Science
When will kids under 5 be able to get vaccinated for COVID-19?
Faculties across the nation are resuming in-person instruction because the extremely infectious Omicron variant surges via their communities. Public well being officers say COVID-19 vaccines, which can be found for kids as younger as 5 years previous, can present an essential layer of safety for youths on campus. However what’s the timeline for approval for kids below 5?
Dr. William Hartman, the principal investigator of one of many Moderna pediatric COVID-19 vaccine trials, says it’s cheap to consider emergency use authorization for kids 6 months to five years previous may very well be granted in late March or early April. He mentioned it’s “extremely potential” Moderna will attain that time earlier than Pfizer does.
Primarily based on the progress he’s noticed thus far, Hartman, who runs the Hartman Laboratory on the College of Wisconsin, expects preliminary knowledge inside roughly the following month.
In December, Pfizer-BioNTech introduced one thing of a setback within the efforts to develop use of its vaccine: Knowledge from its ongoing trial of kids 2 to 4 point out that the vaccine dosage used — 3 micrograms, or one-tenth of the grownup dose — didn’t produce a potent immune response in that group after two pictures. However the two-shot routine did produce a response — corresponding to the one seen in 16-to-25-year-olds — in infants between 6 months and a pair of years previous. Youngsters 5 to 11 obtain a 10-microgram dose, or one-third of the formulation for folks 12 and older.
Moderna is conducting trials for the under-5 age group utilizing a relatively increased dosage that’s a couple of quarter of the grownup dose, Hartman mentioned.
“So far as we will inform,” he mentioned, that two shot-regimen is proving secure and efficient in trial members. He added that they haven’t noticed any incidents of myocarditis, delicate instances of which have been hardly ever noticed in adolescents who obtained the vaccines.
“I consider that that’s held true (in Moderna trials for this age group) nationally, that the myocarditis worry that all of us have isn’t seeking to be an issue on this age group,” he added.
Pfizer mentioned it plans to check trial topics’ immune response after administering a 3rd dose.
“The choice to judge a 3rd dose of three [micrograms] for kids 6 months to below 5 years of age displays the businesses’ dedication to rigorously choose the correct dose to maximise the risk-benefit profile. If the three-dose research is profitable, Pfizer and BioNTech count on to submit knowledge to regulators to assist an Emergency Use Authorization for kids 6 months to below 5 years of age within the first half of 2022,” wrote Jerica Pitts, a consultant for Pfizer, in an electronic mail.
What about Johnson & Johnson?
An emailed assertion from Johnson & Johnson mentioned Part 2 and three medical trials had been underway in adolescents 12 to 17. In the meantime, the CDC has really helpful that almost all eligible Individuals go for one of many mRNA vaccines as a substitute of the Johnson & Johnson shot.
The winter outlook and security
Dr. Leian Chen, the lead doctor at UCLA Well being Pediatrics in Marina del Rey, says she has conversations about vaccination day by day.
“I’ve some households who will very eagerly ask each go to” about when their youthful youngsters would possibly be capable to get vaccinated, she mentioned.
Elementary-age youngsters have been eligible for vaccination since early November, when the Facilities for Illness Management and Prevention gave emergency use authorization to Pfizer’s vaccine for youths 5 to 11. The American Academy of Pediatrics reported that over 1 in 10 youngsters within the U.S. — almost 7.9 million — have examined constructive for COVID because the begin of the pandemic.
However progress has been gradual: Since vaccines grew to become accessible to that age group, the L.A. Instances vaccine tracker signifies, solely 28% of eligible youngsters have obtained at the very least one dose in California — far behind the general state vaccination price of 75.4%.
Chen mentioned in December that she anticipated to see extra COVID-19 instances in youngsters because the Omicron wave hit Southern California. That prediction has come true: By the tip of the primary week of January, instances amongst Los Angeles Unified College District college students and employees had been up almost tenfold in contrast with earlier than the winter break.
“We’ve seen that children undoubtedly do get COVID. And fortuitously, most are OK,” she mentioned. “However some do get severely unwell. And others do have lengthy COVID signs.”
She mentioned she usually fields questions from dad and mom in regards to the long-term security of those vaccines and stories of unintended effects comparable to myocarditis. She has personally reviewed the info, for each her sufferers and herself. Her 7-year-old grew to become eligible for vaccination together with hundreds of thousands of different youngsters this fall. She determined to get him vaccinated.
