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Column: Still searching for the fountain of youth? Don't drown in all the hype

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Column: Still searching for the fountain of youth? Don't drown in all the hype

Given the long list of major catastrophes in the world — melting polar ice, raging wars, the disappearance of early-bird specials, etc. — I’m not sure why so many people want to live forever. But they do, and the multibillion-dollar longevity industry is booming.

Supplements, skincare products, cosmetic surgery, books, diets, podcasts, workout routines — all of this is available to anyone who wants to halt or reverse the aging process, or at least try.

David Sinclair, a 54-year-old Harvard geneticist, told Fortune magazine he’s getting back to his 20-year-old brain. He’s on a plant-based diet with supplements designed to jump-start his longevity genes. He’s also managed to activate his bank account with a bestselling book called “Lifespan: Why We Age — And Why We Don’t Have To.”

California is about to be hit by an aging population wave, and Steve Lopez is riding it. His column focuses on the blessings and burdens of advancing age — and how some folks are challenging the stigma associated with older adults.

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Tech entrepreneur and anti-aging guru Bryan Johnson of Los Angeles takes it a step further. He’s 46 in real time but is trying to get back to 18. He says death is optional, and it’s presumably less likely if you sign up for his $333-monthly line of supplemental products. Johnson downs 100 or so supplements daily and performs about two dozen exercises. He wears a T-shirt that says, “Don’t Die,” eats something he calls “nutty pudding” and sleeps with a penis monitor to count nighttime erections.

Such a routine would actually shorten my life, because after a week or so of that, I’d hurl myself in front of a bus.

Thankfully, not everyone is easily duped by claims of immortality. Charles Brenner, an acclaimed authority on metabolism and disease, first contacted me a year ago to say, “I’m very bothered by bulls— claims in longevity science.”

The City of Hope biochemist has used science to poke holes in one life-extension claim after another, including those of Sinclair and Johnson, and has become known as the longevity skeptic and the great debunker.

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When we met for a cup of coffee one recent morning in Sierra Madre, he began the conversation with a reference to the Greek historian Herodotus, who wrote about dipping in magical waters that can keep you forever young. But there was no fountain of youth back then, Brenner noted, and the latest claims of its existence are sure to ultimately disappoint the long lines of lemmings.

“Partially, it’s media, and a worship of youth as opposed to a respect for aging and wisdom,” Brenner said. “We all want to retain our facilities and our ability to provide for others, so I think that’s normal and healthy. But there’s a lot of anxiety that is driving the obsession with anti-aging, and I do believe there have been some false promises and obfuscation from some figures at the interface of academia and investment.”

That’s not to say there are no pathways to healthier living, or that there is no promising research into detection, prevention and treatment of life-shortening diseases. Brenner discovered in his own research that a vitamin called nicotinamide riboside is useful “in promoting resiliency and repair in aging. “We’re doing randomized clinical trials to test its efficacy in a variety of age-related conditions” including Parkinson’s disease. “I don’t think it’s going to extend life span,” he said, “but I do think … it’s something that can help people maintain their resiliency.”

This brings up an important distinction — that medical breakthroughs and healthier lifestyles can help us lengthen our health span, if not our life span. We all have to eventually “leave the feast of life,” as Brenner puts it, but there’s hope that we can enjoy healthier and more active years while we’re still standing.

Psychology professor Laura Carstensen, director of the Stanford Longevity Center, said she doesn’t know of any evidence that we can live forever, or what kind of nightmare that might be.

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“People are profiting mightily from what might be snake oil,” she said. “But the scientific community doesn’t know what the best measures are right now, and we don’t want people to stop looking for them.”

In Carstensen’s view, we have an astronomically expensive disease-care system rather than a healthcare system, and she wouldn’t bet a nickel on an overhaul by the federal government. So she’s holding out hope for legitimate private sector forays into early detection and intervention. As an example, she points out that preventing diabetes is a lot less expensive than treating it.

“Geroscience is often misrepresented as helping people live forever. It’s not. It’s about health span, and altering the processes that put us at risk for virtually all diseases,” Carstensen said.

Just before I met with Brenner, a PR firm offered me an interview with Irina Conboy, a UC Berkeley professor who has co-founded a company called Generation Lab. I was initially skeptical because the pitch said Conboy was responsible for a number of “research breakthroughs… on the discovery that aging is malleable and can be rapidly reversed, through rejuvenating blood circulation.”

Another fountain of youth proposition?

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But the same pitch said Generation Lab’s process involves peer-reviewed science, and employs a series of cheek swab tests “to measure clinically relevant biological ‘alarm signals’ that report biological age and risk of disease.” Clients would get an assessment of the condition of cardiac, respiratory, urinary and other body systems, and through a pairing with a physician, interventions could be prescribed to “address conditions that rob people of their quality of life and independence as they age — extending the human health span.”

