Science
Research shows huge benefit of COVID-19 booster shots
In analysis prone to provoke U.S. help for booster pictures, scientists discovered that Israel’s aggressive marketing campaign to shore up waning coronavirus immunity with a 3rd dose of COVID-19 vaccine has saved lives and decreased new infections throughout the age spectrum.
Booster pictures drove down circumstances of extreme COVID-19 and dying in older Israelis and decreased infections in senior residents and middle-aged adults, the analysis exhibits. However boosters prevented new infections most dramatically in 16- to 29-year-olds — a discovering with probably far-reaching implications.
Throughout a interval this fall when coronavirus infections in Israel had been surging, older adolescents and adults beneath 50 who received a 3rd shot of Pfizer-BioNTech vaccine had been 13 instances much less prone to check constructive than their vaccinated friends who didn’t get the booster. That protecting impact was seen beginning two weeks after the third jab and continued for an additional few weeks till the examine interval ended.
Israelis 50 and over who received a booster shot had been about 10 instances much less probably than their unboosted friends to check constructive for an an infection whereas they had been tracked — a interval that lasted so long as two months.
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Boosted Israelis who had been 60 and over decreased their danger of turning into severely unwell with COVID-19 by an element of greater than 12 in comparison with their counterparts who didn’t get a 3rd shot. And in these older adults, a booster drove down COVID-19 dying charges by an element of shut to fifteen.
A second examine, which tracked Israelis 50 and over for so long as eight weeks, discovered the same stage of safety. Those that received a booster had been 10 instances much less prone to die of COVID-19 than their vaccinated friends who didn’t get a 3rd shot.
Each research had been revealed Wednesday within the New England Journal of Medication.
At a second when many vaccinated People are hesitant to get a booster shot — even contemplating the unsure dangers posed by the Omicron variant — the brand new analysis means that the additional dose could make a robust distinction. The findings counsel that, if broadly used, boosters would gradual viral transmission and, amongst older individuals, stave off additional waves of significant sickness and dying.
Certainly, the authors of the each research expressed hope that their outcomes would immediate different nations to strengthen their endorsements of booster pictures — particularly for adults beneath 65.
In Israel, as within the U.S., the overwhelming majority of coronavirus infections are as a result of Delta variant. However well being officers are bracing for the likelihood that the quickly spreading Omicron variant might displace Delta.
Coincidentally, the brand new analysis comes on a day when Pfizer and BioNTech acknowledged that two doses of its vaccine “will not be ample to guard in opposition to an infection with the Omicron variant.”
In comparison with the unique model of the coronavirus, lab exams that pitted Omicron in opposition to the blood serum of people that’d had two doses of the vaccine detected a 25-fold discount in neutralizing antibodies, the immune proteins that thwart the virus.
That “might nonetheless provide a ample stage of safety from illness of any severity attributable to the Omicron variant,” stated Dr. Ugur Sahin, BioNTech’s chief govt. However broad use of boosters “all over the world might assist us to raised shield individuals all over the place and to get via the winter season,” he added.
Pfizer and BioNTech reiterated that they may have a vaccine tailor-made to Omicron prepared inside 100 days.
Dr. Anthony Fauci, President’s Biden’s senior advisor on the pandemic, instructed CNN on Wednesday that the preliminary studies from Pfizer “make me breathe somewhat higher.”
To go searching the pandemic’s nook, U.S. well being officers have relied closely on the well-documented experiences of Israel, a rustic of 8.8 million with a nationalized healthcare system that depends completely on the Pfizer-BioNTech vaccine.
Israel’s vaccination marketing campaign has constantly been a step forward of the one in the USA. Researchers within the tiny Jewish state had been among the many first to watch the waning of vaccine-induced immunity. The Israeli authorities reacted swiftly to that information by launching a marketing campaign of almost common boosters in late summer time. The third pictures turned out there July 30 for Israelis over 60, and to all vaccinated Israelis12 and over a month later.
The research revealed Wednesday are the primary to gauge the influence of boosters on a big scale and in a variety of age teams. A kind of research drew from a nationwide database of almost 4.7 million Israelis 16 and over who received at the least two pictures of the Pfizer-BioNTech vaccine. The opposite examine tracked COVID-19 deaths amongst 843,208 Israelis over 50.
Their principal limitation is their comparatively quick span: they seize immunity for as little as 5 weeks and not more than 12 weeks following boosters, although they set up a rigorous baseline for additional monitoring.
“Understanding the protecting impact of the booster in youthful age teams is essential for forming public well being coverage,” wrote the authors of the bigger examine, which was led by Yinon M. Bar-On of the Weizmann Institute of Science. “Booster vaccination applications might present a method to management transmission with out pricey social distancing measures and quarantines.”
