Science
Microplastics discovered in human and dog testes
Researchers have located one more anatomical organ where microplastics — of all shapes and constituents — are found: human testes.
And although they can’t say for sure, they suspect the presence of these jagged bits and strands of polymers such as polyethylene, polyvinyl chloride and polystyrene could be — in part — behind a global trend in diminishing sperm quality and quantity.
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In 2022, a team of researchers published a paper showing that global sperm counts fell about 1.2% per year between 1973 and 2018. From the year 2000, that rate accelerated to more than 2.6% per year.
“What I think will grab people’s attention with this study is the fact that plastic is in the testicles and potentially contributing to disarray in the function of the testicles,” said Leonardo Trasande, a pediatrician and public policy expert at New York University’s Grossman School of Medicine and Wagner School of Public Service.
“What should have gotten people excited all along is the fact that we’ve known that the invisible chemicals — the phthalates, the bisphenols and the PFAS that are used in plastic materials — are already known to be problems,” he said. “And so if this is what it takes to get people’s attention, I’m a bit sad. Because we already had enough evidence that plastics were bad for testicular function.”
Others, including Philip Landrigan, director of the Program for Global Public Health and the Common Good at Boston College, said the study was “consistent with a whole series of papers that have come out now in the last few years” showing these particles in a variety of organs, including the heart, liver, lungs and brain.
“It’s no surprise that microplastics are in the testes. The plastic is ubiquitous in today’s world, the stuff breaks down, and the smaller the particle, the more easily it can move into and throughout the human body,” he said.
Xiaozhong Yu, a professor of environmental health at the University of New Mexico — and an author on this latest research — said he’d been researching the effects of different chemicals on sperm production for years, and it was only recently that a colleague suggested he look for microplastics in testes.
“I said, ‘Are you joking?’,” he said, recalling the conversation, explaining he was pretty certain he wouldn’t find microplastics in tests because — like the brain — these sperm-generating factories are insulated by a protective barrier.
Nevertheless, they gave it a go.
They started by trying it out in dog testes. They were able to acquire 47 from neutering clinics. (The pet owners all provided permission.)
They found microplastics in small dogs, big dogs, young dogs and old dogs. The plastic bits were in every dog testis they examined. The number ranged from 2.36 micrograms per gram to 485.77 micrograms per gram. The average was 122.63 micrograms per gram, and 12 polymers were identified. The most abundant were polyethylene — the material found in plastic packaging, films and bottles — and polyvinyl chloride — a material found in most household water pipes.
He said he immediately went back to investigate their quality control. Maybe the testes had become contaminated at some point during the procedure or testing?
He and his team were able to rule that out, although Landrigan noted that contamination was still possible — unless everything, from procurement to analysis had been done in a “clean” room devoid of all plastic.
Yu and his team then decided to look at human samples. In the end, they were able to examine 23 testes from men ages 16 to 88. The tissue was acquired from males who had died in accidents and whose testes had been preserved post-autopsy. He said all samples were from men who had died in 2016 — made available following a seven-year storage requirement, after which time such samples are usually discarded.
Once again, they found microplastics in every sample they examined, and as with the dog testes, there was wide variation — from 161.22 micrograms per gram to 695.94 micrograms per gram, with an average of 328.44 micrograms per gram — nearly three times greater than what they found in dogs.
The microplastics in human testes were also composed of a variety of polymers, with polyethylene being the most common, followed by ABS (acrylonitrile, butadiene and styrene monomers — which is used to make a variety of products, including toys, automotive parts, medical equipment and consumer electronics), N66 (a kind of nylon), polyvinyl chloride and others.
The researchers also noted a correlation between the concentrations of PVC and polyethylene and testes weight: The higher the concentration, the lower the weight.
“Generally, a decreased testis weight is indicative of reduced spermatogenesis,” wrote the authors in the paper.
Yu said the difference in humans and dogs between polymer types — with dogs showing higher concentrations of PVC than men — likely has to do with lifestyle differences. He said consumer trends show a general aversion to eating or drinking out of bottles and foodware made from PVC, which contains bisphenol A — an additive that has been associated with health and developmental harm.
However, he began looking at dog toys, and noticed many of them are made from this kind of plastic.
“People are choosing to avoid it,” he said. But the market hasn’t budged in the same way for dogs.
Asked what the major route of exposure was for dogs and people, he said “microplastics are everywhere — in the air, in the drinking water, in the food, in our clothes. We don’t exactly know what is the most probable route. But they are everywhere.”
He also noticed variation within the groups. Dog testes acquired from public veterinary clinics showed higher levels of microplastics than those from private clinics, “potentially reflecting the influence of socioeconomic differences on the living environments and lifestyles of dogs.”
The researchers were also not able to find a correlation between age and microplastic concentration — a finding that surprised them. (Although men over the age of 55 had the least amount).
