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As global plastic production grows, so does the concentration of microplastics in our brains

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As global plastic production grows, so does the concentration of microplastics in our brains

Finding microplastics in human body parts is not new: Scientists have uncovered the minuscule waste products in human blood, lungs, brains, hearts and testicles.

But a new study, published Monday in the journal Nature Medicine, shows a lockstep relationship between the amount of plastic found in tissues harvested from human cadavers and the amount being produced by the plastic industry.

As global plastic production has ramped up in the last 20 years, so too has the concentration of these shredded, fossil fuel-derived polymers in human tissue samples.

The findings are “pretty striking,” said Phil Landrigan, director of the Program for Global Public Health and the Common Good at Boston College, who was not affiliated with the research.

The study also showed a concerning correlation between patients who had received a dementia diagnosis before they died and the amount of plastic particles found in their brains — adding to a growing body of research indicating that the presence of these particles in the human body can potentially cause harm.

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The study was published by a team of researchers at the University of New Mexico, Oklahoma State University, Duke University and Universidad del Valle, in Colombia.

The team acquired brain, liver and kidney tissue samples from patients who had undergone autopsies between 2016 and 2024 at the University of New Mexico.

To determine both the concentration and kinds of plastic in the samples, the team visually inspected the samples and applied pyrolysis-gas chromatography–mass spectrometry — a technique that allowed them to analyze the tissue’s chemical composition.

They found that the concentrations of particles in kidney and liver samples were comparable, with an average of 433 micrograms of microplastic per gram of tissue in the liver samples and 404 micrograms per gram of the kidney samples.

But the levels seen in the brain samples — all taken from the frontal lobe — dwarfed those numbers, and showed a jump over time. In the samples they harvested from people who died in 2016, they found average concentrations of 3,345 micrograms/gram. In the 2024 cohort, the average was 4,917.

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“I never would have imagined it was this high,” said Matthew Campen, professor of pharmaceutical sciences at the University of New Mexico. “I certainly don’t feel comfortable with this much plastic in my brain, and I don’t need to wait around 30 more years to find out what happens if the concentrations quadruple.”

The concentrations of microplastics the researchers found were independent of the biological age of the deceased person — it didn’t matter if the person was young or old when they died. What mattered was the year they died — the more recent the death, the more accumulated plastic in the body.

Intrigued by this increase in plastic concentration over time, the researchers obtained more brain tissue samples. This time, they examined brains from people who died between 1997 and 2013. They made sure the cadavers were similarly aged to the ones they had already examined — but could not control for geography. The second cohort all came from people who had died on the East Coast.

Again, the researchers found “significantly increasing trends for total plastics” over time in this second group of samples.

Polyethylene — a plastic polymer used to make things such as plastic bags, milk jugs, shampoo bottles, etc. — was the most common microplastic found in the brain. It comprised 75% of the plastic shards observed in the brain tissue samples. But the researchers also detected polypropylene (the plastic used to make yogurt cups and rigid takeout food containers), polyvinylchloride (which is used in most water pipes), and styrene-butadiene rubber (found in some pneumatic tires, shoe soles, brake pads and electrical insulation).

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The concentration of all of these plastics increased from 2016 to 2024, irrespective of the biological age of the cadaver.

They also noted that brain tissue harvested from patients who’d been diagnosed with dementia had higher concentrations of microplastics than those who hadn’t. Although it was a concerning observation, they noted that their sample size was small, and that hallmarks of dementia include brain tissue atrophy, impaired blood-brain barrier integrity, and poor brain clearance mechanisms — which could themselves lead to microplastic buildup.

Therefore, they could make no claims to causation — just correlation.

Landrigan said the work reinforces our knowledge “that we’re all exposed, that these things actually get into our bodies, into people of all ages” and that it “appears to be getting worse with time.”

He said it adds to the urgency of a Global Plastics Treaty — to cap plastic production — and which reached an impasse at the last round of negotiations in South Korea, in 2024. He said negotiators plan to reconvene later this year.

