Science
A life-saving transplant awaits Arthur Yu — if the U.S. government lets his donor into the country
Arthur Yu was exhausted, but he chalked it up to being a new father.
Usually active, Yu was finding himself winded by the afternoon. He negotiated with his wife Alice to get just a little bit more sleep, thinking his fatigue was just a passing phase.
But four months after the birth of their son Abel, Yu was diagnosed with acute myeloid leukemia, a genetic mutation that formed in his bone marrow and spread to his blood. Thanks to several rounds of chemotherapy, Yu is currently in remission, but his doctors say that status is temporary and his best chance for beating the cancer is a stem cell transplant from a suitable donor.
Yu found an ideal match in a distant cousin, only he now has to convince the U.S. government to let that person into the country. And so far, the feds said no twice to granting a visa to his potential donor.
After the media strategist was diagnosed with leukemia last March, doctors asked his family to take cheek-swab DNA samples to see whether there were any suitable candidates for the procedure. None of his immediate relatives were a match, but a distant cousin was: Noel Talania, who lives in the rural Philippines countryside.
The two had never met, and neither is fluent in Tagalog, the most common language spoken among the Filipino diaspora. (Talania speaks Ilocano, the third-most spoken language in the Philippines.) So the two connected over Facebook Messenger last year and translated their words into their respective languages over translation programs.
Talania agreed to become a donor and understood the severity of the situation. Yu was realistic about all that he was asking from his cousin, and he was gracious about it.
“I feel like I’m asking of you too much,” Yu would write to his cousin. “That’s when it turns into sort of like a reminder of gratitude.”
Talania spent an entire day traveling from his rural town to the U.S. embassy in Manila on Dec. 18, according to 41-year-old Yu, who thought that by the beginning of 2024 he would be in the process of receiving a stem cell transplant at Cedars-Sinai in Los Angeles.
At his embassy interview, Talania was provided an interpreter who spoke Tagalog, not Ilocano, Alice Yu said, which wasn’t ideal for making his case. It was a sign of things to come: At the end of the meeting, an embassy official made it clear that the U.S. government was denying Talania’s application for a tourist visa. The official reason was stated in a boilerplate letter handed to Talania: The government held that Talania could not prove that he would return back to his home country after arriving in the U.S., as required by section 2.14(B) of the Immigration and Nationality Act, despite the facts that his wife and children live in the Philippines and that he has an established business there.
“When we applied for this visa in December, no one warned me that this was going to be a problem,” Yu said. “Even my doctors were surprised.”
Citizens of 41 countries are allowed to travel to the U.S. without a visa for business or tourism purposes, but the Philippines is not one of those nations.
Talania appealed the denial, and Yu’s family and friends reached out to any available resources to find a workaround. Inquiries by aides to U.S. Sen. Alex Padilla (D-Calif.) expedited the application process, and Talania was granted a second interview on Jan. 10.
Talania arrived with documents showing that Yu could afford to house Talania while undergoing the transplant procedure, along with a doctor’s note detailing Yu’s diagnosis and proof that Yu’s family were in contact with Padilla’s office. He also brought his marriage certificate and proof that he wants to return to the Philippines after the procedure.
But he was stopped before he could present any of it.
“They told him, ‘Oh, we don’t need to see that,’” Alice Yu said, recounting what an embassy official told Talania.
This time the embassy didn’t provide an interpreter, and the interviewer spoke to him only in English, Alice Yu said. The official did not look at any of the documents Talania brought with him and told him that his application was denied — again. Talania text messaged his cousin a single screen shot with two words hastily written: “Humanitarian parole.”
The phrase filled Yu with despair.
“I started to ask him, ‘Why are you texting me this? What is this? I know what [parole] is? Are you telling me you got denied?’” Yu recalled asking his cousin.
