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Column: Two Rutgers professors are accused of poisoning the debate over COVID's origins. Here's why

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Column: Two Rutgers professors are accused of poisoning the debate over COVID's origins. Here's why

In a Dec. 2 tweet, Richard H. Ebright, a professor of chemistry and chemical biology at Rutgers University, stated that Anthony Fauci, the respected virologist and retired official of the National Institutes of Health, “is likely a murderer and provably a felon.”

In another tweet a few weeks earlier, he had compared Fauci to the Cambodian dictator Pol Pot, who was responsible for the genocidal massacre of as many as 2 million people in the 1970s.

Referring to an event at Case Western Reserve University honoring Fauci, Ebright wrote: “You may have missed the chance to hobnob with Pol Pot, but, Case Western will give you the chance to hobnob with Fauci, whose policy violations … likely killed 20 million.”

Every time I speak publicly, I now have a thought that there might be someone who has ingested this steady stream of distortions who might shoot me while I’m speaking.

— Michael Worobey, University of Arizona

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In a tweet Aug. 25, 2022, Ebright’s colleague Bryce Nickels, a professor in the Rutgers department of genetics, called the “coordination” among virology researchers including Angela Rasmussen of the University of Saskatchewan and Michael Worobey of the University of Arizona an example of “pure, unfiltered evil.”

He illustrated the tweet with a GIF from the 1976 movie “Marathon Man” showing Dustin Hoffman being tortured by a character played by Lawrence Olivier and plainly inspired by Nazi doctor Josef Mengele.

This is the landscape on which a conflict over two theories about the origin of COVID-19 has been waged. One theory attributes the origin to unregulated trading in China of disease-susceptible wildlife, from which the virus that causes the disease is thought to have leaped to humans in a process known as a zoonotic spillover.

The other, the lab leak hypothesis, posits that the virus escaped from a virology lab in Wuhan, China, where it may have been deliberately concocted.

Let’s be clear: There is no evidence for a lab leak. No one has ever produced anything in its favor other than innuendo and conjecture. By contrast, evidence for a zoonotic transfer is almost overwhelming, has grown ever stronger over the years and is widely accepted by virologists and epidemiologists.

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Ebright and Nickels are advocates of the lab-leak theory. For years they have been posting online insinuations or outright accusations of fraud, perjury, felonies and murder aimed at scientists who advocate for the zoonotic transfer theory.

Now a dozen scientists, some of whom have been direct targets of Ebright and Nickels, have called on Rutgers to open a formal investigation into whether its two faculty members have crossed the line distinguishing between responsible scientific debate and defamation, harassment, intimidation and threats.

Among the concerns the signatories aired in their March 14 complaint letter is that the professors’ actions and “inflammatory language,” such as “comparisons of working scientists to historical war criminals and mass murderers,” could “put some of us and … our colleagues in physical danger.”

Ebright’s and Nickels’ behavior, the complaint says, has unfolded in an atmosphere that had already produced “harassment including threats of death and/or violence because of our … scientific research.”

Ebright and Nickels say the complaint misrepresents their words and activities. “I never have compared any of the signatories to Josef Mengele or Pol Pot, and I never have characterized any of the signatories as murderers,” Ebright told me by email. He adds, “I also never have threatened or incited violence against any of the signatories.”

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He did acknowledge calling four signatories “fraudsters,” based on their authorship of a 2020 scientific paper that favored zoonosis as the origin of COVID-19 and dismissed the lab-leak theory as implausible. “I stand by this characterization,” he wrote. He called the complaint “an effort to silence opponents and to prop up a collapsing narrative.”

Nickels told me by email, “the assertion that I have labeled any of the 12 signatories as murderers or endangered them or their colleagues is false and is defamatory with malice.” In his email, he accused the same four signatories mentioned by Ebright of fraud.

More on that shortly.

The complaint letter says that Ebright and Nickels have engaged in online harassment, intimidation and threats for years. According to Kristian Andersen, an evolutionary biologist at Scripps Research in La Jolla and the organizer of the complaint, a new element in their approach recently appeared: encouraging their followers to engage in physical contact with zoonosis advocates.

On March 12, Nickels tweeted a notice of a scientific conference in Washington at which Peter Daszak, the head of a research funding organization who has long been the target of vituperation by lab-leak advocates, would appear on a panel.