“The absence of a distinct age-dependent accumulation of microplastics in human testes may be due to unique physiological and biological processes of spermatogenesis,” they wrote, noting the continual renewal and release of sperm, which could “help mitigate the buildup of microplastics over time.”
That hypothesis, they noted, was supported by the presence of microplastics in human seminal fluid.
“The reality is that the petrochemical industry has gotten a pass all these years,” said Trasande, the NYU professor. “We know that plastics come from the petrochemical industry … and it’s no secret that we have paid as a society by letting the petrochemical industry pollute us. Now we’re paying the consequences. And if we don’t reverse course fairly quickly, we will have an even bigger problems before us because plastic consumption is growing, not slowing down.”
Landrigan agreed and noted that nations were currently in negotiations to sign a treaty that would curb the use of plastic and cap production.
“Plastic production is increasing exponentially,” he said noting that it’s increased more than 200-fold since the 1950s. He said plastic production is on a trajectory to double by 2040 and triple by 2060. There have been a total of about 8 billion tons of plastic produced since 1950, he said, and about 6 billion tons is “floating around us, most of it in the form of microplastics.”
He said the anatomical location of this latest microplastic discovery may hit close to home for lawmakers, who until this time, have not been too concerned.
He said he’d had to testify in the Senate several years ago about endocrine disruptors, and mentioned that sperm quantity was reduced in men who’d been exposed.
“Two senators sat back and unconsciously crossed their legs,” he said. “The body language was amazing.”
Science
Hospital visits for smoke inhalation spiked during Boyle Heights warehouse fire
The number of Angelenos who went to the hospital with throat pain and concerns about smoke inhalation spiked as a fire burned through the massive Lineage cold storage warehouse in Boyle Heights this month, The Times has learned.
The blaze burned for eight days beginning June 17 and involved solar panels, insulation foam and other industrial materials.
During that time, more than three times as many people went to emergency departments within 10 miles of the warehouse mentioning the fire or smoke inhalation compared with the two weeks prior, according to data from the Los Angeles County Department of Public Health obtained through a public records request.
The agency also noted a near doubling of patients mentioning throat pain within five miles of the fire June 21 — 1.9 times the baseline levels.
Usually, fewer than 50 people go to the emergency room each day for throat pain, and fewer than 20 people for smoke inhalation, the department said.
The hospitalization data was tracked through the department’s syndromic surveillance project, which monitors trends in what people report when they come to emergency departments in L.A. County, as well as diagnosis codes noted by providers. The system is not as comprehensive as full patient health records, and clinicians may not always include key words about “fire,” “smoke” or other circumstantial information in their diagnoses, the public health department said.
As such, it “cannot capture the true number of [emergency department] visits related to symptoms from the fire and likely underestimates the true burden of fire related symptoms,” the department said.
Perhaps unexpectedly, the department said it did not note a substantial increase in asthma, acute respiratory symptoms or chronic obstructive pulmonary disease-related emergency department visits during the fire.
But even these preliminary findings are concerning, experts said. The fire is believed to have started on the solar array on the roof of the 500,000 square-foot building, which housed 85 million pounds of frozen food. It then reached an ammonia line, prompting two brief shelter-in-place orders for nearby residents.
Over the next week, the fire continued to burn through dense insulation foam within the building’s walls and other unknown industrial materials, blanketing much of L.A. in acrid smoke. Residents in downtown L.A., northeast L.A., Burbank, the San Gabriel Valley and many other parts of the city and county reported seeing and smelling the fumes.
The South Coast Air Quality Management District issued multiple warnings about unhealthy levels of PM 2.5, or fine particulate matter. The city and county opened two smoke respite shelters in the immediate area so that people could breath cleaner air.
It is still unclear what exactly was in the smoke that people breathed in. Industrial fires release far more materials than the burned wood smoke that is emitted during wildfires.
“The makeup of the smoke can include toxic chemicals, fine particles and other serious risks to lung health depending on fire conditions and what is burned,” Will Barrett, assistant vice president for nationwide clean air policy at the American Lung Assn., said as the fire was burning. Children and elderly people are particularly at risk.
David Eisenman, director of the UCLA Center for Public Health and Disasters, said urban industrial fires also can represent a hazard that standard PM 2.5 warnings don’t always address. Those advisories are “blunt instruments” that don’t adequately capture emissions from burning man-made goods — or convey that the source of pollution may include burning batteries or toxic refrigerants, he said.
The fact that initial numbers don’t show a spike in asthma attacks is “somewhat reassuring,” Eisenman said. But “people may have gone to their primary care doctors, which this would not capture. This data deserves follow up.”
The air district and the U.S. Environmental Protection Agency deployed air monitors to assess particulate matter, airborne toxic metals and other harmful compounds during the early days of the blaze. The air district said it didn’t find significant levels of air toxics during the first two days of the fire, although it did record significantly elevated concentrations of particulate matter within the plume downwind.
