Science
What is the C.1.2 coronavirus variant — and should we be worried?
Researchers are monitoring a brand new coronavirus variant that was not too long ago recognized in South Africa and seems to have a startling variety of mutations with the potential to present it an evolutionary benefit over different viral strains.
The C.1.2 variant was detected in Could of this 12 months and formally recognized in July. It advanced from C.1, a model of the virus that dominated South Africa’s first wave of infections.
In Could, C.1.2 accounted for 0.2% of 1,054 genomes sequenced by a staff based mostly in South Africa as a part of a surveillance program, in accordance with a preliminary report posted on MedRxiv. In June, that share was as much as 1.6% of two,177 samples, and by July, it had climbed to 2% of 1,326 samples.
That sample is “just like the will increase seen in Beta and Delta in South Africa throughout early detection,” the examine authors wrote, referring to coronavirus variants first recognized in South Africa and India, respectively.
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C.1.2 has made its means from Africa to Asia, Oceania and Europe. Scientists have noticed it in Botswana, Mauritius, China, New Zealand, Portugal, Switzerland and the UK.
Will the USA be subsequent? Ought to we be fearful?
To search out out, we talked with Dr. Stuart Ray, an immunologist and infectious illness knowledgeable at Johns Hopkins College College of Medication, and Ramon Lorenzo-Redondo, a molecular virologist at Northwestern College Feinberg College of Medication.
What’s the C.1.2 variant?
Perhaps the very first thing to know is what it’s not. Presently, the World Well being Group categorizes troubling variants into two classes:
- Variants of curiosity: These have genetic markers linked to adjustments in transmissibility, receptor binding or different traits which will enhance the virus’ health.
- Variants of concern: These are viruses for which there’s precise real-world proof of traits that make them a much bigger problem to take care of. As an illustration, they could unfold extra simply, trigger extra extreme illness or cut back the effectiveness of antibodies produced by the immune system.
By now, you’ve doubtless heard of Delta, the extremely transmissible variant that’s inflicting circumstances to surge in lots of elements of the U.S. That’s one variant of concern, together with Alpha, Beta and Gamma.
Those often known as Eta, Iota, Kappa, Lambda and Mu are all categorized as variants of curiosity.
To date, C.1.2 has not made both listing.
So why are individuals speaking about it?
Scientists have been conducting genomic surveillance on samples from routine coronavirus assessments performed in private and non-private labs in South Africa — and in C.1.2 they’ve discovered a set of worrisome mutations that, in different variants of concern and variants of curiosity, are thought to assist the virus infect cells or evade the physique’s defenses.
And that’s not all: There are additionally “some further mutations that would have significance” to how profitable the virus finally ends up being, Lorenzo-Redondo mentioned.
Ray agreed.
“It has some mutations that may very well be known as ‘mutations of curiosity’ as a result of they’re the sorts of mutations that make a variant turn into a variant of curiosity,” he mentioned.
Lots of the shared mutations, corresponding to one known as N501Y, are linked to an improved potential to bind with the ACE2 receptor on the surface of a cell; the virus targets this receptor with a purpose to “unlock” cells and achieve entry.
Different mutations are linked to decreased effectiveness of antibodies, whether or not they’re generated in response to a COVID-19 vaccine or a previous coronavirus an infection.
Why are individuals saying it’s “extremely mutated”?
The variant appears to have racked up a lot of mutations in a brief time frame. The authors of the MedRXiv report recommend that C.1.2’s fee of evolution is about 1.7 instances as quick as the present world fee for the coronavirus basically.
“It’s hanging as a result of it carries so many adjustments which might be worrisome, and it’s additionally received this attribute that it seems to have advanced quickly,” Ray mentioned.
The report authors mentioned this increased fee of evolution appeared to parallel the early rise of different influential variants, together with Alpha, Beta and Gamma.
Ray was fast to attract a distinction between fee of mutations and fee of evolution. Mutations are mandatory for evolution to happen, however they don’t assure it.
“Mutation is a random course of,” he mentioned. It could happen anytime a virus replicates in an contaminated host’s physique — and viruses replicate so much.
Most mutations don’t truly profit the virus. Just a few could confer some sort of a bonus by serving to a virus adapt when going through explicit environmental pressures or introduced with new alternatives to unfold.
“When an organism good points a brand new area of interest … it has new challenges to face,” Ray mentioned. When that occurs “it would evolve extra quickly for a short while,” he mentioned.