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“Don’t miss your chance to meet Peter Daszak, author of the grant many consider the ‘Blueprint’ for SARS-CoV2!” he wrote. The reference was to a groundless accusation beloved by lab-leak advocates that a grant proposal sponsored by Daszak’s organization involved creating a virus in a Chinese lab that became SARS-CoV-2, the virus that causes COVID. Virologists say the grant proposal would not have produced such a virus. In any event, it was not funded.

“That was so far outside of what I would consider to be normal and ethical conduct in science that I said, we need to file a formal complaint,” Andersen told me. The scientists’ letter to Rutgers administrators doesn’t ask for any disciplinary action, but calls for “immediate and serious review by the administration” of public behavior by Ebright and Nickels.

The call by Ebright and Nickels for followers to show up at a talk by Daszak stepped up the anxiety many scientists feel about their own public appearances.

“Every time I speak publicly, I now have a thought that there might be someone who has ingested this steady stream of distortions who might shoot me while I’m speaking,” says Worobey, a signatory of the complaint whose research helped to establish a seafood and wildlife market in Wuhan, not a lab, as the likely site of the first zoonosis transfers. “With those escalations recently, I thought it was time to deal with it head-on.”

Vaccine science, immigration and elections are all battlegrounds for the war between information and disinformation today. The temperature of debates on these topics is only heightened by the tendency of social media platforms such as Twitter (now X) to encourage intemperate speech. But science and health seem to be areas especially vulnerable to efforts at falsification.

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A brief primer on the lab-leak hypothesis may be useful here. During the earliest weeks of the COVID pandemic, many virologists examining the SARS-CoV-2 virus, including Andersen, spotted unfamiliar features, some so unusual that they conjectured the features might have been man-made.

Further research in the ensuing weeks revealed, however, that these features were not unusual, but common, and that they could develop in viruses such as SARS2 through natural processes. Andersen and others eventually concluded that a laboratory role in COVID’s emergence was implausible.

That conclusion was written into a seminal paper on the virus published in Nature Medicine on March 17, 2020, and titled “The proximal origin of SARS-CoV-2.” Its authors included Andersen, Robert F. Garry of Tulane University, Andrew Rambaut of the University of Edinburgh and Edward C. Holmes of the University of Sydney.

All four signed the complaint letter to Rutgers. They’re the four scientists Ebright and Nickels accused of fraud in their emails to me, based on the Rutgers scientists’ claim that the proximal origin paper was fashioned to serve what Ebright and Nickels assert was the authors’ and Fauci’s desire to downplay
Fauci’s role in funding virology research in China.

Ebright further accused Andersen and Garry of perjury, based on their denials at a congressional hearing in July that Fauci pressured them to advocate for the zoonosis theory in their paper.

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After the paper’s publication, the lab-leak hypothesis moved into the partisan political realm. Republicans in Congress cherish the notion that Andersen and his colleagues deliberately minimized a laboratory role at Fauci’s behest.

There is not a scintilla of evidence for that assertion, as Andersen and Garry made clear by cogently explaining at the July hearing called by conspiracy-addled House Republicans how the normal process of scientific research led them to the paper’s conclusions.

Last March, FBI Director Christopher Wray stated in an interview with Fox News that the bureau had concluded with “moderate confidence” that the virus had escaped from the Chinese lab, but he cited no evidence and didn’t explain its grounds.

The FBI’s assessment had been part of a survey of all U.S. intelligence agencies that largely contradicted the FBI’s position. In June, it was further contradicted by a report from the Office of the Director of National Intelligence, which refuted claims that the Chinese lab had played a role in the pandemic.

That brings us back to Ebright and Nickels. Although insults and invective are hardly uncommon in exchanges over COVID’s origins, their contributions have often carried a remarkably noxious tone.

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The defense by both that they never compared the complainants to Pol Pot or Mengele or characterized them as murderers may be true as far as it goes. But it’s too clever by half. The complainants didn’t say in their letter to Rutgers that they themselves were necessarily the targets of Ebright’s and Nickels’ odious comparisons. Their complaint says the pair had “made comparisons of working scientists” — i.e., other scientists — “to historical war criminals and mass murderers.”

