Science
Robert H. Grubbs, Caltech Nobel Prize winner who revolutionized green chemistry, dies
Robert H. Grubbs, the Caltech Nobel Prize winner whose strategies of breaking up molecules and rebuilding them in response to specification revolutionized the sector of natural chemistry, has died at 79.
Exploiting a course of often known as metathesis, during which carbon compounds trade components with each other, Grubbs confirmed how one can create a broad vary of latest merchandise, from environmentally pleasant plastics to resins to prescribed drugs.
His discoveries constructed on the work of two different scientists, Yves Chauvin of France and Richard Schrock of MIT, with whom he shared the $1.3-million Nobel Prize in chemistry in 2005. “He was the one who took what I did and turned it into one thing sensible,” Schrock mentioned on the time.
A serious advantage of Grubbs’ course of was that it minimized wasteful and dangerous byproducts of chemical reactions, an necessary advance within the discipline of what’s now known as inexperienced chemistry. “Bob’s power as a scientist was his creativity,” mentioned Dennis Dougherty, the Norman Davidson Management Chair in Chemistry at Caltech. “He was essentially the most inventive chemist I ever interacted with.”
Grubbs, who was admired as a lot for his heat and private simplicity as for his achievements, died of a coronary heart assault Dec. 19 on the Metropolis of Hope hospital in Duarte, the place he was being handled for lymphoma, his son Barney mentioned.
Robert H. Grubbs was born Feb. 27, 1942, in a farmhouse his father constructed close to Possum Trot, Ky. The center baby between two sisters, he described his upbringing as one thing out of a rural American novel of manners, with a supportive prolonged household of aunts, uncles and grandparents, a lot of them farmers in tobacco nation. His mom taught faculty for 35 years whereas his father labored as a mechanic for the Tennessee Valley Authority.
A lanky boy — he stood 6 toes, 6 inches in maturity — he was desirous about all issues mechanical; any cash earned was spent on nails as a substitute of sweet. Having spent his summers in farm work and development, he enrolled on the College of Florida as an agricultural chemistry main. There, he landed a summer season job analyzing steer feces.
A good friend working in a chemistry lab saved him from a profession learning animal matter, Grubbs mentioned, by inviting him to assist out at night time. “I discovered that natural chemical compounds smelled a lot better than steer feces and that there was nice pleasure in making new molecules,” he wrote later.
Natural compounds based mostly on advanced preparations of carbon atoms are the idea of all life that we all know. Studying how these compounds react on a molecular stage, and how one can adapt them to new makes use of, fascinated Grubbs as a scholar. “Constructing new molecules was much more enjoyable than constructing homes,” he mentioned.
He earned his bachelor and grasp’s levels on the College of Florida, then acquired his doctorate from Columbia College, the place he met and married his spouse, Helen O’Kane, who turned a particular schooling instructor. He spent a yr at Stanford College as a Nationwide Institutes of Well being fellow earlier than becoming a member of the school of Michigan State College in 1968. A decade later, he was employed by Caltech, the place he turned the Victor and Elizabeth Atkins Professor of Chemistry in 1990.
When his profession started, “organometallic chemistry was in its infancy and it supplied a fertile discipline for a mechanistic chemist,” Grubbs mentioned. He turned significantly desirous about metathesis, a phrase that means altering locations, involving chemical reactions during which two carbon-based molecules trade fragments underneath the affect of a 3rd molecule, often known as a catalyst. On this manner, bits of molecules will be selectively stripped out and changed with items from one other compound.
The pure course of was first noticed within the Nineteen Fifties within the petrochemical business, however scientists didn’t know what was happening, and even how one can use it. Chauvin supplied the primary theoretical mannequin in 1970, suggesting that the method is initiated by a household of chemical compounds known as metallic carbenes, during which a metallic atom is double-bonded to a carbon atom. In what has been likened to a dance, the metal-carbon double-bond binds to a carbon-carbon bond in a goal molecule, forming a hoop of 4 atoms. The 4 then separate into new couplets, with totally different companions.
On the Royal Swedish Academy of Science’s information convention asserting the Nobel award in 2005, the method was demonstrated by two dancing {couples}. All 4 dancers then joined palms earlier than separating once more, with every member dancing off with a brand new accomplice.
After Chauvin’s report, Schrock started looking for a catalyst that might perform the response in a predictable manner, lastly deciding on molybdenum and tungsten. The issue was that these metals weren’t steady in air and had been incompatible with many different compounds.
In 1992, Grubbs solved the issue through the use of ruthenium as a catalyst. It proved to be rather more steady and might be utilized in a wide range of substrates, together with water and alcohol. A type of compounds turned often known as the “Grubbs catalyst” and was the usual towards which all others had been measured.
To Grubbs, it was a shock the method labored. “Carbon-carbon double bonds are normally one of many strongest factors within the molecule,” Grubbs advised the New York Instances. “To have the ability to rip them aside and put them again collectively very cleanly was an entire shock to natural chemists.”
His work was tailored in a brand new household of custom-built compounds with specialised properties, akin to medicine for varied illnesses, plastics made out of vegetable oils, slightly than petroleum, and herbicides.