Science
Cluster of farmworkers diagnosed with rare animal-borne disease in Ventura County
A cluster of workers at Ventura County berry farms have been diagnosed with a rare disease often transmitted through sick animals’ urine, according to a public health advisory distributed to local doctors by county health officials Tuesday.
The bacterial infection, leptospirosis, has resulted in severe symptoms for some workers, including meningitis, an inflammation of the brain lining and spinal cord. Symptoms for mild cases included headaches and fevers.
The disease, which can be fatal, rarely spreads from human to human, according to the U.S. Centers for Disease Control and Prevention.
Ventura County Public Health has not given an official case count but said it had not identified any cases outside of the agriculture sector. The county’s agriculture commissioner was aware of 18 cases, the Ventura County Star reported.
The health department said it was first contacted by a local physician in October, who reported an unusual trend in symptoms among hospital patients.
After launching an investigation, the department identified leptospirosis as a probable cause of the illness and found most patients worked on caneberry farms that utilize hoop houses — greenhouse structures to shelter the crops.
As the investigation to identify any additional cases and the exact sources of exposure continues, Ventura County Public Health has asked healthcare providers to consider a leptospirosis diagnosis for sick agricultural workers, particularly berry harvesters.
Rodents are a common source and transmitter of disease, though other mammals — including livestock, cats and dogs — can transmit it as well.
The disease is spread through bodily fluids, such as urine, and is often contracted through cuts and abrasions that contact contaminated water and soil, where the bacteria can survive for months.
Humans can also contract the illness through contaminated food; however, the county health agency has found no known health risks to the general public, including through the contact or consumption of caneberries such as raspberries and blackberries.
Symptom onset typically occurs between two and 30 days after exposure, and symptoms can last for months if untreated, according to the CDC.
The illness often begins with mild symptoms, with fevers, chills, vomiting and headaches. Some cases can then enter a second, more severe phase that can result in kidney or liver failure.
Ventura County Public Health recommends agriculture and berry harvesters regularly rinse any cuts with soap and water and cover them with bandages. They also recommend wearing waterproof clothing and protection while working outdoors, including gloves and long-sleeve shirts and pants.
While there is no evidence of spread to the larger community, according to the department, residents should wash hands frequently and work to control rodents around their property if possible.
Pet owners can consult a veterinarian about leptospirosis vaccinations and should keep pets away from ponds, lakes and other natural bodies of water.
Science
Political stress: Can you stay engaged without sacrificing your mental health?
It’s been two weeks since Donald Trump won the presidential election, but Stacey Lamirand’s brain hasn’t stopped churning.
“I still think about the election all the time,” said the 60-year-old Bay Area resident, who wanted a Kamala Harris victory so badly that she flew to Pennsylvania and knocked on voters’ doors in the final days of the campaign. “I honestly don’t know what to do about that.”
Neither do the psychologists and political scientists who have been tracking the country’s slide toward toxic levels of partisanship.
Fully 69% of U.S. adults found the presidential election a significant source of stress in their lives, the American Psychological Assn. said in its latest Stress in America report.
The distress was present across the political spectrum, with 80% of Republicans, 79% of Democrats and 73% of independents surveyed saying they were stressed about the country’s future.
That’s unhealthy for the body politic — and for voters themselves. Stress can cause muscle tension, headaches, sleep problems and loss of appetite. Chronic stress can inflict more serious damage to the immune system and make people more vulnerable to heart attacks, strokes, diabetes, infertility, clinical anxiety, depression and other ailments.
In most circumstances, the sound medical advice is to disengage from the source of stress, therapists said. But when stress is coming from politics, that prescription pits the health of the individual against the health of the nation.
“I’m worried about people totally withdrawing from politics because it’s unpleasant,” said Aaron Weinschenk, a political scientist at the University of Wisconsin–Green Bay who studies political behavior and elections. “We don’t want them to do that. But we also don’t want them to feel sick.”
Modern life is full of stressors of all kinds: paying bills, pleasing difficult bosses, getting along with frenemies, caring for children or aging parents (or both).