For his or her half, the report authors say that C.1.2’s excessive variety of mutations may be the results of “a interval of accelerated evolution in a single particular person with extended viral an infection” that lasted far longer than the extra typical two-week run.
With the power to duplicate freely for a protracted time frame in a single particular person’s physique, these uncommon helpful mutations can actually begin to add up.
Are vaccines, or the antibodies from a earlier an infection, much less efficient in opposition to C.1.2?
A lot of C.1.2’s mutations have an effect on the virus’ spike protein, which is what it makes use of to “unlock” goal cells. It’s additionally the protein that mRNA vaccines train the physique’s immune system to acknowledge so that they’ll be ready for an assault.
If antibodies are created in response to an an infection, they’re tailor-made to the actual spike protein utilized by the invading virus.
Both means, adjustments to the spike protein “are worrisome as a result of they will have an effect on antibodies and different immune responses that may intervene with the virus entering into cells,” Ray mentioned.
If these adjustments are important sufficient to stop antibodies from recognizing C.1.2, it could be simpler for it to slide previous the immune system.
“We’ve got to be cautious,” Ray mentioned.
However antibodies aren’t the be-all and end-all of the physique’s immune response, he mentioned. T cells and different so-called lymphocytes can assault overseas our bodies, together with a virus it encounters.
“There’s nonetheless so much that the T cells can acknowledge, Ray mentioned.
How fearful ought to we be?
You possibly can take a breath. Specialists say the emergence of a brand new variant doesn’t essentially spell imminent doom.
“Numerous the variants we hear about, they’re form of flash within the pan — we’re not fairly positive whether or not they’re going to develop into one thing massive,” Ray mentioned.
Proper now, Delta is the a lot greater concern — and, because the dominant pressure right here within the U.S., the variant to beat.
“We’ve discovered that these footraces between variants actually inform us so much about how aggressive they’re,” Ray mentioned, pointing to the way in which Delta rapidly grew to account for many new coronavirus infections. “If a variant can’t outcompete” its rivals, it’s much less prone to be an equally persistent risk.
“We would wish to see this C.1.2 outcompete Delta someplace. And, in fact, one chance is that it’s going to achieve some operate that may enable it to try this,” Ray mentioned. “So we now have to be vigilant.”
The larger fear is that this, Lorenzo-Redondo mentioned: That extra harmful variants will crop up as infections proceed to unfold via susceptible, unvaccinated populations.
“It is a world warfare proper now,” he mentioned.
To keep away from the rise of extra variants that would delay the epidemic, he mentioned, extra individuals all over the world have to have entry to vaccines.
Science
How to protect yourself from the smoke caused by L.A. wildfires
You don’t have to live close to a wildfire to be affected by its smoke. With severe winds fanning the fires in and around Pacific Palisades, the Pasadena foothills and Simi Valley, huge swaths of the Southland are contending with dangerous air quality.
Wildfire smoke can irritate your eyes, nose, throat and lungs. The soot may contain all kinds of dangerous pollutants, including some that may cause cancer. The tiniest particles in smoke can travel deep into your lungs or even enter your bloodstream.
Conditions like these aren’t good for anyone, but they’re particularly bad for people in vulnerable groups, including children, those with asthma or other respiratory conditions, people with heart disease and those who are pregnant.
Here’s what you should know to keep yourself safe.
Stay indoors
Minimize your exposure to unhealthy air by staying inside and keeping your doors and windows shut.
If you have a central heating and air conditioning system, you can keep your indoor air clean by turning it on and keeping it running. Make sure the fresh-air intake is closed so that you’re not drawing in outdoor air.
Keep your pets inside
They shouldn’t breathe the unhealthy air either.
Check your air filters
Clean filters work better than dirty ones, and high-efficiency filters work better than regular ones. The California Air Resources Board and the South Coast Air Quality Management District recommend filters with a MERV rating of 13 or higher.
You might consider using portable high-efficiency air cleaner in a room where you spend the most time. The U.S. Environmental Protection Agency has information about them here, and CARB has a list of certified cleaning devices here.
Don’t pollute your indoor air
That means no burning candles or incense. If your power is out and you need to see in the dark, you’re much better off with a flashlight or headlamp.