So let’s look at the record.

Ebright has repeatedly intimated that Fauci is a murderer, based on his view that his agency funded dangerous virology research in the Chinese lab that produced the pandemic. There is no evidence that any research the U.S. government funded in China produced the SARS-CoV-2 virus, or even that any such research at that lab was scientifically possible.

On Nov. 13, Ebright wrote of Fauci, “any person whose violations of U.S. government policies … resulted in 20 million deaths is, by any rational standard, a murderer.” It’s unclear what “violations” he was referring to.

In a June 27 tweet, Ebright described Fauci as “an octogenarian serially misfeasant, serially malfeasant, serially perjurious, former bureaucrat likely to face criminal charges after Jan 2025” (i.e., presumably assuming that Donald Trump would then take office again).

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On Dec. 23 he tweeted that the “only option” to “mitigate the negative effects” of the proximal origin paper was the referral of Andersen and his colleagues “for criminal prosecution.”

On July 10, 2021, Ebright responded with the following comment to a tweet that apparently had alluded to critics of the lab-leak theory: “Sociopaths will be sociopaths … See Mengele. See Ishii.” The latter reference is to Shirō Ishii, who headed Japan’s World War II bioweapons program, which has been blamed for the deaths of as many as 300,000 people.

On Sept. 5 and 6, 2022, Ebright summarized the case for the lab-leak hypothesis, which he tied to “labs conducting world’s largest research program on bat SARS-like coronaviruses.” He ended the thread with the phrase “The banality of evil” — philosopher Hannah Arendt’s description of the impression left on her by Adolph Eichmann, the architect of the Nazi program of Jewish genocide, whose trial in Israel she reported on.

Nickels, in addition to posting the Mengele-linked film clip, earlier this month tweeted “massive respect to … military veterans that have taken a stand” against scientists he asserted had lied about research “impacting national security.” He called the behavior of such scientists “treasonous” and he specifically named among those deserving respect, one Andrew G. Huff.

One day earlier, Huff, who labels the zoonosis theory a “lie,” tweeted a call for Fauci, Daszak and virologist Ralph Baric of the University of North Carolina to be hauled before a military tribunal. Subsequently, he tweeted that his followers had voted in an online poll that if convicted, they should be hanged. He illustrated that tweet with a film clip of three people plunging to their deaths on a gallows.

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The ball is now in Rutgers’ court. The university says the complaint “will be forwarded to the appropriate offices for review.” It didn’t say what issues would be considered. But certainly a determination would be warranted of whether its faculty members’ actions conform to the school’s policy on free expression, which frowns on actions or behaviors that “threaten individuals or cause an injury to someone” or “harass, threaten violence, or intimidate others.”

Whatever the outcome is of any such inquiry, the scientific community is right to be appalled by Ebright’s and Nickels’ activities. There’s vast latitude in science for disagreement and debate, but calling one’s adversaries or critics criminals or traitors, or placing them in the same category as Mengele, Eichmann and Pol Pot? That isn’t scientific debate.

In the world of science, the reputations of Andersen, Worobey, Garry, Holmes and Rambaut are secure; their finding that COVID most likely originated in the wildlife trade has not only held up over time but also been validated by subsequent studies. The same is true of the other eight signatories of the complaint letter, and Fauci and Daszak (who are not signatories).

Ebright and Nickels? They may be a different story.

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Canny as a crocodile but dumber than a baboon — new research ponders T. rex's brain power

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Canny as a crocodile but dumber than a baboon — new research ponders T. rex's brain power

In December 2022, Vanderbilt University neuroscientist Suzana Herculano-Houzel published a paper that caused an uproar in the dinosaur world.

After analyzing previous research on fossilized dinosaur brain cavities and the neuron counts of birds and other related living animals, Herculano-Houzel extrapolated that the fearsome Tyrannosaurus rex may have had more than 3 billion neurons — more than a baboon.

As a result, she argued, the predators could have been smart enough to make and use tools and to form social cultures akin to those seen in present-day primates.

The original “Jurassic Park” film spooked audiences by imagining velociraptors smart enough to open doors. Herculano-Houzel’s paper described T. rex as essentially wily enough to sharpen their own shivs. The bold claims made headlines, and almost immediately attracted scrutiny and skepticism from paleontologists.

