landowner permits, for those who own at least 40 acres in areas where bear hunting is allowed.

Out-of-state landowners could also soon be able to join in on the black bear hunting season in Louisiana.

A bill by state Rep. Neil Riser, R-Columbia, is moving through the Louisiana Legislature that would allow non-residents who own land to apply for bear tags to hunt on their own property. It has gained House and Senate approval and awaits the governor’s signature.

Applications for this year’s Louisiana bear hunting lottery will be accepted July 28 through Aug. 28. Applicants must pay for a non-refundable $25 bear hunting license and a $50 permit fee, which goes toward the state’s bear conservation programs. Hunters can apply for multiple types of permits but can only win one.

Louisiana Illuminator is part of States Newsroom, a nonprofit news network supported by grants and a coalition of donors as a 501c(3) public charity. Louisiana Illuminator maintains editorial independence. Contact Editor Greg LaRose for questions: info@lailluminator.com.

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Copyright 2026 Louisiana Illuminator. All rights reserved.



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