Grubbs’ unfussy method to his accomplishments revealed itself maybe greatest in his response to being named a Nobelist. “I had simply opened a bottle of fine port,” he advised the Los Angeles Instances’ Tom Maugh by cellphone from New Zealand, “so I continued consuming it.”
In his free time, he turned a climber, scaling rocks in Joshua Tree and Yosemite, and late in life adopted fly-fishing as a passion, his son mentioned.
Over his profession, Grubbs suggested and mentored greater than 100 doctoral candidates and nearly 200 postdoctoral associates. He additionally co-founded a number of firms, together with Materia Inc. of Pasadena, which held the rights to his catalysts.
“Bob was an inspiration to Caltech colleagues and to scientists all over the world, for his human qualities as a lot as for his pathbreaking contributions to analysis and society. We’ll keenly miss his knowledge and imaginative and prescient,” mentioned Caltech President Thomas F. Rosenbaum.
Moreover the Nobel Prize, Grubbs was the recipient of the Benjamin Franklin Medal from the Franklin Institute, the Arthur C. Cope Award from the American Chemical Society and the Gold Medal from the American Institute of Chemists. He was a member of the Nationwide Academy of Sciences, a fellow of the American Academy of Arts and Sciences and a member of the Honorable Order of Kentucky Colonels. He acquired honorary levels from, amongst others, the Georgia Institute of Know-how, the College of Crete in Greece, the College of Warwick in the UK, and Rheinisch-Westfälische Technische Hochschule Aachen College in Germany.
He authored greater than 400 papers and held 80 patents.
Grubbs is survived by his spouse; kids Kathleen, Brendan and Barney; 4 grandchildren; and two sisters.
Johnson is a former Instances employees author. Workers author Gregory Yee contributed to this report.
Science
Cluster of farmworkers diagnosed with rare animal-borne disease in Ventura County
A cluster of workers at Ventura County berry farms have been diagnosed with a rare disease often transmitted through sick animals’ urine, according to a public health advisory distributed to local doctors by county health officials Tuesday.
The bacterial infection, leptospirosis, has resulted in severe symptoms for some workers, including meningitis, an inflammation of the brain lining and spinal cord. Symptoms for mild cases included headaches and fevers.
The disease, which can be fatal, rarely spreads from human to human, according to the U.S. Centers for Disease Control and Prevention.
Ventura County Public Health has not given an official case count but said it had not identified any cases outside of the agriculture sector. The county’s agriculture commissioner was aware of 18 cases, the Ventura County Star reported.
The health department said it was first contacted by a local physician in October, who reported an unusual trend in symptoms among hospital patients.
After launching an investigation, the department identified leptospirosis as a probable cause of the illness and found most patients worked on caneberry farms that utilize hoop houses — greenhouse structures to shelter the crops.
As the investigation to identify any additional cases and the exact sources of exposure continues, Ventura County Public Health has asked healthcare providers to consider a leptospirosis diagnosis for sick agricultural workers, particularly berry harvesters.
Rodents are a common source and transmitter of disease, though other mammals — including livestock, cats and dogs — can transmit it as well.
The disease is spread through bodily fluids, such as urine, and is often contracted through cuts and abrasions that contact contaminated water and soil, where the bacteria can survive for months.
Humans can also contract the illness through contaminated food; however, the county health agency has found no known health risks to the general public, including through the contact or consumption of caneberries such as raspberries and blackberries.
Symptom onset typically occurs between two and 30 days after exposure, and symptoms can last for months if untreated, according to the CDC.
The illness often begins with mild symptoms, with fevers, chills, vomiting and headaches. Some cases can then enter a second, more severe phase that can result in kidney or liver failure.
Ventura County Public Health recommends agriculture and berry harvesters regularly rinse any cuts with soap and water and cover them with bandages. They also recommend wearing waterproof clothing and protection while working outdoors, including gloves and long-sleeve shirts and pants.
While there is no evidence of spread to the larger community, according to the department, residents should wash hands frequently and work to control rodents around their property if possible.
Pet owners can consult a veterinarian about leptospirosis vaccinations and should keep pets away from ponds, lakes and other natural bodies of water.
Science
Political stress: Can you stay engaged without sacrificing your mental health?
It’s been two weeks since Donald Trump won the presidential election, but Stacey Lamirand’s brain hasn’t stopped churning.
“I still think about the election all the time,” said the 60-year-old Bay Area resident, who wanted a Kamala Harris victory so badly that she flew to Pennsylvania and knocked on voters’ doors in the final days of the campaign. “I honestly don’t know what to do about that.”
Neither do the psychologists and political scientists who have been tracking the country’s slide toward toxic levels of partisanship.
Fully 69% of U.S. adults found the presidential election a significant source of stress in their lives, the American Psychological Assn. said in its latest Stress in America report.
The distress was present across the political spectrum, with 80% of Republicans, 79% of Democrats and 73% of independents surveyed saying they were stressed about the country’s future.
