Science
As global plastic production grows, so does the concentration of microplastics in our brains
Finding microplastics in human body parts is not new: Scientists have uncovered the minuscule waste products in human blood, lungs, brains, hearts and testicles.
But a new study, published Monday in the journal Nature Medicine, shows a lockstep relationship between the amount of plastic found in tissues harvested from human cadavers and the amount being produced by the plastic industry.
As global plastic production has ramped up in the last 20 years, so too has the concentration of these shredded, fossil fuel-derived polymers in human tissue samples.
The findings are “pretty striking,” said Phil Landrigan, director of the Program for Global Public Health and the Common Good at Boston College, who was not affiliated with the research.
The study also showed a concerning correlation between patients who had received a dementia diagnosis before they died and the amount of plastic particles found in their brains — adding to a growing body of research indicating that the presence of these particles in the human body can potentially cause harm.
The study was published by a team of researchers at the University of New Mexico, Oklahoma State University, Duke University and Universidad del Valle, in Colombia.
The team acquired brain, liver and kidney tissue samples from patients who had undergone autopsies between 2016 and 2024 at the University of New Mexico.
To determine both the concentration and kinds of plastic in the samples, the team visually inspected the samples and applied pyrolysis-gas chromatography–mass spectrometry — a technique that allowed them to analyze the tissue’s chemical composition.
They found that the concentrations of particles in kidney and liver samples were comparable, with an average of 433 micrograms of microplastic per gram of tissue in the liver samples and 404 micrograms per gram of the kidney samples.
But the levels seen in the brain samples — all taken from the frontal lobe — dwarfed those numbers, and showed a jump over time. In the samples they harvested from people who died in 2016, they found average concentrations of 3,345 micrograms/gram. In the 2024 cohort, the average was 4,917.
“I never would have imagined it was this high,” said Matthew Campen, professor of pharmaceutical sciences at the University of New Mexico. “I certainly don’t feel comfortable with this much plastic in my brain, and I don’t need to wait around 30 more years to find out what happens if the concentrations quadruple.”
The concentrations of microplastics the researchers found were independent of the biological age of the deceased person — it didn’t matter if the person was young or old when they died. What mattered was the year they died — the more recent the death, the more accumulated plastic in the body.
Intrigued by this increase in plastic concentration over time, the researchers obtained more brain tissue samples. This time, they examined brains from people who died between 1997 and 2013. They made sure the cadavers were similarly aged to the ones they had already examined — but could not control for geography. The second cohort all came from people who had died on the East Coast.
Again, the researchers found “significantly increasing trends for total plastics” over time in this second group of samples.
Polyethylene — a plastic polymer used to make things such as plastic bags, milk jugs, shampoo bottles, etc. — was the most common microplastic found in the brain. It comprised 75% of the plastic shards observed in the brain tissue samples. But the researchers also detected polypropylene (the plastic used to make yogurt cups and rigid takeout food containers), polyvinylchloride (which is used in most water pipes), and styrene-butadiene rubber (found in some pneumatic tires, shoe soles, brake pads and electrical insulation).
The concentration of all of these plastics increased from 2016 to 2024, irrespective of the biological age of the cadaver.
They also noted that brain tissue harvested from patients who’d been diagnosed with dementia had higher concentrations of microplastics than those who hadn’t. Although it was a concerning observation, they noted that their sample size was small, and that hallmarks of dementia include brain tissue atrophy, impaired blood-brain barrier integrity, and poor brain clearance mechanisms — which could themselves lead to microplastic buildup.
Therefore, they could make no claims to causation — just correlation.
Landrigan said the work reinforces our knowledge “that we’re all exposed, that these things actually get into our bodies, into people of all ages” and that it “appears to be getting worse with time.”
He said it adds to the urgency of a Global Plastics Treaty — to cap plastic production — and which reached an impasse at the last round of negotiations in South Korea, in 2024. He said negotiators plan to reconvene later this year.
According to Landrigan, it’s unclear how the United States, under President Trump, would approach the treaty. If Trump follows the advice of the fossil fuel proponents in his administration, it’s likely the U.S. will vote the deal down — or not even show up.
But if the Robert F. Kennedy Jr. element gets a seat at the table, the U.S. is a wild card, Landrigan said. Kennedy was openly critical of the Biden administration for not doing enough to stanch the flow of microplastics into the environment, and he penned a detailed plan that would ban most hazardous chemicals, reform the recycling infrastructure and curtail the production of plastics.