Some of the measurements it took with mobile monitors, which are five-minute snapshots, also showed increased bromine and chlorine, which often are found when buildings burn and were at levels “below short-term health-based exposure thresholds,” the air district said. It began continuous PM 2.5. monitoring at two nearby elementary schools on the third day.
The L.A. Fire Department said it detected low-levels of toxic hydrogen fluoride on the second day of the fire, which can be a byproduct of burning lithium-ion batteries.
Lineage, the tenant-operator of the warehouse, said no concentrations of ammonia were detected in the air at any time.
“There’s no doubt this fire has had a huge impact on the local community, and we are committed to showing up in every way we can,” company officials wrote in a statement last week. They said Lineage worked closely with the Fire Department during the blaze and delivered masks, air purifiers and other supplies to the community, and will work to ensure the fastest cleanup possible.
The long-term health effects of the fire and its smoke probably won’t be known unless researchers conduct a follow-up study, said Eisenman of UCLA.
For example, there may have been delayed pulmonary effects from the hydrogen fluoride and burning insulation foam that — when combined with the elevated PM 2.5 levels in a dense urban environment — produced health effects that didn’t show up in the emergency room data.
“They will show up in increased primary care office visits and exacerbations of chronic disease over the next few weeks,” he said. “So from a public health standpoint, this fire is not over.”
Science
Water from Boyle Heights warehouse fire carries foam into L.A. River, sparks testing
LOS ANGELES — All the water unleashed onto the warehouse fire in Boyle Heights — some of it 480 gallons at a time by helicopter — had to end up somewhere.
That somewhere is the Los Angeles River.
Los Angeles Fire Department crews ripped through 50-foot walls filled with foam insulation to get to the building’s steel skeleton and its storage racks.
Charred chunks of foam have been floating from the burn site, partially blocking storm drains. Now organizers from East Yard Communities for Environmental Justice are teaming up with scientists from UCLA and Columbia University to find out more about what’s in the runoff.
“The community here is really interested in knowing, ‘Are there any contaminants that are potentially making their way down to the L.A. River?’” said Yoshira “Yoshi” Ornelas Van Horne, UCLA assistant professor in environmental health sciences. “We really can’t answer that unless we actually have measures and samples analyzed.”
Water samples collected directly from the warehouse fire runoff have been shipped to Columbia‘s Multi-Element Trace Analysis Laboratory in New York, which has a spectrometer that can identify trace levels of elements. The lab also has relationships with researchers in Southern California.
1. Emmanuel Carrera Ruedas, left, and Casey Cooper prep containers to take water samples from the L.A. River. 2. Casey Cooper holds a water sample. (Christina House / Los Angeles Times)
The data will then come back to UCLA for analysis. For now, the scientists and community advocates only have the money to test for copper, lead and arsenic, Ornelas Van Horne said. Residents have expressed interest in testing for more contaminants.
As the water from the firefighting efforts trickles through the warehouse in rivulets, it forms a stream at the corner of S. Indiana and Noakes streets, that gushed into the storm drain. On a recent visit, the water traversed a smoky 10-foot canyon of charred foam and twisted wall panels on its way to the drain.
From there, the water flows to the L.A. River. Despite the fact that its concrete design is intended to whisk water out of the city as fast as possible, life stubbornly persists in the river and nearby. Recreational swimming is not permitted, yet anglers fishing for tilapia, largemouth bass and carp are a common sight along the rocky sides of the soft-bottom areas.
The L.A. River, and all it carries with it, meets the ocean in Long Beach.
The L.A. County Public Works Department said it has deployed three containment booms — floating barriers — on the L.A. River, and is continuing to monitor the water as it makes its way to the ocean.
Emmanuel Carrera Ruedas takes a water sample.
(Christina House / Los Angeles Times)
Before it gets there, the river passes through the Dominguez wetlands, where Public Works is removing some number of dead fish. The wetland has absorbed toxic runoff from a warehouse fire before, resulting in a fish die-off.
“For so long, the L.A. River has been used as a dumping ground for all kinds of chemicals,” said Emmanuel Carrera Ruedas, a community scientist and member of East Yard Communities for Environmental Justice.
Pollution has plagued the L.A. River, but it does have allies. In the 1980s, the Friends of the LA River pushed to address street runoff and trash that had made the water body infamous. Significant progress from advocacy and government initiatives improved water conditions, but these efforts have not been equally distributed.
Carrera said the samples represent “proof of what’s actually going on, and accountability, too, for the city, of not just what’s happening in our air, but what’s actually happening in our waterways.”
The first samples for the project were taken last Friday, the second day of the fire.
They were the first of 20 samples the research groups have agreed to test at no cost to see if any exceed regulatory standards and could pose a risk to people nearby.
