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Health Experts Warily Eye XBB.1.5, the Latest Omicron Subvariant

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Health Experts Warily Eye XBB.1.5, the Latest Omicron Subvariant

Three years into the pandemic, the coronavirus continues to impress virologists with its swift evolution.

A younger model, often known as XBB.1.5, has shortly been spreading in the US over the previous few weeks. As of Friday, the Facilities for Illness Management estimated that it made up 72 p.c of recent instances within the Northeast and 27.6 p.c of instances throughout the nation.

The brand new subvariant, first sampled within the fall in New York State, has a potent array of mutations that seem to assist it evade immune defenses and enhance its potential to invade cells.

“It’s the most transmissible variant that has been detected but,” Maria Van Kerkhove, the Covid-19 technical lead on the World Well being Group, stated at a information convention on Wednesday.

XBB.1.5 stays uncommon in a lot of the world. However Tom Wenseleers, an evolutionary biologist at KU Leuven in Belgium, expects it to unfold shortly and globally. “We’ll have one other an infection wave, probably,” he stated.

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Advisers at W.H.O. are assessing the danger that XBB.1.5 poses. Jacob Lemieux, an infectious illness physician at Massachusetts Common Hospital, stated that the surge in instances wouldn’t match the primary Omicron spike that Individuals skilled a yr in the past. “Is it a Class 5 hurricane?” he stated. “No.”

Nonetheless, he warned that XBB.1.5 might worsen what’s already shaping as much as be a tough Covid winter, as folks collect indoors and don’t obtain boosters that may keep off extreme illness.

Dr. Ashish Okay. Jha, the White Home Covid-19 response coordinator, stated that the Biden administration was monitoring the emergence of XBB.1.5 and urging folks to benefit from current countermeasures. Preliminary research recommend that bivalent vaccines ought to present respectable safety in opposition to XBB and its descendants. Paxlovid can even stay efficient at combating infections.

“We really feel fairly comfy that our countermeasures are going to proceed to work,” Dr. Jha stated. “However we’ve obtained to verify persons are utilizing them.”

One factor Dr. Lemieux and different specialists are assured about is that XBB.1.5 is just not the final chapter within the coronavirus’s evolution. In reality, they count on {that a} descendant of XBB.1.5 might quickly acquire mutations that make it even higher at spreading.

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That descendant might exist already, infecting folks with out elevating discover but. However sequencing efforts have declined a lot worldwide that the invention of the subsequent era of XBB.1.5 could also be delayed. “As sequencing turns into much less and fewer obtainable at a worldwide degree, it’s tough for us to trace every of the subvariants of Omicron,” Dr. Van Kerkhove stated.

Scientists have reconstructed the evolution of XBB.1.5 (which some have nicknamed Kraken) by poring over new sequences of coronaviruses in on-line databases. The primary main step got here final yr when two earlier types of Omicron contaminated the identical particular person. Because the viruses replicated, their genetic materials was shuffled collectively. A brand new hybrid kind emerged, with genetic materials from each viral dad and mom. Virus-watchers named it XBB.

This mixing, known as recombination, occurs pretty typically amongst coronaviruses. Over the course of the pandemic, scientists have discovered a lot of recombinant types of SARS-CoV-2, the reason for Covid-19.

Most recombinant SARS-CoV-2 viruses have dwindled away in a matter of weeks or months, unable to outcompete different lineages. XBB, alternatively, obtained a profitable ticket within the genetic lottery. From one guardian, it gained a set of mutations that helped it evade antibodies from earlier infections and vaccinations. From the opposite guardian, it gained a separate set of mutations that made it much more evasive.

“XBB actually picked up probably the most attainable mutations that it might probably choose up from these two dad and mom,” stated Thomas Peacock, a virologist at Imperial Faculty London. The brand new mixture made XBB probably the most evasive Omicron subvariants in existence final summer time.

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Current experiments recommend that XBB paid a steep value for its energy to evade immunity. The mutations permit it to flee antibodies by altering the form of the protein, known as spike, that covers its floor. However a few of these mutations additionally make it tougher for XBB spike proteins to seize tightly to cells — step one required for an an infection.

That unfastened grip might have lessened XBB’s benefit in opposition to different types of the virus. In late 2022, it jostled alongside a lot of different Omicron subvariants. In Singapore, XBB prompted a surge in October, for instance, whereas remaining uncommon in lots of different elements of the world.

As XBB multiplied, it continued to mutate into new types. The earliest samples of XBB.1.5 had been remoted in October in New York. The brand new subvariant gained one essential mutation, often known as F486P.