If you’re cold, bundle up. This is not the time to start a cozy fire in the fireplace. Don’t use a gas stove or wood-fired appliances, since these will make your indoor air quality worse, not better, the AQMD says.
The CDC also advises against vacuuming, since it can stir up dust and release fine particles into the air.
Take care when cleaning up
You don’t want your skin to come into contact with wildfire ash. That means you should wear long sleeves, pants, gloves, socks and shoes. The AQMD even wants you to wear goggles.
If you’re sweeping up ash outdoors, get a hose and mist it with water first. That will keep it from flying up in the air as you move it around. Once the ash is wet, sweep it up gently with a broom or mop. Bag it up in a plastic bag and throw it away.
It’s a good idea to wash your vehicles and outdoor toys if they’re covered in ash. Try not to send ashy water into storm drains. Direct the dirty water into ground areas instead, the AQMD advises.
Those with lung or heart problems should avoid clean-up activities.
Discard spoiled food…
If you lost power for a significant length of time, the food in your refrigerator or freezer may be spoiled.
Food kept in a fridge should stay safe for up to four hours if you’ve kept the door closed. If you’ve been without power for longer than that, you’ll need to toss all perishable items, including meat, poultry, fish, eggs, milk and cut fruits and vegetables. Anything with “an unusual smell, color, or texture” should be thrown out as well, according to the U.S. Centers for Disease and Control Prevention.
Refrigerated medicines should be OK unless the power was out for more than a day. Check the label to make sure.
…even if it was in the freezer
Your freezer may be in better shape, especially if it’s well-stocked. Items in a full freezer may be safe for up to 48 hours if it’s been kept shut, and a half-full freezer may be OK for up to 24 hours. (The frozen items help keep each other cold, so the more the better.)
If items have remained below 40 degrees Fahrenheit (4 degrees Celsius) or you can still see ice crystals in them, they may be OK to use or refreeze, according to the federal government’s food safety website.
Ice cream and frozen yogurt should be thrown out if the power goes out for any amount of time. Meat, poultry, seafood, eggs, milk and most other dairy products need to go if they were exposed to temperatures above 40 degrees F for two hours or longer. The same goes for frozen meals, casseroles, soups, stews and cakes, pies and pastries with custard or cheese fillings.
Fruit and fruit juices that have started to thaw can be refrozen unless they’ve started to get moldy, slimy or smell like yeast. Vegetables and vegetable juices should be discarded if they’ve been above 40 degrees F for six hours or more, even if they look and smell fine.
Breakfast items like waffles and bagels can be refrozen, as can breads, rolls, muffins and other baked goods without custard fillings.
Consider alternative shelter
If you’ve done everything you can but your eyes are still watering, you can’t stop coughing, or you just don’t feel well, seek alternative shelter where the air quality is better.
Hold off on vigorous exercise
Doing anything that would cause you to breathe in more deeply is a bad idea right now.
Mask up outdoors
If you need to be outside for an extended time, be sure to wear a high-quality mask. A surgical mask or cloth mask won’t cut it — health authorities agree that you should reach for an N95 or P-100 respirator with a tight seal.
Are young children at greater risk of wildfire smoke?
Very young children are especially vulnerable to the effects of wildfire smoke because their lungs are still rapidly developing. And because they breathe much faster than adults, they are taking in more toxic particulate matter relative to their tiny bodies, which can trigger inflammation, coughing and wheezing.
Any kind of air pollution can be dangerous to young children, but wildfire smoke is about 10 times as toxic for children compared to air pollution from burning fossil fuels, said Dr. Lisa Patel, clinical associate professor of pediatrics at Stanford Children’s Health. Young children with preexisting respiratory problems like asthma are at even greater risk.
Patel advises parents to keep their young children indoors as much as possible, create a safe room in their home with an air purifier, and try to avoid using gas stoves to avoid polluting the indoor air.
Children over the age of 2 should also wear a well-fitting KN95 mask if they will be outdoors for a long period of time. Infants and toddlers younger than that don’t need to mask up because it can be a suffocation risk, Patel said.
What are the risks for pregnant people?
Pregnant people should also take extra precautions around wildfire smoke, which can cross the placenta and affect a developing fetus. Studies have found that exposure to wildfire smoke during pregnancy can increase the risk of premature birth and low birth weight. Researchers have also linked the toxic chemicals in smoke with maternal health complications including hypertension and preeclampsia.
What about other high-risk populations?