Humanitarian parole allows foreign nationals to enter the U.S. on a temporary basis due to an ongoing conflict in their home country. The application process has been used recently by Ukrainians fleeing the Russian invasion, but the process can take up to two years, according to immigration attorney Sameen Ahmadnia with the law firm Fragomen, Del Rey, Bernsen & Loewy.
Yu will have to make a sympathetic case to the U.S. government to show why his cousin should be allowed to enter the country.
“Only, there are a lot of sympathetic cases,” Ahmadnia said. “The problem is trying to get your case to stand out to a government official.”
Ahmadnia, who offered to work with Yu pro bono after she heard about his case, helped him file the application for humanitarian parole, with a bolstered list of documents to support his case. The hope is that somewhere along the process, someone will expedite his case.
For Yu, “up to two years” is time he does not have.
“If there’s a word for a rage-infused optimism this is it, because I’m thankful that I have this option, but I’m also furious that I have to use it,” Yu said.
The U.S. State Department did not respond to requests for comment. Yu’s story was first reported by news station KABC 7.
Yu’s survival rate with chemotherapy alone is minimal and comes with added risks to his health, according to his physician Dr. Ron Paquette, clinical director, Stem Cell and Bone Marrow Transplant Program with Cedars-Sinai Medical Center. Yu will need repeated chemotherapy treatments to keep his leukemia in remission, but every delay puts his life at risk.
Yu is in the “perfect place to proceed” with a transplant, Paquette said. There are some alternatives, like flying Talania to Mexico to donate his stem cells or using another donor who is not as close a match to Yu, but Paquette said the best chance is getting Talania to Cedars-Sinai.
While he’s unfamiliar with the visa process, Paquette urges government officials to “weigh the risks and benefits and read carefully” about Yu’s case.
“This is one person’s life on the line, where we can really make a difference in his long-term survival,” Paquette said.
Yu has “golden retriever energy” according to his wife Alice, even with his cancer diagnosis, chemotherapy treatment, the unexpected death of his father and the battle to get Talania a visa.
“If you just met him, you wouldn’t even know that he’s been through all of this in the past year,” Alice Yu said.
Alice Yu is a surgical nurse at Cedars-Sinai, and when she’s not raising their son with Yu, she’s taking care of her husband — when he lets her, that is, because he’s usually such an independent person. During his most recent chemotherapy treatment, Yu continued to clock into work, because he plans to save his remaining sick days for when he receives the stem cell transplant.
When that day comes, Alice Yu will become his caregiver 24/7 because it will take him more than a year for his immune system to recover.
But she’s also noticed her husband taking time to explain mundane tasks he usually tackled around the house, like paying their property taxes or working the remote controls in the home.
“It’s all to prepare me for when he’s not here,” she said, her voice breaking.
When Talania reported from Manila that he was denied a visa for the second time, it was late at night in Los Angeles. The message landed with a crash in the Yu home. Not knowing what to do, Alice and Arthur ate some strudels from Porto’s Bakery.
“We calmed down a bit, and then we went to sleep. There’s nothing else you can do at that point,” Yu said.
Without a transplant, his doctors arranged for another round of chemotherapy. Yu agreed, but before he went into the hospital he took his 14-month-old son to ride the trains at Griffith Park’s Travel Town just like he did when he was a child.
He also hastily arranged to baptize Abel at Cathedral Chapel of St. Vibiana, the same chapel where he married Alice.
Science
Cluster of farmworkers diagnosed with rare animal-borne disease in Ventura County
A cluster of workers at Ventura County berry farms have been diagnosed with a rare disease often transmitted through sick animals’ urine, according to a public health advisory distributed to local doctors by county health officials Tuesday.
The bacterial infection, leptospirosis, has resulted in severe symptoms for some workers, including meningitis, an inflammation of the brain lining and spinal cord. Symptoms for mild cases included headaches and fevers.
The disease, which can be fatal, rarely spreads from human to human, according to the U.S. Centers for Disease Control and Prevention.