In a paper published Monday in “The Anatomical Record,” an international team of paleontologists, neuroscientists and behavioral scientists argue that Herculano-Houzel’s assumptions about brain cavity size and corresponding neuron counts were off-base.

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True T. rex intelligence, the scientists say, was probably much closer to that of modern-day crocodiles than primates — a perfectly respectable amount of smarts for a therapod to have.

“What needs to be emphasized is that reptiles are certainly not as dim-witted as is commonly believed,” said Kai Caspar, a biologist at Heinrich Heine University Düsseldorf and co-author of the paper. “So whereas there is no reason to assume that T. rex had primate-like habits, it was certainly a behaviorally sophisticated animal.”

Brain tissue doesn’t fossilize, and so researchers examine the shape and size of the brain cavity in fossilized dinosaur skulls to deduce what their brains may have been like.

In their analysis, the authors took issue with Herculano-Houzel’s assumption that dinosaur brains filled their skull cavities in a proportion similar to bird brains. Herculano-Houzel’s analysis posited that T. rex brains occupied most of their brain cavity, analogous to that of the modern-day ostrich.

But dinosaur brain cases more closely resemble those of modern-day reptiles like crocodiles, Caspar said. For animals like crocodiles, brain matter occupies only 30% to 50% of the brain cavity. Though brain size isn’t a perfect predictor of neuron numbers, a much smaller organ would have far fewer than the 3 billion neurons Herculano-Houzel projected.

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“T. rex does come out as the biggest-brained big dinosaur we studied, and the biggest one not closely related to modern birds, but we couldn’t find the 2 to 3 billion neurons she found, even under our most generous estimates,” said co-author Thomas R. Holtz, Jr., a vertebrate paleontologist at University of Maryland, College Park.

What’s more, the research team argued, neuron counts aren’t an ideal indicator of an animal’s intelligence.

Giraffes have roughly the same number of neurons that crows and baboons have, Holtz pointed out, but they don’t use tools or display complex social behavior in the way those species do.

“Obviously in broad strokes you need more neurons to create more thoughts and memories and to solve problems,” Holtz said, but the sheer number of neurons an animal has can’t tell us how the animal will use them.

“Neuronal counts really are comparable to the storage capacity and active memory on your laptop, but cognition and behavior is more like the operating system,” he said. “Not all animal brains are running the same software.”

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Based on CT scan reconstructions, the T. rex brain was probably “ a long tube that has very little in terms of the cortical expansion that you see in a primate or a modern bird,” said paleontologist Luis Chiappe, director of the Dinosaur Institute at the Natural History Museum of Los Angeles County.

“The argument that a T. Rex would have been as intelligent as a primate — no. That makes no sense to me,” said Chiappe, who was not involved in the study.

Like many paleontologists, Chiappe and his colleagues at the Dinosaur Institute were skeptical of Herculano-Houzel’s original conclusions. The new paper is more consistent with previous understandings of dinosaur anatomy and intelligence, he said.

“I am delighted to see that my simple study using solid data published by paleontologists opened the way for new studies,” Herculano-Houzel said in an email. “Readers should analyze the evidence and draw their own conclusions. That’s what science is about!”

When thinking about the inner life of T. rex, the most important takeaway is that reptilian intelligence is in fact more sophisticated than our species often assumes, scientists said.

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“These animals engage in play, are capable of being trained, and even show excitement when they see their owners,” Holtz said. “What we found doesn’t mean that T. rex was a mindless automaton; but neither was it going to organize a Triceratops rodeo or pass down stories of the duckbill that was THAT BIG but got away.”

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You're gonna need a bigger number: Scientists consider a Category 6 for mega-hurricane era

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You're gonna need a bigger number: Scientists consider a Category 6 for mega-hurricane era

In 1973, the National Hurricane Center introduced the Saffir-Simpson scale, a five-category rating system that classified hurricanes by wind intensity.

At the bottom of the scale was Category 1, for storms with sustained winds of 74 to 95 mph. At the top was Category 5, for disasters with winds of 157 mph or more.

In the half-century since the scale’s debut, land and ocean temperatures have steadily risen as a result of greenhouse gas emissions. Hurricanes have become more intense, with stronger winds and heavier rainfall.