That’s unhealthy for the body politic — and for voters themselves. Stress can cause muscle tension, headaches, sleep problems and loss of appetite. Chronic stress can inflict more serious damage to the immune system and make people more vulnerable to heart attacks, strokes, diabetes, infertility, clinical anxiety, depression and other ailments.
In most circumstances, the sound medical advice is to disengage from the source of stress, therapists said. But when stress is coming from politics, that prescription pits the health of the individual against the health of the nation.
“I’m worried about people totally withdrawing from politics because it’s unpleasant,” said Aaron Weinschenk, a political scientist at the University of Wisconsin–Green Bay who studies political behavior and elections. “We don’t want them to do that. But we also don’t want them to feel sick.”
Modern life is full of stressors of all kinds: paying bills, pleasing difficult bosses, getting along with frenemies, caring for children or aging parents (or both).
The stress that stems from politics isn’t fundamentally different from other kinds of stress. What’s unique about it is the way it encompasses and enhances other sources of stress, said Brett Ford, a social psychologist at the University of Toronto who studies the link between emotions and political engagement.
For instance, she said, elections have the potential to make everyday stressors like money and health concerns more difficult to manage as candidates debate policies that could raise the price of gas or cut off access to certain kinds of medical care.
Layered on top of that is the fact that political disagreements have morphed into moral conflicts that are perceived as pitting good against evil.
“When someone comes into power who is not on the same page as you morally, that can hit very deeply,” Ford said.
Partisanship and polarization have raised the stakes as well. Voters who feel a strong connection to a political party become more invested in its success. That can make a loss at the ballot box feel like a personal defeat, she said.
There’s also the fact that we have limited control over the outcome of an election. A patient with heart disease can improve their prognosis by taking medicine, changing their diet, getting more exercise or quitting smoking. But a person with political stress is largely at the mercy of others.
“Politics is many forms of stress all rolled into one,” Ford said.
Weinschenk observed this firsthand the day after the election.
“I could feel it when I went into my classroom,” said the professor, whose research has found that people with political anxiety aren’t necessarily anxious in general. “I have a student who’s transgender and a couple of students who are gay. Their emotional state was so closed down.”
That’s almost to be expected in a place like Wisconsin, whose swing-state status caused residents to be bombarded with political messages. The more campaign ads a person is exposed to, the greater the risk of being diagnosed with anxiety, depression or another psychological ailment, according to a 2022 study in the journal PLOS One.
Political messages seem designed to keep voters “emotionally on edge,” said Vaile Wright, a licensed psychologist in Villa Park, Ill., and a member of the APA’s Stress in America team.
“It encourages emotion to drive our decision-making behavior, as opposed to logic,” Wright said. “When we’re really emotionally stimulated, it makes it so much more challenging to have civil conversation. For politicians, I think that’s powerful, because emotions can be very easily manipulated.”
Making voters feel anxious is a tried-and-true way to grab their attention, said Christopher Ojeda, a political scientist at UC Merced who studies mental health and politics.
“Feelings of anxiety can be mobilizing, definitely,” he said. “That’s why politicians make fear appeals — they want people to get engaged.”
On the other hand, “feelings of depression are demobilizing and take you out of the political system,” said Ojeda, author of “The Sad Citizen: How Politics is Depressing and Why it Matters.”
“What [these feelings] can tell you is, ‘Things aren’t going the way I want them to. Maybe I need to step back,’” he said.
Genessa Krasnow has been seeing a lot of that since the election.
The Seattle entrepreneur, who also campaigned for Harris, said it grates on her to see people laughing in restaurants “as if nothing had happened.” At a recent book club meeting, her fellow group members were willing to let her vent about politics for five minutes, but they weren’t interested in discussing ways they could counteract the incoming president.
“They’re in a state of disengagement,” said Krasnow, who is 56. She, meanwhile, is looking for new ways to reach young voters.
“I am exhausted. I am so sad,” she said. “But I don’t believe that disengaging is the answer.”
That’s the fundamental trade-off, Ojeda said, and there’s no one-size-fits-all solution.
“Everyone has to make a decision about how much engagement they can tolerate without undermining their psychological well-being,” he said.
Lamirand took steps to protect her mental health by cutting social media ties with people whose values aren’t aligned with hers. But she will remain politically active and expects to volunteer for phone-banking duty soon.
“Doing something is the only thing that allows me to feel better,” Lamirand said. “It allows me to feel some level of control.”
Ideally, Ford said, people would not have to choose between being politically active and preserving their mental health. She is investigating ways to help people feel hopeful, inspired and compassionate about political challenges, since these emotions can motivate action without triggering stress and anxiety.
“We want to counteract this pattern where the more involved you are, the worse you are,” Ford said.
The benefits would be felt across the political spectrum. In the APA survey, similar shares of Democrats, Republicans and independents agreed with statements like, “It causes me stress that politicians aren’t talking about the things that are most important to me,” and, “The political climate has caused strain between my family members and me.”
“Both sides are very invested in this country, and that is a good thing,” Wright said. “Antipathy and hopelessness really doesn’t serve us in the long run.”
Science
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