The 2 research “reinforce the notion that from a scientific perspective, the mRNA vaccines actually must be regarded as a collection of three doses,” stated Dr. William Schaffner, an infectious illnesses specialist at Vanderbilt College. It’s a sample of deepening immunity seen, for example, within the vaccine that protects in opposition to Hepatitis B, he stated.
With the Omicron variant now current in additional than 20 states, the Facilities for Illness Management and Prevention has really useful that each one absolutely vaccinated adults get a booster shot if it’s been at the least six months since their second dose of an mRNA vaccine or two months since their single dose the Johnson & Johnson shot. Up to now, solely 26% of eligible adults have carried out so.
People who wish to preserve a excessive stage of safety ought to take note of these new findings, Schaffner stated.
“Boosters are actually an excellent factor,” Schaffner stated.
Schaffner stated he was notably intrigued by the discovering that boosters decreased infections in 16- to 29-year-old Israelis.
Younger individuals in lots of elements of the USA “are taking part in a serious function” in maintaining new circumstances excessive, he stated. However as a result of they’re unlikely to be hospitalized with COVID-19, many specialists have argued they shouldn’t be swept right into a blanket name for booster pictures.
Science
Cluster of farmworkers diagnosed with rare animal-borne disease in Ventura County
A cluster of workers at Ventura County berry farms have been diagnosed with a rare disease often transmitted through sick animals’ urine, according to a public health advisory distributed to local doctors by county health officials Tuesday.
The bacterial infection, leptospirosis, has resulted in severe symptoms for some workers, including meningitis, an inflammation of the brain lining and spinal cord. Symptoms for mild cases included headaches and fevers.
The disease, which can be fatal, rarely spreads from human to human, according to the U.S. Centers for Disease Control and Prevention.
Ventura County Public Health has not given an official case count but said it had not identified any cases outside of the agriculture sector. The county’s agriculture commissioner was aware of 18 cases, the Ventura County Star reported.
The health department said it was first contacted by a local physician in October, who reported an unusual trend in symptoms among hospital patients.
After launching an investigation, the department identified leptospirosis as a probable cause of the illness and found most patients worked on caneberry farms that utilize hoop houses — greenhouse structures to shelter the crops.
As the investigation to identify any additional cases and the exact sources of exposure continues, Ventura County Public Health has asked healthcare providers to consider a leptospirosis diagnosis for sick agricultural workers, particularly berry harvesters.
Rodents are a common source and transmitter of disease, though other mammals — including livestock, cats and dogs — can transmit it as well.
The disease is spread through bodily fluids, such as urine, and is often contracted through cuts and abrasions that contact contaminated water and soil, where the bacteria can survive for months.
Humans can also contract the illness through contaminated food; however, the county health agency has found no known health risks to the general public, including through the contact or consumption of caneberries such as raspberries and blackberries.
Symptom onset typically occurs between two and 30 days after exposure, and symptoms can last for months if untreated, according to the CDC.
The illness often begins with mild symptoms, with fevers, chills, vomiting and headaches. Some cases can then enter a second, more severe phase that can result in kidney or liver failure.
Ventura County Public Health recommends agriculture and berry harvesters regularly rinse any cuts with soap and water and cover them with bandages. They also recommend wearing waterproof clothing and protection while working outdoors, including gloves and long-sleeve shirts and pants.
While there is no evidence of spread to the larger community, according to the department, residents should wash hands frequently and work to control rodents around their property if possible.
Pet owners can consult a veterinarian about leptospirosis vaccinations and should keep pets away from ponds, lakes and other natural bodies of water.
Science
Political stress: Can you stay engaged without sacrificing your mental health?
It’s been two weeks since Donald Trump won the presidential election, but Stacey Lamirand’s brain hasn’t stopped churning.
“I still think about the election all the time,” said the 60-year-old Bay Area resident, who wanted a Kamala Harris victory so badly that she flew to Pennsylvania and knocked on voters’ doors in the final days of the campaign. “I honestly don’t know what to do about that.”
Neither do the psychologists and political scientists who have been tracking the country’s slide toward toxic levels of partisanship.
Fully 69% of U.S. adults found the presidential election a significant source of stress in their lives, the American Psychological Assn. said in its latest Stress in America report.
The distress was present across the political spectrum, with 80% of Republicans, 79% of Democrats and 73% of independents surveyed saying they were stressed about the country’s future.
That’s unhealthy for the body politic — and for voters themselves. Stress can cause muscle tension, headaches, sleep problems and loss of appetite. Chronic stress can inflict more serious damage to the immune system and make people more vulnerable to heart attacks, strokes, diabetes, infertility, clinical anxiety, depression and other ailments.