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According to Landrigan, it’s unclear how the United States, under President Trump, would approach the treaty. If Trump follows the advice of the fossil fuel proponents in his administration, it’s likely the U.S. will vote the deal down — or not even show up.

But if the Robert F. Kennedy Jr. element gets a seat at the table, the U.S. is a wild card, Landrigan said. Kennedy was openly critical of the Biden administration for not doing enough to stanch the flow of microplastics into the environment, and he penned a detailed plan that would ban most hazardous chemicals, reform the recycling infrastructure and curtail the production of plastics.

Landrigan said he has known Kennedy for decades, and would happily sit down with him to present this research and the growing number of studies showing the harms these particles — and the chemicals they carry — cause in the human body.

“I’m a pediatrician with the American Academy of Pediatrics, and we’ve always taken the position that the academy will do what it has to do to protect children’s health. We will always stand up for children. So, if there’s an opening there for conversation with Bobby, why not?” he said.

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One in five U.S. food and beverage products is made with synthetic dyes

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One in five U.S. food and beverage products is made with synthetic dyes

Odds are, something in your pantry is colored with petroleum.

Synthetic dyes — which give fruit snacks their bright colors and cereals their rainbow crunch — are embedded into the everyday foods that fill grocery store shelves, often in ways consumers don’t realize. However, concern over their health effects has been growing in recent years, fueled by mounting evidence that certain synthetic dyes may harm children’s long-term health.

A new study shows that the use of these chemicals in the manufacturing of foods and beverages in the U.S. is more widespread than many might expect. Nearly 1 in 5 food items and beverages sold in the U.S. contain synthetic dyes, and many of them are commonly marketed to children.

For many Americans, synthetic dyes such as Red 40 and Yellow 5 have become invisible staples of their diet. These petroleum-derived additives are commonly added to processed food and beverages to increase visual appeal and maintain color consistency. However, emerging research has made it clear that they also increase the risk of a range of adverse neurobehavioral effects — to which children are especially susceptible.

A national study published Tuesday in the Journal of the Academy of Nutrition and Dietetics looked at nearly 40,000 products produced by the top 25 U.S. food and beverage manufacturers, and found that synthetic food dyes were present in 19% of them.

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The study also determined that products using synthetic dyes were significantly more likely to be high in added sugars and low in nutritional quality. Even more concerning, researchers found that 28% of the products in categories most commonly marketed to children, including breakfast cereals, candy and sugar-sweetened beverages, contained synthetic dyes.

Although the study focuses on the prevalence of synthetic dyes in U.S. food and beverages, Elizabeth Dunford, a lecturer at the University of New South Wales and co-author of the study, noted that its findings reinforce concerns among parents and public health experts about the potential neurological and behavioral effects of these additives.

A 2021 assessment from the California Office of Environmental Health Hazard Assessment concluded that these additives can “cause or exacerbate neurobehavioral problems in children.” Similarly, a 2022 review found that 52% of studies found a significant association between synthetic dye consumption and adverse behavioral outcomes in children, both those with and without existing behavioral disorders.

These health concerns are not limited to behavioral problems. Red 3, for example, has been shown to cause cancer in laboratory rats, and Yellow 5 has been associated with allergic reactions in some individuals. However, despite decades of concern, current U.S. Food and Drug Administration registrations are still based on studies performed 35 to 50 years ago.

In the recent study, the most common dyes that Dunford and her team found were Red 40, Yellow 5, and Blue 1, appearing in 14%, 11%, and 11% of products, respectively. Synthetic dyes were found in such products as blueberry bagels, guacamole, corn chips and hot dog buns — items that consumers might not expect them. “Even as an educated person, I’ve been tricked,” Dunford said. “Consumers can be misled … when there are all these claims on the front of the pack that say ‘healthy’ or ‘made with real fruit juice,’ but it still has dyes.”