Ventura County Public Health has not given an official case count but said it had not identified any cases outside of the agriculture sector. The county’s agriculture commissioner was aware of 18 cases, the Ventura County Star reported.
The health department said it was first contacted by a local physician in October, who reported an unusual trend in symptoms among hospital patients.
After launching an investigation, the department identified leptospirosis as a probable cause of the illness and found most patients worked on caneberry farms that utilize hoop houses — greenhouse structures to shelter the crops.
As the investigation to identify any additional cases and the exact sources of exposure continues, Ventura County Public Health has asked healthcare providers to consider a leptospirosis diagnosis for sick agricultural workers, particularly berry harvesters.
Rodents are a common source and transmitter of disease, though other mammals — including livestock, cats and dogs — can transmit it as well.
The disease is spread through bodily fluids, such as urine, and is often contracted through cuts and abrasions that contact contaminated water and soil, where the bacteria can survive for months.
Humans can also contract the illness through contaminated food; however, the county health agency has found no known health risks to the general public, including through the contact or consumption of caneberries such as raspberries and blackberries.
Symptom onset typically occurs between two and 30 days after exposure, and symptoms can last for months if untreated, according to the CDC.
The illness often begins with mild symptoms, with fevers, chills, vomiting and headaches. Some cases can then enter a second, more severe phase that can result in kidney or liver failure.
Ventura County Public Health recommends agriculture and berry harvesters regularly rinse any cuts with soap and water and cover them with bandages. They also recommend wearing waterproof clothing and protection while working outdoors, including gloves and long-sleeve shirts and pants.
While there is no evidence of spread to the larger community, according to the department, residents should wash hands frequently and work to control rodents around their property if possible.
Pet owners can consult a veterinarian about leptospirosis vaccinations and should keep pets away from ponds, lakes and other natural bodies of water.
Science
Political stress: Can you stay engaged without sacrificing your mental health?
It’s been two weeks since Donald Trump won the presidential election, but Stacey Lamirand’s brain hasn’t stopped churning.
“I still think about the election all the time,” said the 60-year-old Bay Area resident, who wanted a Kamala Harris victory so badly that she flew to Pennsylvania and knocked on voters’ doors in the final days of the campaign. “I honestly don’t know what to do about that.”
Neither do the psychologists and political scientists who have been tracking the country’s slide toward toxic levels of partisanship.
Fully 69% of U.S. adults found the presidential election a significant source of stress in their lives, the American Psychological Assn. said in its latest Stress in America report.
The distress was present across the political spectrum, with 80% of Republicans, 79% of Democrats and 73% of independents surveyed saying they were stressed about the country’s future.
That’s unhealthy for the body politic — and for voters themselves. Stress can cause muscle tension, headaches, sleep problems and loss of appetite. Chronic stress can inflict more serious damage to the immune system and make people more vulnerable to heart attacks, strokes, diabetes, infertility, clinical anxiety, depression and other ailments.
In most circumstances, the sound medical advice is to disengage from the source of stress, therapists said. But when stress is coming from politics, that prescription pits the health of the individual against the health of the nation.
“I’m worried about people totally withdrawing from politics because it’s unpleasant,” said Aaron Weinschenk, a political scientist at the University of Wisconsin–Green Bay who studies political behavior and elections. “We don’t want them to do that. But we also don’t want them to feel sick.”
Modern life is full of stressors of all kinds: paying bills, pleasing difficult bosses, getting along with frenemies, caring for children or aging parents (or both).
The stress that stems from politics isn’t fundamentally different from other kinds of stress. What’s unique about it is the way it encompasses and enhances other sources of stress, said Brett Ford, a social psychologist at the University of Toronto who studies the link between emotions and political engagement.
For instance, she said, elections have the potential to make everyday stressors like money and health concerns more difficult to manage as candidates debate policies that could raise the price of gas or cut off access to certain kinds of medical care.