Certain chronic diseases including asthma, chronic obstructive pulmonary disease or other respiratory conditions can also make you particularly vulnerable to wildfire smoke. People with heart disease, diabetes and chronic kidney disease should take extra care to breathe clean air, the CDC says. The tiny particles in wildfire smoke can aggravate existing health problems, and may make heart attacks or strokes more likely, CARB warns.
Get ready for the next emergency
Living in Southern California means another wildfire is coming sooner or later. To prepare for the bad air, you can:
- Stock up on disposable respirators, like N95 or P-100s.
- Have clean filters ready for your A/C system and change them out when things get smoky.
- Know how to check the air quality where you live and work. The AQMD has an interactive map that’s updated hourly. Just type in an address and it will zoom in on the location. You can also sign up to get air quality alerts by email or on your smartphone.
- Know where your fire extinguisher is and keep it handy.
- If you have a heart or lung condition, keep at least five days’ worth of medication on hand.
Times staff writer Karen Garcia contributed to this report.
Science
Punk and Emo Fossils Are a Hot Topic in Paleontology
Mark Sutton, an Imperial College London paleontologist, is not a punk.
“I’m more of a folk and country person,” he said.
But when Dr. Sutton pieced together 3-D renderings of a tiny fossil mollusk, he was struck by the spikes that covered its wormlike body. “This is like a classic punk hairstyle, the way it’s sticking up,” he thought. He called the fossil “Punk.” Then he found a similar fossil with downward-tipped spines reminiscent of long, side-swept “emo” bangs. He nicknamed that specimen after the emotional alt-rock genre.
On Wednesday, Dr. Sutton and his colleagues published a paper in the journal Nature formally naming the creatures as the species Punk ferox and Emo vorticaudum. True to their names, these worm-mollusks are behind something of an upset (if not quite “anarchy in the U.K.”) over scientists’ understanding of the origins of one of the biggest groups of animals on Earth.
In terms of sheer number of species, mollusks are second only to arthropods (the group that contains insects, spiders and crustaceans). The better-known half of the mollusk family tree, conchiferans, contains animals like snails, clams and octopuses. “The other half is this weird and wacky group of spiny things,” Dr. Sutton said. Some animals in this branch, the aculiferans, resemble armored marine slugs, while others are “obscure, weird molluscan worms,” he said.
Punk and Emo, the forerunners of today’s worm-mollusks, lived on the dark seafloor amid gardens of sponges, nearly 200 million years before the first dinosaurs emerged on land. Today, their ancient seafloor is a fossil site at the border between England and Wales.
The site is littered with rounded rocky nodules that “look a bit like potatoes,” Dr. Sutton said. “And then you crack them open, and some of them have got these fossils inside. But the thing is, they don’t really look like much at first.”
While the nodules can preserve an entire animal’s body in 3-D, the cross-section that becomes visible when a nodule is cracked open can be difficult to interpret “because you’re not seeing the full anatomy,” Dr. Sutton said.
Paleontologists can use CT scans to see parts of fossils still hidden in rock, essentially taking thousands of X-rays of the fossil and then stitching those X-ray slices together into one digital 3-D image. But in these nodules, the fossilized creatures and the rock surrounding them are too similar in density to be easily differentiated by X-rays. Instead, Dr. Sutton essentially recreated this process of slicing and imaging by hand.
“We grind away a slice at a time, take a photo, repeat at 20-micron intervals or so, and basically destroy but digitize the fossil as we go,” Dr. Sutton said. At the end of the process, the original fossil nodule is “a sad-looking pile of dust,” but the thousands of images, when painstakingly digitally combined, provide a remarkable picture of the fossil animal.
Punk and Emo’s Hot Topic-worthy spikes set them apart from other fossils from the aculiferan branch of the mollusk family. “We don’t know much about aculiferans, and it’s unusual to find out we’ve suddenly got two,” Dr. Sutton said.
Stewart Edie, the curator of fossil bivalves at the Smithsonian National Museum of Natural History, said that Punk and Emo’s bizarre appearances shook up a long-held understanding of how mollusks evolved. Traditionally, scientists thought that the group of mollusks containing snails, clams and cephalopods “saw all of the evolutionary action,” said Dr. Edie, who was not involved with the new discovery. “And the other major group, the aculiferans, were considerably less adventurous.” But Punk and Emo “buck that trend,” he said.