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The study found that foods and beverages containing synthetic dyes, on average, had 141% more sugar than dye-free products. The correlation between sugar and synthetic dyes was even more pronounced when it came to products marketed to kids: foods and beverages in the five categories most heavily marketed to children had a mean total sugar content of 42.6 grams per 100 grams — 264% higher than comparable products in other categories.

This marketing strategy, which pairs bright colors with high sugar content, may be part of the reason these foods are so appealing to kids.

But Dunford said that in her personal experience, children won’t notice if they’re given replacement options without those additives. When buying snacks for one of her kid’s parties, she opted for a version of a common brand of corn chips with no synthetic dyes or preservatives. “I gave them to kids at a party, and no one said anything.” Dunford said. “This just goes to show that it’s really the marketing that drives the desire for these products and causes the problems.”

Some steps have been taken to remove synthetic dyes from food and beverages. California banned Red 3 from all foods in 2023 and prohibited six other synthetic food dyes in foods sold in schools in 2024. More recently, in January of this year, the FDA announced that Red 3 will be banned nationwide in all food products by 2027. Warning labels are another potential option to limit synthetic dye consumption, and are being used in the European Union to identify foods containing Red 40, Yellow 5, and Yellow 6.

However, the burden still falls largely on consumers to scrutinize ingredient lists and marketing claims. For many families, that means navigating a colorful and oftentimes misleading food landscape, armed with little more than the fine print on the back of a box.

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Video: Axiom-4 Mission Takes Off for the I.S.S.

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Video: Axiom-4 Mission Takes Off for the I.S.S.

new video loaded: Axiom-4 Mission Takes Off for the I.S.S.

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Axiom-4 Mission Takes Off for the I.S.S.

Hungary, India and Poland sent astronauts to the International Space Station for the first time by paying Axiom Space for the journey.

3, 2, 1, ignition and liftoff. The three nations, a new chapter in space takes flight. Godspeed Axiom 4.

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Contributor: Those cuts to 'overhead' costs in research? They do real damage

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Contributor: Those cuts to 'overhead' costs in research? They do real damage

As a professor at UC Santa Barbara, I research the effects of and solutions to ocean pollution, including oil seeps, spills and offshore DDT. I began my career by investigating the interaction of bacteria and hydrocarbon gases in the ocean, looking at the unusual propensity of microbes to consume gases that bubbled in from beneath the ocean floor. Needed funding came from the greatest basic scientific enterprise in the world, the National Science Foundation.

My research was esoteric, or so my in-laws (and everyone else) thought, until 2010, when the Deepwater Horizon offshore drilling rig exploded and an uncontrolled flow of hydrocarbon liquid and gas jetted into the deep ocean offshore from Louisiana. It was an unmitigated disaster in the Gulf, and suddenly my esoteric work was in demand. Additional support from the National Science Foundation allowed me to go offshore to help figure out what was happening to that petroleum in the deep ocean. I was able to help explain, contextualize and predict what would happen next for anxious residents of the Gulf states — all made possible by the foresight of Vannevar Bush, the original architect of the National Science Foundation.

Now the great scientific enterprise that has enabled my research and so much more is on the brink of its own disaster, thanks to actions and proposals from the Trump administration. Setting aside the targeted cuts to centers of discovery such as Harvard and Columbia, and rumors that California’s public universities are next, the most obvious threats to research are the draconian budget reductions proposed across virtually all areas of science and medicine, coupled with moves to prevent foreign scientists from conducting research-based study in the U.S. The president’s latest budget calls for around a 55% cut to the National Science Foundation overall, with a 75% reduction to research support in my area. A reduction so severe and sudden will reverberate for years and decimate ocean discovery and study, and much more.

But a more subtle and equally dire cut is already underway — to funding for the indirect costs that enable universities and other institutions to host research. It seems hard to rally for indirect costs, which are sometimes called “overhead” or “facilities and administration.” But at their core, these funds facilitate science.