Conboy told Fortune she was trying to steer people away “from the dangers of pseudo longevity.” She said that “aging is not something that is set in stone like a train going on a track,” and that “the overarching goal is to delay or perhaps reverse or even prevent diseases.”

Can Generation Lab deliver on its promises? That remains to be seen, but more than 1,000 people are already on a waiting list for the cheek swab intervention, which costs $400. And that brings up a question of medical ethics.

We already have a crisis of inequity when it comes to access to diagnostics and quality healthcare. As the world’s unprecedented age wave accelerates and the percentage of older people grows, are we establishing new barriers between those who can, and can’t, afford the latest trials and interventions?

“We’re trying to get this as accessible as possible” and to make Generation Lab cheaper after the March trials begin, said CEO Alina Rui Su, who told me one goal is to eventually bring down the price of admission.

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I told Conboy the thought of swabbing my cheek and waiting for the results, which might be alarming, could keep me awake at night. And what’s wrong with instead having good old-fashioned regular checkups with my doctor?

Those checkups won’t necessarily identify early signs of trouble, she said, but the Generation Lab diagnostics might.

“Would you want to know that three years from now, or five years from now, you might develop a bad cancer, and knowing might allow you” to begin interventions? she asked.

Good question. I suppose I would, though I think I’ll wait until the price goes down.

Getting more out of our limited time is a worthy endeavor, for sure. But at the risk of being a party pooper, let’s not forget that we’re all dying. Despite the claims of some, it’s the natural order. And there is an aspect of the longevity boom that frames aging, and elderhood, as a wretched disease, to be avoided at any cost. If that’s your outlook, the stress alone might very well kill you, no matter how many pills you take.

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My amateur geroscience prescription, free of charge, is that you avoid buying any snake oil, skip the penis monitors, eat right and sleep tight, get some exercise and do things that give you a sense of purpose and pleasure.

If that gets you through today, try it again tomorrow.

steve.lopez@latimes.com

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What’s in a Name? For These Snails, Legal Protection

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What’s in a Name? For These Snails, Legal Protection

The sun had barely risen over the Pacific Ocean when a small motorboat carrying a team of Indigenous artisans and Mexican biologists dropped anchor in a rocky cove near Bahías de Huatulco.

Mauro Habacuc Avendaño Luis, one of the craftsmen, was the first to wade to shore. With an agility belying his age, he struck out over the boulders exposed by low tide. Crouching on a slippery ledge pounded by surf, he reached inside a crevice between two rocks. There, lodged among the urchins, was a snail with a knobby gray shell the size of a walnut. The sight might not dazzle tourists who travel here to see humpback whales, but for Mr. Avendaño, 85, these drab little mollusks represent a way of life.

Marine snails in the genus Plicopurpura are sacred to the Mixtec people of Pinotepa de Don Luis, a small town in southwestern Oaxaca. Men like Mr. Avendaño have been sustainably “milking” them for radiant purple dye for at least 1,500 years. The color suffuses Mixtec textiles and spiritual beliefs. Called tixinda, it symbolizes fertility and death, as well as mythic ties between lunar cycles, women and the sea.

The future of these traditions — and the fate of the snails — are uncertain. The mollusks are subject to intense poaching pressure despite federal protections intended to protect them. Fishermen break them (and the other mollusks they eat) open and sell the meat to local restaurants. Tourists who comb the beaches pluck snails off the rocks and toss them aside.

A severe earthquake in 2020 thrust formerly submerged parts of their habitat above sea level, fatally tossing other mollusks in the snail’s food web to the air, and making once inaccessible places more available to poachers.

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Decades ago, dense clusters of snails the size of doorknobs were easy to find, according to Mr. Avendaño. “Full of snails,” he said, sweeping a calloused, violet-stained hand across the coves. Now, most of the snails he finds are small, just over an inch, and yield only a few milliliters of dye.

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Video: This Parrot Has No Beak, But Is at the Top of the Pecking Order

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Video: This Parrot Has No Beak, But Is at the Top of the Pecking Order

new video loaded: This Parrot Has No Beak, But Is at the Top of the Pecking Order

Bruce, a disabled kea parrot, is missing his top beak. The bird uses tools to keep himself healthy and developed a jousting technique that has made him the alpha male of his group.

By Meg Felling and Carl Zimmer

April 20, 2026

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Contributor: Focus on the real causes of the shortage in hormone treatments

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Contributor: Focus on the real causes of the shortage in hormone treatments

For months now, menopausal women across the U.S. have been unable to fill prescriptions for the estradiol patch, a long-established and safe hormone treatment. The news media has whipped up a frenzy over this scarcity, warning of a long-lasting nationwide shortage. The problem is real — but the explanations in the media coverage miss the mark. Real solutions depend on an accurate understanding of the causes.