The new alt-rock aculiferans reveal the hidden diversity of their group in the distant past and raise questions about why their descendants make up such a small part of the mollusk class today. “This is really giving us an almost unprecedented window into the sorts of things that were actually around when mollusks were getting going,” Dr. Sutton said. “It’s just this little weird, unexpected, really clear view of what was going on in the early history of one of the most important groups of animals.”
Science
FDA sets limits for lead in many baby foods as California disclosure law takes effect
The U.S. Food and Drug Administration this week set maximum levels for lead in baby foods such as jarred fruits and vegetables, yogurts and dry cereal, part of an effort to cut young kids’ exposure to the toxic metal that causes developmental and neurological problems.
The agency issued final guidance that it estimated could reduce lead exposure from processed baby foods by about 20% to 30%. The limits are voluntary, not mandatory, for food manufacturers, but they allow the FDA to take enforcement action if foods exceed the levels.
It’s part of the FDA’s ongoing effort to “reduce dietary exposure to contaminants, including lead, in foods to as low as possible over time, while maintaining access to nutritious foods,” the agency said in a statement.
Consumer advocates, who have long sought limits on lead in children’s foods, welcomed the guidance first proposed two years ago, but said it didn’t go far enough.
“FDA’s actions today are a step forward and will help protect children,” said Thomas Galligan, a scientist with the Center for Science in the Public Interest. “However, the agency took too long to act and ignored important public input that could have strengthened these standards.”
The new limits on lead for children younger than 2 don’t cover grain-based snacks such as puffs and teething biscuits, which some research has shown contain higher levels of lead. And they don’t limit other metals such as cadmium that have been detected in baby foods.
The FDA’s announcement comes just one week after a new California law took effect that requires baby food makers selling products in California to provide a QR code on their packaging to take consumers to monthly test results for the presence in their product of four heavy metals: lead, mercury, arsenic and cadmium.
The change, required under a law passed by the California Legislature in 2023, will affect consumers nationwide. Because companies are unlikely to create separate packaging for the California market, QR codes are likely to appear on products sold across the country, and consumers everywhere will be able to view the heavy metal concentrations.
Although companies are required to start printing new packaging and publishing test results of products manufactured beginning in January, it may take time for the products to hit grocery shelves.
The law was inspired by a 2021 congressional investigation that found dangerously high levels of heavy metals in packaged foods marketed for babies and toddlers. Baby foods and their ingredients had up to 91 times the arsenic level, up to 177 times the lead level, up to 69 times the cadmium level, and up to five times the mercury level that the U.S. allows to be present in bottled or drinking water, the investigation found.
There’s no safe level of lead exposure for children, according to the U.S. Centers for Disease Control and Prevention. The metal causes “well-documented health effects,” including brain and nervous system damage and slowed growth and development. However, lead occurs naturally in some foods and comes from pollutants in air, water and soil, which can make it impossible to eliminate entirely.
The FDA guidance sets a lead limit of 10 parts per billion for fruits, most vegetables, grain and meat mixtures, yogurts, custards and puddings and single-ingredient meats. It sets a limit of 20 parts per billion for single-ingredient root vegetables and for dry infant cereals. The guidance covers packaged processed foods sold in jars, pouches, tubs or boxes.
Jaclyn Bowen, executive director of the Clean Label Project, an organization that certifies baby foods as having low levels of toxic substances, said consumers can use the new FDA guidance in tandem with the new California law: The FDA, she said, has provided parents a “hard and fast number” to consider a benchmark when looking at the new monthly test results.
But Brian Ronholm, director of food policy for Consumer Reports, called the FDA limits “virtually meaningless because they’re based more on industry feasibility and not on what would best protect public health.” A product with a lead level of 10 parts per billion is “still too high for baby food. What we’ve heard from a lot of these manufacturers is they are testing well below that number.”
The new FDA guidance comes more than a year after lead-tainted pouches of apple cinnamon puree sickened more than 560 children in the U.S. between October 2023 and April 2024, according to the CDC.
The levels of lead detected in those products were more than 2,000 times higher than the FDA’s maximum. Officials stressed that the agency doesn’t need guidance to take action on foods that violate the law.
Aleccia writes for the Associated Press. Gold reports for The Times’ early childhood education initiative, focusing on the learning and development of California children from birth to age 5. For more information about the initiative and its philanthropic funders, go to latimes.com/earlyed.
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