Landrigan said he has known Kennedy for decades, and would happily sit down with him to present this research and the growing number of studies showing the harms these particles — and the chemicals they carry — cause in the human body.
“I’m a pediatrician with the American Academy of Pediatrics, and we’ve always taken the position that the academy will do what it has to do to protect children’s health. We will always stand up for children. So, if there’s an opening there for conversation with Bobby, why not?” he said.
Science
Department of Education finds San Jose State violated Title IX regarding transgender volleyball player
The U.S. Department of Education has given San José State 10 days to comply with a list of demands after finding that the university violated Title IX concerning a transgender volleyball player in 2024.
A federal investigation was launched into San José State a year ago after controversy over a transgender player marred the 2024 volleyball season. Four Mountain West Conference teams — Boise State, Wyoming, Utah State and Nevada-Reno — each chose to forfeit or cancel two conference matches to San José State. Boise State also forfeited its conference tournament semifinal match to the Spartans.
The transgender player, Blaire Fleming, was on the San José State roster for three seasons after transferring from Coastal Carolina, although opponents protested the player’s participation only in 2024.
In a news release Wednesday, the Education Department warned that San José State risks “imminent enforcement action” if it doesn’t voluntarily resolve the violations by taking the following actions, not all of which pertain solely to sports:
1) Issue a public statement that SJSU will adopt biology-based definitions of the words “male” and “female” and acknowledge that the sex of a human — male or female — is unchangeable.
2) Specify that SJSU will follow Title IX by separating sports and intimate facilities based on biological sex.
3) State that SJSU will not delegate its obligation to comply with Title IX to any external association or entity and will not contract with any entity that discriminates on the basis of sex.
4) Restore to female athletes all individual athletic records and titles misappropriated by male athletes competing in women’s categories, and issue a personalized letter of apology on behalf of SJSU to each female athlete for allowing her participation in athletics to be marred by sex discrimination.
5) Send a personalized apology to every woman who played in SJSU’s women’s indoor volleyball from 2022 to 2024, beach volleyball in 2023, and to any woman on a team that forfeited rather than compete against SJSU while a male student was on the roster — expressing sincere regret for placing female athletes in that position.
“SJSU caused significant harm to female athletes by allowing a male to compete on the women’s volleyball team — creating unfairness in competition, compromising safety, and denying women equal opportunities in athletics, including scholarships and playing time,” Kimberly Richey, Education Department assistant secretary for civil rights, said.
“Even worse, when female athletes spoke out, SJSU retaliated — ignoring sex-discrimination claims while subjecting one female SJSU athlete to a Title IX complaint for allegedly ‘misgendering’ the male athlete competing on a women’s team. This is unacceptable.”
San José State responded with a statement acknowledging that the Education Department had informed the university of its investigation and findings.
“The University is in the process of reviewing the Department’s findings and proposed resolution agreement,” the statement said. “We remain committed to providing a safe, respectful, and inclusive educational environment for all students while complying with applicable laws and regulations.”
In a New York Times profile, Fleming said she learned about transgender identity when she was in eighth grade. “It was a lightbulb moment,” she said. “I felt this huge relief and a weight off my shoulders. It made so much sense.”
With the support of her mother and stepfather, Fleming worked with a therapist and a doctor and started to socially and medically transition, according to the Times. When she joined the high school girls’ volleyball team, her coaches and teammates knew she was transgender and accepted her.
Fleming’s first two years at San José State were uneventful, but in 2024 co-captain Brooke Slusser joined lawsuits against the NCAA, the Mountain West Conference and representatives of San José State after alleging she shared hotel rooms and locker rooms with Fleming without being told she is transgender.
The Education Department also determined that Fleming and a Colorado State player conspired to spike Slusser in the face, although a Mountain West investigation found “insufficient evidence to corroborate the allegations of misconduct.” Slusser was not spiked in the face during the match.
President Trump signed an executive order a year ago designed to ban transgender athletes from competing on girls’ and women’s sports teams. The order stated that educational institutions and athletic associations may not ignore “fundamental biological truths between the two sexes.” The NCAA responded by banning transgender athletes.