With catastrophic storms regularly blowing past the 157-mph threshold, some scientists argue, the Saffir-Simpson scale no longer adequately conveys the threat the biggest hurricanes present.

Earlier this year, two climate scientists published a paper that compared historical storm activity to a hypothetical version of the Saffir-Simpson scale that included a Category 6, for storms with sustained winds of 192 mph or more.

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Of the 197 hurricanes classified as Category 5 from 1980 to 2021, five fit the description of a hypothetical Category 6 hurricane: Typhoon Haiyan in 2013, Hurricane Patricia in 2015, Typhoon Meranti in 2016, Typhoon Goni in 2020 and Typhoon Surigae in 2021.

Patricia, which made landfall near Jalisco, Mexico, in October 2015, is the most powerful tropical cyclone ever recorded in terms of maximum sustained winds. (While the paper looked at global storms, only storms in the Atlantic Ocean and the northern Pacific Ocean east of the International Date Line are officially ranked on the Saffir-Simpson scale. Other parts of the world use different classification systems.)

Though the storm had weakened to a Category 4 by the time it made landfall, its sustained winds over the Pacific Ocean hit 215 mph.

“That’s kind of incomprehensible,” said Michael F. Wehner, a senior scientist at the Lawrence Berkeley National Laboratory and co-author of the Category 6 paper. “That’s faster than a racing car in a straightaway. It’s a new and dangerous world.”

In their paper, which was published in the Proceedings of the National Academy of Sciences, Wehner and co-author James P. Kossin of the University of Wisconsin–Madison did not explicitly call for the adoption of a Category 6, primarily because the scale is quickly being supplanted by other measurement tools that more accurately gauge the hazard of a specific storm.

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“The Saffir-Simpson scale is not all that good for warning the public of the impending danger of a storm,” Wehner said.

The category scale measures only sustained wind speeds, which is just one of the threats a major storm presents. Of the 455 direct fatalities in the U.S. due to hurricanes from 2013 to 2023 — a figure that excludes deaths from 2017’s Hurricane Maria — less than 15% were caused by wind, National Hurricane Center director Mike Brennan said during a recent public meeting. The rest were caused by storm surges, flooding and rip tides.

The Saffir-Simpson scale is a relic of an earlier age in forecasting, Brennan said.

“Thirty years ago, that’s basically all we could tell you about a hurricane, is how strong it was right now. We couldn’t really tell you much about where it was going to go, or how strong it was going to be, or what the hazards were going to look like,” Brennan said during the meeting, which was organized by the American Meteorological Society. “We can tell people a lot more than that now.”

He confirmed the National Hurricane Center has no plans to introduce a Category 6, primarily because it is already trying “to not emphasize the scale very much,” Brennan said. Other meteorologists said that’s the right call.

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“I don’t see the value in it at this time,” said Mark Bourassa, a meteorologist at Florida State University’s Center for Ocean-Atmospheric Prediction Studies. “There are other issues that could be better addressed, like the spatial extent of the storm and storm surge, that would convey more useful information [and] help with emergency management as well as individual people’s decisions.”

Simplistic as they are, Herbert Saffir and Robert Simpson’s categories are the first thing many people think of when they try to grasp the scale of a storm. In that sense, the scale’s persistence over the years helps people understand how much the climate has changed since its introduction.

“What the Saffir-Simpson scale is good for is quantifying, showing, that the most intense storms are becoming more intense because of climate change,” Wehner said. “It’s not like it used to be.”

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Opinion: America's 'big glass' dominance hangs on the fate of two powerful new telescopes

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Opinion: America's 'big glass' dominance hangs on the fate of two powerful new telescopes

More than 100 years ago, astronomer George Ellery Hale brought our two Pasadena institutions together to build what was then the largest optical telescope in the world. The Mt. Wilson Observatory changed the conception of humankind’s place in the universe and revealed the mysteries of the heavens to generations of citizens and scientists alike. Ever since then, the United States has been at the forefront of “big glass.”

In fact, our institutions, Carnegie Science and Caltech, still help run some of the largest telescopes for visible-light astronomy ever built.

