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Microplastics discovered in human and dog testes

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Microplastics discovered in human and dog testes

Researchers have located one more anatomical organ where microplastics — of all shapes and constituents — are found: human testes.

And although they can’t say for sure, they suspect the presence of these jagged bits and strands of polymers such as polyethylene, polyvinyl chloride and polystyrene could be — in part — behind a global trend in diminishing sperm quality and quantity.

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In 2022, a team of researchers published a paper showing that global sperm counts fell about 1.2% per year between 1973 and 2018. From the year 2000, that rate accelerated to more than 2.6% per year.

“What I think will grab people’s attention with this study is the fact that plastic is in the testicles and potentially contributing to disarray in the function of the testicles,” said Leonardo Trasande, a pediatrician and public policy expert at New York University’s Grossman School of Medicine and Wagner School of Public Service.

“What should have gotten people excited all along is the fact that we’ve known that the invisible chemicals — the phthalates, the bisphenols and the PFAS that are used in plastic materials — are already known to be problems,” he said. “And so if this is what it takes to get people’s attention, I’m a bit sad. Because we already had enough evidence that plastics were bad for testicular function.”

Others, including Philip Landrigan, director of the Program for Global Public Health and the Common Good at Boston College, said the study was “consistent with a whole series of papers that have come out now in the last few years” showing these particles in a variety of organs, including the heart, liver, lungs and brain.

“It’s no surprise that microplastics are in the testes. The plastic is ubiquitous in today’s world, the stuff breaks down, and the smaller the particle, the more easily it can move into and throughout the human body,” he said.

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Xiaozhong Yu, a professor of environmental health at the University of New Mexico — and an author on this latest research — said he’d been researching the effects of different chemicals on sperm production for years, and it was only recently that a colleague suggested he look for microplastics in testes.

“I said, ‘Are you joking?’,” he said, recalling the conversation, explaining he was pretty certain he wouldn’t find microplastics in tests because — like the brain — these sperm-generating factories are insulated by a protective barrier.

Nevertheless, they gave it a go.

They started by trying it out in dog testes. They were able to acquire 47 from neutering clinics. (The pet owners all provided permission.)

They found microplastics in small dogs, big dogs, young dogs and old dogs. The plastic bits were in every dog testis they examined. The number ranged from 2.36 micrograms per gram to 485.77 micrograms per gram. The average was 122.63 micrograms per gram, and 12 polymers were identified. The most abundant were polyethylene — the material found in plastic packaging, films and bottles — and polyvinyl chloride — a material found in most household water pipes.

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He said he immediately went back to investigate their quality control. Maybe the testes had become contaminated at some point during the procedure or testing?

He and his team were able to rule that out, although Landrigan noted that contamination was still possible — unless everything, from procurement to analysis had been done in a “clean” room devoid of all plastic.

Yu and his team then decided to look at human samples. In the end, they were able to examine 23 testes from men ages 16 to 88. The tissue was acquired from males who had died in accidents and whose testes had been preserved post-autopsy. He said all samples were from men who had died in 2016 — made available following a seven-year storage requirement, after which time such samples are usually discarded.

Once again, they found microplastics in every sample they examined, and as with the dog testes, there was wide variation — from 161.22 micrograms per gram to 695.94 micrograms per gram, with an average of 328.44 micrograms per gram — nearly three times greater than what they found in dogs.

The microplastics in human testes were also composed of a variety of polymers, with polyethylene being the most common, followed by ABS (acrylonitrile, butadiene and styrene monomers — which is used to make a variety of products, including toys, automotive parts, medical equipment and consumer electronics), N66 (a kind of nylon), polyvinyl chloride and others.

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The researchers also noted a correlation between the concentrations of PVC and polyethylene and testes weight: The higher the concentration, the lower the weight.

“Generally, a decreased testis weight is indicative of reduced spermatogenesis,” wrote the authors in the paper.

Yu said the difference in humans and dogs between polymer types — with dogs showing higher concentrations of PVC than men — likely has to do with lifestyle differences. He said consumer trends show a general aversion to eating or drinking out of bottles and foodware made from PVC, which contains bisphenol A — an additive that has been associated with health and developmental harm.