Yunlong Cao of Peking College and his colleagues examined out XBB.1.5 in dishes of cells, evaluating the way it fared in opposition to earlier types of XBB. The researchers discovered that the F486P mutation allowed XBB.1.5 to seize tightly to cells once more. However the brand new subvariant might nonetheless evade antibodies in addition to earlier types of XBB.

Dr. Cao and his colleagues posted their outcomes on-line on Thursday. The information has not but been revealed in a scientific journal.

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XBB.1.5 probably developed someplace within the northeastern United States, the place early samples were first identified and the place it stays most typical. As soon as scientists might acknowledge it, they might monitor its progress.

In Connecticut, for instance, Nathan Grubaugh at Yale College and his colleagues discovered that by mid-December, different Omicron subvariants had been falling. Solely XBB.1.5 instances had been rising. Dr. Grubaugh estimates that it’s about 20 p.c extra transmissible than BQ.1, which had been the dominant kind.

“It doesn’t have these indicators of a very large wave like we noticed earlier than,” he stated. “It’s not going to come back near what it was final yr.”

How extreme XBB.1.5 infections are in contrast with different types of the coronavirus is just not but clear. “It’s critical,” Dr. Grubaugh stated. “I simply don’t essentially know if it’s actually extra critical than among the different Omicron lineages when it comes to the general impression.”

XBB.1.5 has already unfold to different international locations, and is rising quickly in Germany, Denmark and elsewhere in Europe. However its impression is more likely to differ from place to position. In India, as an illustration, it is going to encounter many individuals who had been contaminated with its parental strains final yr, so it could face stronger immunity, Dr. Peacock stated.

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In China, which skilled a big surge of instances in late 2022, its prospects are even tougher to foretell. For a lot of the pandemic, China nearly by no means shared virus sequences with worldwide databases. Cooperation has elevated previously few weeks, however the databases should still not replicate the state of play within the nation.

A lot of XBB.1.5’s benefit in the US comes from its potential to evade current immunity, together with that which is in opposition to different Omicron subvariants. In China, the place there may be much less immunity, it could not have that edge. Dr. Peacock speculated that after different variants unfold by China, it could then be XBB.1.5’s flip to rise.

Dr. Wenseleers stated that the unfold of XBB.1.5 exterior China made him skeptical that restrictions on Chinese language vacationers would preserve instances down. “It’s sort of pointless,” he stated. “It will be higher to verify the aged are well-vaccinated.”

As XBB.1.5 spreads, it continues to mutate, and specialists consider that it will possibly turn into even higher at evading antibodies.

Scientists are already scanning new sequences being uploaded to a global database known as GISAID within the hopes of recognizing an upgraded model of XBB.1.5. However their job is getting tougher as a result of governments are pulling again on sequencing efforts. “Worldwide, sequencing has taken an actual hit,” Dr. Peacock stated.

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The US, which as soon as lagged behind different nations, has managed to take care of a reasonably sturdy sequencing effort. With out it, Dr. Peacock stated, XBB.1.5 may need stayed beneath the radar for for much longer. If XBB.1.5’s subsequent era is evolving someplace with little sequencing, it could go undetected for a while to come back.

Dr. Lemieux stated that paring again on sequencing was a mistake, given what number of infections and deaths the virus remains to be inflicting. “This is part of public well being,” he stated.

And Dr. Peacock stated that XBB.1.5 demonstrated that the evolution of the coronavirus wouldn’t decelerate anytime quickly. “Give it one other two years, and possibly we will reassess the place we predict that is,” he stated.

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Opinion: Most older Americans who need hearing aids don't use them. Here's how to change that

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Opinion: Most older Americans who need hearing aids don't use them. Here's how to change that

Having depended on hearing aids for nearly three decades, I’m astounded by the lack of Medicare coverage for devices that can solve a problem afflicting tens of millions of older Americans.

Nearly two-thirds of Americans over age 70 have some degree of hearing loss, and over half of those 75 and older experience impairment serious enough to be considered disabling. But most don’t wear hearing aids.

Because the legislation that created Medicare nearly 60 years ago specifically excluded hearing aids, those who rely on the program’s traditional coverage must pay for them out of pocket. That expense is among the chief barriers to wider use of the devices.

Age-related hearing loss impedes basic communication and the relationships that depend on it. Expanded access to hearing aids could therefore do no less than enable more older Americans to establish and maintain the social connections that are essential to a meaningful life.