But that legacy is being threatened as the National Science Foundation, the federal agency that supports basic research in the U.S., considers whether to fund two giant telescope projects. What’s at stake is falling behind in astronomy and cosmology, potentially for half a century, and surrendering the scientific and technological agenda to Europe and China.

In 2021, the National Academy of Sciences released Astro2020. This report, a road map of national priorities, recommended funding the $2.5-billion Giant Magellan Telescope at the peak of Cerro Las Campanas in Chile and the $3.9-billion Thirty Meter Telescope at Mauna Kea in Hawaii. According to those plans, the telescopes would be up and running sometime in the 2030s.

NASA and the Department of Energy backed the plan. Still, the National Science Foundation’s governing board on Feb. 27 said it should limit its contribution to $1.6 billion, enough to move ahead with just one telescope. The NSF intends to present their process for making a final decision in early May, when it will also ask for an update on nongovernmental funding for the two telescopes. The ultimate arbiter is Congress, which sets the agency’s budget.

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America has learned the hard way that falling behind in science and technology can be costly. Beginning in the 1970s, the U.S. ceded its powerful manufacturing base, once the nation’s pride, to Asia. Fast forward to 2022, the U.S. government marshaled a genuine effort toward rebuilding and restarting its factories — for advanced manufacturing, clean energy and more — with the Inflation Reduction Act, which is expected to cost more than $1 trillion.

President Biden also signed into law the $280-billion CHIPS and Science Act two years ago to revive domestic research and manufacturing of semiconductors — which the U.S. used to dominate — and narrow the gap with China.

As of 2024, America is the unquestioned leader in astronomy, building powerful telescopes and making significant discoveries. A failure to step up now would cede our dominance in ways that would be difficult to remedy.

The National Science Foundation’s decision will be highly consequential. Europe, which is on the cusp of overtaking the U.S. in astronomy, is building the aptly named Extremely Large Telescope, and the United States hasn’t been invited to partner in the project. Russia aims to create a new space station and link up with China to build an automated nuclear reactor on the moon.

Although we welcome any sizable grant for new telescope projects, it’s crucial to understand that allocating funds sufficient for just one of the two planned telescopes won’t suffice. The Giant Magellan and the Thirty Meter telescopes are designed to work together to create capabilities far greater than the sum of their parts. They are complementary ground stations. The GMT would have an expansive view of the southern hemisphere heavens, and the TMT would do the same for the northern hemisphere.

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The goal is “all-sky” observation, a wide-angle view into deep space. Europe’s Extremely Large Telescope won’t have that capability. Besides boosting America’s competitive edge in astronomy, the powerful dual telescopes, with full coverage of both hemispheres, would allow researchers to gain a better understanding of phenomena that come and go quickly, such as colliding black holes and the massive stellar explosions known as supernovas. They would put us on a path to explore Earth-like planets orbiting other suns and address the question: “Are we alone?

Funding both the GMT and TMT is an investment in basic science research, the kind of fundamental work that typically has led to economic growth and innovation in our uniquely American ecosystem of scientists, investors and entrepreneurs.

Elon Musk’s SpaceX is the most recent example, but the synergy goes back decades. Basic science at the vaunted Bell Labs, in part supported by taxpayer contributions, was responsible for the transistor, the discovery of cosmic microwave background and establishing the basis of modern quantum computing. The internet, in large part, started as a military communications project during the Cold War.

Beyond its economic ripple effect, basic research in space and about the cosmos has played an outsized role in the imagination of Americans. In the 1960s, Dutch-born American astronomer Maarten Schmidt was the first scientist to identify a quasar, a star-like object that emits radio waves, a discovery that supported a new understanding of the creation of the universe: the Big Bang. The first picture of a black hole, seen with the Event Horizon Telescope, was front-page news in 2019.

We understand that competing in astronomy has only gotten more expensive, and there’s a need to concentrate on a limited number of critical projects. But what could get lost in the shuffle are the kind of ambitious projects that have made America the scientific envy of the world, inspiring new generations of researchers and attracting the best minds in math and science to our colleges and universities.

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Do we really want to pay that price?

Eric D. Isaacs is the president of Carnegie Science, prime backer of the Giant Magellan Telescope. Thomas F. Rosenbaum is president of Caltech, key developer of the Thirty Meter Telescope.

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