However, he began looking at dog toys, and noticed many of them are made from this kind of plastic.

“People are choosing to avoid it,” he said. But the market hasn’t budged in the same way for dogs.

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Asked what the major route of exposure was for dogs and people, he said “microplastics are everywhere — in the air, in the drinking water, in the food, in our clothes. We don’t exactly know what is the most probable route. But they are everywhere.”

He also noticed variation within the groups. Dog testes acquired from public veterinary clinics showed higher levels of microplastics than those from private clinics, “potentially reflecting the influence of socioeconomic differences on the living environments and lifestyles of dogs.”

The researchers were also not able to find a correlation between age and microplastic concentration — a finding that surprised them. (Although men over the age of 55 had the least amount).

“The absence of a distinct age-dependent accumulation of microplastics in human testes may be due to unique physiological and biological processes of spermatogenesis,” they wrote, noting the continual renewal and release of sperm, which could “help mitigate the buildup of microplastics over time.”

That hypothesis, they noted, was supported by the presence of microplastics in human seminal fluid.

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“The reality is that the petrochemical industry has gotten a pass all these years,” said Trasande, the NYU professor. “We know that plastics come from the petrochemical industry … and it’s no secret that we have paid as a society by letting the petrochemical industry pollute us. Now we’re paying the consequences. And if we don’t reverse course fairly quickly, we will have an even bigger problems before us because plastic consumption is growing, not slowing down.”

Landrigan agreed and noted that nations were currently in negotiations to sign a treaty that would curb the use of plastic and cap production.

“Plastic production is increasing exponentially,” he said noting that it’s increased more than 200-fold since the 1950s. He said plastic production is on a trajectory to double by 2040 and triple by 2060. There have been a total of about 8 billion tons of plastic produced since 1950, he said, and about 6 billion tons is “floating around us, most of it in the form of microplastics.”

He said the anatomical location of this latest microplastic discovery may hit close to home for lawmakers, who until this time, have not been too concerned.

He said he’d had to testify in the Senate several years ago about endocrine disruptors, and mentioned that sperm quantity was reduced in men who’d been exposed.

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“Two senators sat back and unconsciously crossed their legs,” he said. “The body language was amazing.”

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A full 'strawberry moon' will light up the sky Friday night. Here's when to see it

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A full 'strawberry moon' will light up the sky Friday night. Here's when to see it

Mark your calendars and turn to the sky — there will be another exciting celestial event Friday night, right after the start of summer.

The full moon, called a “strawberry moon” because of its pink or reddish hue, is expected to appear right after the summer solstice, which marks the onset of summer and the longest period of sunlight of the year for the Northern Hemisphere, according to NASA.

The moon is expected at 9:08 p.m. Eastern Standard Time and will be opposite to the sun, according to NASA. In Los Angeles, the moon is expected to rise at about 7:24 p.m. and reach the highest point in the sky at 12:13 a.m. Local times can be found at timeanddate.com.

The full moon only occurs within a day of the summer solstice about every 19 to 20 years, according to Space.com. This time around, the moon is expected to appear full for about three days.

The name “strawberry moon” comes from the Indigenous American Algonquin tribes to describe when strawberries ripen in June and are ready to be collected, according to the Farmer’s Almanac.

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“Since the 2024 June full Moon happens on the solstice, the very day the Sun is absolutely at its highest of the year, this month’s full Moon on the 21st is the very lowest full Moon, indeed, the lowest we’ve seen in years,” the Almanac reported. “Just look at it! Because the Moon is so low, it will appear bigger than ever. This is called the ‘Moon Illusion.’”

The European name for this moon is the “mead” or “honey moon,” according to NASA. Mead, known in some countries as honey wine, is created by fermenting honey with fruits or other spices. Meanwhile, the term “honeymoon” dates back to Europe in the 1500s and references getting married in June because it’s the “sweetest” moon of the year.