The order, titled “Keeping Men Out of Women’s Sports,” gives federal agencies, including the Justice and Education departments, wide latitude to ensure entities that receive federal funding abide by Title IX in alignment with the Trump administration’s view, which interprets a person’s sex as the gender they were assigned at birth.
San José State has been in the federal government’s crosshairs ever since. If the university does not comply voluntarily to the actions listed by the government, it could face a Justice Department lawsuit and risk losing federal funding.
“We will not relent until SJSU is held to account for these abuses and commits to upholding Title IX to protect future athletes from the same indignities,” Richey said.
San José State was found in violation of Title IX in an unrelated case in 2021 and paid $1.6 million to more than a dozen female athletes after the Department of Justice found that the university failed to properly handle the students’ allegations of sexual abuse by a former athletic trainer.
The federal investigation found that San José State did not take adequate action in response to the athletes’ reports and retaliated against two employees who raised repeated concerns about Scott Shaw, the former director of sports medicine. Shaw was sentenced to 24 months in prison for unlawfully touching female student-athletes under the guise of providing medical treatment.
The current findings against San José State came two weeks after federal investigators announced that the California Community College Athletic Assn. and four other state colleges and school districts are the targets of a probe over whether their transgender participation policies violate Title IX.
The investigation targets a California Community College Athletic Assn. rule that allows transgender and nonbinary students to participate on women’s sports teams if the students have completed “at least one calendar year of testosterone suppression.”
Also, the Education Department’s Office of Civil Rights has launched 18 Title IX investigations into school districts across the United States on the heels of the Supreme Court hearing oral arguments on efforts to protect women’s and girls’ sports.
Science
The share of Americans medically obese is projected to rise to almost 50% by 2035
On Wednesday, a new study published in JAMA by researchers at the University of Washington in Seattle projected that by 2035, nearly half of all American adults, about 126 million individuals, will be living with obesity. The study draws on data from more than 11 million participants via the U.S. Centers for Disease Control and Prevention’s National Health and Nutrition Examination and Behavioral Risk Factor Surveillance System, and from the independent Gallup Daily Survey.
The projections show a striking increase in the prevalence of obesity over the past few decades in the U.S. In 1990, only 19.3% of U.S. adults were obese, according to the study. That figure more than doubled to 42.5% by 2022, and is forecast to reach 46.9% by 2035.
The study highlights significant disparities across states, ages, and racial and ethnic groups. While every state is expected to see increases, the sharpest rises are projected for Midwestern and Southern states.
For example, nationwide, by 2035, the study projects that 60% (11.5 million adults) of Black women and 54% (14.5 million) of Latino women will suffer from obesity when compared with 47% (36.5 million) of white women. Similarly, 48% (13.2 million) of Latino men will suffer from the disease compared with 45% (34.4 million) of white men and 43% (7.61 million) of Black men.
The findings say California will see similar trends in gender and racial disparities. The study projects that by 2035, obesity rates among Latino and Black women in California will reach nearly 60%, compared with nearly 40% for their white counterparts. Additionally, Latino men in California could see rates over 50%, compared with nearly 40% for their white counterparts.
“These numbers are not surprising, given the systemic inequalities that exist,” in many California cities, said Dr. Amanda Velazquez, director of obesity medicine at Cedars-Sinai Hospital, pointing to economic instability, chronic stress and the car-dependency of Los Angeles and other California metro areas. “There are challenges for access to nutritious foods, depending on where you’re at in the city,” Velazquez said. ”There’s also disparities in the access to healthcare, especially to treatment for obesity.”
That’s recently become more of a challenge, since changes in Medi-Cal plans that went into effect at the beginning of this year mean obesity medication and treatment are no longer covered for hundreds of thousands of low-income Californians. “To take that away is devastating,” said Velazquez.
Despite these disparities, California is projected to fare better than most other states, with its rates of obesity growing more slowly than the national average.
“There are statewide and local policies that influence food, nutrition and social determinants of health for individuals,” said Velazquez.
Church pointed to measures such as SB 12 and SB 677, passed in the mid 2000s, which set strict nutritional standards for schools, existing menu labeling laws at both the state and federal levels requiring restaurants to provide nutritional facts on menu items, and cities like Berkeley and Oakland imposing local soda taxes as key local and statewide initiatives to keep obesity at bay.