The warehouse fire represents the latest environmental disaster for people in Boyle Heights and East L.A. Just four weeks ago, a telecommunications crew accidentally struck one of the many oil pipelines beneath the L.A. area, spilling 25,000 gallons of crude oil near Eastern and Cesar Chavez avenues — including into storm drains feeding to the L.A. River.
“I think it really is difficult to see disaster after disaster hit the communities here, with not a lot of talk about how we can move through these disasters together,” said Casey Cooper, a volunteer community scientist involved in the sampling. They were inspired, they said, by the response of neighbors, and how people were supporting one another.
Results from the laboratory analysis could be back to Ornelas Van Horne within a month.
Science
EPA touts crackdown on smuggled pesticides in L.A. visit
The U.S. Environmental Protection Agency is ramping up its enforcement of illegal pesticides smuggled through the ports of Long Beach and Los Angeles, officials said during a visit to L.A. on Thursday.
Since President Trump began his second term in January 2025, EPA has blocked more than 2.4 million pounds of illegal pesticides from entering the country, said Lee Zeldin, the agency’s administrator. Much of it comes from China, but some comes from Mexico and, on the East Coast, from Africa.
“We’re very alarmed by any chemical that anyone would seek to bring into this country that our own government hasn’t had the opportunity to vet, to research to fully understand,” Zeldin said. “That’s why it’s so important that these products get stopped at the border.”
The announcement came just hours after the Supreme Court handed a major victory to the makers of the weedkiller Roundup, shielding it from thousands of lawsuits from states alleging the company failed to warn people the product could cause cancer.
Speaking from a U.S. Customs and Border Protection warehouse in Carson, Zeldin pointed to a white bottle with a yellow label reading “SNIPER” — an illegal pesticide product commonly imported from abroad and sold online — that was recently intercepted at the Port of L.A. complex. Sniper contains dichlorvos, or DDVP, a highly toxic insecticide that is not registered or approved for use in the U.S. It is known to cause neurological problems, convulsions and comas, with children particularly at risk.
Illegal pesticides are cause for concern in California, where they are often associated with illegal cannabis operations. Last year, Siskiyou County declared a local emergency in response to the “escalating threat” posed by illegal pesticides, often fumigants, in illicit cannabis operations.
“These chemicals, when burned, create thick, poisonous smoke that presents serious risks to public health, the environment, waterways, and first responder safety,” the county said.
A 2024 Los Angeles Times investigation found that contraband Chinese pesticides used on cannabis farms is a growing problem in the state.
Customs and Border Protection seized containers of an illegal pesticide from China that were packed with legitimate items.
(Myung J. Chun/Los Angeles Times)
Much of the illegal product comes through the ports of L.A. and Long Beach, which together handle more than 30% of the nation’s container traffic, officials said. EPA works closely with Border Patrol officials, who flag suspicious cargo containers at the port for further inspection.
CBP spokesman Jaime Ruiz said the agency is using artificial intelligence tools to help scan incoming cargo manifests for potentially illegal items. Thousands of containers are flagged for inspection each year, although that number also includes drugs, counterfeit goods and other contraband in addition to pesticides, he said. He could not immediately say what percentage were illegal pesticides.
Illegal pesticides have at times been found in California agriculture and the California Department of Pesticide Regulation has taken enforcement action against violators. The DPR operates one of the nation’s largest pesticide residue testing programs, analyzing some 3,500 produce samples each year from wholesale and retail stores and other outlets. The state produces about half of the nation’s fruits and vegetables.
Jeff Hall, assistant administrator of EPA’s Office of Enforcement and Compliance, said the issue should be bipartisan.
“We cannot allow foreign actors to profit by sending toxic and poisonous products into the United States and poisoning American communities,” he said. “This is a message that we should all be able to agree on, especially for pesticides.”
However, the agency’s visit to L.A. arrived at a fractured moment for U.S. pesticide regulation and for the Trump-aligned Make America Healthy Again movement.
On Thursday, the Supreme Court ruled 7-2 in favor of Bayer’s Monsanto, the maker of the powerful weedkiller Roundup, shielding it from thousands of state lawsuits that allege the company failed to warn people the product could cause cancer.
Roundup contains glyphosate, which was classified by the World Health Organization as “probably carcinogenic” in 2015. But the Supreme Court found that the company can’t be sued in state courts because federal agencies — including the EPA — have determined that it’s not likely to cause cancer in humans when used as directed. The EPA has repeatedly approved a label for the product without a cancer warning.
“When people are exposed to pesticides, they deserve honest warnings about the risks,” said Bill Jordan, former deputy director of EPA’s Office of Pesticide Programs, in a statement. “The Court’s decision leaves families, workers, and communities with fewer tools to protect themselves and to recover damages when they are injured by a pesticide.”
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