The moon will take on a reddish orange color due to how low it will hang in the sky and its close proximity to the horizon. Because of how low the moon will be, that also means the sky will be darker due to lower levels of moonlight.

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Opinion: Bird flu is a real threat. Here's a way to fight it

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Opinion: Bird flu is a real threat. Here's a way to fight it

If the last couple years are any indication, bird flu is not just for the birds.

Highly pathogenic avian influenza, also known as H5N1, has been confirmed in 101 dairy herds in 12 states since March, with Michigan, Texas and Idaho leading the pack. Even more troubling, there have been three confirmed human infections among U.S. dairy workers so far. Evidence of transmission from cows back to domestic and wild birds, and even to dairy farm cats, has also been found.

Since early 2022, wild birds have shouldered the blame for the spread of the current iteration of H5N1 to domestic bird populations, ranging from backyard flocks to farms confining several million animals. Viral diseases commonly spread within the same or similar species. But alarm bells go off when they make the leap into species unrelated to the original host.

The latest spillover from birds to dairy cattle is particularly concerning because of the virus’ ability to spread undetected in cows that are in close contact with vulnerable dairy workers and produce meat and milk that may enter the food supply. The current strain of avian flu has infected at least 48 species of mammals worldwide, and recent reports indicate novel mammal-to-mammal transmission, including from cows directly to humans.

Officials still consider the threat to public health low. But even if the spread doesn’t escalate, it should be a warning to the federal government and the dairy industry.

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Each year, millions of dairy cattle are transported long distances in the U.S. under grueling conditions — deprived of food, water and protection from extreme heat and cold. Transport stress additionally compromises animals’ immune systems. In particular, hundreds of thousands of newborn calves are transported on journeys that can exceed 1,000 miles. Male calves, typically considered a “low-value byproduct” of the dairy industry used for veal or beef production, are often fed unpasteurized waste milk, putting them at high risk of contracting H5N1, according to the U.S. Department of Agriculture.

Livestock transport is regulated at the federal level by the Twenty-Eight Hour Law, which requires animals traveling domestically for more than 28 hours to be offloaded for food, water and rest, and the Animal Health Protection Act, which gives the USDA broad authority to restrict the movement of animals to control disease. Livestock transported across state lines must also comply with the receiving state’s import restrictions, which may require that the animals have certificates of veterinary inspection.

In theory, these laws act as important tools in protecting animal health and food safety. Unfortunately, enforcement of the Twenty-Eight Hour Law is virtually nonexistent, according to research conducted by my organization, the Animal Welfare Institute.

Additionally, neither the Twenty-Eight Hour Law nor the Animal Health Protection Act establishes specific requirements to ensure animals are both healthy and strong enough to travel. Although certificates of veterinary inspection can help trace the movement of infected animals during a disease outbreak, this system inevitably falls short. That’s because pre-transport assessments of animal health often amount to a quick visual inspection for outward signs of communicable disease instead of verification that animals can physically withstand the journey. Experts in humane livestock handling, including Temple Grandin, consider “fitness for transport” to be a crucial factor in protecting food safety and animal health and welfare.

Veterinary inspections are not even mandated for all transported animals, including many of the approximately 3 million “cull” dairy cows slaughtered annually. These animals often suffer from debilitating conditions that increase transport-related stress and immunosuppression. Meanwhile, of the more than 97 million U.S. birds affected by H5N1 since 2022, most have been killed to mitigate disease transmission. Many died horrifically after their owners induced heatstroke, according to USDA records.

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This month, Rep. Dina Titus (D-Nev.) introduced federal legislation that would help address health and safety gaps. The Humane Transport of Farmed Animals Act would direct federal officials to develop a process to enforce the Twenty-Eight Hour Law, increasing active monitoring of long-distance transport. The bill would also prohibit interstate transport of livestock considered unfit for travel based on criteria from the World Organisation for Animal Health, the international authority on the health and welfare of animals.

New research suggests that a single H5N1 spillover event from birds to cattle occurred in Texas as early as last year. Subsequent cattle shipments carried the disease to distant herds around the nation. Stricter regulation may well have limited the spread.