To keep up this momentum, both doctors stressed that California must continue to strengthen school nutrition standards, expand transportation infrastructure that encourages walking instead of driving, maintain and expand economic disincentives to unhealthy foods, such as beverage taxes, and address food deserts by incentivizing new grocery stores and farmers’ markets in underserved neighborhoods.
Future efforts, Church says, should prioritize the Black and Latino populations identified by the study as most affected.
Science
Pediatricians urge Americans to stick with previous vaccine schedule despite CDC’s changes
For decades, the American Academy of Pediatrics and the U.S. Centers for Disease Control and Prevention spoke with a single voice when advising the nation’s families on when to vaccinate their children.
Since 1995, the two organizations worked together to publish a single vaccine schedule for parents and healthcare providers that clearly laid out which vaccines children should get and exactly when they should get them.
Today, that united front has fractured. This month, the Department of Health and Human Services announced drastic changes to the CDC’s vaccine schedule, slashing the number of diseases that it recommends U.S. children be routinely vaccinated against to 11 from 17. That follows the CDC’s decision last year to reverse its recommendation that all kids get the COVID-19 vaccine.
On Monday, the AAP released its own immunization guidelines, which now look very different from the federal government’s. The organization, which represents most of the nation’s primary care and specialty doctors for children, recommends that children continue to be routinely vaccinated against 18 diseases, just as the CDC did before Robert F. Kennedy Jr. took over the nation’s health agencies.
Endorsed by a dozen medical groups, the AAP schedule is far and away the preferred version for most healthcare practitioners. California’s public health department recommends that families and physicians follow the AAP schedule.
“As there is a lot of confusion going on with the constant new recommendations coming out of the federal government, it is important that we have a stable, trusted, evidence-based immunization schedule to follow and that’s the AAP schedule,” said Dr. Pia Pannaraj, a member of AAP’s infectious disease committee and professor of pediatrics at UC San Diego.
Both schedules recommend that all children be vaccinated against measles, mumps, rubella, polio, pertussis, tetanus, diphtheria, Haemophilus influenzae type B (Hib), pneumococcal disease, human papillomavirus (HPV) and varicella (better known as chickenpox).
AAP urges families to also routinely vaccinate their kids against hepatitis A and B, COVID-19, rotavirus, flu, meningococcal disease and respiratory syncytial virus (RSV).
The CDC, on the other hand, now says these shots are optional for most kids, though it still recommends them for those in certain high-risk groups.
The schedules also vary in the recommended timing of certain shots. AAP advises that children get two doses of HPV vaccine starting at ages 9 to12, while the CDC recommends one dose at age 11 or 12. The AAP advocates starting the vaccine sooner, as younger immune systems produce more antibodies. While several recent studies found that a single dose of the vaccine confers as much protection as two, there is no single-dose HPV vaccine licensed in the U.S. yet.
The pediatricians’ group also continues to recommend the long-standing practice of a single shot combining the measles, mumps and rubella (MMR) and varicella vaccines in order to limit the number of jabs children get. In September, a key CDC advisory panel stocked with hand-picked Kennedy appointees recommended that the MMR and varicella vaccines be given as separate shots, a move that confounded public health experts for its seeming lack of scientific basis.
The AAP is one of several medical groups suing HHS. The AAP’s suit describes as “arbitrary and capricious” Kennedy’s alterations to the nation’s vaccine policy, most of which have been made without the thorough scientific review that previously preceded changes.
Days before AAP released its new guidelines, it was hit with a lawsuit from Children’s Health Defense, the anti-vaccine group Kennedy founded and previously led, alleging that its vaccine guidance over the years amounted to a form of racketeering.
The CDC’s efforts to collect the data that typically inform public health policy have noticeably slowed under Kennedy’s leadership at HHS. A review published Monday found that of 82 CDC databases previously updated at least once a month, 38 had unexplained interruptions, with most of those pauses lasting six months or longer. Nearly 90% of the paused databases included vaccination information.
“The evidence is damning: The administration’s anti-vaccine stance has interrupted the reliable flow of the data we need to keep Americans safe from preventable infections,” Dr. Jeanne Marrazzo wrote in an editorial for Annals of Internal Medicine, a scientific journal. Marrazzo, an infectious disease specialist, was fired last year as head of the National Institute of Allergy and Infectious Diseases after speaking out against the administration’s public health policies.
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