Layered on top of that is the fact that political disagreements have morphed into moral conflicts that are perceived as pitting good against evil.
“When someone comes into power who is not on the same page as you morally, that can hit very deeply,” Ford said.
Partisanship and polarization have raised the stakes as well. Voters who feel a strong connection to a political party become more invested in its success. That can make a loss at the ballot box feel like a personal defeat, she said.
There’s also the fact that we have limited control over the outcome of an election. A patient with heart disease can improve their prognosis by taking medicine, changing their diet, getting more exercise or quitting smoking. But a person with political stress is largely at the mercy of others.
“Politics is many forms of stress all rolled into one,” Ford said.
Weinschenk observed this firsthand the day after the election.
“I could feel it when I went into my classroom,” said the professor, whose research has found that people with political anxiety aren’t necessarily anxious in general. “I have a student who’s transgender and a couple of students who are gay. Their emotional state was so closed down.”
That’s almost to be expected in a place like Wisconsin, whose swing-state status caused residents to be bombarded with political messages. The more campaign ads a person is exposed to, the greater the risk of being diagnosed with anxiety, depression or another psychological ailment, according to a 2022 study in the journal PLOS One.
Political messages seem designed to keep voters “emotionally on edge,” said Vaile Wright, a licensed psychologist in Villa Park, Ill., and a member of the APA’s Stress in America team.
“It encourages emotion to drive our decision-making behavior, as opposed to logic,” Wright said. “When we’re really emotionally stimulated, it makes it so much more challenging to have civil conversation. For politicians, I think that’s powerful, because emotions can be very easily manipulated.”
Making voters feel anxious is a tried-and-true way to grab their attention, said Christopher Ojeda, a political scientist at UC Merced who studies mental health and politics.
“Feelings of anxiety can be mobilizing, definitely,” he said. “That’s why politicians make fear appeals — they want people to get engaged.”
On the other hand, “feelings of depression are demobilizing and take you out of the political system,” said Ojeda, author of “The Sad Citizen: How Politics is Depressing and Why it Matters.”
“What [these feelings] can tell you is, ‘Things aren’t going the way I want them to. Maybe I need to step back,’” he said.
Genessa Krasnow has been seeing a lot of that since the election.
The Seattle entrepreneur, who also campaigned for Harris, said it grates on her to see people laughing in restaurants “as if nothing had happened.” At a recent book club meeting, her fellow group members were willing to let her vent about politics for five minutes, but they weren’t interested in discussing ways they could counteract the incoming president.
“They’re in a state of disengagement,” said Krasnow, who is 56. She, meanwhile, is looking for new ways to reach young voters.
“I am exhausted. I am so sad,” she said. “But I don’t believe that disengaging is the answer.”
That’s the fundamental trade-off, Ojeda said, and there’s no one-size-fits-all solution.
“Everyone has to make a decision about how much engagement they can tolerate without undermining their psychological well-being,” he said.
Lamirand took steps to protect her mental health by cutting social media ties with people whose values aren’t aligned with hers. But she will remain politically active and expects to volunteer for phone-banking duty soon.
“Doing something is the only thing that allows me to feel better,” Lamirand said. “It allows me to feel some level of control.”
Ideally, Ford said, people would not have to choose between being politically active and preserving their mental health. She is investigating ways to help people feel hopeful, inspired and compassionate about political challenges, since these emotions can motivate action without triggering stress and anxiety.
“We want to counteract this pattern where the more involved you are, the worse you are,” Ford said.
The benefits would be felt across the political spectrum. In the APA survey, similar shares of Democrats, Republicans and independents agreed with statements like, “It causes me stress that politicians aren’t talking about the things that are most important to me,” and, “The political climate has caused strain between my family members and me.”
“Both sides are very invested in this country, and that is a good thing,” Wright said. “Antipathy and hopelessness really doesn’t serve us in the long run.”
Science
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