When billions of animals are intensively raised, transported and slaughtered each year, conditions are ripe for pathogens to mutate, spread and seriously endanger animal and public health. The Humane Transport of Farmed Animals Act cannot stop the spread of bird flu on its own. But it would further essential efforts to provide oversight of the millions of animals — and their pathogens — regularly crossing state lines.

Gwendolen Reyes-Illg is a veterinary medicine consultant for the Animal Welfare Institute.

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Foundation honoring 'Star Trek' creator offers million-dollar prize to develop AI that's 'used for good'

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Foundation honoring 'Star Trek' creator offers million-dollar prize to develop AI that's 'used for good'

To boldly go where no man has gone before.

That’s the mission of the USS Enterprise — and arguably the aim of a $1-million prize being offered through a foundation created to honor the father of the “Star Trek” franchise.

The Roddenberry Foundation — named for Gene Roddenberry — announced Tuesday that this year’s biennial award would focus on artificial intelligence that benefits humanity.

Lior Ipp, chief executive of the foundation, told The Times there’s a growing recognition that AI is becoming more ubiquitous and will affect all aspects of our lives.

“We are trying to … catalyze folks to think about what AI looks like if it’s used for good,” Ipp said, “and what it means to use AI responsibly, ethically and toward solving some of the thorny global challenges that exist in the world.”

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The Roddenberry Prize is open to early-stage ventures — including nonprofits and for-profits — across the globe.

Each cycle, the focal point of the award changes. The spotlight on AI and machine learning arrives as recent strides in the technology have sparked excitement as well as fear.

Concerns abound that AI threatens privacy, intellectual property and jobs, including the work performed by this reporter. Although it can automate busywork, it may also replicate the harmful biases of the people who created it.

California legislators are racing to address anxieties through about 50 AI-related bills, many of which aim to install safeguards around the technology, which lawmakers say could cause societal harm. The proposed legislation targets AI-related fears ranging from data security to racial discrimination.

“We’ve seen with other technologies that we don’t do anything until well after there’s a big problem,” said state Sen. Scott Wiener (D-San Francisco), who wrote a bill that would require companies developing large AI models to do safety testing.

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“Social media had contributed many good things to society … but we know there have been significant downsides to social media, and we did nothing to reduce or to mitigate those harms,” he said. “And now we’re playing catch-up. I prefer not to play catch-up.”

Ipp said the foundation shares the broad concern about AI and sees the award as a means to potentially contribute to creating those guardrails.

The language of the application states that it’s seeking ethical proposals. And much like the multicultural, multi-planetary cast of “Star Trek,” it’s supposed to be inclusive.

“Any use of AI or machine learning must be fair, transparent, respectful of individual rights and privacy, and should explicitly design against bias or discrimination against individuals, communities or groups,” according to the prize website.

Inspiration for the theme was also borne out of the applications the foundation received last time around. Ipp said the prize, which is “issue-agnostic” but focused on early-stage tech, produced compelling uses of AI and machine learning in agriculture, healthcare, biotech and education.

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“So,” he said, “we sort of decided to double down this year on specifically AI and machine learning.”

The most recent winner was Sweden-based Elypta, which Ipp said is using liquid biopsies, such as a blood test, to detect cancer early.

Though the foundation isn’t prioritizing a particular issue, the application states that it is looking for ideas that have the potential to push the needle on one or more of the United Nations’ 17 sustainable development goals, which include eliminating poverty and hunger as well as boosting climate action and protecting life on land and underwater.

“Star Trek,” which first aired in 1966, featured tons of enviable tech, including the universal translator, the tricorder — a handheld device that performed environmental scans, data recording and data analysis — and the transporter, useful for when you need to hop to an alien planet in a pinch.

And you could always trust Capt. Kirk, Mr. Spock and Dr. McCoy to employ the gadgets for good.

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Those who meet the eligibility criteria for the Roddenberry Prize can apply through July 12. The grant will be awarded to one winner in November.

The foundation was launched by Gene Roddenberry’s family after his death in 1991.

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