Hearing loss is like an invisible, muffling curtain that falls in front of anyone speaking. Asking people to repeat themselves can yield irritated and hurtful responses. And it’s hopeless to ask a soft-spoken person to speak up. Sometimes it’s easier just to nod and smile.

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Many older people I know choose to avoid social gatherings altogether because they can’t hear well. Without hearing aids, I’d stay home too.

Hearing loss can harm one’s health in other ways. For example, I’ve written about the need for a comprehensive approach to reducing cancer risk at older ages, including preventive services such as colorectal cancer screening. But these services rely on conversations between patients and their healthcare providers. An older patient’s ability to hear and understand such conversations shouldn’t be taken for granted or ignored.

The Food and Drug Administration did improve access to hearing aids by making some of them available without a prescription in 2022, but the over-the-counter devices are inadequate for serious hearing loss like mine. My private health insurance, meanwhile, started covering hearing aids a few years ago, providing up to $2,500 for them every five years. One hearing aid alone can cost that much or more, however.

Despite its limitations, my private coverage for hearing aids is better than nothing, which is what traditional Medicare provides.

Hearing loss is more common among lower-income people and those without advanced education. The toll from noisy workplaces compounds age-related hearing loss for some. One analysis found that most Americans with a serious hearing disability can’t afford the typical price of hearing aids.

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Many of the older adults who can’t come up with these significant out-of-pocket expenses spent their working years in low-wage jobs that our country depends on. Denying them treatment for their hearing loss is a lousy way to treat people who gave years of service to our society.

Although some older adults with hearing loss won’t benefit from hearing aids, Medicare coverage for the devices might encourage more beneficiaries to get their hearing tested so they can get the treatment that’s right for them. And while Medicare coverage alone won’t address the stigma some people associate with hearing aids, the availability of newer, more comfortable and less obvious technology might win over some refuseniks.

Legislation reintroduced with bipartisan support last year would finally correct this glaring gap in Medicare coverage by removing the hearing aid exclusion from the law. There’s no reason to delay action on this any longer. Are our representatives listening?

Mary C. White is an adjunct professor of environmental health at Emory University’s Rollins School of Public Health, a Public Voices fellow at AcademyHealth in partnership with the OpEd Project and a former federal epidemiologist.

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Second human case of bird flu detected in Michigan dairy worker

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Second human case of bird flu detected in Michigan dairy worker

A second human case of bird flu in a diary worker has been confirmed in Michigan, state and federal health officials announced Wednesday.

The symptoms were mild, consisting of conjunctivitis. The Texas dairy worker who contracted the virus in March also came down with pink eye.

At a press call on Wednesday, Nirav Shah, principal deputy director of the U.S. Centers for Disease Control and Prevention, said the finding was “not unexpected” and that it was a scenario “that we had been preparing for.”

He said that since the discovery of H5N1 in dairy cattle, state and federal health officials have been closely monitoring farmworkers and slaughterhouse workers and urging farmers and farmworker organizations to “be alert, not alarmed.”

Federal officials say they still believe the human health risk of bird flu is low; however, it underscores the need for people who are interacting with infected or potentially infected farm animals or birds to take precautions, including avoiding dead animals and wearing personal protective equipment (PPE) if there’s a need to be in close contact.

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Though a nasal swab from the person in Michigan tested negative for influenza, an eye swab from the patient was shipped to the CDC and tested positive for influenza A(H5N1) virus.

This is the third case of H5N1 reported in the United States. A poultry worker in Colorado was identified in 2022.

Although the symptoms in the three farmworkers in the U.S. have been mild, people elsewhere in the world have suffered more severe illness, including death. According to the World Health Organization, between Jan. 1, 2003, and March 28, 2024, there have been 888 cases of human infection from 23 countries; 463 were fatal.

In preparation for a more widespread outbreak, the CDC updated its guidance for PPE in dairies and issued a nationwide order for healthcare providers to be on the lookout for novel influenza.

On Tuesday, the CDC asked clinical laboratories and health departments to increase the number of influenza samples being analyzed “to maximize the likelihood of catching a case of H5N1 in the community,” Shah said.

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The US Department of Agriculture is also expanding its surveillance and support by providing $1500 to non-infected farms to beef up biosecurity, and $100 to producers who want to buy inline samplers to test their milk. The agency will also provide $2000 per farm to cover veterinary fees for testing, as well as shipping costs to send those tests to laboratories for analysis.

There have been no cases of H5N1 detected in California’s dairy herds.