Reporters, pharmaceutical companies and even some doctors have blamed women for causing the shortage, saying they were inspired by a “menopause moment” that has driven unprecedented demand. Such framing does a dangerous disservice to essential health advocacy.

In this narrative, there has been unprecedented demand, and it is explained in part by the Food and Drug Administration’s recent removal of the “black-box warning” from estradiol patches’ packaging. That inaccurate (and, quite frankly, terrifying) label had been required since a 2002 announcement overstated the link between certain menopause hormone treatments and breast cancer. Right-sizing and rewording the warning was long overdue. But the trouble with this narrative is that even after the black-box warning was removed, there has not been unprecedented demand.

Around 40% of menopausal women were prescribed hormone treatments in some form before the 2002 announcement. Use plummeted in its aftermath, dipping to less than 5% in 2020 and just 1.8% in 2024. According to the most recent data, the number has now settled back at the 5% mark. Unprecedented? Hardly. Modest at best.

Nor is estradiol a new or complex drug; the patch formulation has existed for decades, and generic versions are widely manufactured. There is no exotic ingredient, no rare supply chain dependency, no fluke that explains why women are suddenly being told their pharmacy is out of stock month after month.

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The story is far more an indictment of the broken insurance industry: market concentration, perverse incentives and the consequences of allowing insurance companies to own the pharmacy benefit managers that effectively control drug access for the majority of users. Three companies — CVS Caremark, Express Scripts and OptumRx — manage 79% of all prescription drug claims in the United States. Those companies are wholly owned subsidiaries of three insurance behemoths: CVS Health, Cigna and UnitedHealth Group, respectively. This means that the same corporation that sells you your insurance plan also decides which drugs get covered, at what price, and whether your pharmacy can stock them. This is called vertical integration. In another era, we might have called it a cartel. The resulting problems are not unique to hormone treatments; they have affected widely used medications including blood thinners, inhalers and antibiotics. When a low-cost generic such as estradiol — a medication with no blockbuster profit margins and no patent protection — runs into friction in this system, the friction is not random. It is structural. Every decision in that chain is filtered through the same corporate profit motive. And when the drug in question is an off-patent estradiol patch that has negligible profit margins because of generic competition but requires logistical investment to keep consistently in stock? The math on “how much does this company care about ensuring access” is not complicated.

Unfortunately, there is little financial incentive to ensure smooth, consistent access. There is, however, significant financial incentive to steer patients toward branded alternatives, or simply to let supply tighten — because the companies aren’t losing much profit if sales of that product dwindle. This is not a conspiracy theory: The Federal Trade Commission noted this dynamic in a report that documented how pharmacy benefit managers’ practices inflate costs, reduce competition and harm patient access, particularly for independent pharmacies and for generic drugs.

Any claim that the estradiol patch shortage is meaningfully caused by more women now demanding hormone treatments is a distraction. It is also misogyny, pure and simple, to imply that the solution to the shortage is for women’s health advocates to dial it down and for women to temper their expectations. The scarcity of estradiol patches is the outcome of a broken system refusing to provide adequate supply.

Meanwhile, there are a few strategies to cope.

  • Ask your prescriber about alternatives. Estradiol is available in multiple formulations, including gel, spray, cream, oral tablet, vaginal ring and weekly transdermal patch, which is a different product from the twice-weekly patch and may be more consistently available depending on manufacturer and region.
  • Consider an online pharmacy. Many are doing a good job locating and filling these prescriptions from outside the pharmacy benefit manager system.
  • Call ahead. Patch shortages are inconsistent across regions and distributors. A call to pharmacies in your area, or a broader geographic radius if you’re able, can locate stock that your regular pharmacy doesn’t have.
  • Consider a compounding pharmacy. These sources can sometimes meet needs when commercially manufactured products are inaccessible. The hormones used are the same FDA-regulated bulk ingredients.

Beyond those Band-Aid solutions, more Americans need to fight for systemic change. The FTC report exists because Congress asked for it and committed to legislation that will address at least some of the problems. The FDA took action to change the labeling on estrogen in the face of citizen and medical experts’ pressure; it should do more now to demand transparency from patch manufacturers.

Most importantly, it is on all of us to call out the cracks in the current system. Instead of repeating “there’s a patch shortage” or a “surge in demand,” say that a shockingly small minority of menopausal women still even get hormonal treatments prescribed at all, and three drug companies control the vast majority of claims in this country. Those are the real problems that need real solutions.

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Jennifer Weiss-Wolf, the executive director of the Birnbaum Women’s Leadership Center at New York University School of Law, is the author of the forthcoming book When in Menopause: A User’s Manual & Citizen’s Guide. Suzanne Gilberg, an obstetrician and gynecologist in Los Angeles, is the author of “Menopause Bootcamp.”

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