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For instance, indirect costs don’t pay my salary, but they do pay for small-ticket items like my lab coat and goggles and bigger-ticket items like use of my laboratory space. They don’t pay for the chromatograph I use in my experiments, but they do pay for the electricity to run it. They don’t pay for the sample tubes that feed into my chromatograph, but they do support the purchasing and receiving staff who helped me procure them. They don’t pay for the chemical reagents I put in those sample tubes, but they do support the safe disposal of the used reagents as well as the health and safety staff that facilitates my safe chemical use.

They don’t pay salary for my research assistants, but they do support the human resources unit through which I hire them. They don’t pay for international travel to present my research abroad, but they do cover a federally mandated compliance process to make sure I am not unduly influenced by a foreign entity.

In other words, indirect costs support the deep bench of supporting characters and services that enable me, the scientist, to focus on discovery. Without those services, my research enterprise crumbles, and new discoveries with it.

My indirect cost rate is negotiated every few years between my institution and the federal government. The negotiation is based on hard data showing the actual and acceptable research-related costs incurred by the institution, along with cost projections, often tied to federal mandates. Through this rigorous and iterative mechanism, the overhead rate at my institution — as a percentage of direct research costs — was recently adjusted to 56.5%. I wish it were less, but that is the actual cost of running a research project.

The present model for calculating indirect costs does have flaws and could be improved. But the reduction to 15% — as required by the Trump administration — will be devastating for scientists and institutions. All the functions I rely on to conduct science and train the future workforce will see staggering cuts. Three-quarters of my local research support infrastructure will crumble. The costs are indirect, but the effects will be immediate and direct.

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More concerning is that we will all suffer in the long term because of the discoveries, breakthroughs and life-changing advances that we fail to make.

The scientific greatness of the United States is fragile. Before the inception of the National Science Foundation, my grandfather was required to learn German for his biochemistry PhD at Penn State because Germany was then the world’s scientific leader. Should the president’s efforts to cut direct and indirect costs come to pass, it may be China tomorrow. That’s why today we need to remind our elected officials that the U.S. scientific enterprise pays exceptional dividends and that chaotic and punitive cuts risk irreparable harm to it.

David L. Valentine is a professor of marine microbiology and geochemistry at UC Santa Barbara.

Insights

L.A. Times Insights delivers AI-generated analysis on Voices content to offer all points of view. Insights does not appear on any news articles.

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This article generally aligns with a Center Left point of view. Learn more about this AI-generated analysis
Perspectives

The following AI-generated content is powered by Perplexity. The Los Angeles Times editorial staff does not create or edit the content.

Ideas expressed in the piece

  • The article contends that indirect costs (overhead) are essential for research infrastructure, covering critical expenses like laboratory maintenance, equipment operation, safety compliance, administrative support, and regulatory processes, without which scientific discovery cannot function[1].
  • It argues that the Trump administration’s policy capping indirect cost reimbursement at 15% would inflict “staggering cuts” to research support systems, collapsing three-quarters of existing infrastructure and crippling scientific progress[2][3].
  • The piece warns that broader proposed NSF budget cuts—57% agency-wide and 75% in ocean research—threaten to “decimate” U.S. scientific leadership, risking a shift in global innovation dominance to nations like China[3].
  • It emphasizes that these cuts ignore the actual negotiated costs of research (e.g., UC Santa Barbara’s 56.5% rate) and would undermine “discoveries, breakthroughs, and life-changing advances”[1].

Different views on the topic

  • The Trump administration frames indirect costs as excessive “overhead” unrelated to core research, justifying the 15% cap as a cost-saving measure to redirect funds toward prioritized fields like AI and biotechnology[1][2].
  • Officials assert that budget cuts focus resources on “national priorities” such as quantum computing, nuclear energy, and semiconductors, arguing that funding “all areas of science” is unsustainable under fiscal constraints[1][3].
  • The administration defends its stance against funding research on “misinformation” or “disinformation,” citing constitutional free speech protections and rejecting studies that could “advance a preferred narrative” on public issues[1].
  • Policymakers contend that reductions compel universities to streamline operations, though federal judges have blocked similar caps at other agencies (e.g., NIH, Energy Department) as “arbitrary and capricious”[2].
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