Officials said ongoing analysis of the nation’s dairy supply suggests it is safe to consume, Despite the risk to human health being low, an official with the Administration for Strategic Preparedness and Response said it will make Tamiflu available upon request “to jurisdictions that do not have their own stockpile and are responding to pre-symptomatic persons with exposure to confirmed or suspected infected birds, cattle or other animal exposures.”

Dawn O’Connell, assistant secretary of the preparedness agency, said it started the “fill and finish” process for approximately 4.8 million doses of vaccine “that is well matched to the currently circulating strain of H5N1 through the national pre-pandemic influenza vaccine stockpile program.”

She said the decision to get started on H5N1 vaccines was not a response to any heightened concern, but since it takes several months to fill and finish vaccine doses, the agency “thought it made sense given what we were seeing.”

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Gas stoves may contribute to early deaths and childhood asthma, new Stanford study finds

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Gas stoves may contribute to early deaths and childhood asthma, new Stanford study finds

Lung-irritating pollution created by cooking with gas stoves may be contributing to tens of thousands of premature deaths and cases of childhood asthma in the United States, according to a new study published in the journal Science Advances.

For decades, scientists have known the flames from a gas stovetop produce nitrogen dioxide, a pungent gas that can inflame a person’s lungs when inhaled. But for the first time, a team of researchers from Stanford University and Oakland-based research institute PSE Healthy Energy published a nationwide estimate of the long-term health consequences associated with cooking with natural gas and propane stoves.

Researchers concluded that exposure to nitrogen dioxide emissions alone may contribute to nearly 19,000 premature deaths in the United States each year. It has also resulted in as many as 200,000 current cases of pediatric asthma compared with cooking with electric stoves, which do not produce nitrogen dioxide.

Aggressive and impactful reporting on climate change, the environment, health and science.

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Stanford researcher Yannai Kashtan noted higher levels of pollution were correlated with the amount of gas that was burned. But pollution also accumulated at higher levels inside smaller homes.

“If you live in a smaller house, you’re exposed to more pollution, and that can lead to income and racial disparities in exposure,” Kashtan said. “In general, folks living in neighborhoods with higher levels of outdoor pollution also tend to have higher indoor pollution. So this environmental injustice extends indoors as well.”

The American Gas Assn., a trade organization representing more than 200 local energy companies nationwide, dismissed the findings as “misleading and unsupported.”

“Despite the impressive names on this study, the data presented here clearly does not support any linkages between gas stoves and childhood asthma or adult mortality,” the association’s president and CEO, Karen Harbert said in a statement earlier this month.

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The study is the latest examining the serious health effects associated with breathing fumes from gas stoves, which release planet-warming carbon emissions and a variety of air pollutants. In recent years, the popular household appliance has become a political hot-button issue as policymakers and regulators have weighed environmental impacts against consumer choice.

Many large cities in California, including Los Angeles, have moved toward phasing out gas stoves in newly constructed residences. Earlier this month, the California Assembly advanced a bill to the Senate that would require gas stoves to come with warning labels detailing the pollution and health effects that can arise from cooking with gas.

Gas stoves emit a variety of pollutants, including asphyxiating carbon monoxide, cancer-causing formaldehyde and benzene. The flame also creates nitrogen dioxide, a precursor to smog and a pollutant that can cause difficulty breathing.

Environmental groups say consumers should be notified about these pollutants and the potential harm they can cause.

“Gas stoves create pollution in our homes, increasing the risk of childhood asthma and other respiratory problems for our families,” said Jenn Engstrom, state director for California Public Interest Research Group. “However, this risk has largely been hidden from the public. Consumers deserve the truth when it comes to the danger of cooking with gas. Warning labels will give consumers what they need to make informed decisions when they purchase appliances for their homes.”

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Kashtan and other researchers had previously discovered cooking with gas stoves presented a similar cancer risk as inhaling second-hand cigarette smoke. They also found some gas stoves leaked contaminants even when the burners were off.

The effects are especially devastating to children, whose smaller and still-developing lungs need to take more breaths than adults, Kashtan said. Older adults, especially those with cardiovascular or respiratory illness, are also more vulnerable to pollution from gas stoves.

To alleviate indoor air pollution, experts recommend using ventilation hoods and opening windows while cooking,

Starting in 2008, California required new and redeveloped homes to have ventilation that could prevent pollution from building up indoors. But during their research, measuring emissions in more than 100 households across the country, Yannai said they found many kitchens didn’t have ventilation hoods at all.

Although the health effects of breathing these pollutants are clear, researchers still wonder to what degree these conditions could be reversible. As communities take steps to mitigate their exposure or transition away, he said we could soon see the results.

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“It’s never too late to stop breathing in pollution,” he said.

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