The stress that stems from politics isn’t fundamentally different from other kinds of stress. What’s unique about it is the way it encompasses and enhances other sources of stress, said Brett Ford, a social psychologist at the University of Toronto who studies the link between emotions and political engagement.
For instance, she said, elections have the potential to make everyday stressors like money and health concerns more difficult to manage as candidates debate policies that could raise the price of gas or cut off access to certain kinds of medical care.
Layered on top of that is the fact that political disagreements have morphed into moral conflicts that are perceived as pitting good against evil.
“When someone comes into power who is not on the same page as you morally, that can hit very deeply,” Ford said.
Partisanship and polarization have raised the stakes as well. Voters who feel a strong connection to a political party become more invested in its success. That can make a loss at the ballot box feel like a personal defeat, she said.
There’s also the fact that we have limited control over the outcome of an election. A patient with heart disease can improve their prognosis by taking medicine, changing their diet, getting more exercise or quitting smoking. But a person with political stress is largely at the mercy of others.
“Politics is many forms of stress all rolled into one,” Ford said.
Weinschenk observed this firsthand the day after the election.
“I could feel it when I went into my classroom,” said the professor, whose research has found that people with political anxiety aren’t necessarily anxious in general. “I have a student who’s transgender and a couple of students who are gay. Their emotional state was so closed down.”
That’s almost to be expected in a place like Wisconsin, whose swing-state status caused residents to be bombarded with political messages. The more campaign ads a person is exposed to, the greater the risk of being diagnosed with anxiety, depression or another psychological ailment, according to a 2022 study in the journal PLOS One.
Political messages seem designed to keep voters “emotionally on edge,” said Vaile Wright, a licensed psychologist in Villa Park, Ill., and a member of the APA’s Stress in America team.
“It encourages emotion to drive our decision-making behavior, as opposed to logic,” Wright said. “When we’re really emotionally stimulated, it makes it so much more challenging to have civil conversation. For politicians, I think that’s powerful, because emotions can be very easily manipulated.”
Making voters feel anxious is a tried-and-true way to grab their attention, said Christopher Ojeda, a political scientist at UC Merced who studies mental health and politics.
“Feelings of anxiety can be mobilizing, definitely,” he said. “That’s why politicians make fear appeals — they want people to get engaged.”
On the other hand, “feelings of depression are demobilizing and take you out of the political system,” said Ojeda, author of “The Sad Citizen: How Politics is Depressing and Why it Matters.”
“What [these feelings] can tell you is, ‘Things aren’t going the way I want them to. Maybe I need to step back,’” he said.
Genessa Krasnow has been seeing a lot of that since the election.
The Seattle entrepreneur, who also campaigned for Harris, said it grates on her to see people laughing in restaurants “as if nothing had happened.” At a recent book club meeting, her fellow group members were willing to let her vent about politics for five minutes, but they weren’t interested in discussing ways they could counteract the incoming president.
“They’re in a state of disengagement,” said Krasnow, who is 56. She, meanwhile, is looking for new ways to reach young voters.
“I am exhausted. I am so sad,” she said. “But I don’t believe that disengaging is the answer.”
That’s the fundamental trade-off, Ojeda said, and there’s no one-size-fits-all solution.
“Everyone has to make a decision about how much engagement they can tolerate without undermining their psychological well-being,” he said.
Lamirand took steps to protect her mental health by cutting social media ties with people whose values aren’t aligned with hers. But she will remain politically active and expects to volunteer for phone-banking duty soon.
“Doing something is the only thing that allows me to feel better,” Lamirand said. “It allows me to feel some level of control.”
Ideally, Ford said, people would not have to choose between being politically active and preserving their mental health. She is investigating ways to help people feel hopeful, inspired and compassionate about political challenges, since these emotions can motivate action without triggering stress and anxiety.
“We want to counteract this pattern where the more involved you are, the worse you are,” Ford said.
The benefits would be felt across the political spectrum. In the APA survey, similar shares of Democrats, Republicans and independents agreed with statements like, “It causes me stress that politicians aren’t talking about the things that are most important to me,” and, “The political climate has caused strain between my family members and me.”
“Both sides are very invested in this country, and that is a good thing,” Wright said. “Antipathy and hopelessness really doesn’t serve us in the long run.”
Science
Video: SpaceX Unable to Recover Booster Stage During Sixth Test Flight
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