In most circumstances, the sound medical advice is to disengage from the source of stress, therapists said. But when stress is coming from politics, that prescription pits the health of the individual against the health of the nation.
“I’m worried about people totally withdrawing from politics because it’s unpleasant,” said Aaron Weinschenk, a political scientist at the University of Wisconsin–Green Bay who studies political behavior and elections. “We don’t want them to do that. But we also don’t want them to feel sick.”
Modern life is full of stressors of all kinds: paying bills, pleasing difficult bosses, getting along with frenemies, caring for children or aging parents (or both).
The stress that stems from politics isn’t fundamentally different from other kinds of stress. What’s unique about it is the way it encompasses and enhances other sources of stress, said Brett Ford, a social psychologist at the University of Toronto who studies the link between emotions and political engagement.
For instance, she said, elections have the potential to make everyday stressors like money and health concerns more difficult to manage as candidates debate policies that could raise the price of gas or cut off access to certain kinds of medical care.
Layered on top of that is the fact that political disagreements have morphed into moral conflicts that are perceived as pitting good against evil.
“When someone comes into power who is not on the same page as you morally, that can hit very deeply,” Ford said.
Partisanship and polarization have raised the stakes as well. Voters who feel a strong connection to a political party become more invested in its success. That can make a loss at the ballot box feel like a personal defeat, she said.
There’s also the fact that we have limited control over the outcome of an election. A patient with heart disease can improve their prognosis by taking medicine, changing their diet, getting more exercise or quitting smoking. But a person with political stress is largely at the mercy of others.
“Politics is many forms of stress all rolled into one,” Ford said.
Weinschenk observed this firsthand the day after the election.
“I could feel it when I went into my classroom,” said the professor, whose research has found that people with political anxiety aren’t necessarily anxious in general. “I have a student who’s transgender and a couple of students who are gay. Their emotional state was so closed down.”
That’s almost to be expected in a place like Wisconsin, whose swing-state status caused residents to be bombarded with political messages. The more campaign ads a person is exposed to, the greater the risk of being diagnosed with anxiety, depression or another psychological ailment, according to a 2022 study in the journal PLOS One.
Political messages seem designed to keep voters “emotionally on edge,” said Vaile Wright, a licensed psychologist in Villa Park, Ill., and a member of the APA’s Stress in America team.
“It encourages emotion to drive our decision-making behavior, as opposed to logic,” Wright said. “When we’re really emotionally stimulated, it makes it so much more challenging to have civil conversation. For politicians, I think that’s powerful, because emotions can be very easily manipulated.”
Making voters feel anxious is a tried-and-true way to grab their attention, said Christopher Ojeda, a political scientist at UC Merced who studies mental health and politics.
“Feelings of anxiety can be mobilizing, definitely,” he said. “That’s why politicians make fear appeals — they want people to get engaged.”
On the other hand, “feelings of depression are demobilizing and take you out of the political system,” said Ojeda, author of “The Sad Citizen: How Politics is Depressing and Why it Matters.”
“What [these feelings] can tell you is, ‘Things aren’t going the way I want them to. Maybe I need to step back,’” he said.
Genessa Krasnow has been seeing a lot of that since the election.
The Seattle entrepreneur, who also campaigned for Harris, said it grates on her to see people laughing in restaurants “as if nothing had happened.” At a recent book club meeting, her fellow group members were willing to let her vent about politics for five minutes, but they weren’t interested in discussing ways they could counteract the incoming president.
“They’re in a state of disengagement,” said Krasnow, who is 56. She, meanwhile, is looking for new ways to reach young voters.
“I am exhausted. I am so sad,” she said. “But I don’t believe that disengaging is the answer.”
That’s the fundamental trade-off, Ojeda said, and there’s no one-size-fits-all solution.
“Everyone has to make a decision about how much engagement they can tolerate without undermining their psychological well-being,” he said.
Lamirand took steps to protect her mental health by cutting social media ties with people whose values aren’t aligned with hers. But she will remain politically active and expects to volunteer for phone-banking duty soon.
“Doing something is the only thing that allows me to feel better,” Lamirand said. “It allows me to feel some level of control.”
Ideally, Ford said, people would not have to choose between being politically active and preserving their mental health. She is investigating ways to help people feel hopeful, inspired and compassionate about political challenges, since these emotions can motivate action without triggering stress and anxiety.
“We want to counteract this pattern where the more involved you are, the worse you are,” Ford said.
The benefits would be felt across the political spectrum. In the APA survey, similar shares of Democrats, Republicans and independents agreed with statements like, “It causes me stress that politicians aren’t talking about the things that are most important to me,” and, “The political climate has caused strain between my family members and me.”
“Both sides are very invested in this country, and that is a good thing,” Wright said. “Antipathy and hopelessness really doesn’t serve us in the long run.”
Science
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